EA201170702A1 - Способ получения производных дезоксирибофуранозы - Google Patents

Способ получения производных дезоксирибофуранозы

Info

Publication number
EA201170702A1
EA201170702A1 EA201170702A EA201170702A EA201170702A1 EA 201170702 A1 EA201170702 A1 EA 201170702A1 EA 201170702 A EA201170702 A EA 201170702A EA 201170702 A EA201170702 A EA 201170702A EA 201170702 A1 EA201170702 A1 EA 201170702A1
Authority
EA
Eurasian Patent Office
Prior art keywords
desoxyribrofuranose
producing derivatives
compounds
producing
derivatives
Prior art date
Application number
EA201170702A
Other languages
English (en)
Other versions
EA020552B1 (ru
Inventor
Грегори Дж. Хейли
Original Assignee
Анадис Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Анадис Фармасьютикалз, Инк. filed Critical Анадис Фармасьютикалз, Инк.
Publication of EA201170702A1 publication Critical patent/EA201170702A1/ru
Publication of EA020552B1 publication Critical patent/EA020552B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Настоящее изобретение относится к способам получения соединений дезоксирибофуранозы, в том числе соединения (2), которые представляют собой промежуточные соединения для синтеза используемых в фармацевтике соединений, таких как 5-амино-3-(2'-О-ацетил-3'-дезокси-β-D-рибофуранозил)-3Н-тиазоло[4,5-d]пиримидин-2-он и аналогичные.
EA201170702A 2008-11-17 2009-11-16 Способ получения производных дезоксирибофуранозы EA020552B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11513408P 2008-11-17 2008-11-17
PCT/US2009/064605 WO2010057103A1 (en) 2008-11-17 2009-11-16 Method of preparing deoxyribofuranose compounds

Publications (2)

Publication Number Publication Date
EA201170702A1 true EA201170702A1 (ru) 2011-12-30
EA020552B1 EA020552B1 (ru) 2014-12-30

Family

ID=42170391

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170702A EA020552B1 (ru) 2008-11-17 2009-11-16 Способ получения производных дезоксирибофуранозы

Country Status (21)

Country Link
US (2) US8829168B2 (ru)
EP (1) EP2365753B1 (ru)
JP (1) JP5613168B2 (ru)
KR (1) KR101643661B1 (ru)
CN (1) CN102300464B (ru)
AU (1) AU2009313842B2 (ru)
BR (1) BRPI0922008A2 (ru)
CA (1) CA2743796C (ru)
DK (1) DK2365753T3 (ru)
EA (1) EA020552B1 (ru)
ES (1) ES2431269T3 (ru)
HK (1) HK1162856A1 (ru)
IL (1) IL212902A0 (ru)
MX (1) MX2011005170A (ru)
MY (1) MY159745A (ru)
NZ (1) NZ593021A (ru)
PL (1) PL2365753T3 (ru)
SI (1) SI2365753T1 (ru)
TW (1) TWI450904B (ru)
UA (1) UA103637C2 (ru)
WO (1) WO2010057103A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101864807B1 (ko) * 2010-12-29 2018-06-05 아크조노벨코팅스인터내셔널비.브이. 라텍스 에멀젼 및 라텍스 에멀젼으로부터 형성되는 코팅 조성물
CN103172682B (zh) * 2013-03-14 2015-11-18 北京瑞博奥生物科技有限公司 2-脱氧-l-呋喃核糖的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE234318T1 (de) * 1996-05-16 2003-03-15 Taiho Pharmaceutical Co Ltd D-pentofuranose-derivate und verfahren zu ihrer herstellung
TR200601784T2 (tr) * 1999-11-12 2007-01-22 Pharmasset Ltd. 2'-deoksi-L-nükleositlerin sentezi
US6863782B2 (en) * 2002-11-15 2005-03-08 A.P. Pharma, Inc. Method of preparing di(ketene acetals)
US7034167B2 (en) * 2002-12-06 2006-04-25 Merck & Co., Inc. Process to ribofuranose sugar derivatives as intermediates to branched-chain nucleosides
US7309717B2 (en) * 2003-06-17 2007-12-18 Schering Corporation Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof
WO2005023827A1 (en) * 2003-09-11 2005-03-17 F. Hoffmann-La Roche Ag Process for preparing antiviral nucleoside derivatives
JP2007137843A (ja) * 2005-11-21 2007-06-07 Sumitomo Chemical Co Ltd リボフラノース化合物およびプリンヌクレオシド化合物の製造方法
US20070225246A1 (en) * 2006-03-27 2007-09-27 Denu John M O-acetyl-ADP-ribose non-hydrolyzable analogs
CN101172989B (zh) * 2006-11-03 2012-06-06 上海睿智化学研究有限公司 5-O-乙酰基-3-脱氧-1,2-异亚丙基-α-D-呋喃木糖的制备方法及一种中间体
EP2231687A4 (en) * 2008-01-10 2012-11-14 Sun Pharma Advanced Res Co Ltd NEW DERIVATIVES OF ACYL-CYANPYRROLIDINES

Also Published As

Publication number Publication date
HK1162856A1 (en) 2012-09-07
NZ593021A (en) 2013-04-26
EP2365753A1 (en) 2011-09-21
CA2743796A1 (en) 2010-05-20
AU2009313842B2 (en) 2015-08-20
KR20110084542A (ko) 2011-07-25
KR101643661B1 (ko) 2016-07-28
UA103637C2 (ru) 2013-11-11
US8829168B2 (en) 2014-09-09
EP2365753A4 (en) 2012-07-04
JP2012509268A (ja) 2012-04-19
CN102300464B (zh) 2014-11-12
BRPI0922008A2 (pt) 2016-05-10
TW201028430A (en) 2010-08-01
US20110288282A1 (en) 2011-11-24
TWI450904B (zh) 2014-09-01
ES2431269T3 (es) 2013-11-25
EP2365753B1 (en) 2013-07-17
WO2010057103A1 (en) 2010-05-20
MX2011005170A (es) 2011-05-30
PL2365753T3 (pl) 2013-12-31
US20140350231A1 (en) 2014-11-27
AU2009313842A1 (en) 2010-05-20
EA020552B1 (ru) 2014-12-30
JP5613168B2 (ja) 2014-10-22
MY159745A (en) 2017-01-31
US9227992B2 (en) 2016-01-05
DK2365753T3 (da) 2013-10-21
CA2743796C (en) 2016-10-25
SI2365753T1 (sl) 2014-01-31
IL212902A0 (en) 2011-07-31
CN102300464A (zh) 2011-12-28

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU