ECSP045077A - Derivados del 3-azabiciclico[3.1.0]hexano como antagonistas del receptor de opioides - Google Patents

Derivados del 3-azabiciclico[3.1.0]hexano como antagonistas del receptor de opioides

Info

Publication number
ECSP045077A
ECSP045077A EC2004005077A ECSP045077A ECSP045077A EC SP045077 A ECSP045077 A EC SP045077A EC 2004005077 A EC2004005077 A EC 2004005077A EC SP045077 A ECSP045077 A EC SP045077A EC SP045077 A ECSP045077 A EC SP045077A
Authority
EC
Ecuador
Prior art keywords
azabiciclico
antagonist
hexane
derivatives
formula
Prior art date
Application number
EC2004005077A
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English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ECSP045077A publication Critical patent/ECSP045077A/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/04Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención proporciona un compuesto de fórmula I, en la que X, Q, n, R1, R2, R3, R4, R5,R6, R7, R8, R9 y R10 son como se han definido. Los compuestos de fórmula I tienen actividad como antagonistas del receptor de opio idees. La invención además proporciona composiciones farmacéuticas y procedimientos terapéuticos que comprenden los compuestos de la fórmula I.
EC2004005077A 2001-10-22 2004-04-22 Derivados del 3-azabiciclico[3.1.0]hexano como antagonistas del receptor de opioides ECSP045077A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33851101P 2001-10-22 2001-10-22

Publications (1)

Publication Number Publication Date
ECSP045077A true ECSP045077A (es) 2004-05-28

Family

ID=23325099

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005077A ECSP045077A (es) 2001-10-22 2004-04-22 Derivados del 3-azabiciclico[3.1.0]hexano como antagonistas del receptor de opioides

Country Status (42)

Country Link
US (3) US7049335B2 (es)
EP (1) EP1440059B1 (es)
JP (2) JP4155522B2 (es)
KR (1) KR100621292B1 (es)
CN (1) CN100368398C (es)
AP (1) AP1816A (es)
AR (1) AR036905A1 (es)
AT (1) ATE392415T1 (es)
AU (1) AU2002329557B2 (es)
BR (1) BR0213464A (es)
CA (1) CA2463264C (es)
CR (1) CR7317A (es)
DE (1) DE60226161T2 (es)
DK (1) DK1440059T3 (es)
EA (1) EA006708B1 (es)
EC (1) ECSP045077A (es)
ES (1) ES2302839T3 (es)
GE (1) GEP20084300B (es)
GT (1) GT200200216A (es)
HK (1) HK1072052A1 (es)
HN (1) HN2002000299A (es)
HR (1) HRP20040288A2 (es)
HU (1) HUP0401884A2 (es)
IL (2) IL161157A0 (es)
IS (1) IS7187A (es)
MA (1) MA27141A1 (es)
MX (1) MXPA04003730A (es)
MY (1) MY136580A (es)
NO (1) NO329092B1 (es)
NZ (1) NZ531807A (es)
OA (1) OA12711A (es)
PA (1) PA8556701A1 (es)
PE (1) PE20030610A1 (es)
PL (1) PL368919A1 (es)
PT (1) PT1440059E (es)
RS (1) RS25104A (es)
SI (1) SI1440059T1 (es)
SV (1) SV2004001363A (es)
TN (1) TNSN04071A1 (es)
UA (1) UA75714C2 (es)
WO (1) WO2003035622A1 (es)
ZA (1) ZA200402172B (es)

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JP4155522B2 (ja) * 2001-10-22 2008-09-24 ファイザー・プロダクツ・インク オピオイド受容体アンタゴニストとしての3−アザビシクロ(3.1.0)ヘキサン誘導体
MXPA05011070A (es) * 2003-04-14 2005-12-12 Pfizer Prod Inc Derivados de 3-azabiciclo [3.2.1] octano.
US20050043327A1 (en) * 2003-08-21 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7153976B2 (en) * 2003-10-06 2006-12-26 Pfizer Inc. Purification process for an azabicyclo[3.1.0]hexane compound
CN101838271A (zh) * 2003-10-14 2010-09-22 辉瑞产品公司 作为甘氨酸转运蛋白抑制剂的二环[3.1.0]衍生物
EP1675829A1 (en) * 2003-10-16 2006-07-05 Pfizer Products Inc. Preparation of 3-azabicyclo [3.1.0] hexane derivatives
KR101143718B1 (ko) * 2004-02-23 2012-07-05 글락소 그룹 리미티드 도파민 d3 수용체의 조절제로서 유용한 아자비시클로(3.1.0) 헥산 유도체
CN1930145B (zh) * 2004-03-05 2011-06-15 Msdk.K.公司 环烷吡啶衍生物
US20080227803A1 (en) * 2004-12-14 2008-09-18 Shioonogi & Co., Ltd., A Legal Entity Of Japan Indolomorphinan Derivative Having Carboxy in 6'-Position
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US7592461B2 (en) 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
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TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之8-氮雜雙環〔3.2.1〕辛基-2-羥基苯甲醯胺化合物
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EP3072884B1 (en) * 2013-11-20 2020-01-01 Sanwa Kagaku Kenkyusho Co., Ltd. 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purposes
RU2017144548A (ru) * 2015-05-20 2019-06-20 Санва Кагаку Кенкюсо Ко., Лтд. Кристаллическая соль нового производного 3-азабицикло[3.1.0]гексана и ее применение в медицине
CN110352055A (zh) 2017-03-02 2019-10-18 株式会社三和化学研究所 酒精使用障碍的治疗药物

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Also Published As

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PL368919A1 (en) 2005-04-04
GEP20084300B (en) 2008-02-11
US20030087898A1 (en) 2003-05-08
BR0213464A (pt) 2004-11-09
EA200400467A1 (ru) 2004-08-26
ES2302839T3 (es) 2008-08-01
HK1072052A1 (en) 2005-08-12
DK1440059T3 (da) 2008-07-14
US20070054950A1 (en) 2007-03-08
TNSN04071A1 (fr) 2006-06-01
US7049335B2 (en) 2006-05-23
US20050171178A1 (en) 2005-08-04
JP4155522B2 (ja) 2008-09-24
IL161157A0 (en) 2004-08-31
AR036905A1 (es) 2004-10-13
NO329092B1 (no) 2010-08-23
SI1440059T1 (sl) 2008-08-31
IL161157A (en) 2009-09-01
CN100368398C (zh) 2008-02-13
AP2004003007A0 (en) 2004-06-30
PA8556701A1 (es) 2003-07-28
KR100621292B1 (ko) 2006-09-13
PT1440059E (pt) 2008-05-16
CN1610664A (zh) 2005-04-27
CR7317A (es) 2006-08-09
KR20040048984A (ko) 2004-06-10
HN2002000299A (es) 2002-11-21
HUP0401884A2 (hu) 2005-01-28
ZA200402172B (en) 2006-09-27
UA75714C2 (en) 2006-05-15
DE60226161D1 (de) 2008-05-29
DE60226161T2 (de) 2009-07-02
ATE392415T1 (de) 2008-05-15
NZ531807A (en) 2006-03-31
JP2008069169A (ja) 2008-03-27
IS7187A (is) 2004-03-18
PE20030610A1 (es) 2003-07-12
JP2005511545A (ja) 2005-04-28
EA006708B1 (ru) 2006-02-24
WO2003035622A1 (en) 2003-05-01
HRP20040288A2 (en) 2004-12-31
EP1440059B1 (en) 2008-04-16
CA2463264C (en) 2009-05-26
CA2463264A1 (en) 2003-05-01
AU2002329557B2 (en) 2008-07-31
RS25104A (en) 2007-02-05
SV2004001363A (es) 2004-02-24
OA12711A (en) 2006-06-27
NO20041626L (no) 2004-05-26
MY136580A (en) 2008-10-31
MA27141A1 (fr) 2005-01-03
MXPA04003730A (es) 2004-07-23
AP1816A (en) 2008-01-04
GT200200216A (es) 2003-05-23
EP1440059A1 (en) 2004-07-28

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