ATE494289T1 - Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin - Google Patents

Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin

Info

Publication number
ATE494289T1
ATE494289T1 AT07788196T AT07788196T ATE494289T1 AT E494289 T1 ATE494289 T1 AT E494289T1 AT 07788196 T AT07788196 T AT 07788196T AT 07788196 T AT07788196 T AT 07788196T AT E494289 T1 ATE494289 T1 AT E494289T1
Authority
AT
Austria
Prior art keywords
medicine
production
substituted pyrazolopyrimidines
pyrazolopyrimidines
substituted
Prior art date
Application number
AT07788196T
Other languages
English (en)
Inventor
Wojciech Danysz
Andrzej Dekundy
Mirko Hechenberger
Markus Henrich
Claudia Jatzke
Jens Nagel
Christopher Graham Raphael Parsons
Tanja Weil
Juris Fotins
Aleksandra Gutcaits
Ivars Kalvinsh
Ronalds Zemribo
Valerjans Kauss
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
Application granted granted Critical
Publication of ATE494289T1 publication Critical patent/ATE494289T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Anesthesiology (AREA)
AT07788196T 2006-08-04 2007-08-03 Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin ATE494289T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83582006P 2006-08-04 2006-08-04
US87754406P 2006-12-28 2006-12-28
PCT/EP2007/058060 WO2008015269A1 (en) 2006-08-04 2007-08-03 Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine

Publications (1)

Publication Number Publication Date
ATE494289T1 true ATE494289T1 (de) 2011-01-15

Family

ID=38710494

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07788197T ATE488520T1 (de) 2006-08-04 2007-08-03 Pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin
AT07788196T ATE494289T1 (de) 2006-08-04 2007-08-03 Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT07788197T ATE488520T1 (de) 2006-08-04 2007-08-03 Pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin

Country Status (21)

Country Link
US (4) US7947689B2 (de)
EP (3) EP2054416B8 (de)
JP (2) JP2009545569A (de)
KR (1) KR20090047450A (de)
AR (3) AR062210A1 (de)
AT (2) ATE488520T1 (de)
AU (2) AU2007280429A1 (de)
BR (2) BRPI0714766A2 (de)
CA (2) CA2659871A1 (de)
CY (1) CY1112003T1 (de)
DE (2) DE602007010640D1 (de)
DK (1) DK2054416T3 (de)
HR (1) HRP20110128T1 (de)
IL (2) IL196008A0 (de)
MX (2) MX2009000919A (de)
PL (1) PL2054416T3 (de)
PT (1) PT2054416E (de)
RU (2) RU2450004C2 (de)
TW (3) TW200815432A (de)
WO (3) WO2008015269A1 (de)
ZA (1) ZA200810605B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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WO2008056176A1 (en) * 2006-11-10 2008-05-15 Scottish Biomedical Limited Pyrazolopyrimidines as phosphodiesterase inhibitors
JP5856990B2 (ja) * 2007-03-31 2016-02-10 インターベット インターナショナル ベー． フェー． ジルパテロールおよびこの塩の製造方法
EP2090576A1 (de) * 2008-02-01 2009-08-19 Merz Pharma GmbH & Co.KGaA 6-halo-Pyrazolo[1,5-a]pyridin-Verbindungen, Verfahren zu ihrer Herstellung und Verwendung als Modulatoren des Metabotropen Glutamatrezeptoren (mGluR)
EP2320892A2 (de) 2008-06-30 2011-05-18 Novartis AG Kombinationsprodukte
EP2504340A1 (de) 2009-11-25 2012-10-03 Merz Pharma GmbH & Co. KGaA Kristalline formen von substituierten pyrazolopyrimidinen
US8703946B2 (en) 2010-12-08 2014-04-22 Vanderbilt University Substituted pyrazolo[1,5-A]pyrazine compounds as allosteric modulators of mGluR5 receptors
US8865725B2 (en) 2011-03-15 2014-10-21 Vanderbilt University Substituted imidazopyrimidin-5(6H)-ones as allosteric modulators of MGLUR5 receptors
WO2012125732A1 (en) * 2011-03-15 2012-09-20 Vanderbilt University Substituted imadazapyrinidin-5(6h)-ones as allosteric modulators of mglur5 receptors
WO2012139876A1 (en) 2011-04-14 2012-10-18 Merz Pharma Gmbh & Co. Kgaa Enteric formulations of metabotropic glutamate receptor modulators
US8791108B2 (en) 2011-08-18 2014-07-29 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2013087815A1 (en) 2011-12-15 2013-06-20 Merz Pharma Gmbh & Co. Kgaa Liquid pharmaceutical composition containing a pyrazolopyrimidine derivative and pharmaceutical uses thereof
WO2013087808A1 (en) 2011-12-15 2013-06-20 Merz Pharma Gmbh & Co. Kgaa Pharmaceutical composition comprising a pyrazolopyrimidme and cyclodextrin
US9006235B2 (en) 2012-03-06 2015-04-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2013144172A1 (en) * 2012-03-29 2013-10-03 Boehringer Ingelheim International Gmbh Novel pyrazolopyrimidines
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
US20150218103A1 (en) 2012-08-25 2015-08-06 The Johns Hopkins University Gapdh cascade inhibitor compounds and methods of use and treatment of stress induced disorders including mental illness
CA2900302C (en) 2013-02-19 2018-07-03 Pfizer Inc. Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders
ES2619708T3 (es) 2013-03-13 2017-06-26 VIIV Healthcare UK (No.5) Limited Inhibidores de la replicación del virus de inmunodeficiencia humana
EP2970298A1 (de) 2013-03-13 2016-01-20 Bristol-Myers Squibb Company Hemmer der neubildung menschlicher immundefektviren
CN105008369B (zh) 2013-03-14 2017-07-11 百时美施贵宝公司 人类免疫缺陷病毒复制抑制剂
EP3036219A4 (de) * 2013-06-04 2017-08-23 Temple University Of The Commonwealth System Of Higher Education Neuartige beta-lactame als modulatoren einer glutamataufnahme und verfahren zur verwendung davon
AU2014346846A1 (en) 2013-11-05 2016-06-09 Temple University Of The Commonwealth System Of Higher Education Polycationic amphiphiles as antimicrobial agents
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