BR0015530A - Sìntese de 2'-desoxi-l-nucleosìdeo - Google Patents

Sìntese de 2'-desoxi-l-nucleosìdeo

Info

Publication number
BR0015530A
BR0015530A BR0015530-6A BR0015530A BR0015530A BR 0015530 A BR0015530 A BR 0015530A BR 0015530 A BR0015530 A BR 0015530A BR 0015530 A BR0015530 A BR 0015530A
Authority
BR
Brazil
Prior art keywords
deoxy
nucleoside
synthesis
chr
nhr
Prior art date
Application number
BR0015530-6A
Other languages
English (en)
Inventor
Kyoichi A Watanabe
Woo-Baeg Choi
Original Assignee
Pharmasset Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmasset Ltd filed Critical Pharmasset Ltd
Publication of BR0015530A publication Critical patent/BR0015530A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor

Abstract

"SìNTESE DE 2'-DESOXI-L-NUCLEOSìDEO". Essa invenção fornece processos para a preparação de compostos tendo estrutura (A) onde X e Y são o mesmo ou diferente, e H, OH, SH, SR, NH~ 2~, NHR', ou NR'R''; Z é H, F, Cl, Br, I, CN, ou NH~ 2~. R é hidrogênio, halogênio, alquil inferior, de C~ 1~-C~ 6~ ou aralquil, NO~ 2~, NH~ 2~, NHR', NR'R'', OH, OR, SGH, SR, CN, CONH~ 2~, CSNH~ 2~, CO~ 2~H, CO~ 2~R' , - CH~ 2~CO~ 2~H, CH~ 2~CO~ 2~R' , CH=CHR, CH~ 2~CH-CHR, ou C-CR. R' e R'' são o mesmo ou diferente, e alquil inferior de C~ 1~-C~ 6~. R^ 13^ é hidrogênio, alquil, acil, fosfato (monofosfato, difosfato, trifosfato, ou fosfato estabilizado) ou silil.
BR0015530-6A 1999-11-12 2000-11-13 Sìntese de 2'-desoxi-l-nucleosìdeo BR0015530A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16508799P 1999-11-12 1999-11-12
PCT/US2000/031107 WO2001034618A2 (en) 1999-11-12 2000-11-13 Synthesis of 2'-deoxy-l-nucleosides

Publications (1)

Publication Number Publication Date
BR0015530A true BR0015530A (pt) 2003-02-18

Family

ID=22597367

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015530-6A BR0015530A (pt) 1999-11-12 2000-11-13 Sìntese de 2'-desoxi-l-nucleosìdeo

Country Status (12)

