ECSP045077A - Derivados del 3-azabiciclico[3.1.0]hexano como antagonistas del receptor de opioides - Google Patents
Derivados del 3-azabiciclico[3.1.0]hexano como antagonistas del receptor de opioidesInfo
- Publication number
- ECSP045077A ECSP045077A EC2004005077A ECSP045077A ECSP045077A EC SP045077 A ECSP045077 A EC SP045077A EC 2004005077 A EC2004005077 A EC 2004005077A EC SP045077 A ECSP045077 A EC SP045077A EC SP045077 A ECSP045077 A EC SP045077A
- Authority
- EC
- Ecuador
- Prior art keywords
- azabiciclico
- antagonist
- hexane
- derivatives
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Gynecology & Obstetrics (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención proporciona un compuesto de fórmula I, en la que X, Q, n, R1, R2, R3, R4, R5,R6, R7, R8, R9 y R10 son como se han definido. Los compuestos de fórmula I tienen actividad como antagonistas del receptor de opio idees. La invención además proporciona composiciones farmacéuticas y procedimientos terapéuticos que comprenden los compuestos de la fórmula I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33851101P | 2001-10-22 | 2001-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP045077A true ECSP045077A (es) | 2004-05-28 |
Family
ID=23325099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2004005077A ECSP045077A (es) | 2001-10-22 | 2004-04-22 | Derivados del 3-azabiciclico[3.1.0]hexano como antagonistas del receptor de opioides |
Country Status (42)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1598340T1 (sl) | 2001-04-18 | 2009-08-31 | Euro Celtique Sa | Derivati 1-(4-piperidinil)-1,3-dihidro-2H-benzoksazol-2-ona in sorodne spojine kot analogi nociceptina in ligandi ORL1 za zdravljenje bolečine |
| PL368919A1 (en) * | 2001-10-22 | 2005-04-04 | Pfizer Products Inc. | 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists |
| EP1615894A2 (en) * | 2003-04-14 | 2006-01-18 | Pfizer Products Inc. | 3-azabicyclo 3.2.1 octane derivatives |
| US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US7153976B2 (en) * | 2003-10-06 | 2006-12-26 | Pfizer Inc. | Purification process for an azabicyclo[3.1.0]hexane compound |
| AP2006003592A0 (en) * | 2003-10-14 | 2006-04-30 | Pfizer Prod Inc | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors. |
| WO2005037790A1 (en) * | 2003-10-16 | 2005-04-28 | Pfizer Products Inc. | Preparation of 3-azabicyclo [3.1.0] hexane derivatives |
| EP2070922B1 (en) | 2004-02-23 | 2011-08-17 | Glaxo Group Limited | Azabicyclo(3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors |
| WO2005085228A1 (ja) * | 2004-03-05 | 2005-09-15 | Banyu Pharmaceutical Co., Ltd. | シクロアルカノピリジン誘導体 |
| EP1837022A4 (en) * | 2004-12-14 | 2009-12-16 | Toray Industries | INDOLOMORPHINANE DERIVATIVE WITH CARBOXY IN 6 'POSITION |
| GB0512099D0 (en) * | 2005-06-14 | 2005-07-20 | Glaxo Group Ltd | Compounds |
| GB0517191D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| US7592461B2 (en) | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| MY145633A (en) | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| WO2008075162A2 (en) * | 2006-12-15 | 2008-06-26 | Pfizer Limited | Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction |
| TWI409067B (zh) | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
