EA200400117A1 - Производные 6-[2-(фосфонометокси)алкокси]пиримидинов, обладающие антивирусной активностью, способ их получения (варианты) и способ лечения вирусной инфекции - Google Patents

Производные 6-[2-(фосфонометокси)алкокси]пиримидинов, обладающие антивирусной активностью, способ их получения (варианты) и способ лечения вирусной инфекции

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Publication number
EA200400117A1
EA200400117A1 EA200400117A EA200400117A EA200400117A1 EA 200400117 A1 EA200400117 A1 EA 200400117A1 EA 200400117 A EA200400117 A EA 200400117A EA 200400117 A EA200400117 A EA 200400117A EA 200400117 A1 EA200400117 A1 EA 200400117A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phosphonomotoxy
alkoxi
variants
derivatives
producing
Prior art date
Application number
EA200400117A
Other languages
English (en)
Other versions
EA006020B1 (ru
Inventor
Ян М. Р. Бальзарини
Эрик Десире Алиса Де Клерк
Антонин Голи
Original Assignee
Инститьют Оф Оргэник Кемистри Энд Байокемистри Оф Зе Экэдеми Оф Сайэнс Оф Зе Чек Рипаблик
Рега Стихтинг, В.З.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Инститьют Оф Оргэник Кемистри Энд Байокемистри Оф Зе Экэдеми Оф Сайэнс Оф Зе Чек Рипаблик, Рега Стихтинг, В.З.В. filed Critical Инститьют Оф Оргэник Кемистри Энд Байокемистри Оф Зе Экэдеми Оф Сайэнс Оф Зе Чек Рипаблик
Publication of EA200400117A1 publication Critical patent/EA200400117A1/ru
Publication of EA006020B1 publication Critical patent/EA006020B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Описаны новые соединения формулы Iгде R, R, R, R, Z, X и * определены в описании изобретения. Разработаны также способы их использования в антивирусной терапии и способы синтеза соединений формулы I.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400117A 2001-06-29 2002-06-28 Производные 6-[2-(фосфонометокси)алкокси]пиримидинов, обладающие антивирусной активностью, способ их получения (варианты) и способ лечения вирусной инфекции EA006020B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30221201P 2001-06-29 2001-06-29
PCT/CZ2002/000038 WO2003002580A1 (en) 2001-06-29 2002-06-28 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity

Publications (2)

Publication Number Publication Date
EA200400117A1 true EA200400117A1 (ru) 2004-08-26
EA006020B1 EA006020B1 (ru) 2005-08-25

Family

ID=23166777

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400117A EA006020B1 (ru) 2001-06-29 2002-06-28 Производные 6-[2-(фосфонометокси)алкокси]пиримидинов, обладающие антивирусной активностью, способ их получения (варианты) и способ лечения вирусной инфекции

Country Status (21)

Country Link
US (2) US6818633B2 (ru)
EP (1) EP1406911B1 (ru)
JP (1) JP4545434B2 (ru)
KR (1) KR100891366B1 (ru)
CN (1) CN1329404C (ru)
AP (1) AP1622A (ru)
AU (1) AU2002315625B2 (ru)
BR (1) BRPI0210746B8 (ru)
CA (1) CA2452036C (ru)
CZ (1) CZ297267B6 (ru)
EA (1) EA006020B1 (ru)
ES (1) ES2564144T3 (ru)
HU (1) HU230519B1 (ru)
IL (2) IL159494A0 (ru)
MX (1) MXPA04000138A (ru)
NO (2) NO333788B1 (ru)
NZ (1) NZ530685A (ru)
PL (1) PL207187B1 (ru)
TR (1) TR200302288T2 (ru)
WO (1) WO2003002580A1 (ru)
ZA (1) ZA200400236B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1644389T1 (sl) * 2003-06-16 2011-06-30 Acad Of Science Czech Republic Pirimidinske spojine s fosfonatnimi skupinami kot antivirusni nukleotidni analogi
US20060211650A1 (en) * 2004-12-16 2006-09-21 Forest Laboratories, Inc. Reducing carbohydrate derivatives of adamantane amines, and synthesis and methods of use thereof
WO2006066074A2 (en) 2004-12-16 2006-06-22 The Regents Of The University Of California Lung-targeted drugs
AU2006272521A1 (en) * 2005-07-27 2007-02-01 Gilead Sciences, Inc. Antiviral phosphonate conjugates for inhibition of HIV
US7473683B2 (en) 2005-09-14 2009-01-06 The Board Of Trustees Of The Leland Stanford Junior University Nonpolar thymidine analogs
WO2007047405A1 (en) * 2005-10-13 2007-04-26 Allergan, Inc. Ddc compositions
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
CA2835321A1 (en) * 2011-05-10 2012-11-15 Okapi Sciences Nv Compounds for use in the treatment of feline retroviral infections
SG10201800188SA (en) 2013-03-15 2018-02-27 Univ California Acyclic nucleoside phosphonate diesters
CN104119385B (zh) * 2014-07-24 2017-04-05 廖国超 核苷类似物的磷酸酯前药及其应用
JP6708329B2 (ja) 2014-09-15 2020-06-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ヌクレオチド類似体
WO2017048956A1 (en) 2015-09-15 2017-03-23 The Regents Of The University Of California Nucleotide analogs
US11603380B2 (en) 2018-04-23 2023-03-14 Centre National De La Recherche Scientifique Antiviral acyclonucleoside analogues for use in treating a viral infection

