MA22054A1 - Procede de production de derives de triazole antifongiques. - Google Patents

Procede de production de derives de triazole antifongiques.

Info

Publication number
MA22054A1
MA22054A1 MA22327A MA22327A MA22054A1 MA 22054 A1 MA22054 A1 MA 22054A1 MA 22327 A MA22327 A MA 22327A MA 22327 A MA22327 A MA 22327A MA 22054 A1 MA22054 A1 MA 22054A1
Authority
MA
Morocco
Prior art keywords
triazole derivatives
antifungal triazole
producing antifungal
producing
derivatives
Prior art date
Application number
MA22327A
Other languages
English (en)
Inventor
K Richardson
S I Ray
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10670334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA22054(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of MA22054A1 publication Critical patent/MA22054A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MA22327A 1990-02-02 1991-02-01 Procede de production de derives de triazole antifongiques. MA22054A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909002375A GB9002375D0 (en) 1990-02-02 1990-02-02 Triazole antifungal agents

Publications (1)

Publication Number Publication Date
MA22054A1 true MA22054A1 (fr) 1991-10-01

Family

ID=10670334

Family Applications (1)

Application Number Title Priority Date Filing Date
MA22327A MA22054A1 (fr) 1990-02-02 1991-02-01 Procede de production de derives de triazole antifongiques.

Country Status (42)

Country Link
US (2) US5567817A (fr)
EP (1) EP0440372B1 (fr)
JP (2) JP2625584B2 (fr)
KR (1) KR930011039B1 (fr)
CN (2) CN1026788C (fr)
AP (2) AP9000237A0 (fr)
AT (1) ATE90090T1 (fr)
AU (1) AU625188B2 (fr)
BA (1) BA97298A (fr)
BG (1) BG60032B2 (fr)
BR (1) BR9100435A (fr)
CA (2) CA2285891C (fr)
CZ (1) CZ279339B6 (fr)
DE (2) DE10299035I2 (fr)
DK (1) DK0440372T3 (fr)
EG (1) EG19750A (fr)
ES (1) ES2055523T4 (fr)
FI (3) FI107608B (fr)
GB (1) GB9002375D0 (fr)
HK (1) HK219396A (fr)
HU (2) HU205351B (fr)
IE (1) IE64774B1 (fr)
IL (2) IL110322A (fr)
IN (1) IN176148B (fr)
IS (1) IS1629B (fr)
LU (1) LU90960I2 (fr)
LV (1) LV10615B (fr)
MA (1) MA22054A1 (fr)
MX (1) MX24363A (fr)
MY (1) MY105494A (fr)
NL (1) NL300100I2 (fr)
NO (2) NO176796C (fr)
NZ (1) NZ247205A (fr)
OA (1) OA09480A (fr)
PE (1) PE31691A1 (fr)
PL (3) PL169332B1 (fr)
PT (1) PT96617B (fr)
RO (1) RO109648B1 (fr)
RU (2) RU2036194C1 (fr)
SK (1) SK278215B6 (fr)
YU (1) YU48105B (fr)
ZA (1) ZA91761B (fr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
GB9121456D0 (en) * 1991-10-10 1991-11-27 Pfizer Ltd Triazole antifungal agents
GB2281297A (en) * 1993-08-27 1995-03-01 Merck & Co Inc Quinazoline compounds
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
DE19500379A1 (de) * 1995-01-09 1996-07-11 Basf Ag Fluorierte Pyrimidine als Herbizide
GB9516121D0 (en) * 1995-08-05 1995-10-04 Pfizer Ltd Organometallic addition to ketones
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
GB9605705D0 (en) * 1996-03-19 1996-05-22 Pfizer Ltd Therapeutic agents
US7193083B2 (en) * 1996-07-26 2007-03-20 Pfizer, Inc. Preparation of triazoles by organometallic addition to ketones and intermediates therefor
GB9713149D0 (en) * 1997-06-21 1997-08-27 Pfizer Ltd Pharmaceutical formulations
CN1081189C (zh) * 1998-07-17 2002-03-20 国家医药管理局四川抗菌素工业研究所 唑醇类新衍生物及其制备方法和医药用途
GB9818258D0 (en) * 1998-08-21 1998-10-14 Pfizer Ltd Antifungal compositions
JP2003501488A (ja) * 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6391903B1 (en) * 1999-09-09 2002-05-21 Sankyo Company, Limited Triazole derivatives having antifungal activity
US6319933B1 (en) 2000-04-17 2001-11-20 Basilea Pharmaceutica Ag Azole derivatives
CA2434302A1 (fr) * 2001-01-08 2002-08-15 Neorx Corporation Composes, compositions et methodes therapeutiques et diagnostiques
HUP0303249A3 (en) 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
WO2003051403A1 (fr) 2001-12-13 2003-06-26 Dow Global Technologies Inc. Traitement de l'osteomyelite avec des produits radiopharmaceutiques
EP2316468A1 (fr) 2002-02-22 2011-05-04 Shire LLC Système de distribution et méthodes de protection et d'administration de dextroamphetamine
CN100379733C (zh) * 2002-10-08 2008-04-09 南京康泽医药科技有限公司 三唑类抗真菌药物及其制备方法
US20040098839A1 (en) * 2002-11-27 2004-05-27 Pfizer Inc. Crystallization method and apparatus using an impinging plate assembly
CA2590687C (fr) 2004-12-14 2013-09-10 Dr. Reddy's Laboratories Ltd. Procede de preparation de voriconazole
WO2006109933A1 (fr) 2005-03-30 2006-10-19 Daewoong Pharmaceutical Co., Ltd. Derives de triazole antifongiques
EP2024344A2 (fr) * 2006-02-01 2009-02-18 Medichem, S.A. Procédé de préparation de voriconazole, nouvelle forme polymorphe d'un produit intermédiaire de ce composé et utilisations dudit composé
AR061889A1 (es) * 2006-07-13 2008-10-01 Medichem Sa Proceso mejorado para la preparacion de voriconazol
CN1919846B (zh) * 2006-09-14 2013-01-02 大道隆达（北京）医药科技发展有限公司 伏立康唑及其药用盐、中间体的一种新定向合成制备方法
EP2086546B1 (fr) * 2006-11-21 2013-07-10 Viamet Pharmaceuticals, Inc. Inhibiteurs de la métallo-oxydoréductase faisant appel à des fractions se liant aux métaux en combinaison avec des fractions de ciblage
KR100889937B1 (ko) * 2007-08-06 2009-03-20 한미약품 주식회사 보리코나졸의 제조방법
GB2452049A (en) * 2007-08-21 2009-02-25 Alpharma Aps Process for the preparation of voriconazole
