AR061567A1 - Compuestos puros enantiomericamente para el tratamiento de desordenes proliferativos - Google Patents
Compuestos puros enantiomericamente para el tratamiento de desordenes proliferativosInfo
- Publication number
- AR061567A1 AR061567A1 ARP070102738A ARP070102738A AR061567A1 AR 061567 A1 AR061567 A1 AR 061567A1 AR P070102738 A ARP070102738 A AR P070102738A AR P070102738 A ARP070102738 A AR P070102738A AR 061567 A1 AR061567 A1 AR 061567A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- unsubstituted
- alkylenehydroxy
- alkoxycarbonyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Se refiere además a intermediarios puros enantioméricamente de la misma, para procesos para la preparacion del compuesto puro enantioméricamente y sus intermediarios, y para una composicion farmacéutica que comprende el compuesto puro enantioméricamente. El compuesto de la formula (1) es util para el tratamiento de enfermedades o desordenes transmitidos por la inhibicion de la ciclina dependiente de la quinasa, como ser el cáncer. Reivindicacion 1: Compuesto puro enantioméricamente representado por la siguiente formula (1) o un metabolito, prodroga, sal farmacéuticamente aceptable, solvato farmacéuticamente aceptable o polimorfo de los mismos; en donde R1 es fenilo, que se encuentra no sustituido o sustituido por 1, 2, o 3 sustituyentes idénticos o diferentes seleccionados de: halogeno, nitro, ciano, alquilo C1-4, fluorometilo, difluorometilo, trifluorometilo, alcoxi C1-4, hidroxilo, carboxi, alcoxicarbonilo C1-4, alquilenohidroxilo C1-4, CONH2, CONR5R6, SO2NR5R6, cicloalquilo, NR5R6 y SR7; o es un heterociclo, que es un anillo saturado, parcialmente no saturado o aromático que contiene cinco o seis átomos en el anillo de los cuales 1, 2 o 3 son heteroátomos idénticos o diferentes seleccionados de: nitrogeno, oxígeno y azufre, y donde el heterociclo se encuentra no sustituido o sustituido por 1, 2, o 3 sustituyentes idénticos o diferentes seleccionados de: halogeno, nitro, ciano, alquilo C1-4, fluorometilo, difluorometilo, trifluorometilo, alcoxi C1-4, hidroxilo, carboxi, alcoxicarbonilo C1-4, alquilenohidroxilo C1-4, CONH2, CONR5R6, SO2NR5R6, cicloalquilo, NR5R6 y SR7; en donde R5 y R6 se seleccionan independientemente de: hidrogeno, alquilo C1-4, alcoxicarbonilo C1- 4, alquilcarbonilo C1-4, arilo; o R5 y R6 juntos con el átomo de nitrogeno al cual están unidos podrán formar un anillo de cinco o seis miembros que podrá contener opcionalmente un heteroátomo adicional; y R7 podrá seleccionarse de hidrogeno, alquilo C1-4, arilo, SR10 en donde R10 podrá seleccionarse de alquilo C1-4, alquilo o arilo; R2 y R3 se seleccionan independientemente de: halogeno, hidroxilo y OR8; en donde R8 se encuentra sustituido o no sustituido por alquilo C1-10, alcanoil C1- 4, aroil sustituido o no sustituido; R4 es alquilenohidroxilo C1-4; y R9 es hidrogeno o alquilo C1-4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IB2006/052002 WO2007148158A1 (en) | 2006-06-21 | 2006-06-21 | Enantiomerically pure flavone derivatives for the treatment of poliferative disorders and processes for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061567A1 true AR061567A1 (es) | 2008-09-03 |
Family
ID=37744533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102738A AR061567A1 (es) | 2006-06-21 | 2007-06-21 | Compuestos puros enantiomericamente para el tratamiento de desordenes proliferativos |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8563596B2 (es) |
| EP (1) | EP2046738B1 (es) |
| JP (1) | JP5498782B2 (es) |
| KR (1) | KR101209397B1 (es) |
| CN (1) | CN101472888B (es) |
| AR (1) | AR061567A1 (es) |
