BR112022017382A2 - Composto, composição farmacêutica, uso do composto, e, métodos para tratar ou prevenir uma doença relacionada a ep4 e para tratar uma doença selecionada a partir de uma doença inflamatória, uma dor, um câncer, uma doença metabólica e uma doença do sistema urinário - Google Patents
Composto, composição farmacêutica, uso do composto, e, métodos para tratar ou prevenir uma doença relacionada a ep4 e para tratar uma doença selecionada a partir de uma doença inflamatória, uma dor, um câncer, uma doença metabólica e uma doença do sistema urinárioInfo
- Publication number
- BR112022017382A2 BR112022017382A2 BR112022017382A BR112022017382A BR112022017382A2 BR 112022017382 A2 BR112022017382 A2 BR 112022017382A2 BR 112022017382 A BR112022017382 A BR 112022017382A BR 112022017382 A BR112022017382 A BR 112022017382A BR 112022017382 A2 BR112022017382 A2 BR 112022017382A2
- Authority
- BR
- Brazil
- Prior art keywords
- disease
- compound
- treat
- alkyl
- pain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
COMPOSTO, COMPOSIÇÃO FARMACÊUTICA, USO DO COMPOSTO, E, MÉTODOS PARA TRATAR OU PREVENIR UMA DOENÇA RELACIONADA A EP4 E PARA TRATAR UMA DOENÇA SELECIONADA A PARTIR DE UMA DOENÇA INFLAMATÓRIA, UMA DOR, UM CÂNCER, UMA DOENÇA METABÓLICA E UMA DOENÇA DO SISTEMA URINÁRIO. A presente invenção refere-se a um composto capaz de antagonizar efetivamente EP4, que é um composto representado pela Fórmula I, ou um tautômero, um estereoisômero, um hidrato, um solvato, um sal farmaceuticamente aceitável ou um pró-fármaco do composto representado pela Fórmula I. R1 é selecionado a partir de -CH3, -CHF2 e -CF3; R2 é selecionado a partir de alquila C2-C6, cicloalquila C3-C6 , alquila C2-C6 halogenada e cicloalquila C3-C6 halogenada; R3 é selecionado a partir de hidrogênio, halogênio, alquila C1-C2 e alquila C1-C2 fluorada; R4 é selecionado a partir de hidrogênio, halogênio, alquila C1-C6 , alcoxila C1-C6 , alquila C1-C6 halogenada e alcóxi C1-C6 halogenado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010144983 | 2020-03-04 | ||
PCT/CN2021/079073 WO2021175283A1 (zh) | 2020-03-04 | 2021-03-04 | 新型ep4拮抗剂的合成及其在癌症和炎症中的用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022017382A2 true BR112022017382A2 (pt) | 2022-11-29 |
Family
ID=77524867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022017382A BR112022017382A2 (pt) | 2020-03-04 | 2021-03-04 | Composto, composição farmacêutica, uso do composto, e, métodos para tratar ou prevenir uma doença relacionada a ep4 e para tratar uma doença selecionada a partir de uma doença inflamatória, uma dor, um câncer, uma doença metabólica e uma doença do sistema urinário |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230125494A1 (pt) |
EP (1) | EP4116291A4 (pt) |
JP (1) | JP7446460B2 (pt) |
KR (1) | KR20220143062A (pt) |
CN (1) | CN113354585A (pt) |
AU (1) | AU2021229414B2 (pt) |
BR (1) | BR112022017382A2 (pt) |
CA (1) | CA3170288A1 (pt) |
IL (1) | IL296007A (pt) |
WO (1) | WO2021175283A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116801879A (zh) * | 2021-01-28 | 2023-09-22 | 深圳众格生物科技有限公司 | 吡唑酰胺衍生物及其制备方法和应用 |
KR20240042482A (ko) * | 2021-09-03 | 2024-04-02 | 우한 휴먼웰 이노베이티브 드러그 리서치 앤드 디벨롭먼트 센터 리미티드 컴퍼니 | Ep4 길항제 화합물, 이의 염, 다형체 및 용도 |
CN114380682A (zh) * | 2021-10-27 | 2022-04-22 | 上海毕得医药科技股份有限公司 | 一种2,3-二氟-4-甲氧基苯乙酸合成方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2576516T3 (pl) | 2010-06-03 | 2015-06-30 | Bayer Ip Gmbh | N-[(het)aryloetylo)]pirazolo(tio)karboksyamidy i ich analogi heteropodstawione |
KR101911105B1 (ko) * | 2010-09-21 | 2018-10-23 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 제약 조성물 |
MA39906A (fr) * | 2014-05-23 | 2017-03-01 | Eisai R&D Man Co Ltd | Polythérapies pour le traitement du cancer |
-
