AR063680A1 - Derivados de pirazolo[1, 5-a]pirimidina, metodos e intermediario para su preparacion, composiciones farmaceuticas que los comprenden y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mediadas por la modulacion de mglur5. - Google Patents
Derivados de pirazolo[1, 5-a]pirimidina, metodos e intermediario para su preparacion, composiciones farmaceuticas que los comprenden y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mediadas por la modulacion de mglur5.Info
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- AR063680A1 AR063680A1 ARP070103437A ARP070103437A AR063680A1 AR 063680 A1 AR063680 A1 AR 063680A1 AR P070103437 A ARP070103437 A AR P070103437A AR P070103437 A ARP070103437 A AR P070103437A AR 063680 A1 AR063680 A1 AR 063680A1
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- Prior art keywords
- alkylaminocarbonyl
- alkylamino
- alkyl
- aryl
- heterocyclyl
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Abstract
Estos compuestos son potentes moduladores de mGluR5 y son útiles, por ejemplo, para el tratamiento de diversos trastornos neurológicos. Reivindicación 1: Un compuesto de pirazolo-pirimidina de fórmula (1) donde Y1, Y2 e Y3 independientemente son CR10, CR11, CR10R11, NR12, S o O, donde al menos uno de Y1, Y2 e Y3 denota CR10; o Y1 e Y2 juntos denotan un grupo R10C=N; R10C=CR11; R10R11C-C(=O) o R12N-(C=O); o Y2 e Y3 juntos denotan un grupo R10C=N; R10C=CR11; R10R11C-C(=O) o R12N-(C=O); R1 representa cloro o bromo; R2 representa hidrógeno, alquilo C1-6, cicloalquiIo C3-7 o trifluorometilo; R3 representa hidrógeno, alquilo C1-6, cicloaIquilo C3-7 o trifluorometilo; o R2 y R3, junto con el átomo de carbono del anillo, representan un grupo carbonilo; R4 representa hidrógeno, alquilo C1-6, cicloalquilo C3-7 o trifluorometilo; R5 representa hidrógeno, alquilo C1-6, cicloalquilo C3-7 o trifluorometilo; o R4 y R5, junto con el átomo de carbono del anillo, representan un grupo carbonilo; R6 representa hidrógeno, alquilo C1-6, cicloalquilo C3-7 o trifluorometilo; R7 representa hidrógeno, alquilo C1-6, cicloalquilo C3-7 o trifluorometilo; R6 y R7, junto con el átomo de carbono del anillo, representan un grupo carbonilo; R2 o R3, junto con R6 o R7, pueden formar un radical bivalente del tipo CH2-CH2 o CH2-O; R10 y R11 independientemente representan hidrógeno, halógeno, amino, hidroxi, nitro, ciano, trifluorometilo, trifluorometoxi, arilo, alquilo C1-6, cicloalquilo C3- 7, alquenilo C2-6, alquinilo C2-6, alcoxi C1-6, cicloalquiloxi C3-7, alqueniloxi C2-6, alquiniloxi C2-6, heteroarilo, heterociclilo, ariloxi, heteroariloxi, heterocicliloxi, alquilamino C1-6, di-alquilamino C1-6, cicloalquilamino C3-7, di- cicloalquilamino C3-7, alquil C1-6-cicloalquilamino C3-7, alquenilamino C2-6, alquinilamino C2-6, di-alquenilamino C2-6, di-alquinilamino C2-6, alquil C1-6-alquenilamino C2-6, alquil C1-6-alquinilamino C2-6, alquenil C2-6-cicloalquilamino C3-7, alquinil C2-6-cicloalquilamino C3-7, alquenil C2-6-alquinilamino C2-6, arilamino, diarilamino, aril-alquilamino C1-6, aril-alquenilamino C2-6, aril-alquinilamino C2-6, aril-cicloalquilamino C3-7, heteroarilamino, diheteroarilamino, heteroaril- alquilamino C1-6, heteroaril-alquenilamino C2-6, heteroaril-alquinilamino C2-6, heteroaril-cicloalquilamino C3-7, heteroarilarilamino, heterociclilamino, diheterociclilamino, heterociclilalquilamino C1-6, heterociclil-alquenilamino C2-6, heterociclil-alquinilamino C2-6, heterociclil-cicloalquilamino C3-7, heterociclilarilamino, heterociclilheteroarilamino, acil, aciloxi, acilamino, alcoxicarbonilo C1-6, cicloalcoxicarbonilo C3-7, alqueniloxicarbonilo C2-6, alquiniloxicarbonilo C2-6, ariloxicarbonilo, heteroariloxicarbonilo, heterocicliloxicarbonilo, aminocarbonilo, alquilamino-carbonilo C1-6, di-alquilaminocarbonilo C1-6, cicloalquilaminocarbonilo C3-7, di-cicloalquilaminocarbonilo C3-7, aIquil C1-6-cicloalquilaminocarbonilo C3- 7, alquenil-aminocarbonilo C2-6, alquinil-aminocarbonilo C2-6, di-alquenilaminocarbonilo C2-6, di-alquinilaminocarbonilo C2-6, alquil C1-6-alquenilaminocarbonilo C2-6, aIquil C1-6-alquinil-aminocarbonilo C2-6, alquenil C2-6- cicloalquilaminocarbonilo C3-7, alquinil C2-6-cicloalquilaminocarbonilo C3-7, alqueniI C2-6-alquinilaminocarbonilo C2-6, arilaminocarbonilo, diarilaminocarbonilo, aril-alquilaminocarbonilo C1-6, aril-alquenilaminocarbonilo C2-6, aril- alquinilaminocarbonilo C2-6, aril- cicloalquilaminocarbonilo C3-7, heteroarilaminocarbonilo, diheteroarilaminocarbonilo, heteroaril-alquilaminocarbonilo C1-6, heteroaril-alquenilaminocarbonilo C2-6, heteroaril-alquinilaminocarbonilo C2-6, heteroaril- cicloalquilaminocarbonilo C3-7, heteroarilarilaminocarbonilo, heterociclilaminocarbonilo, diheterociclilamino-carbonilo, heterociclil-alquilaminocarbonilo C1-6, heterociclil-alquenilamino-carbonilo C2-6, heterociclil-alquinilaminocarbonilo C2-6, heterociclil- cicloalquilaminocarbonilo C3-7, heterociclilarilaminocarbonilo, heterociclilheteroarilamino-carbonilo, alquilsulfinilo C1-6, cicloalquilsulfinilo C3-7, alquenilsulfinilo C2-6, alquinilsulfinilo C2-6, arilsulfinilo, heteroarilsulfinilo, heterociclilsulfinilo, alquilsulfonilo C1-6, cicloalquilsulfonilo C3-7, alquenilsulfonilo C2-6, alquinilsulfonilo C2-6, arilsulfonilo, heteroarilsulfonilo, heterociclilsulfonilo, alquilsulfonilamino C1-6 o arilsulfonilamino; y R12 representa hidrógeno, alquilo C1-6, cicloalquilo C3-7, alquenilo C2-6, alquinilo C2-6, acilo, arilo, heteroarilo, heterociclilo, alquilamino-carbonilo C1-6, di-alquilamino-carbonilo C1-6, alquilsulfonilo C1-6, arilsulfonilo o heteroarilsulfonilo; e isómeros ópticos, sales, hidratos, solvatos y polimorfos farmacéuticamente aceptables de dicho compuesto. Reivindicación 29: Un proceso para la síntesis de un compuesto seleccionado entre aquellos de fórmula (1) donde: Y1, Y2 e Y3 independientemente son CR10, CR11, CR10R11, NR12, S o O, donde al menos uno de Y1, Y2 e Y3 denota CR10; o Y1 e Y2 juntos denotan un grupo R10C=N; R10C=CR11; R10R11C-C(=O) o