ECSP066768A - Procedimiento para la preparacion de compuestos triazol sustituidos - Google Patents
Procedimiento para la preparacion de compuestos triazol sustituidosInfo
- Publication number
- ECSP066768A ECSP066768A EC2006006768A ECSP066768A ECSP066768A EC SP066768 A ECSP066768 A EC SP066768A EC 2006006768 A EC2006006768 A EC 2006006768A EC SP066768 A ECSP066768 A EC SP066768A EC SP066768 A ECSP066768 A EC SP066768A
- Authority
- EC
- Ecuador
- Prior art keywords
- preparation
- procedure
- substituted triazol
- triazol compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se dirige a un procedimiento novedoso para la preparación de compuestos triazol sustituidos, útiles en el tratamiento o mejoría de un trastorno mediado por cinasa selectiva o mediado por cinasa dual; el procedimiento de la presente invención preferencialmente produce el regioisómero deseado de los compuestos triazol sustituidos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54372104P | 2004-02-11 | 2004-02-11 | |
US62368104P | 2004-10-29 | 2004-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP066768A true ECSP066768A (es) | 2006-11-16 |
Family
ID=34864531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2006006768A ECSP066768A (es) | 2004-02-11 | 2006-08-10 | Procedimiento para la preparacion de compuestos triazol sustituidos |
Country Status (16)
Country | Link |
---|---|
US (1) | US20060100259A1 (es) |
EP (1) | EP1720843A2 (es) |
JP (1) | JP2007522213A (es) |
KR (1) | KR20070036025A (es) |
AR (1) | AR047544A1 (es) |
AU (1) | AU2005212218A1 (es) |
BR (1) | BRPI0507634A (es) |
CA (1) | CA2555825A1 (es) |
CR (1) | CR8562A (es) |
EA (1) | EA200601441A1 (es) |
EC (1) | ECSP066768A (es) |
IL (1) | IL177315A0 (es) |
MX (1) | MXPA06009193A (es) |
NO (1) | NO20063991L (es) |
TW (1) | TW200538116A (es) |
WO (1) | WO2005077922A2 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA200700818A1 (ru) * | 2004-10-08 | 2007-08-31 | Янссен Фармацевтика, Н.В. | Производные 1,2,4-триазолиламиноарил(гетероарил)сульфонамидов |
JP2009507080A (ja) * | 2005-09-07 | 2009-02-19 | リゲル ファーマシューティカルズ,インコーポレーテッド | Axl阻害剤として有用なトリアゾール誘導体 |
PT2114955E (pt) | 2006-12-29 | 2013-04-18 | Rigel Pharmaceuticals Inc | Triazoles substituídos com arilo bicíclico em ponte ou heteroarilo bicíclico em ponte úteis como inibidores de axl |
CN110551105B (zh) | 2006-12-29 | 2022-10-18 | 里格尔制药公司 | 用作axl抑制剂的取代三唑 |
WO2008083353A1 (en) | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
CN101622248B (zh) | 2006-12-29 | 2013-04-17 | 里格尔制药公司 | 用作axl抑制剂的n3-杂芳基取代的三唑和n5-杂芳基取代的三唑 |
US7709482B2 (en) | 2006-12-29 | 2010-05-04 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors |
CA2704052C (en) | 2007-10-26 | 2015-04-21 | Rigel Pharmaceuticals, Inc. | Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
CA2730251C (en) | 2008-07-09 | 2016-08-09 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
US8349838B2 (en) | 2008-07-09 | 2013-01-08 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors |
CN102281875B (zh) | 2009-01-16 | 2017-09-22 | 里格尔药品股份有限公司 | 预防、治疗或应对转移癌的使用axl抑制剂的组合疗法 |
US20140010783A1 (en) * | 2012-07-06 | 2014-01-09 | Hoffmann-La Roche Inc. | Antiviral compounds |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU51803A (sh) * | 2000-12-22 | 2006-05-25 | Ortho Mc Neil Pharmaceutical Inc. | Supstituisani derivati triazol diamina kao inhibitori kinaza |
CL2003002353A1 (es) * | 2002-11-15 | 2005-02-04 | Vertex Pharma | Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic |
-
2005
- 2005-01-21 JP JP2006553136A patent/JP2007522213A/ja not_active Withdrawn
- 2005-01-21 CA CA002555825A patent/CA2555825A1/en not_active Abandoned
- 2005-01-21 WO PCT/US2005/001917 patent/WO2005077922A2/en active Application Filing
- 2005-01-21 US US11/040,757 patent/US20060100259A1/en not_active Abandoned
- 2005-01-21 MX MXPA06009193A patent/MXPA06009193A/es unknown
- 2005-01-21 EA EA200601441A patent/EA200601441A1/ru unknown
- 2005-01-21 EP EP05711766A patent/EP1720843A2/en not_active Withdrawn
- 2005-01-21 BR BRPI0507634-0A patent/BRPI0507634A/pt not_active Application Discontinuation
- 2005-01-21 KR KR1020067018359A patent/KR20070036025A/ko not_active Application Discontinuation
- 2005-01-21 AU AU2005212218A patent/AU2005212218A1/en not_active Abandoned
- 2005-02-03 TW TW094103283A patent/TW200538116A/zh unknown
- 2005-02-10 AR ARP050100485A patent/AR047544A1/es unknown
-
2006
- 2006-08-06 IL IL177315A patent/IL177315A0/en unknown
- 2006-08-10 EC EC2006006768A patent/ECSP066768A/es unknown
- 2006-08-14 CR CR8562A patent/CR8562A/es not_active Application Discontinuation
- 2006-09-06 NO NO20063991A patent/NO20063991L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA06009193A (es) | 2007-01-26 |
EP1720843A2 (en) | 2006-11-15 |
WO2005077922A2 (en) | 2005-08-25 |
TW200538116A (en) | 2005-12-01 |
BRPI0507634A (pt) | 2007-07-03 |
WO2005077922A3 (en) | 2006-01-26 |
KR20070036025A (ko) | 2007-04-02 |
CA2555825A1 (en) | 2005-08-25 |
EA200601441A1 (ru) | 2007-02-27 |
CR8562A (es) | 2008-09-09 |
IL177315A0 (en) | 2006-12-10 |
AR047544A1 (es) | 2006-01-25 |
JP2007522213A (ja) | 2007-08-09 |
NO20063991L (no) | 2006-11-08 |
US20060100259A1 (en) | 2006-05-11 |
AU2005212218A1 (en) | 2005-08-25 |
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