TR200601783T2 - 2'-Deoksi-L-nükleositlerin sentezi - Google Patents

2'-Deoksi-L-nükleositlerin sentezi

Info

Publication number
TR200601783T2
TR200601783T2 TR2006/01783T TR200601783T TR200601783T2 TR 200601783 T2 TR200601783 T2 TR 200601783T2 TR 2006/01783 T TR2006/01783 T TR 2006/01783T TR 200601783 T TR200601783 T TR 200601783T TR 200601783 T2 TR200601783 T2 TR 200601783T2
Authority
TR
Turkey
Prior art keywords
nucleosides
deoxy
synthesis
chr
nhr
Prior art date
Application number
TR2006/01783T
Other languages
English (en)
Inventor
A. Watanabe Kyoichi
Baeg Choi Woo
Original Assignee
Pharmasset Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmasset Ltd filed Critical Pharmasset Ltd
Publication of TR200601783T2 publication Critical patent/TR200601783T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Mevcut buluş; (A) yapısına sahip bileşiklerin hazırlanması için prosesler sağlamakta olup, söz konusu yapı içerisindeki X ve Y; aynı veya farklıdır ve H,OH,OR,SH,SR,NH2,NHR' veya NR'R''dür; Z; H,F,CI,Br,I,CN veya CN veya NH2'dir.R; hidrojen, halojen, C1-C6 düşük alkil, aralkil, NO2, NH2,NHR', NR'R'', OH, OR, SH, SR, CN, CONH2, CSNH2, CO2H, CO2R', CH2CO2H, CH2CO2R', CH=CHR, CH2CH=CHR veya C=CR'dir. R' veR''; aynı veya farklıdır ve C1-C6 düşük alkildir. R13; hidrojen, alkil, asil, fosfat(monofosfat difosfat, trifosfat, veya stabilize fosfat) veya silildir.
TR2006/01783T 1999-11-12 2000-11-13 2'-Deoksi-L-nükleositlerin sentezi TR200601783T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16508799P 1999-11-12 1999-11-12

Publications (1)

Publication Number Publication Date
TR200601783T2 true TR200601783T2 (tr) 2007-01-22

Family

ID=22597367

Family Applications (3)

Application Number Title Priority Date Filing Date
TR2006/01782T TR200601782T2 (tr) 1999-11-12 2000-11-13 2'-Deoksi-L-Nükleositlerin sentezi.
TR2006/01784T TR200601784T2 (tr) 1999-11-12 2000-11-13 2'-deoksi-L-nükleositlerin sentezi
TR2006/01783T TR200601783T2 (tr) 1999-11-12 2000-11-13 2'-Deoksi-L-nükleositlerin sentezi

Family Applications Before (2)

Application Number Title Priority Date Filing Date
TR2006/01782T TR200601782T2 (tr) 1999-11-12 2000-11-13 2'-Deoksi-L-Nükleositlerin sentezi.
TR2006/01784T TR200601784T2 (tr) 1999-11-12 2000-11-13 2'-deoksi-L-nükleositlerin sentezi

Country Status (12)