R12N-(C=O); o Y2 e Y3 juntos denotan un grupo R10C=N; R10C=CR11; R10R11C-C(=O) o R12N-(C=O); R1 representa cloro o bromo; R2 representa hidrógeno, alquilo C1-6, cicloalquiIo C3-7 o trifluorometilo; R3 representa hidrógeno, alquilo C1-6, cicloaIquilo C3-7 o trifluorometilo; o R2 y R3, junto con el átomo de carbono del anillo, representan un grupo carbonilo; R4 representa hidrógeno, alquilo C1-6, cicloalquilo C3-7 o trifluorometilo; R5 representa hidrógeno, alquilo C1-6, cicloalquilo C3-7 o trifluorometilo; o R4 y R5, junto con el átomo de carbono del anillo, representan un grupo carbonilo; R6 representa hidrógeno, alquilo C1-6, cicloalquilo C3-7 o trifluorometilo; R7 representa hidrógeno, alquilo C1-6, cicloalquilo C3-7 o trifluorometilo; R6 y R7, junto con el átomo de carbono del anillo, representan un grupo carbonilo; R2 o R3, junto con R6 o R7, pueden formar un radical bivalente del tipo CH2-CH2 o CH2-O; R10 y R11 independientemente representan hidrógeno, halógeno, amino, hidroxi, nitro, ciano, trifluorometilo, trifluorometoxi, arilo, alquilo C1-6, cicloalquilo C3- 7, alquenilo C2-6, alquinilo C2-6, alcoxi C1-6, cicloalquiloxi C3-7, alqueniloxi C2-6, alquiniloxi C2-6, heteroarilo, heterociclilo, ariloxi, heteroariloxi, heterocicliloxi, alquilamino C1-6, di-alquilamino C1-6, cicloalquilamino C3-7, di- cicloalquilamino C3-7, alquil C1-6-cicloalquilamino C3-7, alquenilamino C2-6, alquinilamino C2-6, di-alquenilamino C2-6, di-alquinilamino C2-6, alquil C1-6-alquenilamino C2-6, alquil C1-6-alquinilamino C2-6, alquenil C2-6-cicloalquilamino C3-7, alquinil C2-6-cicloalquilamino C3-7, alquenil C2-6-alquinilamino C2-6, arilamino, diarilamino, aril-alquilamino C1-6, aril-alquenilamino C2-6, aril-alquinilamino C2-6, aril-cicloalquilamino C3-7, heteroarilamino, diheteroarilamino, heteroaril- alquilamino C1-6, heteroaril-alquenilamino C2-6, heteroaril-alquinilamino C2-6, heteroaril-cicloalquilamino C3-7, heteroarilarilamino, heterociclilamino, diheterociclilamino, heterociclilalquilamino C1-6, heterociclil-alquenilamino C2-6, heterociclil-alquinilamino C2-6, heterociclil-cicloalquilamino C3-7, heterociclilarilamino, heterociclilheteroarilamino, acil, aciloxi, acilamino, alcoxicarbonilo C1-6, cicloalcoxicarbonilo C3-7, alqueniloxicarbonilo C2-6, alquiniloxicarbonilo C2-6, ariloxicarbonilo, heteroariloxicarbonilo, heterocicliloxicarbonilo, aminocarbonilo, alquilamino-carbonilo C1-6, di-alquilaminocarbonilo C1-6, cicloalquilaminocarbonilo C3-7, di-cicloalquilaminocarbonilo C3-7, aIquil C1-6-cicloalquilaminocarbonilo C3- 7, alquenil-aminocarbonilo C2-6, alquinil-aminocarbonilo C2-6, di-alquenilaminocarbonilo C2-6, di-alquinilaminocarbonilo C2-6, alquil C1-6-alquenilaminocarbonilo C2-6, aIquil C1-6-alquinil-aminocarbonilo C2-6, alquenil C2-6- cicloalquilaminocarbonilo C3-7, alquinil C2-6-cicloalquilaminocarbonilo C3-7, alqueniI C2-6-alquinilaminocarbonilo C2-6, arilaminocarbonilo, diarilaminocarbonilo, aril-alquilaminocarbonilo C1-6, aril-alquenilaminocarbonilo