CN101575330B (zh) * 2008-05-05 2012-10-31 丽珠医药集团股份有限公司 伏立康唑广谱抗真菌药物化合物、其组合物及用途
WO2009137611A2 (fr) * 2008-05-06 2009-11-12 Board Of Regents, The University Of Texas System Traitement d’infection fongique pulmonaire avec du voriconazole et par inhalation
JP2009286756A (ja) 2008-05-30 2009-12-10 Fujifilm Finechemicals Co Ltd トリアゾール誘導体またはその塩
EP2303265B1 (fr) * 2008-06-06 2014-12-10 Glenmark Pharmaceuticals Limited Formulation topique stable comprenant du voriconazole
WO2010095145A1 (fr) * 2009-02-17 2010-08-26 Glenmark Generics Limited Procédé de préparation de voriconazole
KR101109215B1 (ko) 2009-06-17 2012-01-30 보령제약 주식회사 보리코나졸의 신규 중간체 및 이를 이용한 보리코나졸의 제조방법
WO2011020605A1 (fr) 2009-08-19 2011-02-24 Ratiopharm Gmbh Procédé de production de co-évaporats et de complexes comprenant un voriconazole et une cyclodextrine
KR20120104975A (ko) 2009-10-01 2012-09-24 앱탈리스 파마테크, 인코포레이티드 경구 투여용 코르티코스테로이드 조성물
WO2011064558A2 (fr) 2009-11-30 2011-06-03 Cipla Limited Composition pharmaceutique
MTP4285B (en) 2009-12-30 2011-07-04 Medichem Sa A 1-(1h-1,2,3-triazol-1-yl)butan-2-ol derivative for pharmaceutical use, and the use of a 1-(1h-1, 2, 4- triazol-1yl) butan-2-ol derivative with substially undefined crystal shap for preparing said 1-(1h-1, 2, 4-triazol-1-yl0 butan-2-ol derivative
KR100971371B1 (ko) 2010-02-04 2010-07-20 동국제약 주식회사 신규한 중간체를 이용한 보리코나졸의 제조방법
EP2545039A1 (fr) 2010-03-10 2013-01-16 Synthon BV Procédé de préparation de voriconazole
EP2409699B1 (fr) * 2010-07-23 2014-04-30 Combino Pharm, S.L. Compositions stables de voriconazole
CN101914091B (zh) * 2010-07-25 2015-05-27 浙江华海药业股份有限公司 一种制备伏立康唑中间体的方法
PL2678333T3 (pl) 2011-02-21 2015-08-31 Ranbaxy Laboratories Ltd Ulepszony sposób otrzymywania worykonazolu i jego produktów pośrednich
PL2720723T3 (pl) 2011-06-15 2018-10-31 Synthon Bv Stabilizowana kompozycja worykonazolu
EP2561863A1 (fr) 2011-08-22 2013-02-27 Farmaprojects, S.A.U. Compositions pharmaceutiques comportant du voriconazole
US20150133472A1 (en) 2012-05-11 2015-05-14 Cipla Limited Pharmaceutical composition
DK2906555T3 (en) 2012-10-15 2017-02-06 Pfizer Ireland Pharmaceuticals Process for the preparation of voriconazole and analogs thereof
ES2621386T3 (es) * 2013-02-04 2017-07-03 Syngenta Participations Ag Microbicidas novedosos
WO2015034678A2 (fr) 2013-09-06 2015-03-12 Aptalis Pharmatech, Inc. Corticostéroïde contenant des compositions de comprimés se désintégrant par voie orale pour œsophagite à éonisophiles
JP6262972B2 (ja) * 2013-09-17 2018-01-17 公益財団法人微生物化学研究会 化合物、及びその製造方法、並びにボリコナゾールの製造方法
WO2016156294A1 (fr) 2015-04-02 2016-10-06 Bayer Cropscience Aktiengesellschaft Dérivés de triazole utiles en tant que fongicides
CN104987325B (zh) * 2015-06-30 2017-03-29 扬子江药业集团南京海陵药业有限公司 一种伏立康唑的制备方法
CN106117186B (zh) * 2016-06-12 2018-08-24 重庆莱美隆宇药业有限公司 一种伏立康唑及其中间体的制备方法
CN107556294A (zh) * 2016-06-30 2018-01-09 陕西合成药业股份有限公司 一种新型抗真菌感染药物及其制备方法和用途
TWI777515B (zh) 2016-08-18 2022-09-11 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
BR112019010816A2 (pt) * 2016-11-28 2019-10-01 Cellix Bio Private Ltd composto de fórmula i, composto de fórmula ii, composto de fórmula iii, composto de fórmula iv, composto de fórmula v, composição farmacêutica, compostos, composto de fórmula viii, composto de fórmula ix, e composto de fórmula x
US11185548B2 (en) 2016-12-23 2021-11-30 Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases
CN108456194B (zh) * 2017-02-17 2021-06-22 武汉朗来科技发展有限公司 三氮唑抗菌衍生物、其药物组合物和用途
CN109705102A (zh) 2019-02-19 2019-05-03 浙江华海立诚药业有限公司 伏立康唑及其中间体的制备方法
CN111440152B (zh) * 2020-05-18 2022-09-27 浙江诚意药业股份有限公司 一种伏立康唑的制备方法
CN112079819B (zh) * 2020-09-24 2022-06-17 南京易亨制药有限公司 一种改进的伏立康唑消旋体制备方法
CN114907319B (zh) * 2021-02-06 2024-06-14 华创合成制药股份有限公司 一种氘代三唑类化合物及其制备方法和用途
CN115724829A (zh) * 2022-12-23 2023-03-03 天津力生制药股份有限公司 一种分离真菌药物中间体杂质的液相色谱制备方法