| US7902221B2 (en) * | 2007-08-27 | 2011-03-08 | Theravance, Inc. | Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| TWI423801B (zh) | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物 |
| WO2009029253A1 (en) * | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| WO2009029257A1 (en) * | 2007-08-27 | 2009-03-05 | Theravance, Inc. | Disubstituted alkyl-8-azabicyclo [3.2.1.] octane compounds as mu opioid receptor antagonists |
| EP2621902B1 (en) | 2010-09-28 | 2017-04-12 | Panacea Biotec Ltd | 3-azabicyclo[3.1.0]hexane compounds useful for the treatment of cns disorders |
| CN105764888B (zh) | 2013-11-20 | 2018-04-06 | 株式会社三和化学研究所 | 一种新的3‑氮杂双环[3.1.0]己烷衍生物以及其医药用途 |
| CN113307760A (zh) * | 2015-05-20 | 2021-08-27 | 宇部兴产株式会社 | 一种新型的3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用 |
| JPWO2018159716A1 (ja) | 2017-03-02 | 2019-12-26 | 株式会社三和化学研究所 | アルコール使用障害の治療薬 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2099214A (en) * | 1937-11-16 | Process fob forming the sulphuric | ||
| US2099216A (en) * | 1934-05-04 | 1937-11-16 | Frederick H Nass | Metal testing machine |
| US3004340A (en) * | 1959-09-24 | 1961-10-17 | Bernice L Collins | Kitchen utensil |
| US3078282A (en) * | 1960-01-02 | 1963-02-19 | Bayer Ag | Anthraquinone dyestuffs |
| IL86061A (en) | 1987-04-16 | 1992-07-15 | Lilly Co Eli | Derivatives of trans-3,4-isomer of 4-methyl-4-phenyl-piperidines,process for their preparation and pharmaceutical compositions containing them |
| JPH04155522A (ja) * | 1990-10-19 | 1992-05-28 | Nec Corp | ファースト・イン・ランダム・アウト回路 |
| ZA922180B (en) | 1991-03-29 | 1993-09-27 | Lilly Co Eli | Piperidine derivatives |
| US5159081A (en) | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| GB9725114D0 (en) * | 1997-11-28 | 1998-01-28 | Pfizer Ltd | Treatment of pruritus |
| GB9810671D0 (en) * | 1998-05-18 | 1998-07-15 | Pfizer Ltd | Anti-pruritic agents |
| TWI244481B (en) * | 1998-12-23 | 2005-12-01 | Pfizer | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| GB9912415D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912410D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9912413D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| US20020064825A1 (en) * | 2000-05-19 | 2002-05-30 | Lewis Marilyn Evelyn | Novel polypeptide |
| US20030207876A1 (en) * | 2000-06-23 | 2003-11-06 | Banks Bernard Joseph | 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy |
| US20020025948A1 (en) * | 2000-06-23 | 2002-02-28 | Banks Bernard Joseph | 3-azabicyclo[3.1.0]hexane derivatives useful in therapy |
| GB0015562D0 (en) * | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
| DE10042885A1 (de) * | 2000-08-31 | 2002-03-14 | Heidelberger Druckmasch Ag | Bogentransportzylinder |
| PL368919A1 (en) | 2001-10-22 | 2005-04-04 | Pfizer Products Inc. | 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists |
| ATE308522T1 (de) | 2002-05-30 | 2005-11-15 | Lilly Co Eli | Opioidrezeptorantagonisten |
| US7056930B2 (en) * | 2003-04-14 | 2006-06-06 | Pfizer Inc. | 2-Azabicyclo[3.3.1]nonane derivatives |
| US20040204453A1 (en) * | 2003-04-14 | 2004-10-14 | Pfizer Inc | 4-Phenyl-piperidine compounds and their use as modulators of opioid receptors |
| US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US7153976B2 (en) * | 2003-10-06 | 2006-12-26 | Pfizer Inc. | Purification process for an azabicyclo[3.1.0]hexane compound |