C2-6, aril- alquinilaminocarbonilo C2-6, aril- cicloalquilaminocarbonilo C3-7, heteroarilaminocarbonilo, diheteroarilaminocarbonilo, heteroaril-alquilaminocarbonilo C1-6, heteroaril-alquenilaminocarbonilo C2-6, heteroaril-alquinilaminocarbonilo C2-6, heteroaril- cicloalquilaminocarbonilo C3-7, heteroarilarilaminocarbonilo, heterociclilaminocarbonilo, diheterociclilamino-carbonilo, heterociclil-alquilaminocarbonilo C1-6, heterociclil-alquenilamino-carbonilo C2-6, heterociclil-alquinilaminocarbonilo C2-6, heterociclil- cicloalquilaminocarbonilo C3-7, heterociclilarilaminocarbonilo, heterociclilheteroarilamino-carbonilo, alquilsulfinilo C1-6, cicloalquilsulfinilo C3-7, alquenilsulfinilo C2-6, alquinilsulfinilo C2-6, arilsulfinilo, heteroarilsulfinilo, heterociclilsulfinilo, alquilsulfonilo C1-6, cicloalquilsulfonilo C3-7, alquenilsulfonilo C2-6, alquinilsulfonilo C2-6, arilsulfonilo, heteroarilsulfonilo, heterociclilsulfonilo, alquilsulfonilamino C1-6 o arilsulfonilamino; y R12 representa hidrógeno, alquilo C1-6, cicloalquilo C3-7, alquenilo C2-6, alquinilo C2-6, acilo, arilo, heteroarilo, heterociclilo, alquilamino-carbonilo C1-6, di-alquilamino-carbonilo C1-6, alquilsulfonilo C1-6, arilsulfonilo o heteroarilsulfonilo; e isómeros ópticos, sales, hidratos, solvatos y polimorfos farmacéuticamente aceptables de dicho compuesto, donde un compuesto de fórmula (2) se suspende en una mezcla de etanol y agua y se trata con ácido clorhídrico, seguido por la reacción con H2NNHCOOCH3, para proporcionar un compuesto de fórmula (3), el cual se hace reaccionar con un compuesto de fórmula (4) para proporcionar un compuesto de fórmula (5) el cual se hidroliza en condiciones ácidas para proporcionar un compuesto de fórmula (6) el cual se trata con una amina de fórmula (7) en presencia de un agente de condensación, para proporcionar un compuesto de fórmula (1), el cual se convierte, si así se desea, en una sal, hidrato, solvato o polimorfo farmacé
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Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008056176A1 (en) * | 2006-11-10 | 2008-05-15 | Scottish Biomedical Limited | Pyrazolopyrimidines as phosphodiesterase inhibitors |
HK1136565A1 (en) * | 2007-03-31 | 2010-07-02 | Intervet Int Bv | Processes for making zilpaterol and salts thereof |
EP2090576A1 (en) * | 2008-02-01 | 2009-08-19 | Merz Pharma GmbH & Co.KGaA | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators |
CA2729595C (en) * | 2008-06-30 | 2017-01-03 | Novartis Ag | Combinations comprising mglur modulators for the treatment of parkinson's disease |
RU2012126150A (ru) | 2009-11-25 | 2013-12-27 | Мерц Фарма Гмбх Унд Ко. Кгаа | Кристаллические формы замещенных пиразолопиримидинов |
WO2012078817A1 (en) | 2010-12-08 | 2012-06-14 | Vanderbilt University | Bicyclic pyrazole compounds as allosteric modulators of mglur5 receptors |
US8865725B2 (en) | 2011-03-15 | 2014-10-21 | Vanderbilt University | Substituted imidazopyrimidin-5(6H)-ones as allosteric modulators of MGLUR5 receptors |