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000138A (en) * 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
US3980781A (en) * 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
DE2431407C2 (de) * 1974-06-29 1982-12-02 Bayer Ag, 5090 Leverkusen 1,2,4-Triazol-1-yl-alkanone und -alkanole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
US4927839A (en) * 1979-03-07 1990-05-22 Imperial Chemical Industries Plc Method of preventing fungal attack on wood, hides, leather or paint films using a triazole
US4551469A (en) * 1979-03-07 1985-11-05 Imperial Chemical Industries Plc Antifungal triazole ethanol derivatives
US4654332A (en) * 1979-03-07 1987-03-31 Imperial Chemical Industries Plc Heterocyclic compounds
US4259505A (en) * 1980-03-04 1981-03-31 Ciba-Geigy Corporation Process for the preparation of 1H-azole derivatives
US5395942A (en) * 1980-06-02 1995-03-07 Zeneca Limited Heterocyclic compounds
GB2078719B (en) * 1980-06-02 1984-04-26 Ici Ltd Heterocyclic compounds
NZ198085A (en) * 1980-08-18 1985-09-13 Ici Plc Regulation of plant growth with certain 2,2-di(hydrocarbyl)-1-(1,2,4-triazol-1-yl)ethan-2-ols
EP0158741A3 (fr) * 1980-11-19 1986-02-12 Imperial Chemical Industries Plc Intermédiaires pour composés fongicides triazoles ou imidazoles
US5466821A (en) * 1981-03-18 1995-11-14 Zeneca Limited Heterocyclic compounds
US5204363A (en) * 1981-03-18 1993-04-20 Imperial Chemical Industries Plc Heterocyclic compounds
EP0061835B1 (fr) * 1981-03-18 1989-02-01 Imperial Chemical Industries Plc Composés de triazole , procédé pour leur préparation, leur utilisation comme fongicides de plantes et leurs compositions fongicides
EP0069442B1 (fr) * 1981-06-06 1985-02-20 Pfizer Limited Agents antifongiques, procédé de leur préparation et compositions pharmaceutiques les contenant
US4510148A (en) * 1982-06-12 1985-04-09 Pfizer Inc. 2-Heterocyclic-1,3-bis(1H-1,2,4-triazol-1-yl)-propan-2-ols as antifungal agents
ES8503680A1 (es) * 1982-06-17 1985-04-01 Pfizer Un procedimiento para la preparacion de un compuesto dotado de propiedades fungicidas
DE3228870A1 (de) * 1982-08-03 1984-02-09 Bayer Ag, 5090 Leverkusen Diazolyl-alkanole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
US4505919A (en) * 1982-10-09 1985-03-19 Pfizer Inc. Antifungal S-arylmethyl- and S-heterocyclylmethyl ethers of 2-aryl-3-mercapto-1-(1H-1,2,4-triazol-1-yl) propan-2-ols
DE3242236A1 (de) * 1982-11-15 1984-05-17 Bayer Ag, 5090 Leverkusen "antimykotische mittel"
DE3242252A1 (de) * 1982-11-15 1984-05-17 Bayer Ag, 5090 Leverkusen Heterocyclisch substituierte hydroxyalkyl-azolyl-derivate
DE3245504A1 (de) * 1982-12-09 1984-06-14 Bayer Ag, 5090 Leverkusen Fungizide mittel, deren herstellung und verwendung
GB8301699D0 (en) * 1983-01-21 1983-02-23 Pfizer Ltd Antifungal agents
DE3307218A1 (de) * 1983-03-02 1984-09-06 Bayer Ag, 5090 Leverkusen Substituierte diazolylalkyl-carbinole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
GB8306351D0 (en) * 1983-03-08 1983-04-13 Ici Plc Azole fungicides
JPS59142480U (ja) * 1983-03-15 1984-09-22 サンデン株式会社 スクロ−ル型流体装置
