SI1644389T1 - Pirimidinske spojine s fosfonatnimi skupinami kot antivirusni nukleotidni analogi - Google Patents
Pirimidinske spojine s fosfonatnimi skupinami kot antivirusni nukleotidni analogiInfo
- Publication number
- SI1644389T1 SI1644389T1 SI200431649T SI200431649T SI1644389T1 SI 1644389 T1 SI1644389 T1 SI 1644389T1 SI 200431649 T SI200431649 T SI 200431649T SI 200431649 T SI200431649 T SI 200431649T SI 1644389 T1 SI1644389 T1 SI 1644389T1
- Authority
- SI
- Slovenia
- Prior art keywords
- nucleotide analogs
- pyrimidine compounds
- phosphonate groups
- sub
- antiviral nucleotide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47889303P | 2003-06-16 | 2003-06-16 | |
EP04738454A EP1644389B1 (en) | 2003-06-16 | 2004-06-16 | Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs |
PCT/CZ2004/000034 WO2004111064A1 (en) | 2003-06-16 | 2004-06-16 | Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1644389T1 true SI1644389T1 (sl) | 2011-06-30 |
Family
ID=33551859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200431649T SI1644389T1 (sl) | 2003-06-16 | 2004-06-16 | Pirimidinske spojine s fosfonatnimi skupinami kot antivirusni nukleotidni analogi |
Country Status (16)
Country | Link |
---|---|
US (2) | US7115592B2 (sl) |
EP (1) | EP1644389B1 (sl) |
JP (2) | JP5280631B2 (sl) |
KR (1) | KR101102815B1 (sl) |
CN (1) | CN1805966B (sl) |
AT (1) | ATE496056T1 (sl) |
AU (1) | AU2004247305B2 (sl) |
CA (1) | CA2527805C (sl) |
DE (1) | DE602004031115D1 (sl) |
DK (1) | DK1644389T3 (sl) |
EA (1) | EA011948B1 (sl) |
HK (1) | HK1088013A1 (sl) |
IL (1) | IL172015A (sl) |
NZ (1) | NZ543864A (sl) |
SI (1) | SI1644389T1 (sl) |
WO (1) | WO2004111064A1 (sl) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009502964A (ja) * | 2005-07-27 | 2009-01-29 | ギリアード サイエンシーズ, インコーポレイテッド | Hivを阻害するための抗ウイルス性ホスホン酸結合体 |
FR2908133B1 (fr) | 2006-11-08 | 2012-12-14 | Centre Nat Rech Scient | Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux |
ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
AU2011239560B2 (en) | 2010-04-14 | 2016-11-03 | The Regents Of The University Of California | Phosphonates with reduced toxicity for treatment of viral infections |
EP2611818B1 (en) * | 2010-08-31 | 2016-08-24 | Chimerix, Inc. | Phosphonate ester derivatives and methods of synthesis thereof |
CA2810011A1 (en) * | 2010-09-01 | 2012-03-08 | Novartis Ag | Adsorption of immunopotentiators to insoluble metal salts |
JP5932829B2 (ja) | 2010-12-10 | 2016-06-08 | シグマファーム ラボラトリーズ エルエルシー | 経口活性ヌクレオチドアナログ又は経口活性ヌクレオチドアナログプロドラッグの高度に安定な組成物 |
KR20140026392A (ko) | 2011-03-02 | 2014-03-05 | 노파르티스 아게 | 저용량의 항원 및/또는 보조제를 갖는 조합 백신 |
EP2794624B1 (en) | 2011-12-22 | 2019-05-15 | Geron Corporation | Guanine analogs as telomerase substrates and telomere length affectors |
RU2014140521A (ru) | 2012-03-08 | 2016-04-27 | Новартис Аг | Адъювантные составы бустерных вакцин |
CN103665043B (zh) * | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
CN102796138B (zh) * | 2012-09-07 | 2014-10-22 | 山东大学 | (2-(3-甲硫基-1,2,4-噻二嗪)乙氧基)甲基膦酸酯类衍生物及其制备与应用 |
PT2970346T (pt) | 2013-03-15 | 2018-11-09 | Univ California | Diésteres de fosfonato nucleosídico acíclico |
EP3194411B1 (en) | 2014-09-15 | 2022-05-04 | The Regents of the University of California | Nucleotide analogs |
WO2017048956A1 (en) | 2015-09-15 | 2017-03-23 | The Regents Of The University Of California | Nucleotide analogs |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS233665B1 (en) | 1983-01-06 | 1985-03-14 | Antonin Holy | Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene |
DE3580384D1 (de) | 1984-04-09 | 1990-12-13 | Toyo Boseki | Praeparat mit verzoegerter freigabe zum aufbringen auf die schleimhaeute der mundhoehle. |
CS263951B1 (en) | 1985-04-25 | 1989-05-12 | Antonin Holy | 9-(phosponylmethoxyalkyl)adenines and method of their preparation |
CS263952B1 (en) | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
EP0232276B1 (de) * | 1985-10-30 | 1988-12-07 | Planert, Jens, Dr. med dent. | Vorrichtung zum entfernen von kronen, brücken o. dgl. von zahnstümpfen |
US5141752A (en) | 1986-05-09 | 1992-08-25 | Alza Corporation | Delayed drug delivery device |
CS264222B1 (en) | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
NZ222553A (en) | 1986-11-18 | 1991-07-26 | Bristol Myers Co | Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions |
CA2001715C (en) | 1988-11-14 | 1999-12-28 | Muzammil M. Mansuri | Carbocyclic nucleosides and nucleotides |
US5098443A (en) | 1989-03-23 | 1992-03-24 | University Of Miami | Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents |
CA2479846C (en) | 1989-05-15 | 2007-07-24 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Scienc Es Of The Czech Republic | Phosphonomethoxymethylpurine/pyrimidine derivatives |
MY104575A (en) | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
US5302585A (en) | 1990-04-20 | 1994-04-12 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents |
SK280313B6 (sk) | 1990-04-24 | 1999-11-08 | �Stav Organick� Chemie A Biochemie Av �R | N-(3-fluór-2-fosfonylmetoxypropyl)deriváty purínov |
WO1992001698A1 (en) | 1990-07-19 | 1992-02-06 | Beecham Group Plc | Antiviral phosphono-alken derivatives of purines |
EP0468119A1 (en) | 1990-07-24 | 1992-01-29 | Merrell Dow Pharmaceuticals Inc. | Novel carbocyclic analogs of certain nucleosides |
DE69129650T2 (de) | 1990-09-14 | 1999-03-25 | Acad Of Science Czech Republic | Wirkstoffvorläufer von Phosphonaten |
US5208221A (en) | 1990-11-29 | 1993-05-04 | Bristol-Myers Squibb Company | Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives |
US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
CZ284678B6 (cs) | 1991-05-20 | 1999-01-13 | Ústav Organické Chemie A Biochemie Avčr | Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití |
JP3497505B2 (ja) | 1991-10-11 | 2004-02-16 | インスティテュート オブ オルガニック ケミストリー アンド バイオケミストリー オブ ザ アカデミー オブ サイエンシズ オブ ザ チェコ パブリック | 抗ウイルス性非環式ホスホノメトキシアルキル置換アルケニル及びアルキニルプリン及びピリミジン誘導体 |
US6057305A (en) | 1992-08-05 | 2000-05-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Antiretroviral enantiomeric nucleotide analogs |
EP0618214A1 (en) | 1993-04-01 | 1994-10-05 | Merrell Dow Pharmaceuticals Inc. | Unsaturated phosphonate derivatives of purines and pyrimidines |
BR9407510A (pt) | 1993-09-17 | 1997-01-07 | Gilead Sciences Inc | Análogos de nucleotideo |
HU228450B1 (en) | 1995-02-27 | 2013-03-28 | Gilead Sciences Inc | Novel selective inhibitors of viral or bacterial neuraminidases |
US5977061A (en) | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
CA2261619C (en) | 1996-07-26 | 2006-05-23 | Gilead Sciences, Inc. | Nucleotide analogs |
WO2003002580A1 (en) * | 2001-06-29 | 2003-01-09 | Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic | 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity |
-
2004
- 2004-06-16 KR KR1020057024279A patent/KR101102815B1/ko active IP Right Grant
- 2004-06-16 DE DE602004031115T patent/DE602004031115D1/de active Active
- 2004-06-16 DK DK04738454.0T patent/DK1644389T3/da active
- 2004-06-16 EP EP04738454A patent/EP1644389B1/en active Active
- 2004-06-16 NZ NZ543864A patent/NZ543864A/en unknown
- 2004-06-16 JP JP2006515644A patent/JP5280631B2/ja active Active
- 2004-06-16 CN CN2004800168859A patent/CN1805966B/zh active Active
- 2004-06-16 AU AU2004247305A patent/AU2004247305B2/en active Active
- 2004-06-16 US US10/869,005 patent/US7115592B2/en active Active
- 2004-06-16 CA CA2527805A patent/CA2527805C/en active Active
- 2004-06-16 SI SI200431649T patent/SI1644389T1/sl unknown
- 2004-06-16 EA EA200600046A patent/EA011948B1/ru not_active IP Right Cessation
- 2004-06-16 AT AT04738454T patent/ATE496056T1/de not_active IP Right Cessation
- 2004-06-16 WO PCT/CZ2004/000034 patent/WO2004111064A1/en active Application Filing
-
2005
- 2005-11-17 IL IL172015A patent/IL172015A/en active IP Right Grant
-
2006
- 2006-06-23 US US11/473,924 patent/US20060241081A1/en not_active Abandoned
- 2006-09-07 HK HK06109982.5A patent/HK1088013A1/xx unknown
-
2012
- 2012-05-21 JP JP2012115602A patent/JP2012153731A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20060241081A1 (en) | 2006-10-26 |
JP2006527702A (ja) | 2006-12-07 |
WO2004111064A1 (en) | 2004-12-23 |
EP1644389B1 (en) | 2011-01-19 |
DK1644389T3 (da) | 2011-05-09 |
NZ543864A (en) | 2009-10-30 |
AU2004247305A1 (en) | 2004-12-23 |
CN1805966A (zh) | 2006-07-19 |
AU2004247305B2 (en) | 2010-02-18 |
DE602004031115D1 (de) | 2011-03-03 |
EA200600046A1 (ru) | 2006-06-30 |
JP2012153731A (ja) | 2012-08-16 |
IL172015A0 (en) | 2009-02-11 |
US7115592B2 (en) | 2006-10-03 |
EP1644389A1 (en) | 2006-04-12 |
EA011948B1 (ru) | 2009-06-30 |
KR20060041182A (ko) | 2006-05-11 |
ATE496056T1 (de) | 2011-02-15 |
CN1805966B (zh) | 2013-03-13 |
CA2527805A1 (en) | 2004-12-23 |
JP5280631B2 (ja) | 2013-09-04 |
US20050075318A1 (en) | 2005-04-07 |
HK1088013A1 (en) | 2006-10-27 |
CA2527805C (en) | 2012-08-21 |
KR101102815B1 (ko) | 2012-01-05 |
IL172015A (en) | 2016-07-31 |
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