TR200601784T2 - 2'-deoksi-L-nükleositlerin sentezi - Google Patents

2'-deoksi-L-nükleositlerin sentezi

Info

Publication number
TR200601784T2
TR200601784T2 TR2006/01784T TR200601784T TR200601784T2 TR 200601784 T2 TR200601784 T2 TR 200601784T2 TR 2006/01784 T TR2006/01784 T TR 2006/01784T TR 200601784 T TR200601784 T TR 200601784T TR 200601784 T2 TR200601784 T2 TR 200601784T2
Authority
TR
Turkey
Prior art keywords
alkyl
nucleosides
deoxy
synthesis
chr
Prior art date
Application number
TR2006/01784T
Other languages
English (en)
Inventor
A Watanabe Kyoichi
Baeg Choi Woo
Original Assignee
Pharmasset Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmasset Ltd. filed Critical Pharmasset Ltd.
Publication of TR200601784T2 publication Critical patent/TR200601784T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor

Abstract

Mevcut buluş;(A) yapısına sahip bileşiklerin hazırlanması için prosesler sağlamakta olup,söz konusuyapı içerisindeki X ve Y;aynı veya farklıdır ve H,OH,OR,SH,SR,NH2,NHR'veya NR'R'' dir. Z; H, F, CL,BR, I, CN veya NH2dir.R; hidrojen, halojen, C1-C6düşük alkil,aralkil, NO2,NH2,NHR',NR'R'',OH,OR,SH,SR, N,CONH2,CSNH2,CO2H,CO2R',CH2CO2H, CH2CO2R', CH=CHR, CH2CH=CHR veya C=CR'dir. R' ve R'', aynı veya farklıdır, ve C1-C6 düşük alkildir. R13, hidrojen, alkil, asil, fosfat (monofosfat difosfat,trifosfat, veya stabilize fosfat) veya silildir.
TR2006/01784T 1999-11-12 2000-11-13 2'-deoksi-L-nükleositlerin sentezi TR200601784T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16508799P 1999-11-12 1999-11-12

Publications (1)

Publication Number Publication Date
TR200601784T2 true TR200601784T2 (tr) 2007-01-22

Family

ID=22597367

Family Applications (3)

Application Number Title Priority Date Filing Date
TR2006/01782T TR200601782T2 (tr) 1999-11-12 2000-11-13 2'-Deoksi-L-Nükleositlerin sentezi.
TR2006/01783T TR200601783T2 (tr) 1999-11-12 2000-11-13 2'-Deoksi-L-nükleositlerin sentezi
TR2006/01784T TR200601784T2 (tr) 1999-11-12 2000-11-13 2'-deoksi-L-nükleositlerin sentezi

Family Applications Before (2)

Application Number Title Priority Date Filing Date
TR2006/01782T TR200601782T2 (tr) 1999-11-12 2000-11-13 2'-Deoksi-L-Nükleositlerin sentezi.
TR2006/01783T TR200601783T2 (tr) 1999-11-12 2000-11-13 2'-Deoksi-L-nükleositlerin sentezi

Country Status (12)

Country Link
US (1) US20050090660A1 (tr)
EP (1) EP1232166A2 (tr)
JP (1) JP2003513984A (tr)
KR (1) KR100789162B1 (tr)
CN (4) CN1919860A (tr)
AU (3) AU784374C (tr)
BR (1) BR0015530A (tr)
CA (1) CA2391279A1 (tr)
IL (2) IL149592A0 (tr)
MX (1) MXPA02004779A (tr)
TR (3) TR200601782T2 (tr)
WO (1) WO2001034618A2 (tr)

