ES2055523T3 - Agentes antifungicos de triazol. - Google Patents

Agentes antifungicos de triazol.

Info

Publication number
ES2055523T3
ES2055523T3 ES91300553T ES91300553T ES2055523T3 ES 2055523 T3 ES2055523 T3 ES 2055523T3 ES 91300553 T ES91300553 T ES 91300553T ES 91300553 T ES91300553 T ES 91300553T ES 2055523 T3 ES2055523 T3 ES 2055523T3
Authority
ES
Spain
Prior art keywords
sub
triazol
antifungal agents
alcali
ocf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91300553T
Other languages
English (en)
Other versions
ES2055523T4 (es
Inventor
Stephen James Dr Ray
Kenneth Dr Richardson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10670334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2055523(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2055523T3 publication Critical patent/ES2055523T3/es
Anticipated expiration legal-status Critical
Publication of ES2055523T4 publication Critical patent/ES2055523T4/es
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION PROPORCIONA COMPUESTOS ANTIHONGOS DE LA FORMULA: Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, DONDE: R ES UN FENILO SUSTITUIDO POR 1 A 3 SUSTITUTOS, CADA UNO SELECCIONADO INDEPENDIENTEMENTE DEL HALO, -CF SUB 3 Y -OCF SUB 3; R ELEVADO 1 EN UN ALCALI C SUB 1 -C SUB 6; R (AL CUADRADO) EN H O UN ALCALI C SUB 1 -C SUB 4; X ES CH O N; Y Y ES F O CL.
ES91300553T 1990-02-02 1991-01-24 Agentes antifungicos de triazol. Expired - Lifetime ES2055523T4 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909002375A GB9002375D0 (en) 1990-02-02 1990-02-02 Triazole antifungal agents

Publications (2)

Publication Number Publication Date
ES2055523T3 true ES2055523T3 (es) 1994-08-16
ES2055523T4 ES2055523T4 (es) 2011-04-11

Family

ID=10670334

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91300553T Expired - Lifetime ES2055523T4 (es) 1990-02-02 1991-01-24 Agentes antifungicos de triazol.

Country Status (42)

Country Link
US (2) US5567817A (es)
EP (1) EP0440372B1 (es)
JP (2) JP2625584B2 (es)
KR (1) KR930011039B1 (es)
CN (2) CN1026788C (es)
AP (2) AP9000237A0 (es)
AT (1) ATE90090T1 (es)
AU (1) AU625188B2 (es)
BA (1) BA97298A (es)
BG (1) BG60032A3 (es)
BR (1) BR9100435A (es)
CA (2) CA2035314C (es)
CZ (1) CZ279339B6 (es)
DE (2) DE10299035I2 (es)
DK (1) DK0440372T3 (es)
EG (1) EG19750A (es)
ES (1) ES2055523T4 (es)
FI (3) FI107608B (es)
GB (1) GB9002375D0 (es)
HK (1) HK219396A (es)
HU (2) HU205351B (es)
IE (1) IE64774B1 (es)
IL (2) IL110322A (es)
IN (1) IN176148B (es)
IS (1) IS1629B (es)
LU (1) LU90960I2 (es)
LV (1) LV10615B (es)
MA (1) MA22054A1 (es)
MX (1) MX24363A (es)
MY (1) MY105494A (es)
NL (1) NL300100I2 (es)
NO (2) NO176796C (es)
NZ (1) NZ247205A (es)
OA (1) OA09480A (es)
PE (1) PE31691A1 (es)
PL (3) PL169332B1 (es)
PT (1) PT96617B (es)
RO (1) RO109648B1 (es)
RU (2) RU2114838C1 (es)
SK (1) SK278215B6 (es)
YU (1) YU48105B (es)
ZA (1) ZA91761B (es)

