NO2002006I2 - Vorikonazol - Google Patents

Vorikonazol

Info

Publication number
NO2002006I2
NO2002006I2 NO2002006C NO2002006C NO2002006I2 NO 2002006 I2 NO2002006 I2 NO 2002006I2 NO 2002006 C NO2002006 C NO 2002006C NO 2002006 C NO2002006 C NO 2002006C NO 2002006 I2 NO2002006 I2 NO 2002006I2
Authority
NO
Norway
Prior art keywords
voriconazole
Prior art date
Application number
NO2002006C
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10670334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2002006(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of NO2002006I2 publication Critical patent/NO2002006I2/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO2002006C 1990-02-02 2002-09-05 Vorikonazol NO2002006I2 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909002375A GB9002375D0 (en) 1990-02-02 1990-02-02 Triazole antifungal agents

Publications (1)

Publication Number Publication Date
NO2002006I2 true NO2002006I2 (no) 2004-10-11

Family

ID=10670334

Family Applications (2)

Application Number Title Priority Date Filing Date
NO910368A NO176796C (no) 1990-02-02 1991-01-31 Analogifremgangsmåte ved fremstilling av terapeutisk aktive triazolderivater
NO2002006C NO2002006I2 (no) 1990-02-02 2002-09-05 Vorikonazol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO910368A NO176796C (no) 1990-02-02 1991-01-31 Analogifremgangsmåte ved fremstilling av terapeutisk aktive triazolderivater

Country Status (42)

Country Link
US (2) US5567817A (no)
EP (1) EP0440372B1 (no)
JP (2) JP2625584B2 (no)
KR (1) KR930011039B1 (no)
CN (2) CN1026788C (no)
AP (2) AP223A (no)
AT (1) ATE90090T1 (no)
AU (1) AU625188B2 (no)
BA (1) BA97298A (no)
BG (1) BG60032A3 (no)
BR (1) BR9100435A (no)
CA (2) CA2035314C (no)
CZ (1) CZ279339B6 (no)
DE (2) DE10299035I2 (no)
DK (1) DK0440372T3 (no)
EG (1) EG19750A (no)
ES (1) ES2055523T4 (no)
FI (3) FI107608B (no)
GB (1) GB9002375D0 (no)
HK (1) HK219396A (no)
HU (2) HU205351B (no)
IE (1) IE64774B1 (no)
IL (2) IL110322A (no)
IN (1) IN176148B (no)
IS (1) IS1629B (no)
LU (1) LU90960I2 (no)
LV (1) LV10615B (no)
MA (1) MA22054A1 (no)
MX (1) MX24363A (no)
MY (1) MY105494A (no)
NL (1) NL300100I2 (no)
NO (2) NO176796C (no)
NZ (1) NZ247205A (no)
OA (1) OA09480A (no)
PE (1) PE31691A1 (no)
PL (3) PL169307B1 (no)
PT (1) PT96617B (no)
RO (1) RO109648B1 (no)
RU (2) RU2114838C1 (no)
SK (1) SK278215B6 (no)
YU (1) YU48105B (no)
ZA (1) ZA91761B (no)

