DK0715628T3 - Substituerede azaindolyliden-forbindelser og fremgangsmåde til fremstilling deraf - Google Patents

Substituerede azaindolyliden-forbindelser og fremgangsmåde til fremstilling deraf

Info

Publication number
DK0715628T3
DK0715628T3 DK95921777T DK95921777T DK0715628T3 DK 0715628 T3 DK0715628 T3 DK 0715628T3 DK 95921777 T DK95921777 T DK 95921777T DK 95921777 T DK95921777 T DK 95921777T DK 0715628 T3 DK0715628 T3 DK 0715628T3
Authority
DK
Denmark
Prior art keywords
choh
image
nch2oh
alkyl
pct
Prior art date
Application number
DK95921777T
Other languages
English (en)
Inventor
Antonio Longo
Franco Buzzetti
Gabriella Maria Brasca
Dario Ballinari
Original Assignee
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa
Application granted granted Critical
Publication of DK0715628T3 publication Critical patent/DK0715628T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
DK95921777T 1994-06-24 1995-05-30 Substituerede azaindolyliden-forbindelser og fremgangsmåde til fremstilling deraf DK0715628T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9412719A GB9412719D0 (en) 1994-06-24 1994-06-24 Substituted azaindolylidene compounds and process for their preparation
PCT/EP1995/002043 WO1996000226A1 (en) 1994-06-24 1995-05-30 Substituted azaindolylidene compounds and process for their preparation

Publications (1)

Publication Number Publication Date
DK0715628T3 true DK0715628T3 (da) 2003-02-10

Family

ID=10757269

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95921777T DK0715628T3 (da) 1994-06-24 1995-05-30 Substituerede azaindolyliden-forbindelser og fremgangsmåde til fremstilling deraf

Country Status (21)

Country Link
US (1) US5663346A (da)
EP (1) EP0715628B1 (da)
JP (1) JP3773257B2 (da)
KR (1) KR960703911A (da)
CN (1) CN1129941A (da)
AT (1) ATE225348T1 (da)
AU (1) AU2671695A (da)
CA (1) CA2168659C (da)
DE (1) DE69528437T2 (da)
DK (1) DK0715628T3 (da)
ES (1) ES2186721T3 (da)
FI (1) FI960751A0 (da)
GB (1) GB9412719D0 (da)
HU (1) HUT74609A (da)
IL (1) IL114156A0 (da)
MX (1) MX9600686A (da)
NO (1) NO960713D0 (da)
PL (1) PL313166A1 (da)
PT (1) PT715628E (da)
WO (1) WO1996000226A1 (da)
ZA (1) ZA955223B (da)

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US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
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US6153634A (en) * 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
JP2002532503A (ja) 1998-12-17 2002-10-02 エフ．ホフマン−ラ ロシュ アーゲー プロテインキナーゼ阻害剤としての４，５−ピラジノオキシンドール
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
US6689806B1 (en) 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6541477B2 (en) 1999-08-27 2003-04-01 Scios, Inc. Inhibitors of p38-a kinase
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
MY128450A (en) 2000-05-24 2007-02-28 Upjohn Co 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US6706709B2 (en) 2000-06-02 2004-03-16 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
US6335342B1 (en) 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
PE20030062A1 (es) 2001-05-30 2003-02-08 Sugen Inc Derivados aralquilsulfonil-3-(pirrol-2-ilmetiliden)-2-indolinona como inhibidores de quinasas
US6960572B2 (en) 2001-06-21 2005-11-01 Ariad Pharmaceuticals, Inc. Indolinones and uses thereof
US6797825B2 (en) * 2001-12-13 2004-09-28 Abbott Laboratories Protein kinase inhibitors
EP1696920B8 (en) 2003-12-19 2015-05-06 Plexxikon Inc. Compounds and methods for development of ret modulators
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EA201290073A1 (ru) 2009-08-24 2013-01-30 Эсэпиен Фармасьютикалз, Инк. Соединения мочевины, содержащие 5,6-бициклический гетероарил, как ингибиторы киназ
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CN102711765A (zh) 2009-11-16 2012-10-03 加利福尼亚大学董事会 激酶抑制剂
WO2011153049A1 (en) 2010-06-02 2011-12-08 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to her2/neu receptor complex
US9265739B2 (en) 2010-06-02 2016-02-23 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to HER2/neu receptor complex
PT2672967T (pt) 2011-02-07 2018-12-07 Plexxikon Inc Compostos e métodos de modulação da quinase e suas indicações
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
WO2014018888A1 (en) * 2012-07-26 2014-01-30 Confluence Life Sciences Inc. 4-alkoxy/aralkoxy-5-substituted-pyrrolopyrimidine compounds as tak1 inhibitors in disease treatment
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EP2837626A1 (en) * 2013-08-16 2015-02-18 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Indolinone derivatives as GRK5 modulators
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AU2015233686B2 (en) * 2014-03-18 2019-07-11 Algiax Pharmaceuticals Gmbh 2-Cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives
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Also Published As

Publication number Publication date
NO960713L (no) 1996-02-22
ES2186721T3 (es) 2003-05-16
ZA955223B (en) 1996-01-31
MX9600686A (es) 1997-06-28
PL313166A1 (en) 1996-06-10
AU2671695A (en) 1996-01-19
GB9412719D0 (en) 1994-08-17
ATE225348T1 (de) 2002-10-15
JPH09502457A (ja) 1997-03-11
CA2168659A1 (en) 1996-01-04
DE69528437T2 (de) 2003-06-12
EP0715628A1 (en) 1996-06-12
WO1996000226A1 (en) 1996-01-04
US5663346A (en) 1997-09-02
KR960703911A (ko) 1996-08-31
PT715628E (pt) 2003-02-28
FI960751A (fi) 1996-02-19
NO960713D0 (no) 1996-02-22
HUT74609A (en) 1997-01-28
JP3773257B2 (ja) 2006-05-10
FI960751A0 (fi) 1996-02-19
HU9600729D0 (en) 1996-05-28
IL114156A0 (en) 1995-10-31
CN1129941A (zh) 1996-08-28
EP0715628B1 (en) 2002-10-02
CA2168659C (en) 2006-12-19
DE69528437D1 (de) 2002-11-07

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