Country Link
US (1) US20050090660A1 (tr)
EP (1) EP1232166A2 (tr)
JP (1) JP2003513984A (tr)
KR (1) KR100789162B1 (tr)
CN (4) CN1423654A (tr)
AU (3) AU784374C (tr)
BR (1) BR0015530A (tr)
CA (1) CA2391279A1 (tr)
IL (2) IL149592A0 (tr)
MX (1) MXPA02004779A (tr)
TR (3) TR200601782T2 (tr)
WO (1) WO2001034618A2 (tr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6822089B1 (en) 2000-03-29 2004-11-23 Isis Pharmaceuticals, Inc. Preparation of deoxynucleosides
PT1411954E (pt) * 2000-10-18 2011-03-16 Pharmasset Inc Nucleosídeos modificados para o tratamento de infecções virais e proliferação celular anormal
DE10216426A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
TWI244393B (en) * 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
US7429572B2 (en) 2003-05-30 2008-09-30 Pharmasset, Inc. Modified fluorinated nucleoside analogues
WO2005026186A1 (de) * 2003-09-12 2005-03-24 Max-Delbrück-Centrum für Molekulare Medizin Β-l-nucleoside und ihre verwendung als pharmazeutische mittel zur behandlung viraler erkrankungen
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
WO2006031725A2 (en) 2004-09-14 2006-03-23 Pharmasset, Inc. Preparation of 2'­fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
US7723340B2 (en) 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
US7521446B2 (en) 2005-01-13 2009-04-21 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
US7759342B2 (en) 2005-01-13 2010-07-20 Signal Pharmaceuticals, Llc Methods of treatment and prevention using haloaryl substituted aminopurines
EP2532310A3 (en) * 2005-04-29 2014-08-20 Cook Biotech Incorporated Volumetric grafts for treatment of fistulae and related methods and systems
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8173621B2 (en) * 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CN102159126A (zh) * 2008-07-21 2011-08-17 阿尔斯塔西斯公司 在组织中形成管道的装置、方法和成套用具
MY159745A (en) 2008-11-17 2017-01-31 Anadys Pharmaceuticals Inc Method of preparing deoxyribofuranose compounds
EP2376088B1 (en) 2008-12-23 2017-02-22 Gilead Pharmasset LLC 6-O-Substituted-2-amino-purine nucleoside phosphoramidates
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
EA019295B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Соединения пуриновых нуклеозидов и способ их получения
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
CN101555266B (zh) * 2009-05-25 2011-11-30 上海医药工业研究院 一种替比夫定的制备方法
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
JP2013527145A (ja) 2010-03-31 2013-06-27 ギリード・ファーマセット・エルエルシー リン含有活性化剤の立体選択的合成
KR101198302B1 (ko) 2010-11-02 2012-11-07 서울대학교산학협력단 Ｃｄｋ를 저해하는 피롤로피리미디논 카복사미드 유도체 또는 이의 약학적으로 허용가능한 염, 이를 유효성분으로 함유하는 간세포암의 예방 또는 치료용 약학적 조성물
AR084044A1 (es) 2010-11-30 2013-04-17 Pharmasset Inc Compuestos 2’-espiro-nucleosidos
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US9868733B2 (en) 2012-08-22 2018-01-16 Merck Sharp & Dohme Corp. Azabenzimidazole tetrahydrofuran derivatives
PL3650014T3 (pl) 2013-08-27 2022-01-31 Gilead Pharmasset Llc Preparat złożony dwóch związków przeciwwirusowych
SG11202011667WA (en) * 2018-05-25 2020-12-30 Primmune Therapeutics Inc Tlr7 agonists
CN109111445B (zh) * 2018-11-02 2020-12-18 哈尔滨商业大学 5’-呋喃甲酰酯-3’-脱氧腺苷的合成方法及应用
CN109020974B (zh) * 2018-11-02 2021-01-05 哈尔滨商业大学 5′-噻吩甲酰酯-3′-脱氧腺苷的合成方法及其应用
CN109369758B (zh) * 2018-11-02 2021-04-13 哈尔滨商业大学 5′-(6-氯烟酰酯)-3′-脱氧腺苷的合成方法及其应用
EP4065155A4 (en) 2019-11-26 2023-11-29 Primmune Therapeutics, Inc. TLR7 AGONISTS

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5041449A (en) * 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5200514A (en) * 1990-01-19 1993-04-06 University Of Georgia Research Foundation, Inc. Synthesis of 2'-deoxypyrimidine nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
IT1246983B (it) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
FR2709754B1 (fr) * 1993-09-10 1995-12-01 Centre Nat Rech Scient Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale.
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
US6025335A (en) * 1995-09-21 2000-02-15 Lipitek International, Inc. L-Nucleoside Dimer Compounds and therapeutic uses
US6444652B1 (en) * 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
DK2415776T3 (en) * 1998-08-10 2016-07-04 Novartis Ag Beta-L-2'-deoxy nucleosides for the treatment of Hepatitis B
US6407077B1 (en) * 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection

Also Published As

Publication number Publication date
CN1919858A (zh) 2007-02-28
AU2005204267B2 (en) 2008-10-23
EP1232166A2 (en) 2002-08-21
AU784374B2 (en) 2006-03-23
MXPA02004779A (es) 2004-07-01
KR20030025220A (ko) 2003-03-28
CN1423654A (zh) 2003-06-11
AU2005204266B2 (en) 2008-11-06
US20050090660A1 (en) 2005-04-28
KR100789162B1 (ko) 2007-12-28
CN1919860A (zh) 2007-02-28
CN1919859A (zh) 2007-02-28
BR0015530A (pt) 2003-02-18
JP2003513984A (ja) 2003-04-15
AU784374C (en) 2007-06-28
IL149592A0 (en) 2002-11-10
AU2005204267A1 (en) 2005-09-22
AU2005204266A1 (en) 2005-09-22
AU1485801A (en) 2001-06-06
TR200601784T2 (tr) 2007-01-22
CA2391279A1 (en) 2001-05-17
WO2001034618A2 (en) 2001-05-17
WO2001034618A3 (en) 2002-01-03
IL149592A (en) 2008-11-26
TR200601782T2 (tr) 2006-09-21

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