JP2014508172A (ja) * | 2011-03-15 | 2014-04-03 | ヴァンダービルト ユニバーシティー | Mglur5受容体のアロステリック調節剤としての置換イミダゾピリミジン−5(6h)−オン |
WO2012139876A1 (en) | 2011-04-14 | 2012-10-18 | Merz Pharma Gmbh & Co. Kgaa | Enteric formulations of metabotropic glutamate receptor modulators |
US8791108B2 (en) | 2011-08-18 | 2014-07-29 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
WO2013087808A1 (en) | 2011-12-15 | 2013-06-20 | Merz Pharma Gmbh & Co. Kgaa | Pharmaceutical composition comprising a pyrazolopyrimidme and cyclodextrin |
WO2013087815A1 (en) | 2011-12-15 | 2013-06-20 | Merz Pharma Gmbh & Co. Kgaa | Liquid pharmaceutical composition containing a pyrazolopyrimidine derivative and pharmaceutical uses thereof |
US9006235B2 (en) | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
JP5898815B2 (ja) * | 2012-03-29 | 2016-04-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なピラゾロピリミジン |
JO3407B1 (ar) * | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
WO2014035707A1 (en) * | 2012-08-25 | 2014-03-06 | The Johns Hopkins University | Gapdh cascade inhibitor compounds and methods of use and treatment of stress induced disorders including mental illness |
KR20150119370A (ko) | 2013-02-19 | 2015-10-23 | 화이자 인코포레이티드 | Cns 장애 및 다른 장애의 치료를 위한 pde4 동종효소의 억제제로서의 아자벤즈이미다졸 화합물 |
CN105189510B (zh) | 2013-03-13 | 2017-05-17 | 百时美施贵宝公司 | 人免疫缺陷病毒复制的抑制剂 |
CN105189511B (zh) | 2013-03-13 | 2017-05-24 | 百时美施贵宝公司 | 人免疫缺陷病毒复制的抑制剂 |
US9540393B2 (en) | 2013-03-14 | 2017-01-10 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
WO2014197536A2 (en) | 2013-06-04 | 2014-12-11 | Temple University Of The Commonwealth | Novel beta lactams as modulators of glutamate uptake and methods for use thereof |
AU2014346846A1 (en) | 2013-11-05 | 2016-06-09 | Temple University Of The Commonwealth System Of Higher Education | Polycationic amphiphiles as antimicrobial agents |
US10398142B2 (en) | 2013-11-05 | 2019-09-03 | Temple University Of The Commonwealth System Of Higher Education | Polycationic amphiphiles as antimicrobial agents |
GB201320905D0 (en) | 2013-11-27 | 2014-01-08 | Takeda Pharmaceutical | Therapeutic compounds |
US9273067B2 (en) | 2014-02-19 | 2016-03-01 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
US10131669B2 (en) | 2014-07-24 | 2018-11-20 | Pfizer Inc. | Pyrazolopyrimidine compounds |
BR112017001334A2 (pt) | 2014-08-06 | 2017-11-14 | Pfizer | compostos de imidazopiridazina, seu uso e composição farmacêutica que os compreende |
UA125463C2 (uk) | 2016-01-27 | 2022-03-16 | Універсітет Цюріх | ЗАСТОСУВАННЯ МОДУЛЯТОРІВ GABA<sub>A</sub>-РЕЦЕПТОРА ДЛЯ ЛІКУВАННЯ СВЕРБЕЖУ |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH603545A5 (es) | 1972-04-20 | 1978-08-31 | Merz & Co | |
GB1383409A (en) * | 1972-09-09 | 1974-02-12 | Pfizer Ltd | Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them |
US3988339A (en) * | 1974-02-08 | 1976-10-26 | Smithkline Corporation | Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase |
US3974283A (en) * | 1974-03-18 | 1976-08-10 | Sandoz, Inc. | N-substituted-4-T-butyl-1-pyridinethiocarboxamides and their use for treatment of inflammation or pain |
NZ190915A (en) * | 1978-07-31 | 1984-07-31 | Hoffmann La Roche | Oxadiazolotriazine derivatives and pharmaceutical compositions |
DE2856393C2 (de) | 1978-12-27 | 1983-04-28 | Merz + Co GmbH & Co, 6000 Frankfurt | Arzneimittel zur Behandlung von Morbus Parkinson |
SU768177A1 (ru) * | 1979-04-23 | 1985-08-07 | МГУ им.М.В.Ломоносова | Способ получени ( @ )-(-) или ( @ )-(+)-1=метил-1,2,3,4-тетрагидроизохинолина |
ZA803591B (en) * | 1979-07-09 | 1981-06-24 | American Cyanamid Co | Substituted pyrazolo(1,5-a)pyrimidines |
US4340597A (en) * | 1981-04-13 | 1982-07-20 | Schering Corporation | 1-Substituted-4-aryl-1,2,5,6-tetrahydro and hexahydropyridines |
DE3308554A1 (de) | 1983-03-10 | 1984-09-13 | Hoechst Ag, 6230 Frankfurt | 1-/1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung und ihre verwendung |
WO1989005643A1 (en) * | 1987-12-18 | 1989-06-29 | Pfizer Inc. | Heterocyclic-substituted quinoline-carboxylic acids |
DE10299048I2 (de) | 1989-04-14 | 2006-07-13 | Merz Pharma Gmbh & Co Kgaa | Verwendung von Adamantan-Derivaten zur Pr{vention und Behandlung der cerebralen Isch{mie |
US6177443B1 (en) * | 1997-03-07 | 2001-01-23 | Novo Nordisk A/S | 4,5,6,7-tetrahydro-thieno[3, 2-C]pyridine derivatives, their preparation and use |
CZ293248B6 (cs) | 1997-06-30 | 2004-03-17 | Merz Pharma Gmbh & Co. Kgaa | 1-Aminocyklohexanový derivát a farmaceutická kompozice na jeho bázi |
US6071966A (en) | 1997-06-30 | 2000-06-06 | Merz + Co. Gmbh & Co. | 1-amino-alkylcyclohexane NMDA receptor antagonists |
DE19732589A1 (de) * | 1997-07-29 | 1999-02-04 | Huels Chemische Werke Ag | Verfahren zur Herstellung von 1,2,3,6-tetrahydro-2,2,6,6-tetramethylpyridin |
FR2769313B1 (fr) * | 1997-10-06 | 2000-04-21 | Sanofi Sa | Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese |
WO1999026927A2 (en) | 1997-11-21 | 1999-06-03 | Nps Pharmaceuticals, Inc. | Metabotropic glutamate receptor antagonists for treating central nervous system diseases |
JP4459437B2 (ja) * | 1997-12-25 | 2010-04-28 | 明治製菓株式会社 | テトラヒドロベンズインドール誘導体 |
EP1107758A2 (en) | 1998-08-28 | 2001-06-20 | Scios Inc. | Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase |
US20020049223A1 (en) | 1999-11-05 | 2002-04-25 | Elmore Steven W. | Quinoline and naphthyridine carboxylic acid antibacterials |
WO2001047891A1 (fr) * | 1999-12-28 | 2001-07-05 | Eisai Co., Ltd. | Composes heterocylciques contenant des groupes de sulfamide |
GB0110338D0 (en) | 2001-04-27 | 2001-06-20 | Sb Pharmco Inc | Novel processes |
GB0118752D0 (en) * | 2001-08-01 | 2001-09-26 | Pfizer Ltd | Process for the production of quinazolines |
WO2003037900A2 (en) | 2001-11-01 | 2003-05-08 | Icagen, Inc. | Pyrazolopyrimidines |
KR20040097375A (ko) | 2002-04-23 | 2004-11-17 | 시오노기 앤드 컴파니, 리미티드 | 피라졸로[1, 5-에이]피리미딘 유도체 및 이를 함유한엔에이디(피)에이취 산화효소 저해제 |
WO2003101993A1 (en) | 2002-06-04 | 2003-12-11 | Neogenesis Pharmaceuticals, Inc. | Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents |
AU2003264018A1 (en) * | 2002-08-09 | 2004-02-25 | Astrazeneca Ab | Compounds having an activity at metabotropic glutamate receptors |
ES2423800T3 (es) | 2003-03-28 | 2013-09-24 | Novartis Vaccines And Diagnostics, Inc. | Uso de compuestos orgánicos para la inmunopotenciación |
JP2006522750A (ja) | 2003-04-11 | 2006-10-05 | ノボ ノルディスク アクティーゼルスカブ | 代謝性症候群ならびに関連の疾患および障害を治療するために、11β−ヒドロキシステロイドデヒドロゲナーゼ1型阻害剤および抗高血圧剤を使用する併用療法 |
WO2004089415A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST |
EP1615697A2 (en) * | 2003-04-11 | 2006-01-18 | Novo Nordisk A/S | New pyrazolo[1,5-a] pyrimidine derivatives and pharmaceutical use thereof |
CA2570043A1 (en) | 2004-06-08 | 2005-12-22 | Chiron Corporation | Env polypeptide complexes and methods of use |
BRPI0514015A (pt) | 2004-08-02 | 2008-05-27 | Sanol Arznei Schwarz Gmbh | carboxamidas da indolizina e seus derivados aza e diaza |
JP2008527031A (ja) | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なピロロピリジン誘導体 |
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2007
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- 2007-08-03 AT AT07788196T patent/ATE494289T1/de active
- 2007-08-03 CA CA002659871A patent/CA2659871A1/en not_active Abandoned
- 2007-08-03 BR BRPI0714766-0A patent/BRPI0714766A2/pt not_active IP Right Cessation
- 2007-08-03 CA CA002659876A patent/CA2659876A1/en not_active Abandoned
- 2007-08-03 JP JP2009522284A patent/JP2010500288A/ja active Pending
- 2007-08-03 TW TW096128671A patent/TWI399376B/zh not_active IP Right Cessation
- 2007-08-03 EP EP10190596A patent/EP2295439A1/en not_active Withdrawn
- 2007-08-03 US US11/890,211 patent/US7947689B2/en not_active Expired - Fee Related
- 2007-08-03 MX MX2009001036A patent/MX2009001036A/es active IP Right Grant
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- 2007-08-03 US US11/890,230 patent/US20080032998A1/en not_active Abandoned
- 2007-08-03 WO PCT/EP2007/058060 patent/WO2008015269A1/en active Application Filing
- 2007-08-03 WO PCT/EP2007/058061 patent/WO2008015270A1/en active Application Filing
- 2007-08-03 KR KR1020097002224A patent/KR20090047450A/ko not_active Application Discontinuation
- 2007-08-03 AU AU2007280428A patent/AU2007280428B2/en not_active Ceased
- 2007-08-03 EP EP07788197A patent/EP2054421B1/en active Active
- 2007-08-03 JP JP2009522285A patent/JP2009545569A/ja not_active Abandoned
- 2007-08-03 AT AT07788197T patent/ATE488520T1/de active
- 2007-08-03 PT PT07788196T patent/PT2054416E/pt unknown
- 2007-08-03 US US11/890,199 patent/US7985753B2/en not_active Expired - Fee Related
- 2007-08-03 DK DK07788196.9T patent/DK2054416T3/da active
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- 2007-08-03 AR ARP070103438A patent/AR062209A1/es unknown
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- 2007-08-03 EP EP07788196.9A patent/EP2054416B8/en active Active
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2008
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