Country Link
US (1) US20050090660A1 (pt)
EP (1) EP1232166A2 (pt)
JP (1) JP2003513984A (pt)
KR (1) KR100789162B1 (pt)
CN (4) CN1423654A (pt)
AU (3) AU784374C (pt)
BR (1) BR0015530A (pt)
CA (1) CA2391279A1 (pt)
IL (2) IL149592A0 (pt)
MX (1) MXPA02004779A (pt)
TR (3) TR200601784T2 (pt)
WO (1) WO2001034618A2 (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6822089B1 (en) 2000-03-29 2004-11-23 Isis Pharmaceuticals, Inc. Preparation of deoxynucleosides
CN1646141B (zh) 2000-10-18 2014-06-25 吉利德制药有限责任公司 用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物
DE10216426A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
TWI244393B (en) * 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
BR122018015050B1 (pt) * 2003-05-30 2021-07-13 Gilead Pharmasset Llc Derivados fosfatados de nucleosídeo e composição farmacêutica dos mesmos
EP1668023A1 (de) * 2003-09-12 2006-06-14 Max-Delbrück-Centrum Für Molekulare Medizin B-l-nucleoside und ihre verwendung als pharmazeutische mittel zur behandlung viraler erkrankungen
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
ES2725457T3 (es) * 2004-09-14 2019-09-24 Gilead Pharmasset Llc Preparación de ribofuranosil pirimidinas y purinas 2'fluoro-2'-alquil-sustituidas u otras opcionalmente sustituidas y sus derivados
US7759342B2 (en) 2005-01-13 2010-07-20 Signal Pharmaceuticals, Llc Methods of treatment and prevention using haloaryl substituted aminopurines
US7723340B2 (en) 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
US7521446B2 (en) 2005-01-13 2009-04-21 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
EP2532310A3 (en) * 2005-04-29 2014-08-20 Cook Biotech Incorporated Volumetric grafts for treatment of fistulae and related methods and systems
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8173621B2 (en) * 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
JP2011528605A (ja) * 2008-07-21 2011-11-24 アルスタシス，インコーポレイテッド 組織内に管を形成するデバイス、方法、及びキット
ES2431269T3 (es) * 2008-11-17 2013-11-25 Anadys Pharmaceuticals, Inc. Método de preparación de compuestos de desoxirribofuranosa
KR20110104074A (ko) 2008-12-23 2011-09-21 파마셋 인코포레이티드 퓨린 뉴클레오시드의 합성
CN102753563A (zh) 2008-12-23 2012-10-24 吉利德制药有限责任公司 核苷类似物
AU2009329867B2 (en) 2008-12-23 2015-01-29 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
CN101555266B (zh) * 2009-05-25 2011-11-30 上海医药工业研究院 一种替比夫定的制备方法
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
EP2752422B1 (en) 2010-03-31 2017-08-16 Gilead Pharmasset LLC Stereoselective synthesis of phosphorus containing actives
KR101198302B1 (ko) 2010-11-02 2012-11-07 서울대학교산학협력단 Ｃｄｋ를 저해하는 피롤로피리미디논 카복사미드 유도체 또는 이의 약학적으로 허용가능한 염, 이를 유효성분으로 함유하는 간세포암의 예방 또는 치료용 약학적 조성물
EP2646453A1 (en) 2010-11-30 2013-10-09 Gilead Pharmasset LLC Compounds
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US9868733B2 (en) 2012-08-22 2018-01-16 Merck Sharp & Dohme Corp. Azabenzimidazole tetrahydrofuran derivatives
EP3038601B1 (en) 2013-08-27 2020-04-08 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
EP3801538A4 (en) * 2018-05-25 2022-03-09 Primmune Therapeutics, Inc. TLR7 AGONISTS
CN109020974B (zh) * 2018-11-02 2021-01-05 哈尔滨商业大学 5′-噻吩甲酰酯-3′-脱氧腺苷的合成方法及其应用
CN109369758B (zh) * 2018-11-02 2021-04-13 哈尔滨商业大学 5′-(6-氯烟酰酯)-3′-脱氧腺苷的合成方法及其应用
CN109111445B (zh) * 2018-11-02 2020-12-18 哈尔滨商业大学 5’-呋喃甲酰酯-3’-脱氧腺苷的合成方法及应用
CA3163093A1 (en) 2019-11-26 2021-06-03 Primmune Therapeutics, Inc. Tlr7 agonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5041449A (en) * 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5200514A (en) * 1990-01-19 1993-04-06 University Of Georgia Research Foundation, Inc. Synthesis of 2'-deoxypyrimidine nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
IT1246983B (it) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
FR2709754B1 (fr) * 1993-09-10 1995-12-01 Centre Nat Rech Scient Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale.
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
US6025335A (en) * 1995-09-21 2000-02-15 Lipitek International, Inc. L-Nucleoside Dimer Compounds and therapeutic uses
AU5475799A (en) * 1998-08-10 2000-03-06 Centre National De La Recherche Scientifique Beta-l-2'-deoxy-nucleosides for the treatment of hepatitis
US6444652B1 (en) * 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
US6407077B1 (en) * 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection

Also Published As

Publication number Publication date
CN1919860A (zh) 2007-02-28
JP2003513984A (ja) 2003-04-15
WO2001034618A2 (en) 2001-05-17
WO2001034618A3 (en) 2002-01-03
CN1919858A (zh) 2007-02-28
TR200601783T2 (tr) 2007-01-22
AU2005204267A1 (en) 2005-09-22
AU1485801A (en) 2001-06-06
CA2391279A1 (en) 2001-05-17
CN1423654A (zh) 2003-06-11
KR20030025220A (ko) 2003-03-28
AU2005204266B2 (en) 2008-11-06
AU2005204266A1 (en) 2005-09-22
MXPA02004779A (es) 2004-07-01
AU2005204267B2 (en) 2008-10-23
US20050090660A1 (en) 2005-04-28
AU784374B2 (en) 2006-03-23
TR200601784T2 (tr) 2007-01-22
CN1919859A (zh) 2007-02-28
TR200601782T2 (tr) 2006-09-21
AU784374C (en) 2007-06-28
IL149592A (en) 2008-11-26
EP1232166A2 (en) 2002-08-21
IL149592A0 (en) 2002-11-10
KR100789162B1 (ko) 2007-12-28

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: PHARMASSET, INC. (US)

Free format text: ALTERADO DE: PHARMASSET LIMITED

B25G Requested change of headquarter approved

Owner name: PHARMASSET, INC. (US)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020060040045/RJ DE 23/03/2006.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A , 10A E 11A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2138 DE 27/12/2011.