HK1088013A1 - Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs - Google Patents

Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs

Info

Publication number
HK1088013A1
HK1088013A1 HK06109982.5A HK06109982A HK1088013A1 HK 1088013 A1 HK1088013 A1 HK 1088013A1 HK 06109982 A HK06109982 A HK 06109982A HK 1088013 A1 HK1088013 A1 HK 1088013A1
Authority
HK
Hong Kong
Prior art keywords
nucleotide analogs
pyrimidine compounds
phosphonate groups
sub
antiviral nucleotide
Prior art date
Application number
HK06109982.5A
Other languages
English (en)
Inventor
Antonin Holy
Clercq Erik Desire Alice De
Jan Marie Rene Balzarini
Dana Hockova
Original Assignee
Acad Of Science Czech Republic
Leuven K U Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acad Of Science Czech Republic, Leuven K U Res & Dev filed Critical Acad Of Science Czech Republic
Publication of HK1088013A1 publication Critical patent/HK1088013A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK06109982.5A 2003-06-16 2006-09-07 Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs HK1088013A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47889303P 2003-06-16 2003-06-16
PCT/CZ2004/000034 WO2004111064A1 (en) 2003-06-16 2004-06-16 Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs

Publications (1)

Publication Number Publication Date
HK1088013A1 true HK1088013A1 (en) 2006-10-27

Family

ID=33551859

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06109982.5A HK1088013A1 (en) 2003-06-16 2006-09-07 Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs

Country Status (16)

Country Link
US (2) US7115592B2 (xx)
EP (1) EP1644389B1 (xx)
JP (2) JP5280631B2 (xx)
KR (1) KR101102815B1 (xx)
CN (1) CN1805966B (xx)
AT (1) ATE496056T1 (xx)
AU (1) AU2004247305B2 (xx)
CA (1) CA2527805C (xx)
DE (1) DE602004031115D1 (xx)
DK (1) DK1644389T3 (xx)
EA (1) EA011948B1 (xx)
HK (1) HK1088013A1 (xx)
IL (1) IL172015A (xx)
NZ (1) NZ543864A (xx)
SI (1) SI1644389T1 (xx)
WO (1) WO2004111064A1 (xx)

Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
CA2616314A1 (en) * 2005-07-27 2007-02-01 Gilead Sciences, Inc. Antiviral phosphonate conjugates for inhibition of hiv
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
CA2772916C (en) 2009-09-02 2019-01-15 Novartis Ag Immunogenic compositions including tlr activity modulators
EP2558466A4 (en) * 2010-04-14 2013-11-13 Univ California PHOSPHONATES HAVING REDUCED TOXICITY FOR THE TREATMENT OF VIRAL INFECTIONS
RU2015141024A (ru) * 2010-08-31 2018-12-26 Чимерикс, Инк. Производные эфиров фосфоновых кислот и способы их синтеза
EA201390341A1 (ru) * 2010-09-01 2013-08-30 Новартис Аг Адсорбция иммунопотенциаторов на нерастворимых солях металлов
MX2013006127A (es) 2010-12-10 2013-09-26 Sigmapharm Lab Llc Composiciones sumamente estables de analogos nucleotidicoas oralmente activos o profarmacos analogos nucleotidicos oralmente activos.
KR20140026392A (ko) 2011-03-02 2014-03-05 노파르티스 아게 저용량의 항원 및/또는 보조제를 갖는 조합 백신
DK2794624T3 (da) 2011-12-22 2019-07-22 Geron Corp Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde
US9375471B2 (en) 2012-03-08 2016-06-28 Glaxosmithkline Biologicals Sa Adjuvanted formulations of booster vaccines
CN103665043B (zh) * 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
CN102796138B (zh) * 2012-09-07 2014-10-22 山东大学 (2-(3-甲硫基-1,2,4-噻二嗪)乙氧基)甲基膦酸酯类衍生物及其制备与应用
SI2970346T1 (sl) 2013-03-15 2018-12-31 The Regents Of The University Of California Aciklični diestri nukleozid fosfonata
EP3194411B1 (en) 2014-09-15 2022-05-04 The Regents of the University of California Nucleotide analogs
US10377782B2 (en) 2015-09-15 2019-08-13 The Regents Of The University Of California Nucleotide analogs

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
US4740365A (en) 1984-04-09 1988-04-26 Toyo Boseki Kabushiki Kaisha Sustained-release preparation applicable to mucous membrane in oral cavity
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
EP0232276B1 (de) * 1985-10-30 1988-12-07 Planert, Jens, Dr. med dent. Vorrichtung zum entfernen von kronen, brücken o. dgl. von zahnstümpfen
US5141752A (en) 1986-05-09 1992-08-25 Alza Corporation Delayed drug delivery device
CS264222B1 (en) 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
CA2001715C (en) 1988-11-14 1999-12-28 Muzammil M. Mansuri Carbocyclic nucleosides and nucleotides
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
CA2479846C (en) 1989-05-15 2007-07-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Scienc Es Of The Czech Republic Phosphonomethoxymethylpurine/pyrimidine derivatives
MY104575A (en) 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5302585A (en) 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CZ285420B6 (cs) 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
JPH05509307A (ja) 1990-07-19 1993-12-22 ビーチャム・グループ・パブリック・リミテッド・カンパニー プリンの抗ウイルス性ホスホノ―アルケン誘導体
EP0468119A1 (en) 1990-07-24 1992-01-29 Merrell Dow Pharmaceuticals Inc. Novel carbocyclic analogs of certain nucleosides
EP0481214B1 (en) 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
US5208221A (en) 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
CZ284678B6 (cs) 1991-05-20 1999-01-13 Ústav Organické Chemie A Biochemie Avčr Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
CZ287745B6 (cs) 1991-10-11 2001-01-17 Ústav organické chemie a biochemie AV ČR Acyklické fosfonomethoxyalkylsubstituované alkenylové a alkinylové deriváty purinu a pyrimidinu
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
EP0618214A1 (en) 1993-04-01 1994-10-05 Merrell Dow Pharmaceuticals Inc. Unsaturated phosphonate derivatives of purines and pyrimidines
WO1995007920A1 (en) 1993-09-17 1995-03-23 Gilead Sciences, Inc. Nucleotide analogs
BR9607098B8 (pt) 1995-02-27 2014-11-18 Gilead Sciences Inc Composto e composição farmacêutica.
US5977061A (en) 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
CA2261619C (en) 1996-07-26 2006-05-23 Gilead Sciences, Inc. Nucleotide analogs
IL159494A0 (en) * 2001-06-29 2004-06-01 Acad Of Science Czech Republic 6-2'-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity

Also Published As

Publication number Publication date
IL172015A0 (en) 2009-02-11
AU2004247305B2 (en) 2010-02-18
JP5280631B2 (ja) 2013-09-04
KR101102815B1 (ko) 2012-01-05
NZ543864A (en) 2009-10-30
US20050075318A1 (en) 2005-04-07
CA2527805A1 (en) 2004-12-23
JP2006527702A (ja) 2006-12-07
EP1644389B1 (en) 2011-01-19
DE602004031115D1 (de) 2011-03-03
AU2004247305A1 (en) 2004-12-23
CN1805966A (zh) 2006-07-19
EP1644389A1 (en) 2006-04-12
CN1805966B (zh) 2013-03-13
EA011948B1 (ru) 2009-06-30
WO2004111064A1 (en) 2004-12-23
EA200600046A1 (ru) 2006-06-30
CA2527805C (en) 2012-08-21
DK1644389T3 (da) 2011-05-09
KR20060041182A (ko) 2006-05-11
JP2012153731A (ja) 2012-08-16
US20060241081A1 (en) 2006-10-26
ATE496056T1 (de) 2011-02-15
SI1644389T1 (sl) 2011-06-30
IL172015A (en) 2016-07-31
US7115592B2 (en) 2006-10-03

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Legal Events

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PE Patent expired

Effective date: 20240615