NO960713D0 - Substituerte azaindolylidenforbindelser og fremgangsmåte for deres fremstilling - Google Patents

Substituerte azaindolylidenforbindelser og fremgangsmåte for deres fremstilling

Info

Publication number
NO960713D0
NO960713D0 NO960713A NO960713A NO960713D0 NO 960713 D0 NO960713 D0 NO 960713D0 NO 960713 A NO960713 A NO 960713A NO 960713 A NO960713 A NO 960713A NO 960713 D0 NO960713 D0 NO 960713D0
Authority
NO
Norway
Prior art keywords
choh
image
nch2oh
alkyl
pct
Prior art date
Application number
NO960713A
Other languages
English (en)
Norwegian (no)
Other versions
NO960713L (no
Inventor
Franco Buzzetti
Gabriella Maria Brasca
Antonio Longo
Dario Ballinari
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of NO960713D0 publication Critical patent/NO960713D0/no
Publication of NO960713L publication Critical patent/NO960713L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
NO960713A 1994-06-24 1996-02-22 Substituerte azaindolylidenforbindelser og fremgangsmåte for deres fremstilling NO960713L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9412719A GB9412719D0 (en) 1994-06-24 1994-06-24 Substituted azaindolylidene compounds and process for their preparation
PCT/EP1995/002043 WO1996000226A1 (en) 1994-06-24 1995-05-30 Substituted azaindolylidene compounds and process for their preparation

Publications (2)

Publication Number Publication Date
NO960713D0 true NO960713D0 (no) 1996-02-22
NO960713L NO960713L (no) 1996-02-22

Family

ID=10757269

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960713A NO960713L (no) 1994-06-24 1996-02-22 Substituerte azaindolylidenforbindelser og fremgangsmåte for deres fremstilling

Country Status (21)

Country Link
US (1) US5663346A (da)
EP (1) EP0715628B1 (da)
JP (1) JP3773257B2 (da)
KR (1) KR960703911A (da)
CN (1) CN1129941A (da)
AT (1) ATE225348T1 (da)
AU (1) AU2671695A (da)
CA (1) CA2168659C (da)
DE (1) DE69528437T2 (da)
DK (1) DK0715628T3 (da)
ES (1) ES2186721T3 (da)
FI (1) FI960751A0 (da)
GB (1) GB9412719D0 (da)
HU (1) HUT74609A (da)
IL (1) IL114156A0 (da)
MX (1) MX9600686A (da)
NO (1) NO960713L (da)
PL (1) PL313166A1 (da)
PT (1) PT715628E (da)
WO (1) WO1996000226A1 (da)
ZA (1) ZA955223B (da)