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GB9818258D0 (en) * 1998-08-21 1998-10-14 Pfizer Ltd Antifungal compositions
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US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
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US6319933B1 (en) 2000-04-17 2001-11-20 Basilea Pharmaceutica Ag Azole derivatives
JP2004536034A (ja) * 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
HUP0303249A3 (en) 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
JP2005516933A (ja) 2001-12-13 2005-06-09 ダウ グローバル テクノロジーズ インコーポレイティド 放射性医薬による骨髄炎の治療
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
CN100579977C (zh) * 2002-10-08 2010-01-13 许永翔 制备三唑类抗真菌药物的方法
US20040098839A1 (en) * 2002-11-27 2004-05-27 Pfizer Inc. Crystallization method and apparatus using an impinging plate assembly
WO2006065726A2 (en) * 2004-12-14 2006-06-22 Dr. Reddy's Laboratories Ltd. Process for preparing voriconazole
CN101213191B (zh) 2005-03-30 2011-08-24 （株）大熊制药 抗真菌三唑衍生物
CA2640922A1 (en) * 2006-02-01 2007-11-22 Medichem, S.A. Process for preparing voriconazole, new polymorphic form of intermediate thereof, and uses thereof
AR061889A1 (es) 2006-07-13 2008-10-01 Medichem Sa Proceso mejorado para la preparacion de voriconazol
CN1919846B (zh) * 2006-09-14 2013-01-02 大道隆达（北京）医药科技发展有限公司 伏立康唑及其药用盐、中间体的一种新定向合成制备方法
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KR100889937B1 (ko) 2007-08-06 2009-03-20 한미약품 주식회사 보리코나졸의 제조방법
GB2452049A (en) * 2007-08-21 2009-02-25 Alpharma Aps Process for the preparation of voriconazole
CN101575330B (zh) * 2008-05-05 2012-10-31 丽珠医药集团股份有限公司 伏立康唑广谱抗真菌药物化合物、其组合物及用途
WO2009137611A2 (en) * 2008-05-06 2009-11-12 Board Of Regents, The University Of Texas System Treatment of pulmonary fungal infection with voriconazole via inhalation
JP2009286756A (ja) 2008-05-30 2009-12-10 Fujifilm Finechemicals Co Ltd トリアゾール誘導体またはその塩
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WO2010095145A1 (en) * 2009-02-17 2010-08-26 Glenmark Generics Limited Process for the preparation of voriconazole
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CN107252488A (zh) 2009-10-01 2017-10-17 艾戴尔医药公司 口服给予的皮质类固醇组合物
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KR100971371B1 (ko) * 2010-02-04 2010-07-20 동국제약 주식회사 신규한 중간체를 이용한 보리코나졸의 제조방법
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EP2409699B1 (en) * 2010-07-23 2014-04-30 Combino Pharm, S.L. Stable compositions of voriconazole
CN101914091B (zh) * 2010-07-25 2015-05-27 浙江华海药业股份有限公司 一种制备伏立康唑中间体的方法
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RU2566262C2 (ru) 2011-06-15 2015-10-20 Синтон Бв Стабилизированная композиция вориконазола
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BR112015018547A2 (pt) * 2013-02-04 2017-07-18 Syngenta Participations Ag microbiocidas
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JP6262972B2 (ja) * 2013-09-17 2018-01-17 公益財団法人微生物化学研究会 化合物、及びその製造方法、並びにボリコナゾールの製造方法
CN107660203A (zh) 2015-04-02 2018-02-02 拜耳作物科学股份公司 作为杀真菌剂的三唑衍生物
CN104987325B (zh) * 2015-06-30 2017-03-29 扬子江药业集团南京海陵药业有限公司 一种伏立康唑的制备方法
CN106117186B (zh) * 2016-06-12 2018-08-24 重庆莱美隆宇药业有限公司 一种伏立康唑及其中间体的制备方法
CN107556294A (zh) * 2016-06-30 2018-01-09 陕西合成药业股份有限公司 一种新型抗真菌感染药物及其制备方法和用途
TWI777515B (zh) 2016-08-18 2022-09-11 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
EP3558304A2 (en) 2016-12-23 2019-10-30 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases
US11040958B2 (en) * 2017-02-17 2021-06-22 Wuhan Ll Science And Technology Development Co., Ltd. Triazole antimicrobial derivative, pharmaceutical composition and use thereof
CN109705102A (zh) 2019-02-19 2019-05-03 浙江华海立诚药业有限公司 伏立康唑及其中间体的制备方法
CN111440152B (zh) * 2020-05-18 2022-09-27 浙江诚意药业股份有限公司 一种伏立康唑的制备方法
CN112079819B (zh) * 2020-09-24 2022-06-17 南京易亨制药有限公司 一种改进的伏立康唑消旋体制备方法
CN114907319A (zh) * 2021-02-06 2022-08-16 华创合成制药股份有限公司 一种氘代三唑类化合物及其制备方法和用途
CN115724829A (zh) * 2022-12-23 2023-03-03 天津力生制药股份有限公司 一种分离真菌药物中间体杂质的液相色谱制备方法

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IL97045A0 (en) 1992-03-29
IN176148B (no) 1996-02-10
IE64774B1 (en) 1995-09-06
CN1040504C (zh) 1998-11-04
DE69100095D1 (de) 1993-07-08
CA2285891C (en) 2004-01-06
CZ279339B6 (cs) 1995-04-12
RU2036194C1 (ru) 1995-05-27
CS9100249A2 (en) 1991-09-15
YU17591A (sh) 1994-01-20
DE69100095T2 (de) 1993-09-09
IL110322A0 (en) 1994-10-21
OA09480A (fr) 1992-11-15
HU211582A9 (en) 1995-12-28
FI971238A (fi) 1997-03-25
HK219396A (en) 1997-01-03
KR910021398A (ko) 1991-12-20
EP0440372A1 (en) 1991-08-07
ATE90090T1 (de) 1993-06-15
US5567817A (en) 1996-10-22
PT96617A (pt) 1991-10-15
LV10615A (lv) 1995-04-20
YU48105B (sh) 1997-03-07
PL288901A1 (en) 1992-01-27
RU2114838C1 (ru) 1998-07-10
CN1053787A (zh) 1991-08-14
IL97045A (en) 1995-11-27
IL110322A (en) 1996-10-31
BG60032A3 (en) 1993-07-15
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IS3671A7 (is) 1991-08-03
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AP223A (en) 1992-08-27
CA2035314C (en) 2000-01-18
JPH04211078A (ja) 1992-08-03
NZ247205A (en) 1993-09-27
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MX24363A (es) 1993-09-01
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SK278215B6 (en) 1996-04-03
DE10299035I1 (de) 2003-05-22
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AU7022391A (en) 1991-09-05
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DE10299035I2 (de) 2003-06-26
MA22054A1 (fr) 1991-10-01
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HU205351B (en) 1992-04-28

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