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GB9121456D0 (en) * 1991-10-10 1991-11-27 Pfizer Ltd Triazole antifungal agents
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GB9516121D0 (en) * 1995-08-05 1995-10-04 Pfizer Ltd Organometallic addition to ketones
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GB9713149D0 (en) * 1997-06-21 1997-08-27 Pfizer Ltd Pharmaceutical formulations
CN1081189C (zh) * 1998-07-17 2002-03-20 国家医药管理局四川抗菌素工业研究所 唑醇类新衍生物及其制备方法和医药用途
GB9818258D0 (en) * 1998-08-21 1998-10-14 Pfizer Ltd Antifungal compositions
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US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6391903B1 (en) * 1999-09-09 2002-05-21 Sankyo Company, Limited Triazole derivatives having antifungal activity
US6319933B1 (en) 2000-04-17 2001-11-20 Basilea Pharmaceutica Ag Azole derivatives
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
AU2002249935A1 (en) 2001-01-08 2002-08-19 Neorx Corporation Radioactively labelled conjugates of phosphonates
HUP0303249A3 (en) 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
WO2003051403A1 (en) 2001-12-13 2003-06-26 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
CN100579977C (zh) * 2002-10-08 2010-01-13 许永翔 制备三唑类抗真菌药物的方法
US20040098839A1 (en) * 2002-11-27 2004-05-27 Pfizer Inc. Crystallization method and apparatus using an impinging plate assembly
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US20110224232A1 (en) * 2008-05-06 2011-09-15 Board Of Regents, The University Of Texas System Treatment of Pulmonary Fungal Infection With Voriconazole via Inhalation
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US20110312977A1 (en) * 2009-02-17 2011-12-22 Glenmark Generics Limited Process for the preparation of voriconazole
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CN106117186B (zh) * 2016-06-12 2018-08-24 重庆莱美隆宇药业有限公司 一种伏立康唑及其中间体的制备方法
CN107556294A (zh) * 2016-06-30 2018-01-09 陕西合成药业股份有限公司 一种新型抗真菌感染药物及其制备方法和用途
TWI728172B (zh) 2016-08-18 2021-05-21 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
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CN111440152B (zh) * 2020-05-18 2022-09-27 浙江诚意药业股份有限公司 一种伏立康唑的制备方法
CN112079819B (zh) * 2020-09-24 2022-06-17 南京易亨制药有限公司 一种改进的伏立康唑消旋体制备方法
CN114907319A (zh) * 2021-02-06 2022-08-16 华创合成制药股份有限公司 一种氘代三唑类化合物及其制备方法和用途
CN115724829A (zh) * 2022-12-23 2023-03-03 天津力生制药股份有限公司 一种分离真菌药物中间体杂质的液相色谱制备方法

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ZA91761B (en) 1992-09-30
FI20000084A (fi) 2000-01-17
AP223A (en) 1992-08-27
IE910342A1 (en) 1991-08-14
IL97045A0 (en) 1992-03-29
ES2055523T4 (es) 2011-04-11
NZ247205A (en) 1993-09-27
CS9100249A2 (en) 1991-09-15
JP2625584B2 (ja) 1997-07-02
JPH04211078A (ja) 1992-08-03
ATE90090T1 (de) 1993-06-15
NO176796C (no) 1995-05-31
IS3671A7 (is) 1991-08-03
CZ279339B6 (cs) 1995-04-12
RU2114838C1 (ru) 1998-07-10
FI971238A0 (fi) 1997-03-25
EP0440372B1 (en) 1993-06-02
IN176148B (es) 1996-02-10
CA2285891C (en) 2004-01-06
HUT56361A (en) 1991-08-28
CN1053787A (zh) 1991-08-14
FI910508A0 (fi) 1991-02-01
MA22054A1 (fr) 1991-10-01
FI971238A (fi) 1997-03-25
DE69100095D1 (de) 1993-07-08
EP0440372A1 (en) 1991-08-07
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NO910368L (no) 1991-08-05
FI107608B (fi) 2001-09-14
AU7022391A (en) 1991-09-05
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US5567817A (en) 1996-10-22
IL110322A (en) 1996-10-31
US5773443A (en) 1998-06-30
BR9100435A (pt) 1991-10-22
IL110322A0 (en) 1994-10-21
YU17591A (sh) 1994-01-20
DE10299035I1 (de) 2003-05-22
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PL167294B1 (pl) 1995-08-31
LV10615B (en) 1995-12-20
BG60032A3 (en) 1993-07-15
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MX24363A (es) 1993-09-01
CA2285891A1 (en) 1991-08-03
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CA2035314A1 (en) 1991-08-03
IL97045A (en) 1995-11-27
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HU211582A9 (en) 1995-12-28
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FI910508A (fi) 1991-08-03
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LV10615A (lv) 1995-04-20
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