RS25104A - 3-azabicyclo(3.1.0)hexane derivatives as opoid receptor antagonists - Google Patents

3-azabicyclo(3.1.0)hexane derivatives as opoid receptor antagonists

Info

Publication number
RS25104A
RS25104A YUP-251/04A YUP25104A RS25104A RS 25104 A RS25104 A RS 25104A YU P25104 A YUP25104 A YU P25104A RS 25104 A RS25104 A RS 25104A
Authority
RS
Serbia
Prior art keywords
receptor antagonists
azabicyclo
hexane derivatives
opoid receptor
formula
Prior art date
Application number
YUP-251/04A
Other languages
English (en)
Inventor
Stanton Furst MCHARDY
Spiros Liras
Steven Donald Heck
Original Assignee
Pfizer Products Inc.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc., filed Critical Pfizer Products Inc.,
Publication of RS25104A publication Critical patent/RS25104A/sr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/04Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Dati pronalazak daje jedinjenja formule (I), gde su X, Q, n, R1, R2, R3, R4, R5, R6, R7, R8, R9 i R10 kao što je odredjeno. Jedinjenja formule (I) deluju kao antagonisti opijatnih receptora. Dati pronalazak dalje daje farmaceutske kompozicije i terapeutske postupke koji sadrže jedinjenja formule (I).
YUP-251/04A 2001-10-22 2002-09-09 3-azabicyclo(3.1.0)hexane derivatives as opoid receptor antagonists RS25104A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33851101P 2001-10-22 2001-10-22
PCT/IB2002/003668 WO2003035622A1 (en) 2001-10-22 2002-09-09 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists

Publications (1)

Publication Number Publication Date
RS25104A true RS25104A (en) 2007-02-05

Family

ID=23325099

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-251/04A RS25104A (en) 2001-10-22 2002-09-09 3-azabicyclo(3.1.0)hexane derivatives as opoid receptor antagonists

Country Status (42)

Country Link
US (3) US7049335B2 (sr)
EP (1) EP1440059B1 (sr)
JP (2) JP4155522B2 (sr)
KR (1) KR100621292B1 (sr)
CN (1) CN100368398C (sr)
AP (1) AP1816A (sr)
AR (1) AR036905A1 (sr)
AT (1) ATE392415T1 (sr)
AU (1) AU2002329557B2 (sr)
BR (1) BR0213464A (sr)
CA (1) CA2463264C (sr)
CR (1) CR7317A (sr)
DE (1) DE60226161T2 (sr)
DK (1) DK1440059T3 (sr)
EA (1) EA006708B1 (sr)
EC (1) ECSP045077A (sr)
ES (1) ES2302839T3 (sr)
GE (1) GEP20084300B (sr)
GT (1) GT200200216A (sr)
HK (1) HK1072052A1 (sr)
HN (1) HN2002000299A (sr)
HR (1) HRP20040288A2 (sr)
HU (1) HUP0401884A2 (sr)
IL (2) IL161157A0 (sr)
IS (1) IS7187A (sr)
MA (1) MA27141A1 (sr)
MX (1) MXPA04003730A (sr)
MY (1) MY136580A (sr)
NO (1) NO329092B1 (sr)
NZ (1) NZ531807A (sr)
OA (1) OA12711A (sr)
PA (1) PA8556701A1 (sr)
PE (1) PE20030610A1 (sr)
PL (1) PL368919A1 (sr)
PT (1) PT1440059E (sr)
RS (1) RS25104A (sr)
SI (1) SI1440059T1 (sr)
SV (1) SV2004001363A (sr)
TN (1) TNSN04071A1 (sr)
UA (1) UA75714C2 (sr)
WO (1) WO2003035622A1 (sr)
ZA (1) ZA200402172B (sr)

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US7153976B2 (en) * 2003-10-06 2006-12-26 Pfizer Inc. Purification process for an azabicyclo[3.1.0]hexane compound
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MY145633A (en) 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
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TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之8-氮雜雙環〔3.2.1〕辛基-2-羥基苯甲醯胺化合物
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WO2009029257A1 (en) * 2007-08-27 2009-03-05 Theravance, Inc. Disubstituted alkyl-8-azabicyclo [3.2.1.] octane compounds as mu opioid receptor antagonists
EP2621902B1 (en) 2010-09-28 2017-04-12 Panacea Biotec Ltd 3-azabicyclo[3.1.0]hexane compounds useful for the treatment of cns disorders
CN105764888B (zh) 2013-11-20 2018-04-06 株式会社三和化学研究所 一种新的3‑氮杂双环[3.1.0]己烷衍生物以及其医药用途
CN113307760A (zh) * 2015-05-20 2021-08-27 宇部兴产株式会社 一种新型的3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用
JPWO2018159716A1 (ja) 2017-03-02 2019-12-26 株式会社三和化学研究所 アルコール使用障害の治療薬

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Also Published As

Publication number Publication date
HRP20040288A2 (en) 2004-12-31
BR0213464A (pt) 2004-11-09
GT200200216A (es) 2003-05-23
IL161157A0 (en) 2004-08-31
CR7317A (es) 2006-08-09
CN1610664A (zh) 2005-04-27
CN100368398C (zh) 2008-02-13
AP1816A (en) 2008-01-04
HK1072052A1 (en) 2005-08-12
EA006708B1 (ru) 2006-02-24
HN2002000299A (es) 2002-11-21
PL368919A1 (en) 2005-04-04
UA75714C2 (en) 2006-05-15
CA2463264A1 (en) 2003-05-01
PA8556701A1 (es) 2003-07-28
DE60226161D1 (de) 2008-05-29
DE60226161T2 (de) 2009-07-02
MXPA04003730A (es) 2004-07-23
ATE392415T1 (de) 2008-05-15
OA12711A (en) 2006-06-27
NO329092B1 (no) 2010-08-23
TNSN04071A1 (fr) 2006-06-01
MA27141A1 (fr) 2005-01-03
EP1440059A1 (en) 2004-07-28
JP2005511545A (ja) 2005-04-28
PT1440059E (pt) 2008-05-16
IS7187A (is) 2004-03-18
SV2004001363A (es) 2004-02-24
AR036905A1 (es) 2004-10-13
KR100621292B1 (ko) 2006-09-13
EA200400467A1 (ru) 2004-08-26
JP2008069169A (ja) 2008-03-27
CA2463264C (en) 2009-05-26
MY136580A (en) 2008-10-31
AU2002329557B2 (en) 2008-07-31
SI1440059T1 (sl) 2008-08-31
ECSP045077A (es) 2004-05-28
DK1440059T3 (da) 2008-07-14
ZA200402172B (en) 2006-09-27
ES2302839T3 (es) 2008-08-01
KR20040048984A (ko) 2004-06-10
NO20041626L (no) 2004-05-26
NZ531807A (en) 2006-03-31
US20070054950A1 (en) 2007-03-08
PE20030610A1 (es) 2003-07-12
IL161157A (en) 2009-09-01
US20050171178A1 (en) 2005-08-04
US7049335B2 (en) 2006-05-23
US20030087898A1 (en) 2003-05-08
JP4155522B2 (ja) 2008-09-24
GEP20084300B (en) 2008-02-11
AP2004003007A0 (en) 2004-06-30
WO2003035622A1 (en) 2003-05-01
EP1440059B1 (en) 2008-04-16
HUP0401884A2 (hu) 2005-01-28

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