BRPI0210746A8 - derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina tendo atividade antiviral - Google Patents

derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina tendo atividade antiviral Download PDF

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Publication number
BRPI0210746A8
BRPI0210746A8 BRPI0210746A BRPI0210746A BRPI0210746A8 BR PI0210746 A8 BRPI0210746 A8 BR PI0210746A8 BR PI0210746 A BRPI0210746 A BR PI0210746A BR PI0210746 A BRPI0210746 A BR PI0210746A BR PI0210746 A8 BRPI0210746 A8 BR PI0210746A8
Authority
BR
Brazil
Prior art keywords
phosphonomethoxy
antiviral activity
pyrimidine derivatives
alkoxy pyrimidine
alkoxy
Prior art date
Application number
BRPI0210746A
Other languages
English (en)
Inventor
Holy Antonin
Desire Alice De Clercq Erik
M R Balzarini Jan
Original Assignee
Inst Of Organic Chemistry And Biochemistry Ascr
Rega Stichting
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Of Organic Chemistry And Biochemistry Ascr, Rega Stichting filed Critical Inst Of Organic Chemistry And Biochemistry Ascr
Publication of BR0210746A publication Critical patent/BR0210746A/pt
Publication of BRPI0210746A8 publication Critical patent/BRPI0210746A8/pt
Publication of BRPI0210746B1 publication Critical patent/BRPI0210746B1/pt
Publication of BRPI0210746B8 publication Critical patent/BRPI0210746B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

"derivados de 6-<39>2-(fosfonometóxi)alcóxipirimidina tendo atividade antiviral". são providos compostos tendo a fórmula (i) onde r~ 1~, r~ 2~, r~ 3~, r~ 4~, z, x e * são definidos aqui. são também providos métodos antivirais para uso e processos para síntese dos compostos da fórmula (i).
BRPI0210746 2001-06-29 2002-06-28 derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina e seu método de preparação BRPI0210746B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30221201P 2001-06-29 2001-06-29
PCT/CZ2002/000038 WO2003002580A1 (en) 2001-06-29 2002-06-28 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity

Publications (4)

Publication Number Publication Date
BR0210746A BR0210746A (pt) 2004-07-20
BRPI0210746A8 true BRPI0210746A8 (pt) 2018-07-10
BRPI0210746B1 BRPI0210746B1 (pt) 2018-09-18
BRPI0210746B8 BRPI0210746B8 (pt) 2021-05-25

Family

ID=23166777

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0210746 BRPI0210746B8 (pt) 2001-06-29 2002-06-28 derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina e seu método de preparação

Country Status (21)

Country Link
US (2) US6818633B2 (pt)
EP (1) EP1406911B1 (pt)
JP (1) JP4545434B2 (pt)
KR (1) KR100891366B1 (pt)
CN (1) CN1329404C (pt)
AP (1) AP1622A (pt)
AU (1) AU2002315625B2 (pt)
BR (1) BRPI0210746B8 (pt)
CA (1) CA2452036C (pt)
CZ (1) CZ297267B6 (pt)
EA (1) EA006020B1 (pt)
ES (1) ES2564144T3 (pt)
HU (1) HU230519B1 (pt)
IL (2) IL159494A0 (pt)
MX (1) MXPA04000138A (pt)
NO (2) NO333788B1 (pt)
NZ (1) NZ530685A (pt)
PL (1) PL207187B1 (pt)
TR (1) TR200302288T2 (pt)
WO (1) WO2003002580A1 (pt)
ZA (1) ZA200400236B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1805966B (zh) * 2003-06-16 2013-03-13 捷克科学院有机化学和生物化学研究所 作为抗病毒核苷酸类似物的含膦酸酯基团的嘧啶化合物
ES2401285T3 (es) 2004-12-16 2013-04-18 The Regents Of The University Of California Fármacos con el pulmón como diana
US20060211650A1 (en) * 2004-12-16 2006-09-21 Forest Laboratories, Inc. Reducing carbohydrate derivatives of adamantane amines, and synthesis and methods of use thereof
CA2616314A1 (en) * 2005-07-27 2007-02-01 Gilead Sciences, Inc. Antiviral phosphonate conjugates for inhibition of hiv
US7473683B2 (en) 2005-09-14 2009-01-06 The Board Of Trustees Of The Leland Stanford Junior University Nonpolar thymidine analogs
WO2007047405A1 (en) * 2005-10-13 2007-04-26 Allergan, Inc. Ddc compositions
FR2908133B1 (fr) 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
JP5847296B2 (ja) * 2011-05-10 2016-01-20 アラタナ セラピューティクス エン ヴェー ネコレトロウイルス感染症の治療に使用するための化合物
CN107056838A (zh) 2013-03-15 2017-08-18 加利福尼亚大学董事会 无环核苷膦酸二酯
CN104119385B (zh) * 2014-07-24 2017-04-05 廖国超 核苷类似物的磷酸酯前药及其应用
HRP20220651T1 (hr) 2014-09-15 2022-08-19 The Regents Of The University Of California Nukleotidni analozi
EP3875462A1 (en) 2015-09-15 2021-09-08 The Regents of The University of California Nucleotide analogs
CA3097255A1 (en) * 2018-04-23 2019-10-31 Centre National De La Recherche Scientifique New antiviral acyclonucleoside analogues

