EA200601441A1 - Способ получения соединений замещённого триазола - Google Patents

Способ получения соединений замещённого триазола

Info

Publication number
EA200601441A1
EA200601441A1 EA200601441A EA200601441A EA200601441A1 EA 200601441 A1 EA200601441 A1 EA 200601441A1 EA 200601441 A EA200601441 A EA 200601441A EA 200601441 A EA200601441 A EA 200601441A EA 200601441 A1 EA200601441 A1 EA 200601441A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted triazole
obtaining compounds
triazole compounds
kinase
symptoms
Prior art date
Application number
EA200601441A
Other languages
English (en)
Inventor
Дэвид К. Палмер
Кирк Л. Сорги
Серджио Ческо-Канчиан
Тонг Сяо
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34864531&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200601441(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200601441A1 publication Critical patent/EA200601441A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новому способу получения соединений замещенного триазола, применимых для лечения или уменьшения интенсивности симптомов расстройства, опосредованного селективной киназой или двойственной киназой. Способ по данному изобретению предпочтительно обеспечивает получение требуемого региоизомера соединений замещенного триазола.
EA200601441A 2004-02-11 2005-01-21 Способ получения соединений замещённого триазола EA200601441A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US54372104P 2004-02-11 2004-02-11
US62368104P 2004-10-29 2004-10-29
PCT/US2005/001917 WO2005077922A2 (en) 2004-02-11 2005-01-21 Process for the preparation of substituted triazole compounds

Publications (1)

Publication Number Publication Date
EA200601441A1 true EA200601441A1 (ru) 2007-02-27

Family

ID=34864531

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601441A EA200601441A1 (ru) 2004-02-11 2005-01-21 Способ получения соединений замещённого триазола

Country Status (16)

Country Link
US (1) US20060100259A1 (ru)
EP (1) EP1720843A2 (ru)
JP (1) JP2007522213A (ru)
KR (1) KR20070036025A (ru)
AR (1) AR047544A1 (ru)
AU (1) AU2005212218A1 (ru)
BR (1) BRPI0507634A (ru)
CA (1) CA2555825A1 (ru)
CR (1) CR8562A (ru)
EA (1) EA200601441A1 (ru)
EC (1) ECSP066768A (ru)
IL (1) IL177315A0 (ru)
MX (1) MXPA06009193A (ru)
NO (1) NO20063991L (ru)
TW (1) TW200538116A (ru)
WO (1) WO2005077922A2 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007004155A (es) * 2004-10-08 2007-09-11 Johnson & Johnson Derivados de 1,2,4-triazoloaminoaril (heteroaril) sulfonamida.
JP2009507080A (ja) * 2005-09-07 2009-02-19 リゲル ファーマシューティカルズ，インコーポレーテッド Ａｘｌ阻害剤として有用なトリアゾール誘導体
CA2710046C (en) 2006-12-29 2016-02-09 Rigel Pharmaceuticals, Inc. N3-heteroaryl substituted triazoles and n5-heteroaryl substituted triazoles useful as axl inhibitors
WO2008083353A1 (en) 2006-12-29 2008-07-10 Rigel Pharmaceuticals, Inc. Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors
CN110551105B (zh) 2006-12-29 2022-10-18 里格尔制药公司 用作axl抑制剂的取代三唑
AU2007341937B2 (en) 2006-12-29 2013-07-11 Rigel Pharmaceuticals, Inc. Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors
PT2114955E (pt) 2006-12-29 2013-04-18 Rigel Pharmaceuticals Inc Triazoles substituídos com arilo bicíclico em ponte ou heteroarilo bicíclico em ponte úteis como inibidores de axl
WO2009054864A1 (en) 2007-10-26 2009-04-30 Rigel Pharmaceuticals, Inc. Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors
JP5592884B2 (ja) 2008-07-09 2014-09-17 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌ阻害剤として有用な多環式ヘテロアリール置換トリアゾール
ES2399319T3 (es) 2008-07-09 2013-03-27 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con heteroarilos bicíclicos que contienen puentes útiles como inhibidores de AXL
US8546433B2 (en) 2009-01-16 2013-10-01 Rigel Pharmaceuticals, Inc. Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer
US20140010783A1 (en) * 2012-07-06 2014-01-09 Hoffmann-La Roche Inc. Antiviral compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1355889E (pt) * 2000-12-22 2006-09-29 Ortho Mcneil Pharm Inc Derivados diamina triazole substituidos como inibidores de cinase
AR042052A1 (es) * 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas

Also Published As

Publication number Publication date
NO20063991L (no) 2006-11-08
ECSP066768A (es) 2006-11-16
AR047544A1 (es) 2006-01-25
EP1720843A2 (en) 2006-11-15
WO2005077922A3 (en) 2006-01-26
WO2005077922A2 (en) 2005-08-25
AU2005212218A1 (en) 2005-08-25
IL177315A0 (en) 2006-12-10
CA2555825A1 (en) 2005-08-25
KR20070036025A (ko) 2007-04-02
BRPI0507634A (pt) 2007-07-03
TW200538116A (en) 2005-12-01
US20060100259A1 (en) 2006-05-11
CR8562A (es) 2008-09-09
JP2007522213A (ja) 2007-08-09
MXPA06009193A (es) 2007-01-26

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