2021
- 2021-03-04 AU AU2021229414A patent/AU2021229414B2/en active Active
- 2021-03-04 WO PCT/CN2021/079073 patent/WO2021175283A1/zh unknown
- 2021-03-04 CN CN202110240347.3A patent/CN113354585A/zh active Pending
- 2021-03-04 BR BR112022017382A patent/BR112022017382A2/pt unknown
- 2021-03-04 JP JP2022552881A patent/JP7446460B2/ja active Active
- 2021-03-04 US US17/905,559 patent/US20230125494A1/en active Pending
- 2021-03-04 IL IL296007A patent/IL296007A/en unknown
- 2021-03-04 EP EP21765389.8A patent/EP4116291A4/en active Pending
- 2021-03-04 KR KR1020227031652A patent/KR20220143062A/ko active Search and Examination
- 2021-03-04 CA CA3170288A patent/CA3170288A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3170288A1 (en) | 2021-09-10 |
IL296007A (en) | 2022-10-01 |
AU2021229414A1 (en) | 2022-10-20 |
KR20220143062A (ko) | 2022-10-24 |
JP7446460B2 (ja) | 2024-03-08 |
JP2023516714A (ja) | 2023-04-20 |
CN113354585A (zh) | 2021-09-07 |
EP4116291A4 (en) | 2024-03-06 |
US20230125494A1 (en) | 2023-04-27 |
AU2021229414B2 (en) | 2023-07-06 |
WO2021175283A1 (zh) | 2021-09-10 |
EP4116291A1 (en) | 2023-01-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112022017382A2 (pt) | Composto, composição farmacêutica, uso do composto, e, métodos para tratar ou prevenir uma doença relacionada a ep4 e para tratar uma doença selecionada a partir de uma doença inflamatória, uma dor, um câncer, uma doença metabólica e uma doença do sistema urinário | |
MX2022008066A (es) | Compuestos triciclicos sustituidos. | |
MX2022006475A (es) | Compuestos triciclicos sustituidos. | |
AR063680A1 (es) | Derivados de pirazolo[1, 5-a]pirimidina, metodos e intermediario para su preparacion, composiciones farmaceuticas que los comprenden y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mediadas por la modulacion de mglur5. | |
MX2020005363A (es) | Compuestos heterociclicos como inhibidores de prmt5. | |
AR057531A1 (es) | Pirazolopirimidinas como inhibidores de quinasa dependientes de ciclina y composicion farmaceutica | |
PH12015502675A1 (en) | Cycloaklane derivative | |
MX2020008570A (es) | Inhibidores de arginasa y sus metodos de uso. | |
MX2018012711A (es) | Inhibidores de mcl-1 y metodos de uso de los mismos. | |
RU2018121834A (ru) | Новое соединение бифенила или его соль | |
AR061567A1 (es) | Compuestos puros enantiomericamente para el tratamiento de desordenes proliferativos | |
PE20240765A1 (es) | Compuestos para la inhibicion de nlrp3 y usos de estos | |
AR077292A1 (es) | Derivados de piperazin - quinolin sulfonamidas y composiciones farmaceuticas | |
BR112017017529A2 (pt) | derivado de ácido quenodeoxicólico deuterado e composição farmacêutica que compreende composto do mesmo | |
AR067599A1 (es) | Derivados de indazol sustituido activos como inhibidores de quinasa | |
CA3180846A1 (en) | Inhibitors of transcriptional enhanced associate domain (tead) and uses thereof | |
MX2009003874A (es) | Derivados de espiro-oxindol triciclicos y sus usos como agentes terapeuticos. | |
JP2009541223A5 (pt) | ||
EA200900593A1 (ru) | Производные птеридина как ингибиторы polo-подобной киназы, применяющиеся при лечении рака | |
NZ592238A (en) | Pharmaceutical compositions comprising 4-isopropyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridine derivatives | |
BR112015026478A2 (pt) | derivados de dolastatina 10 e auristatinas | |
NO20081582L (no) | Benzamidforbindelser anvendbare som histon-deacetylaseinhibitorer | |
PH12020552244A1 (en) | Heterocyclic compounds as trk inhibitors | |
WO2007134827A8 (en) | 5-phenyl-thiaz0l-2-yl-urea derivatives and use as pi3 kinase inhibitors | |
MX2019010096A (es) | Derivados de 1, 4, 6-trisustituidos-2-alquil-1h-benzo[d]imidazol como inhibidores de dihidroorotato oxigenasa. |