-
2002
- 2002-09-09 PL PL02368919A patent/PL368919A1/xx not_active Application Discontinuation
- 2002-09-09 JP JP2003538138A patent/JP4155522B2/ja not_active Expired - Fee Related
- 2002-09-09 AU AU2002329557A patent/AU2002329557B2/en not_active Ceased
- 2002-09-09 UA UA20040402979A patent/UA75714C2/uk unknown
- 2002-09-09 WO PCT/IB2002/003668 patent/WO2003035622A1/en active IP Right Grant
- 2002-09-09 OA OA1200400109A patent/OA12711A/en unknown
- 2002-09-09 KR KR1020047006011A patent/KR100621292B1/ko not_active IP Right Cessation
- 2002-09-09 NZ NZ531807A patent/NZ531807A/xx unknown
- 2002-09-09 CA CA002463264A patent/CA2463264C/en not_active Expired - Fee Related
- 2002-09-09 HU HU0401884A patent/HUP0401884A2/hu unknown
- 2002-09-09 EP EP02765197A patent/EP1440059B1/en not_active Expired - Lifetime
- 2002-09-09 SI SI200230688T patent/SI1440059T1/sl unknown
- 2002-09-09 AT AT02765197T patent/ATE392415T1/de not_active IP Right Cessation
- 2002-09-09 DE DE60226161T patent/DE60226161T2/de not_active Expired - Lifetime
- 2002-09-09 CN CNB028208854A patent/CN100368398C/zh not_active Expired - Fee Related
- 2002-09-09 DK DK02765197T patent/DK1440059T3/da active
- 2002-09-09 PT PT02765197T patent/PT1440059E/pt unknown
- 2002-09-09 BR BR0213464-0A patent/BR0213464A/pt not_active IP Right Cessation
- 2002-09-09 AP APAP/P/2004/003007A patent/AP1816A/en active
- 2002-09-09 IL IL16115702A patent/IL161157A0/xx unknown
- 2002-09-09 MX MXPA04003730A patent/MXPA04003730A/es active IP Right Grant
- 2002-09-09 ES ES02765197T patent/ES2302839T3/es not_active Expired - Lifetime
- 2002-09-09 EA EA200400467A patent/EA006708B1/ru not_active IP Right Cessation
- 2002-09-09 GE GEAP20028173A patent/GEP20084300B/en unknown
- 2002-09-09 RS YUP-251/04A patent/RS25104A/sr unknown
- 2002-10-17 PA PA20028556701A patent/PA8556701A1/es unknown
- 2002-10-17 MY MYPI20023878A patent/MY136580A/en unknown
- 2002-10-18 PE PE2002001032A patent/PE20030610A1/es not_active Application Discontinuation
- 2002-10-18 HN HN2002000299A patent/HN2002000299A/es unknown
- 2002-10-21 AR ARP020103960A patent/AR036905A1/es unknown
- 2002-10-21 SV SV2002001363A patent/SV2004001363A/es not_active Application Discontinuation
- 2002-10-22 GT GT200200216A patent/GT200200216A/es unknown
- 2002-10-22 US US10/278,142 patent/US7049335B2/en not_active Expired - Fee Related
-
2004
- 2004-03-18 ZA ZA200402172A patent/ZA200402172B/en unknown
- 2004-03-18 IS IS7187A patent/IS7187A/is unknown
- 2004-03-23 HR HRP20040288 patent/HRP20040288A2/hr not_active Application Discontinuation
- 2004-03-29 IL IL161157A patent/IL161157A/en not_active IP Right Cessation
- 2004-04-15 MA MA27630A patent/MA27141A1/fr unknown
- 2004-04-20 CR CR7317A patent/CR7317A/es unknown
- 2004-04-21 NO NO20041626A patent/NO329092B1/no not_active IP Right Cessation
- 2004-04-21 TN TNP2004000071A patent/TNSN04071A1/fr unknown
- 2004-04-22 EC EC2004005077A patent/ECSP045077A/es unknown
-
2005
- 2005-02-24 US US11/066,095 patent/US20050171178A1/en not_active Abandoned
- 2005-06-08 HK HK05104840A patent/HK1072052A1/xx not_active IP Right Cessation
-
2006
- 2006-03-01 US US11/366,903 patent/US20070054950A1/en not_active Abandoned
-
2007
- 2007-10-19 JP JP2007272602A patent/JP2008069169A/ja active Pending
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