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US6696448B2 (en) 1996-06-05 2004-02-24 Sugen, Inc. 3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
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US6486185B1 (en) 1997-05-07 2002-11-26 Sugen, Inc. 3-heteroarylidene-2-indolinone protein kinase inhibitors
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US6316429B1 (en) 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
US6987113B2 (en) 1997-06-11 2006-01-17 Sugen, Inc. Tyrosine kinase inhibitors
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6531502B1 (en) 1998-01-21 2003-03-11 Sugen, Inc. 3-Methylidenyl-2-indolinone modulators of protein kinase
EP1060160A2 (en) 1998-02-27 2000-12-20 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs
EP1066257A2 (en) * 1998-03-26 2001-01-10 Sugen, Inc. Heterocylic classes of compounds for the modulating tyrosine protein kinase
US6514981B1 (en) 1998-04-02 2003-02-04 Sugen, Inc. Methods of modulating tyrosine protein kinase function with indolinone compounds
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
CN1250526C (zh) 1998-05-29 2006-04-12 苏根公司 吡咯取代的2－吲哚满酮蛋白激酶抑制剂
JP2002523448A (ja) 1998-08-28 2002-07-30 サイオス インコーポレイテッド ｐ３８−αキナーゼのインヒビター
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JP2002532503A (ja) 1998-12-17 2002-10-02 エフ．ホフマン−ラ ロシュ アーゲー プロテインキナーゼ阻害剤としての４，５−ピラジノオキシンドール
US6153634A (en) 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
KR20010101266A (ko) 1998-12-17 2001-11-14 프리돌린 클라우스너, 롤란드 비. 보레르 Ｊｎｋ 단백질 키나제의 억제제로서의 4-아릴옥신돌
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6492398B1 (en) 1999-03-04 2002-12-10 Smithkline Beechman Corporation Thiazoloindolinone compounds
US6689806B1 (en) 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6541477B2 (en) 1999-08-27 2003-04-01 Scios, Inc. Inhibitors of p38-a kinase
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
US6620818B1 (en) 2000-03-01 2003-09-16 Smithkline Beecham Corporation Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
MY128450A (en) 2000-05-24 2007-02-28 Upjohn Co 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
EP1294688A2 (en) 2000-06-02 2003-03-26 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
US6335342B1 (en) 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
WO2002096361A2 (en) 2001-05-30 2002-12-05 Sugen, Inc. 5-aralkylsulfonyl-3- (pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
WO2003000251A1 (en) 2001-06-21 2003-01-03 Ariad Pharmaceuticals, Inc. Novel idolinones and uses thereof
US6797825B2 (en) * 2001-12-13 2004-09-28 Abbott Laboratories Protein kinase inhibitors
AU2004308299B2 (en) 2003-12-19 2011-11-24 Plexxikon, Inc. Compounds and methods for development of Ret modulators
GB0330042D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
CN101142184A (zh) * 2004-10-12 2008-03-12 解码遗传Ehf公司 用于阻塞性动脉疾病的磺酰胺迫位取代的双环化合物
US7371862B2 (en) 2005-11-11 2008-05-13 Pfizer Italia S.R.L. Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
CA2628179A1 (en) 2005-11-15 2007-05-24 Vertex Pharmaceuticals Incorporated Azaindazoles useful as inhibitors of kinases
CN101490045A (zh) * 2006-05-16 2009-07-22 解码遗传Ehf公司 7-(丙烯酰基)吲哚的制备方法
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
BRPI0814423B1 (pt) 2007-07-17 2022-04-19 Plexxikon, Inc Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos
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BR112013020041B1 (pt) 2011-02-07 2021-11-23 Plexxikon, Inc Compostos e composições para a modulação de quinases e uso dos mesmos
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US9505765B2 (en) 2012-07-26 2016-11-29 Confluence Life Sciences Inc. 4-alkoxy/aralkoxy-5-substituted-pyrrolopyrimidine compounds as TAK1 inhibitors in disease treatment
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
EP2837626A1 (en) * 2013-08-16 2015-02-18 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Indolinone derivatives as GRK5 modulators
CN105934248A (zh) 2014-01-24 2016-09-07 融合生命科学公司 取代的吡咯并吡啶和吡咯并吡嗪用于治疗癌症或炎性疾病
US10472324B2 (en) * 2014-03-18 2019-11-12 Algiax Pharmaceuticals Gmbh 2-cyano-3-cyclopropyl-3-hydroxy-N-aryl-thioacrylamide derivatives
EP3247353A4 (en) 2015-01-23 2018-07-04 Confluence Life Sciences, Inc. Heterocyclic itk inhibitors for treating inflammation and cancer
ES2882255T3 (es) 2015-07-01 2021-12-01 California Inst Of Techn Sistemas de administración basados en polímeros de ácido múcico catiónicos
JP7221227B2 (ja) 2017-06-30 2023-02-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 発毛を調節するための組成物及び方法
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GB9004483D0 (en) * 1990-02-28 1990-04-25 Erba Carlo Spa New aryl-and heteroarylethenylene derivatives and process for their preparation
GB9115160D0 (en) * 1991-07-12 1991-08-28 Erba Carlo Spa Methylen-oxindole derivatives and process for their preparation
GB9226855D0 (en) * 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation

Also Published As

Publication number Publication date
MX9600686A (es) 1997-06-28
FI960751A (fi) 1996-02-19
HUT74609A (en) 1997-01-28
DE69528437T2 (de) 2003-06-12
PT715628E (pt) 2003-02-28
US5663346A (en) 1997-09-02
ES2186721T3 (es) 2003-05-16
EP0715628A1 (en) 1996-06-12
PL313166A1 (en) 1996-06-10
FI960751A0 (fi) 1996-02-19
KR960703911A (ko) 1996-08-31
HU9600729D0 (en) 1996-05-28
EP0715628B1 (en) 2002-10-02
JPH09502457A (ja) 1997-03-11
DE69528437D1 (de) 2002-11-07
AU2671695A (en) 1996-01-19
CA2168659C (en) 2006-12-19
IL114156A0 (en) 1995-10-31
ATE225348T1 (de) 2002-10-15
WO1996000226A1 (en) 1996-01-04
CN1129941A (zh) 1996-08-28
CA2168659A1 (en) 1996-01-04
GB9412719D0 (en) 1994-08-17
NO960713L (no) 1996-02-22
JP3773257B2 (ja) 2006-05-10
ZA955223B (en) 1996-01-31
DK0715628T3 (da) 2003-02-10

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