| AU (1) | AU2006344987B8 (es) |
| BR (1) | BRPI0621777A2 (es) |
| CA (1) | CA2655789C (es) |
| DK (1) | DK2046738T3 (es) |
| ES (1) | ES2491140T3 (es) |
| HK (1) | HK1126761A1 (es) |
| IL (1) | IL195850A0 (es) |
| MX (1) | MX2008016398A (es) |
| NZ (1) | NZ574266A (es) |
| PT (1) | PT2046738E (es) |
| TW (1) | TWI461420B (es) |
| WO (1) | WO2007148158A1 (es) |
| ZA (1) | ZA200810756B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7915301B2 (en) | 2002-07-08 | 2011-03-29 | Piramal Life Science Limited | Inhibitors of cyclin dependent kinases and their use |
| US7884127B2 (en) | 2002-07-08 | 2011-02-08 | Pirimal Life Sciences Ltd. | Inhibitors of cyclin dependent kinases and their use |
| KR101285957B1 (ko) | 2006-07-07 | 2013-07-12 | 피라말 엔터프라이지즈 리미티드 | 플라본으로 치환된 피롤리딘의 광학선택적 합성방법 및 이의 중간체 |
| TWI461194B (zh) * | 2009-05-05 | 2014-11-21 | Piramal Entpr Ltd | 吡咯啶取代黃酮作為輻射致敏劑 |
| WO2011097522A2 (en) | 2010-02-05 | 2011-08-11 | Whitehead Institute For Biomedical Research | Combination methods for treatment of disease |
| AU2010346973A1 (en) | 2010-02-26 | 2012-10-18 | Piramal Enterprises Limited | Pyrrolidine substituted flavones for the treatment of inflammatory disorders |
| EP2552886A1 (en) | 2010-03-29 | 2013-02-06 | Piramal Healthcare Limited | Cytokine inhibitors |
| WO2012069972A1 (en) | 2010-11-19 | 2012-05-31 | Piramal Life Sciences Limited | A pharmaceutical combination for the treatment of breast cancer |
| WO2012123889A1 (en) | 2011-03-14 | 2012-09-20 | Piramal Healthcare Limited | A synergistic pharmaceutical combination for the treatment of pancreatic cancer |
| US8530470B2 (en) * | 2011-04-13 | 2013-09-10 | Astrazeneca Ab | Chromenone derivatives |
| TW201300105A (zh) | 2011-05-31 | 2013-01-01 | Piramal Life Sciences Ltd | 治療頭頸鱗狀細胞癌之相乘藥物組合物 |
| MX2013014950A (es) | 2011-06-24 | 2014-04-16 | Piramal Entpr Ltd | Compuestos para el tratamiento del cancer asociado con el papilomavirus humano. |
| US20140348950A1 (en) | 2012-01-13 | 2014-11-27 | Piramal Enterprises Limited | Pyrrolidine- substituted flavone derivatives for prevention or treatment of oral mucositis |
| CN104487429B (zh) | 2012-07-27 | 2017-07-14 | 爱默蕾大学 | 杂环黄酮衍生物、组合物及与其相关的方法 |
| KR101389407B1 (ko) * | 2012-08-27 | 2014-05-27 | 한림대학교 산학협력단 | 척추 고정용 임플란트 |
| WO2014049515A1 (en) * | 2012-09-25 | 2014-04-03 | Piramal Enterprises Limited | Pyrrolidine substituted flavones for treatment of renal cystic diseases |
| EP3369730B1 (en) | 2012-11-05 | 2020-08-05 | Emory University | 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto |
| US20140199728A1 (en) | 2013-01-14 | 2014-07-17 | Amgen Inc. | Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture |
| WO2014128523A1 (en) * | 2013-02-19 | 2014-08-28 | Piramal Enterprises Limited | A process for preparation of an intermediate of the pyrrolidine substituted flavones |
| WO2014128524A1 (en) * | 2013-02-19 | 2014-08-28 | Piramal Enterprises Limited | An improved process for preparation of an intermediate of the pyrrolidine substituted flavones |
| WO2014140695A1 (en) * | 2013-03-15 | 2014-09-18 | Piramal Enterprises Limited | Solid oral formulation of a pyrrolidine substituted flavone compound |
| TW202031253A (zh) * | 2013-07-12 | 2020-09-01 | 印度商皮拉馬爾企業有限公司 | 治療黑色素瘤的藥物組合 |
| DK3148532T3 (en) | 2014-05-28 | 2021-04-26 | Piramal Entpr Ltd | Pharmaceutical Combination Comprising a CDK Inhibitor and a Thioredoxin Reductase Inhibitor for the Treatment of Cancer |
| WO2017172826A1 (en) * | 2016-03-28 | 2017-10-05 | Presage Biosciences, Inc. | Pharmaceutical combinations for the treatment of cancer |