GR81556B (fr) * 1983-05-09 1984-12-11 Stauffer Chemical Co
DE3325313A1 (de) * 1983-07-13 1985-01-31 Bayer Ag, 5090 Leverkusen Fungizide mittel, deren herstellung und verwendung
US4483863A (en) * 1984-01-20 1984-11-20 Pfizer Inc. Triazole antifungal agents
US4801594A (en) * 1984-06-18 1989-01-31 Eli Lilly And Company Aromatase inhibitors
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors
IE58738B1 (en) * 1984-09-05 1993-11-03 Ici Plc Antifungal azole compounds
GB8424799D0 (en) * 1984-10-02 1984-11-07 Ici Plc Biocide composition
GB8506619D0 (en) * 1985-03-14 1985-04-17 Pfizer Ltd Triazole antifungal agents
US4760083A (en) * 1986-04-10 1988-07-26 E. I. Dupont De Nemours & Company 3,3-disubstituted indolines
US4952232A (en) * 1987-04-29 1990-08-28 E. I. Du Pont De Nemours And Company Antifungal carbinols
US5084465A (en) * 1986-06-23 1992-01-28 Du Pont Merck Pharmaceutical Company Antifungal carbinols
DE3784787T2 (de) * 1986-06-23 1994-01-20 Du Pont Merck Pharma Fungizide Karbinole.
US4965281A (en) * 1986-06-23 1990-10-23 E. I. Du Pont De Nemours And Cmopany Antifungal carbinols
US4980367A (en) * 1987-12-17 1990-12-25 E. I. Du Pont De Nemours And Company Antifungal carbinols
US4876259A (en) * 1987-01-05 1989-10-24 E. I. Du Pont De Nemours And Company 3,3-disubstituted indolines
ES2059408T3 (es) * 1987-02-10 1994-11-16 Abbott Lab Un proceso para la preparacion de un compuesto.
DE3813841A1 (de) * 1987-06-03 1988-12-15 Bayer Ag Heterocyclische hydroxyethylazole
GB8716651D0 (en) * 1987-07-15 1987-08-19 Ici Plc 2-propanol derivatives
GB8729083D0 (en) * 1987-12-12 1988-01-27 Pfizer Ltd Triazole antifungal agents
US5002935A (en) * 1987-12-30 1991-03-26 University Of Florida Improvements in redox systems for brain-targeted drug delivery
DE3806089A1 (de) * 1988-02-26 1989-09-07 Basf Ag Azolylmethyloxirane und diese enthaltende fungizide
FI97382C (fi) * 1988-03-04 1996-12-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten 1,2,4-triatsolijohdannaisten valmistamiseksi
DE3809069A1 (de) * 1988-03-18 1989-09-28 Basf Ag Azolylmethylallylalkohole und diese enthaltende fungizide
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
US5278175A (en) * 1990-02-02 1994-01-11 Pfizer Inc. Triazole antifungal agents
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
KR900016822A (ko) * 1990-04-20 1990-11-14 하라 레이노스께 슬라이드 프로젝터
US5132319A (en) * 1991-03-28 1992-07-21 Merck Frosst Canada, Inc. 1-(hydroxylaminoalkyl) indole derivatives as inhibitors of leukotriene biosynthesis
US5205354A (en) * 1992-01-28 1993-04-27 Lesage Philip G Vehicle radiator and method of making
EP0613890A1 (fr) * 1993-02-28 1994-09-07 Nihon Nohyaku Co., Ltd. Dérivé de triazole, son procédé de préparation et agent fongicide le contenant
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
DE4408404A1 (de) * 1994-03-12 1995-09-14 Huels Chemische Werke Ag Verfahren zur Herstellung von Chlorpyrimidinen
CA2145458A1 (fr) * 1994-03-28 1995-09-29 Hiroki Kodama Derive du triazole; methode de preparation et utilisation
CN1137099C (zh) * 1995-01-30 2004-02-04 曾尼卡有限公司 4,6-二氯嘧啶的制法