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DE10216426A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
TWI244393B (en) * 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
ES2726998T3 (es) * 2003-05-30 2019-10-11 Gilead Pharmasset Llc Análogos de nucleósidos fluorados modificados
WO2005026186A1 (de) * 2003-09-12 2005-03-24 Max-Delbrück-Centrum für Molekulare Medizin Β-l-nucleoside und ihre verwendung als pharmazeutische mittel zur behandlung viraler erkrankungen
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
NZ554442A (en) * 2004-09-14 2011-05-27 Pharmasset Inc Preparation of 2'fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
US7759342B2 (en) 2005-01-13 2010-07-20 Signal Pharmaceuticals, Llc Methods of treatment and prevention using haloaryl substituted aminopurines
US7521446B2 (en) 2005-01-13 2009-04-21 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
US7723340B2 (en) 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
JP4995811B2 (ja) * 2005-04-29 2012-08-08 クック・バイオテック・インコーポレーテッド 瘻治療用容積式移植片並びに関連の方法及びシステム
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
AU2009274127A1 (en) * 2008-07-21 2010-01-28 Arstasis, Inc. Devices, methods, and kits for forming tracts in tissue
MY159745A (en) * 2008-11-17 2017-01-31 Anadys Pharmaceuticals Inc Method of preparing deoxyribofuranose compounds
PA8855601A1 (es) 2008-12-23 2010-07-27 Forformidatos de nucleósidos
CA2748034A1 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Purified 2'-deoxy'2'-fluoro-2'-c-methyl-nucleoside-phosphoramidate prodrugs for the treatment of viral infections
CN102325783A (zh) 2008-12-23 2012-01-18 法莫赛特股份有限公司 嘌呤核苷的合成
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
CN101555266B (zh) * 2009-05-25 2011-11-30 上海医药工业研究院 一种替比夫定的制备方法
SG184323A1 (en) 2010-03-31 2012-11-29 Gilead Pharmasett Llc Stereoselective synthesis of phosphorus containing actives
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
KR101198302B1 (ko) 2010-11-02 2012-11-07 서울대학교산학협력단 Ｃｄｋ를 저해하는 피롤로피리미디논 카복사미드 유도체 또는 이의 약학적으로 허용가능한 염, 이를 유효성분으로 함유하는 간세포암의 예방 또는 치료용 약학적 조성물
CA2818853A1 (en) 2010-11-30 2012-06-07 Gilead Pharmasset Llc 2'-spirocyclo-nucleosides for use in therapy of hcv or dengue virus
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US9868733B2 (en) 2012-08-22 2018-01-16 Merck Sharp & Dohme Corp. Azabenzimidazole tetrahydrofuran derivatives
PL3038601T3 (pl) 2013-08-27 2020-08-24 Gilead Pharmasset Llc Formulacja złożona dwóch związków przeciwwirusowych
BR112020023866A2 (pt) * 2018-05-25 2021-04-06 Primmune Therapeutics, Inc. Agonistas de tlr7
CN109020974B (zh) * 2018-11-02 2021-01-05 哈尔滨商业大学 5′-噻吩甲酰酯-3′-脱氧腺苷的合成方法及其应用
CN109111445B (zh) * 2018-11-02 2020-12-18 哈尔滨商业大学 5’-呋喃甲酰酯-3’-脱氧腺苷的合成方法及应用
CN109369758B (zh) * 2018-11-02 2021-04-13 哈尔滨商业大学 5′-(6-氯烟酰酯)-3′-脱氧腺苷的合成方法及其应用
BR112022010165A2 (pt) 2019-11-26 2022-08-09 Primmune Therapeutics Inc Agonistas de tlr7

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Also Published As

Publication number Publication date
AU2005204267A1 (en) 2005-09-22
BR0015530A (pt) 2003-02-18
CN1919860A (zh) 2007-02-28
CN1919858A (zh) 2007-02-28
WO2001034618A2 (en) 2001-05-17
TR200601783T2 (tr) 2007-01-22
AU1485801A (en) 2001-06-06
AU2005204266A1 (en) 2005-09-22
CN1919859A (zh) 2007-02-28
AU2005204267B2 (en) 2008-10-23
AU2005204266B2 (en) 2008-11-06
KR20030025220A (ko) 2003-03-28
IL149592A (en) 2008-11-26
AU784374B2 (en) 2006-03-23
JP2003513984A (ja) 2003-04-15
EP1232166A2 (en) 2002-08-21
CA2391279A1 (en) 2001-05-17
CN1423654A (zh) 2003-06-11
IL149592A0 (en) 2002-11-10
KR100789162B1 (ko) 2007-12-28
MXPA02004779A (es) 2004-07-01
AU784374C (en) 2007-06-28
WO2001034618A3 (en) 2002-01-03
US20050090660A1 (en) 2005-04-28
TR200601782T2 (tr) 2006-09-21

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