| WO2020033604A1 (en) | 2018-08-07 | 2020-02-13 | Emory University | Heterocyclic flavone derivatives, compositions, and methods related thereto |
| US20210161909A1 (en) * | 2018-08-14 | 2021-06-03 | Mei Pharma, Inc. | Combination therapy |
| SG11202106635WA (en) | 2018-12-21 | 2021-07-29 | Daiichi Sankyo Co Ltd | Combination of antibody-drug conjugate and kinase inhibitor |
| WO2020210760A1 (en) * | 2019-04-11 | 2020-10-15 | Mei Pharma, Inc. | Voruciclib poly morphs and methods of making and using thereof |
| CN110028475B (zh) * | 2019-05-13 | 2022-07-01 | 中国药科大学 | 基于苯并吡喃结构的新型cdk9抑制剂、其制备方法及应用 |
| CN114957182B (zh) * | 2022-03-30 | 2024-03-15 | 中国药科大学 | 一类含有黄酮骨架结构的usp8抑制剂及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN164232B (es) | 1986-04-11 | 1989-02-04 | Hoechst India | |
| JP3451099B2 (ja) | 1991-12-06 | 2003-09-29 | 株式会社日立製作所 | 外部記憶サブシステム |
| TWI331034B (en) * | 2002-07-08 | 2010-10-01 | Piramal Life Sciences Ltd | Inhibitors of cyclin-dependent kinases and their use |
| US7271193B2 (en) | 2002-07-08 | 2007-09-18 | Nicholas Piramal India, Ltd. | Inhibitors of cyclin-dependent kinases and their use |
| US8017651B2 (en) | 2002-11-22 | 2011-09-13 | Bionexus, Ltd. | Compositions and methods for the treatment of HIV-associated fat maldistribution and hyperlipidemia |
-
2006
- 2006-06-21 NZ NZ574266A patent/NZ574266A/en unknown
- 2006-06-21 CN CN200680055077.2A patent/CN101472888B/zh active Active
- 2006-06-21 PT PT67658039T patent/PT2046738E/pt unknown
- 2006-06-21 EP EP06765803.9A patent/EP2046738B1/en active Active
- 2006-06-21 ES ES06765803.9T patent/ES2491140T3/es active Active
- 2006-06-21 AU AU2006344987A patent/AU2006344987B8/en active Active
- 2006-06-21 WO PCT/IB2006/052002 patent/WO2007148158A1/en active Application Filing
- 2006-06-21 MX MX2008016398A patent/MX2008016398A/es not_active Application Discontinuation
- 2006-06-21 US US12/305,815 patent/US8563596B2/en active Active
- 2006-06-21 CA CA2655789A patent/CA2655789C/en active Active
- 2006-06-21 JP JP2009515971A patent/JP5498782B2/ja active Active
- 2006-06-21 BR BRPI0621777-0A patent/BRPI0621777A2/pt not_active IP Right Cessation
- 2006-06-21 DK DK06765803.9T patent/DK2046738T3/da active
- 2006-06-21 KR KR1020097001021A patent/KR101209397B1/ko not_active IP Right Cessation
-
2007
- 2007-06-20 TW TW096122190A patent/TWI461420B/zh not_active IP Right Cessation
- 2007-06-21 AR ARP070102738A patent/AR061567A1/es unknown
-
2008
- 2008-12-10 IL IL195850A patent/IL195850A0/en active IP Right Grant
- 2008-12-19 ZA ZA2008/10756A patent/ZA200810756B/en unknown
-
2009
- 2009-06-22 HK HK09105576.2A patent/HK1126761A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20100179210A1 (en) | 2010-07-15 |
| US8563596B2 (en) | 2013-10-22 |
| AU2006344987B2 (en) | 2012-11-15 |
| AU2006344987A1 (en) | 2007-12-27 |
| BRPI0621777A2 (pt) | 2013-03-12 |
| TW200813030A (en) | 2008-03-16 |
| ES2491140T3 (es) | 2014-09-05 |
| AU2006344987A2 (en) | 2009-01-29 |
| EP2046738B1 (en) | 2014-06-11 |
| KR101209397B1 (ko) | 2012-12-06 |
| EP2046738A1 (en) | 2009-04-15 |
| NZ574266A (en) | 2011-10-28 |
| CN101472888B (zh) | 2014-02-26 |
| IL195850A0 (en) | 2009-09-01 |
| AU2006344987B8 (en) | 2013-07-11 |
| JP2009541294A (ja) | 2009-11-26 |
| PT2046738E (pt) | 2014-08-29 |
| WO2007148158A1 (en) | 2007-12-27 |
| CA2655789C (en) | 2014-04-01 |
| DK2046738T3 (da) | 2014-08-04 |
| ZA200810756B (en) | 2013-05-29 |
| JP5498782B2 (ja) | 2014-05-21 |
| CA2655789A1 (en) | 2007-12-27 |
| MX2008016398A (es) | 2009-01-21 |
| TWI461420B (zh) | 2014-11-21 |
| CN101472888A (zh) | 2009-07-01 |
| KR20090023705A (ko) | 2009-03-05 |
| HK1126761A1 (en) | 2009-09-11 |
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