Also Published As

Publication number Publication date
JPH09208583A (ja) 1997-08-12
YU17591A (sh) 1994-01-20
AU625188B2 (en) 1992-07-02
KR910021398A (ko) 1991-12-20
BR9100435A (pt) 1991-10-22
MX24363A (es) 1993-09-01
NL300100I1 (nl) 2002-11-01
IL97045A0 (en) 1992-03-29
NO910368D0 (no) 1991-01-31
PL169332B1 (pl) 1996-07-31
NO2002006I2 (no) 2004-10-11
PL167294B1 (pl) 1995-08-31
CA2035314A1 (fr) 1991-08-03
OA09480A (fr) 1992-11-15
AU7022391A (en) 1991-09-05
PT96617B (pt) 1998-07-31
FI910508A0 (fi) 1991-02-01
GB9002375D0 (en) 1990-04-04
KR930011039B1 (ko) 1993-11-20
JPH04211078A (ja) 1992-08-03
JP2848811B2 (ja) 1999-01-20
HUT56361A (en) 1991-08-28
DE69100095D1 (de) 1993-07-08
LU90960I2 (fr) 2003-04-02
CN1100421A (zh) 1995-03-22
US5773443A (en) 1998-06-30
ES2055523T4 (es) 2011-04-11
RU2036194C1 (ru) 1995-05-27
LV10615B (en) 1995-12-20
AP9000237A0 (en) 1991-01-31
IE64774B1 (en) 1995-09-06
IN176148B (fr) 1996-02-10
AP223A (en) 1992-08-27
NO176796C (no) 1995-05-31
DK0440372T3 (da) 1993-06-28
IS1629B (is) 1996-07-19
CN1053787A (zh) 1991-08-14
EP0440372A1 (fr) 1991-08-07
RO109648B1 (ro) 1995-04-28
DE69100095T2 (de) 1993-09-09
IL110322A0 (en) 1994-10-21
ATE90090T1 (de) 1993-06-15
ES2055523T3 (es) 1994-08-16
CA2285891A1 (fr) 1991-08-03
BG60032B2 (en) 1993-07-30
MY105494A (en) 1994-10-31
PT96617A (pt) 1991-10-15
PE31691A1 (es) 1991-11-29
HK219396A (en) 1997-01-03
PL169307B1 (pl) 1996-06-28
YU48105B (sh) 1997-03-07
HU205351B (en) 1992-04-28
JP2625584B2 (ja) 1997-07-02
BA97298A (bs) 2001-09-14
FI107608B (fi) 2001-09-14
ZA91761B (en) 1992-09-30
CZ279339B6 (cs) 1995-04-12
IL110322A (en) 1996-10-31
HU211582A9 (en) 1995-12-28
FI20000084A (fi) 2000-01-17
RU2114838C1 (ru) 1998-07-10
NO910368L (no) 1991-08-05
FI971238A0 (fi) 1997-03-25
EG19750A (en) 1996-01-31
DE10299035I2 (de) 2003-06-26
EP0440372B1 (fr) 1993-06-02
IE910342A1 (en) 1991-08-14
CA2285891C (fr) 2004-01-06
FI910508A (fi) 1991-08-03
LV10615A (lv) 1995-04-20
CN1040504C (zh) 1998-11-04
CS9100249A2 (en) 1991-09-15
IS3671A7 (is) 1991-08-03
US5567817A (en) 1996-10-22
FI971238A (fi) 1997-03-25
SK278215B6 (en) 1996-04-03
DE10299035I1 (de) 2003-05-22
CN1026788C (zh) 1994-11-30
NL300100I2 (nl) 2003-01-06
PL288901A1 (en) 1992-01-27
NZ247205A (en) 1993-09-27
IL97045A (en) 1995-11-27
NO176796B (no) 1995-02-20
CA2035314C (fr) 2000-01-18

Similar Documents

Publication Publication Date Title
MA22054A1 (fr) Procede de production de derives de triazole antifongiques.
MA21610A1 (fr) Procede de production de composes triazoliques .
FR2729159B1 (fr) Procede de fabrication de cellulose micro-dimensionnee
FR2671801B1 (fr) Procede de production de glycomacropeptides de kappa-caseine.
HUT64033A (en) Process for producing phenyhlpyrazole derivatives having fungicidal effect, as well as fungicidal composiitons comprising such compounds
MX9206450A (es) Proceso para la produccion de isoleucina-l.
ITTO920136A1 (it) Procedimento di produzione di organopolisilossani.
FR2661913B1 (fr) Procede de production de polychloroprene.
FR2668163B1 (fr) Procede de fabrication de beta-cyclodextrine.
FR2678625B1 (fr) Procede de production d'acetate de cellulose.
FR2669636B1 (fr) Procede de fabrication de furane 2,5-dicarboxaldehyde.
IT1244234B (it) Metodo per la realizzazione di incarti tubolari.
MA22151A1 (fr) Procede de production d'azabenzimidazoles
FR2686875B1 (fr) Procede de fabrication du 1,1,1,2-tetrafluoroethane.
FR2663941B1 (fr) Procede de production d'organosiloxanes.
FI960332A (fi) Menetelmä substituoitujan 4,6-diamino-5-syanopyrinidiinien valmistamiseksi
IT9047683A0 (it) Procedimento perfezionato per la produzione di zeoliti.
FR2696475B1 (fr) Procede de production de micro-algues.
MA21966A1 (fr) Procede de production de tetrathiocarbonates .
FR2671355B1 (fr) Procede de desalcoolisation.
FR2667600B1 (fr) Procede de synthese de monohalogenoalcanoylferrocenes.
HUT58295A (en) Process for producing 5-chloro-carbonyl-5h-dibenz(b,f)-azepine
FR2658194B1 (fr) Procede de stockage de chloroisocyanurates.
FR2679066B1 (fr) Procede de production d'ions multicharges.
FR2668783B1 (fr) Procede de finissage des nontisses.