MX9600686A - Compuestos de azaindolilideno substituidos y proceso para su preparacion. - Google Patents

Compuestos de azaindolilideno substituidos y proceso para su preparacion.

Info

Publication number
MX9600686A
MX9600686A MX9600686A MX9600686A MX9600686A MX 9600686 A MX9600686 A MX 9600686A MX 9600686 A MX9600686 A MX 9600686A MX 9600686 A MX9600686 A MX 9600686A MX 9600686 A MX9600686 A MX 9600686A
Authority
MX
Mexico
Prior art keywords
choh
nch2oh
alkyl
substituted
ch2oh
Prior art date
Application number
MX9600686A
Other languages
English (en)
Inventor
Franco Buzzetti
Maria Gabriella Brasca
Antonio Longo
Dario Ballinari
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of MX9600686A publication Critical patent/MX9600686A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invencion se refiere a los compuestos utiles como inhibidores de la tirosina-cinasa, que tienen la siguiente formula general (I): en donde uno de los grupos Xü, X², Xü, X4 es N y los otros son CH; R es un grupo de la formula (a), (b), (c) o (d) cada uno de Rü y Rü independientemente es hidrogeno, amino, carboxilo, ciano, -SO2R4, -SO2NHR5, -SO2-NZ, -COOR6, -CONH(CH2)oPh, -CONHCH2(CHOH)nCH2OH, -CO-NZ, -N(CH2CH2OH)2, -NHCH2(CHOH)nCH2OH, -NHCONH2, -NHC(NH2)=NH, -NHCO(CHOH)nCH2OH, -NHCO(CH2)p-NZ. -NHSO2R7, -OCH2(CHOH)nCH2OH, -OOC(CHOH)nCH2OH, -OPO(OH2), -OCH2SO2NH2, -CH2NH2, -C(NH2)=NH; -CH2NHC(NH2)=NH, -CH2-NZ, -CH2OH, -CH2OOC(CHOH)nC2OH, -CH2OPO(OH)2, -PO(OH)2; R2 es hidrogeno, alquilo de 1 a 6 átomos de carbono, alcanoílo de 2 a 6 átomos de carbono, -CH2OH, -CH2CH2CONH2, -SO2Me, -COCH2SO2NH2; R4 es hidrogeno, -CH2(CHOH)nCH2OH, alquilo de 1 a 6 átomos de carbono; R5 es hidrogeno, alquilo de 1 a 6 átomos de carbono -CH2(CHOH)nCH2OH, -(CH2)mNMe2; R6 es alquilo de 1 a 6 átomos de carbono, no substituido o substituido por fenilo, -CH2(CHOH)nCH2OH; R7 es Me, -C6H4Me; Z es CH2, O, NH, NCH2CH2OH; n es 0 o 1; m es 2 o 3; o es 0, 1, 2 o 3; p es 1, 2 o 3; con la condicion de que cuando R sea (a), (b), o (c), entonces R1 no es hidrogeno; y las sales farmacéuticamente aceptables de los mismos.
MX9600686A 1994-06-24 1995-05-30 Compuestos de azaindolilideno substituidos y proceso para su preparacion. MX9600686A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9412719A GB9412719D0 (en) 1994-06-24 1994-06-24 Substituted azaindolylidene compounds and process for their preparation
PCT/EP1995/002043 WO1996000226A1 (en) 1994-06-24 1995-05-30 Substituted azaindolylidene compounds and process for their preparation

Publications (1)

Publication Number Publication Date
MX9600686A true MX9600686A (es) 1997-06-28

Family

ID=10757269

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9600686A MX9600686A (es) 1994-06-24 1995-05-30 Compuestos de azaindolilideno substituidos y proceso para su preparacion.

Country Status (21)

Country Link
US (1) US5663346A (es)
EP (1) EP0715628B1 (es)
JP (1) JP3773257B2 (es)
KR (1) KR960703911A (es)
CN (1) CN1129941A (es)
AT (1) ATE225348T1 (es)
AU (1) AU2671695A (es)
CA (1) CA2168659C (es)
DE (1) DE69528437T2 (es)
DK (1) DK0715628T3 (es)
ES (1) ES2186721T3 (es)
FI (1) FI960751A (es)
GB (1) GB9412719D0 (es)
HU (1) HUT74609A (es)
IL (1) IL114156A0 (es)
MX (1) MX9600686A (es)
NO (1) NO960713L (es)
PL (1) PL313166A1 (es)
PT (1) PT715628E (es)
WO (1) WO1996000226A1 (es)
ZA (1) ZA955223B (es)

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US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
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TWI270545B (en) 2000-05-24 2007-01-11 Sugen Inc Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
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US6335342B1 (en) 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
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Also Published As

Publication number Publication date
KR960703911A (ko) 1996-08-31
EP0715628A1 (en) 1996-06-12
PL313166A1 (en) 1996-06-10
CA2168659A1 (en) 1996-01-04
CN1129941A (zh) 1996-08-28
IL114156A0 (en) 1995-10-31
JP3773257B2 (ja) 2006-05-10
AU2671695A (en) 1996-01-19
FI960751A0 (fi) 1996-02-19
DE69528437T2 (de) 2003-06-12
HU9600729D0 (en) 1996-05-28
DE69528437D1 (de) 2002-11-07
GB9412719D0 (en) 1994-08-17
DK0715628T3 (da) 2003-02-10
NO960713D0 (no) 1996-02-22
PT715628E (pt) 2003-02-28
WO1996000226A1 (en) 1996-01-04
EP0715628B1 (en) 2002-10-02
ATE225348T1 (de) 2002-10-15
CA2168659C (en) 2006-12-19
US5663346A (en) 1997-09-02
NO960713L (no) 1996-02-22
HUT74609A (en) 1997-01-28
FI960751A (fi) 1996-02-19
ZA955223B (en) 1996-01-31
ES2186721T3 (es) 2003-05-16
JPH09502457A (ja) 1997-03-11

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