ZA200402172B - 3-Azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists - Google Patents

3-Azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists Download PDF

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Publication number
ZA200402172B
ZA200402172B ZA200402172A ZA200402172A ZA200402172B ZA 200402172 B ZA200402172 B ZA 200402172B ZA 200402172 A ZA200402172 A ZA 200402172A ZA 200402172 A ZA200402172 A ZA 200402172A ZA 200402172 B ZA200402172 B ZA 200402172B
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South Africa
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alkyl
aza
exo
hydroxy
phenyl
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ZA200402172A
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Inventor
Stanton F Mchardy
Spiros Liras
Steven D Heck
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Pfizer Prod Inc
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Publication of ZA200402172B publication Critical patent/ZA200402172B/en

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/04Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200402172A 2001-10-22 2004-03-18 3-Azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists ZA200402172B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33851101P 2001-10-22 2001-10-22

Publications (1)

Publication Number Publication Date
ZA200402172B true ZA200402172B (en) 2006-09-27

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ZA200402172A ZA200402172B (en) 2001-10-22 2004-03-18 3-Azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists

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US (3) US7049335B2 (es)
EP (1) EP1440059B1 (es)
JP (2) JP4155522B2 (es)
KR (1) KR100621292B1 (es)
CN (1) CN100368398C (es)
AP (1) AP1816A (es)
AR (1) AR036905A1 (es)
AT (1) ATE392415T1 (es)
AU (1) AU2002329557B2 (es)
BR (1) BR0213464A (es)
CA (1) CA2463264C (es)
CR (1) CR7317A (es)
DE (1) DE60226161T2 (es)
DK (1) DK1440059T3 (es)
EA (1) EA006708B1 (es)
EC (1) ECSP045077A (es)
ES (1) ES2302839T3 (es)
GE (1) GEP20084300B (es)
GT (1) GT200200216A (es)
HK (1) HK1072052A1 (es)
HN (1) HN2002000299A (es)
HR (1) HRP20040288A2 (es)
HU (1) HUP0401884A2 (es)
IL (2) IL161157A0 (es)
IS (1) IS7187A (es)
MA (1) MA27141A1 (es)
MX (1) MXPA04003730A (es)
MY (1) MY136580A (es)
NO (1) NO329092B1 (es)
NZ (1) NZ531807A (es)
OA (1) OA12711A (es)
PA (1) PA8556701A1 (es)
PE (1) PE20030610A1 (es)
PL (1) PL368919A1 (es)
PT (1) PT1440059E (es)
RS (1) RS25104A (es)
SI (1) SI1440059T1 (es)
SV (1) SV2004001363A (es)
TN (1) TNSN04071A1 (es)
UA (1) UA75714C2 (es)
WO (1) WO2003035622A1 (es)
ZA (1) ZA200402172B (es)

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US20050043327A1 (en) * 2003-08-21 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US7153976B2 (en) * 2003-10-06 2006-12-26 Pfizer Inc. Purification process for an azabicyclo[3.1.0]hexane compound
CN101838271A (zh) * 2003-10-14 2010-09-22 辉瑞产品公司 作为甘氨酸转运蛋白抑制剂的二环[3.1.0]衍生物
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KR101143718B1 (ko) * 2004-02-23 2012-07-05 글락소 그룹 리미티드 도파민 d3 수용체의 조절제로서 유용한 아자비시클로(3.1.0) 헥산 유도체
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TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之8-氮雜雙環〔3.2.1〕辛基-2-羥基苯甲醯胺化合物
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EP3072884B1 (en) * 2013-11-20 2020-01-01 Sanwa Kagaku Kenkyusho Co., Ltd. 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purposes
RU2017144548A (ru) * 2015-05-20 2019-06-20 Санва Кагаку Кенкюсо Ко., Лтд. Кристаллическая соль нового производного 3-азабицикло[3.1.0]гексана и ее применение в медицине
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PL368919A1 (en) 2005-04-04
GEP20084300B (en) 2008-02-11
US20030087898A1 (en) 2003-05-08
BR0213464A (pt) 2004-11-09
EA200400467A1 (ru) 2004-08-26
ES2302839T3 (es) 2008-08-01
HK1072052A1 (en) 2005-08-12
DK1440059T3 (da) 2008-07-14
US20070054950A1 (en) 2007-03-08
TNSN04071A1 (fr) 2006-06-01
US7049335B2 (en) 2006-05-23
US20050171178A1 (en) 2005-08-04
JP4155522B2 (ja) 2008-09-24
IL161157A0 (en) 2004-08-31
AR036905A1 (es) 2004-10-13
NO329092B1 (no) 2010-08-23
SI1440059T1 (sl) 2008-08-31
IL161157A (en) 2009-09-01
CN100368398C (zh) 2008-02-13
AP2004003007A0 (en) 2004-06-30
PA8556701A1 (es) 2003-07-28
KR100621292B1 (ko) 2006-09-13
PT1440059E (pt) 2008-05-16
CN1610664A (zh) 2005-04-27
CR7317A (es) 2006-08-09
KR20040048984A (ko) 2004-06-10
HN2002000299A (es) 2002-11-21
HUP0401884A2 (hu) 2005-01-28
UA75714C2 (en) 2006-05-15
DE60226161D1 (de) 2008-05-29
DE60226161T2 (de) 2009-07-02
ATE392415T1 (de) 2008-05-15
NZ531807A (en) 2006-03-31
JP2008069169A (ja) 2008-03-27
IS7187A (is) 2004-03-18
PE20030610A1 (es) 2003-07-12
JP2005511545A (ja) 2005-04-28
EA006708B1 (ru) 2006-02-24
WO2003035622A1 (en) 2003-05-01
HRP20040288A2 (en) 2004-12-31
EP1440059B1 (en) 2008-04-16
CA2463264C (en) 2009-05-26
ECSP045077A (es) 2004-05-28
CA2463264A1 (en) 2003-05-01
AU2002329557B2 (en) 2008-07-31
RS25104A (en) 2007-02-05
SV2004001363A (es) 2004-02-24
OA12711A (en) 2006-06-27
NO20041626L (no) 2004-05-26
MY136580A (en) 2008-10-31
MA27141A1 (fr) 2005-01-03
MXPA04003730A (es) 2004-07-23
AP1816A (en) 2008-01-04
GT200200216A (es) 2003-05-23
EP1440059A1 (en) 2004-07-28

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