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
AU613592B2 (en) 1986-11-18 1991-08-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
CA2001715C (en) 1988-11-14 1999-12-28 Muzammil M. Mansuri Carbocyclic nucleosides and nucleotides
CA2479846C (en) * 1989-05-15 2007-07-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Scienc Es Of The Czech Republic Phosphonomethoxymethylpurine/pyrimidine derivatives
MY104575A (en) 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CZ285420B6 (cs) 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
AU653542B2 (en) * 1990-07-19 1994-10-06 Beecham Group Plc Antiviral phosphono-alken derivatives of purines
EP0468119A1 (en) 1990-07-24 1992-01-29 Merrell Dow Pharmaceuticals Inc. Novel carbocyclic analogs of certain nucleosides
DE69129650T2 (de) 1990-09-14 1999-03-25 Acad Of Science Czech Republic Wirkstoffvorläufer von Phosphonaten
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
CZ284678B6 (cs) 1991-05-20 1999-01-13 Ústav Organické Chemie A Biochemie Avčr Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
EP0531597A1 (en) * 1991-09-12 1993-03-17 Merrell Dow Pharmaceuticals Inc. Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine
HU225970B1 (en) 1991-10-11 2008-01-28 Acad Of Science Czech Republic Antiviral acyclic phosphonomethoxyalkyl-substituted alkenyl purine and pyrimidine derivatives, and pharmaceutical preparations containing them
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
EP0618214A1 (en) 1993-04-01 1994-10-05 Merrell Dow Pharmaceuticals Inc. Unsaturated phosphonate derivatives of purines and pyrimidines
WO1995007920A1 (en) 1993-09-17 1995-03-23 Gilead Sciences, Inc. Nucleotide analogs
US5977061A (en) 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use

Also Published As

Publication number Publication date
PL207187B1 (pl) 2010-11-30
CA2452036C (en) 2009-09-29
AU2002315625B2 (en) 2008-05-01
HU230519B1 (hu) 2016-10-28
AP1622A (en) 2006-06-16
CN1533397A (zh) 2004-09-29
NO20035797L (no) 2004-02-24
KR100891366B1 (ko) 2009-04-02
EP1406911B1 (en) 2016-01-06
HUP0400345A2 (hu) 2004-09-28
NO333788B1 (no) 2013-09-16
CN1329404C (zh) 2007-08-01
BR0210746A (pt) 2004-07-20
NZ530685A (en) 2006-09-29
IL159494A0 (en) 2004-06-01
US6818633B2 (en) 2004-11-16
EA200400117A1 (ru) 2004-08-26
BRPI0210746B8 (pt) 2021-05-25
CZ297267B6 (cs) 2006-10-11
HUP0400345A3 (en) 2007-05-29
JP4545434B2 (ja) 2010-09-15
BRPI0210746B1 (pt) 2018-09-18
WO2003002580A1 (en) 2003-01-09
TR200302288T2 (tr) 2004-12-21
IL159494A (en) 2008-06-05
ZA200400236B (en) 2004-08-18
ES2564144T3 (es) 2016-03-18
CA2452036A1 (en) 2003-01-09
CZ2004142A3 (cs) 2004-05-12
EP1406911A1 (en) 2004-04-14
KR20040027521A (ko) 2004-04-01
AP2004002953A0 (en) 2004-03-31
WO2003002580A8 (en) 2003-01-30
JP2005511490A (ja) 2005-04-28
NO20131091L (no) 2004-02-24
EA006020B1 (ru) 2005-08-25
US20030109499A1 (en) 2003-06-12
NO335725B1 (no) 2015-02-02
MXPA04000138A (es) 2005-06-06
US20050038058A1 (en) 2005-02-17
PL366852A1 (en) 2005-02-07

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07F 9/6512; A61K 31/675; A61P 31/18, 31/20, 31/12

Ipc: C07F 9/6512 (2011.01), A61K 31/675 (2011.01), A61P

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 18/09/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/06/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 28/06/2022