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
CS263952B1 (en) 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS264222B1 (en) 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
CA2001715C (en) 1988-11-14 1999-12-28 Muzammil M. Mansuri Carbocyclic nucleosides and nucleotides
CA2297294C (en) * 1989-05-15 2005-11-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Phosphonomethoxymethylpurine/pyrimidine derivatives
MY104575A (en) 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5302585A (en) 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
SK280313B6 (sk) 1990-04-24 1999-11-08 �Stav Organick� Chemie A Biochemie Av �R N-(3-fluór-2-fosfonylmetoxypropyl)deriváty purínov
US5356886A (en) 1990-07-19 1994-10-18 Beecham Group P.L.C. Antiviral phosphono-alken derivatives of purines
EP0468119A1 (en) 1990-07-24 1992-01-29 Merrell Dow Pharmaceuticals Inc. Novel carbocyclic analogs of certain nucleosides
ATE167679T1 (de) 1990-09-14 1998-07-15 Acad Of Science Czech Republic Wirkstoffvorläufer von phosphonaten
US5208221A (en) 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
CZ284678B6 (cs) 1991-05-20 1999-01-13 Ústav Organické Chemie A Biochemie Avčr Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
EP0531597A1 (en) * 1991-09-12 1993-03-17 Merrell Dow Pharmaceuticals Inc. Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine
CA2120743C (en) 1991-10-11 2005-03-08 John C. Martin Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
EP0618214A1 (en) 1993-04-01 1994-10-05 Merrell Dow Pharmaceuticals Inc. Unsaturated phosphonate derivatives of purines and pyrimidines
BR9407510A (pt) 1993-09-17 1997-01-07 Gilead Sciences Inc Análogos de nucleotideo
US5977061A (en) 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use

Also Published As

Publication number Publication date
PL366852A1 (en) 2005-02-07
HUP0400345A3 (en) 2007-05-29
NO20131091L (no) 2004-02-24
IL159494A (en) 2008-06-05
AU2002315625B2 (en) 2008-05-01
CA2452036A1 (en) 2003-01-09
US20030109499A1 (en) 2003-06-12
WO2003002580A8 (en) 2003-01-30
IL159494A0 (en) 2004-06-01
KR100891366B1 (ko) 2009-04-02
AP1622A (en) 2006-06-16
BRPI0210746B1 (pt) 2018-09-18
NZ530685A (en) 2006-09-29
JP4545434B2 (ja) 2010-09-15
EA006020B1 (ru) 2005-08-25
CN1329404C (zh) 2007-08-01
EP1406911B1 (en) 2016-01-06
BRPI0210746B8 (pt) 2021-05-25
NO20035797L (no) 2004-02-24
WO2003002580A1 (en) 2003-01-09
CZ2004142A3 (cs) 2004-05-12
BRPI0210746A8 (pt) 2018-07-10
KR20040027521A (ko) 2004-04-01
MXPA04000138A (es) 2005-06-06
ES2564144T3 (es) 2016-03-18
JP2005511490A (ja) 2005-04-28
CN1533397A (zh) 2004-09-29
EP1406911A1 (en) 2004-04-14
US6818633B2 (en) 2004-11-16
HUP0400345A2 (hu) 2004-09-28
AP2004002953A0 (en) 2004-03-31
PL207187B1 (pl) 2010-11-30
CA2452036C (en) 2009-09-29
HU230519B1 (hu) 2016-10-28
ZA200400236B (en) 2004-08-18
NO333788B1 (no) 2013-09-16
US20050038058A1 (en) 2005-02-17
CZ297267B6 (cs) 2006-10-11
TR200302288T2 (tr) 2004-12-21
BR0210746A (pt) 2004-07-20
NO335725B1 (no) 2015-02-02

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