CY1112003T1 - Υποκατεστημενες πυραζολοπυριμιδινες, μεθοδος για την παρασκευη αυτων και χρηση αυτων ως φαρμακο - Google Patents

Υποκατεστημενες πυραζολοπυριμιδινες, μεθοδος για την παρασκευη αυτων και χρηση αυτων ως φαρμακο

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Publication number
CY1112003T1
CY1112003T1 CY20111100303T CY111100303T CY1112003T1 CY 1112003 T1 CY1112003 T1 CY 1112003T1 CY 20111100303 T CY20111100303 T CY 20111100303T CY 111100303 T CY111100303 T CY 111100303T CY 1112003 T1 CY1112003 T1 CY 1112003T1
Authority
CY
Cyprus
Prior art keywords
drug
preparation
hydrogen
substituted pyrazolopyrimidines
substituted
Prior art date
Application number
CY20111100303T
Other languages
English (en)
Inventor
Wojciech Danysz
Andrzej Dekundy
Mirko Hechenberger
Markus Henrich
Claudia Jatzke
Jens Nagel
Christopher Graham Raphael Parsons
Tanja Weil
Juris Fotins
Aleksandra Gutcaits
Ivars Kalvinsh
Ronalds Zemribo
Valerjans Kauss
Original Assignee
Merz Pharma Gmbh & Co. Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co. Kgaa filed Critical Merz Pharma Gmbh & Co. Kgaa
Publication of CY1112003T1 publication Critical patent/CY1112003T1/el

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Communicable Diseases (AREA)

Abstract

Υποκατεστημένης πυραζολοπυριμιδίνης παράγωγα του τύπου (I) όπου τα Υ1, Υ2, Υ3, Υ4, αντιπροσωπεύουν Ν ή C-, όπου τουλάχιστον δύο των ομάδων Υ1 έως Υ4 υποδηλώνουν άτομο άνθρακα, το R1 αντιπροσωπεύει χλώρο ή βρώμο, το R2 έως R7 αντιπροσωπεύει π.χ., υδρογόνο, μεθύλ ή αιθύλ και τα R10 και R11 ανεξαρτήτως αντιπροσωπεύουν π.χ. υδρογόνο ή C1- C6αλκύλ, είναι ισχυροί ρυθμιστές mGluR5 και είναι χρήσιμοι για την αποτροπή οξέων και χρόνιων νευρολογικών διαταραχών.
CY20111100303T 2006-08-04 2011-03-21 Υποκατεστημενες πυραζολοπυριμιδινες, μεθοδος για την παρασκευη αυτων και χρηση αυτων ως φαρμακο CY1112003T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83582006P 2006-08-04 2006-08-04
US87754406P 2006-12-28 2006-12-28
EP07788196.9A EP2054416B8 (en) 2006-08-04 2007-08-03 Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine

Publications (1)

Publication Number Publication Date
CY1112003T1 true CY1112003T1 (el) 2015-11-04

Family

ID=38710494

Family Applications (1)

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CY20111100303T CY1112003T1 (el) 2006-08-04 2011-03-21 Υποκατεστημενες πυραζολοπυριμιδινες, μεθοδος για την παρασκευη αυτων και χρηση αυτων ως φαρμακο

Country Status (21)

Country Link
US (4) US20080032998A1 (el)
EP (3) EP2295439A1 (el)
JP (2) JP2010500288A (el)
KR (1) KR20090047450A (el)
AR (3) AR063680A1 (el)
AT (2) ATE494289T1 (el)
AU (2) AU2007280428B2 (el)
BR (2) BRPI0714622A2 (el)
CA (2) CA2659876A1 (el)
CY (1) CY1112003T1 (el)
DE (2) DE602007011773D1 (el)
DK (1) DK2054416T3 (el)
HR (1) HRP20110128T1 (el)
IL (2) IL196008A0 (el)
MX (2) MX2009001036A (el)
PL (1) PL2054416T3 (el)
PT (1) PT2054416E (el)
RU (2) RU2009107688A (el)
TW (3) TWI399376B (el)
WO (3) WO2008015270A1 (el)
ZA (1) ZA200810605B (el)

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EP2090576A1 (en) * 2008-02-01 2009-08-19 Merz Pharma GmbH & Co.KGaA 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators
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US20120283274A1 (en) 2009-11-25 2012-11-08 Patrick Plitt Crystalline forms of substituted pyrazolopyrimidines
EP2648723A4 (en) 2010-12-08 2014-04-02 Univ Vanderbilt USE OF BICYCLIC PYRAZOLE COMPOUNDS AS ALLUSTERIC MODULATORS OF MGLUR5 RECEPTORS
US8865725B2 (en) 2011-03-15 2014-10-21 Vanderbilt University Substituted imidazopyrimidin-5(6H)-ones as allosteric modulators of MGLUR5 receptors
CA2830220A1 (en) * 2011-03-15 2012-09-20 Vanderbilt University Substituted imidazopyrimidin-5(6h)-ones as allosteric modulators of mglur5 receptors
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US9006235B2 (en) 2012-03-06 2015-04-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
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JO3407B1 (ar) * 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
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WO2014164467A1 (en) 2013-03-13 2014-10-09 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
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