ATE496056T1 - Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga - Google Patents

Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga

Info

Publication number
ATE496056T1
ATE496056T1 AT04738454T AT04738454T ATE496056T1 AT E496056 T1 ATE496056 T1 AT E496056T1 AT 04738454 T AT04738454 T AT 04738454T AT 04738454 T AT04738454 T AT 04738454T AT E496056 T1 ATE496056 T1 AT E496056T1
Authority
AT
Austria
Prior art keywords
nucleotide analogs
pyrimidine compounds
phosphonate groups
sub
antiviral nucleotide
Prior art date
Application number
AT04738454T
Other languages
English (en)
Inventor
Jan Balzarini
Clercq Erik De
Dana Hockova
Antonin Holy
Original Assignee
Acad Of Science Czech Republic
Leuven K U Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acad Of Science Czech Republic, Leuven K U Res & Dev filed Critical Acad Of Science Czech Republic
Application granted granted Critical
Publication of ATE496056T1 publication Critical patent/ATE496056T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT04738454T 2003-06-16 2004-06-16 Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga ATE496056T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47889303P 2003-06-16 2003-06-16
PCT/CZ2004/000034 WO2004111064A1 (en) 2003-06-16 2004-06-16 Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs

Publications (1)

Publication Number Publication Date
ATE496056T1 true ATE496056T1 (de) 2011-02-15

Family

ID=33551859

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04738454T ATE496056T1 (de) 2003-06-16 2004-06-16 Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga

Country Status (15)

Country Link
US (2) US7115592B2 (de)
EP (1) EP1644389B1 (de)
JP (2) JP5280631B2 (de)
KR (1) KR101102815B1 (de)
CN (1) CN1805966B (de)
AT (1) ATE496056T1 (de)
AU (1) AU2004247305B2 (de)
CA (1) CA2527805C (de)
DE (1) DE602004031115D1 (de)
DK (1) DK1644389T3 (de)
EA (1) EA011948B1 (de)
IL (1) IL172015A (de)
NZ (1) NZ543864A (de)
SI (1) SI1644389T1 (de)
WO (1) WO2004111064A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009502964A (ja) * 2005-07-27 2009-01-29 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖを阻害するための抗ウイルス性ホスホン酸結合体
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
SG178954A1 (en) 2009-09-02 2012-04-27 Novartis Ag Immunogenic compositions including tlr activity modulators
WO2011130557A2 (en) * 2010-04-14 2011-10-20 The Regents Of The University Of California Phosphonates with reduced toxicity for treatment of viral infections
AU2011295937B2 (en) * 2010-08-31 2015-04-16 Emergent Biodefence Operations Lansing Llc Phosphonate ester derivatives and methods of synthesis thereof
CN103313725B (zh) * 2010-09-01 2016-06-29 诺华有限公司 免疫增强剂吸附不溶性金属离子
BR112013014485B1 (pt) 2010-12-10 2021-03-30 Sigmapharm Laboratories, Llc Composições farmacêuticas compreendendo pró-fármacos análogos de nucleotídeos de fosfonato ativos por via oral e sistema de embalagem de recipiente/fechamento contendo as ditas composições
KR20140026392A (ko) 2011-03-02 2014-03-05 노파르티스 아게 저용량의 항원 및/또는 보조제를 갖는 조합 백신
WO2013095684A1 (en) 2011-12-22 2013-06-27 Geron Corporation Guanine analogs as telomerase substrates and telomere length affectors
AU2013229432A1 (en) 2012-03-08 2014-10-16 Novartis Ag Adjuvanted formulations of booster vaccines
CN103665043B (zh) * 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
CN102796138B (zh) * 2012-09-07 2014-10-22 山东大学 (2-(3-甲硫基-1,2,4-噻二嗪)乙氧基)甲基膦酸酯类衍生物及其制备与应用
CN107056838A (zh) 2013-03-15 2017-08-18 加利福尼亚大学董事会 无环核苷膦酸二酯
SG11201701957XA (en) 2014-09-15 2017-04-27 Univ California Nucleotide analogs
WO2017048956A1 (en) 2015-09-15 2017-03-23 The Regents Of The University Of California Nucleotide analogs
KR20250052378A (ko) 2022-07-21 2025-04-18 안티바 바이오사이언시즈, 인크. Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
EP0159604B1 (de) 1984-04-09 1990-11-07 Toyo Boseki Kabushiki Kaisha Präparat mit verzögerter Freigabe zum Aufbringen auf die Schleimhäute der Mundhöhle
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
US4725233A (en) * 1985-10-30 1988-02-16 Jens Planert Device for removing crowns, bridges, and similar structures from the stumps of teeth
US5141752A (en) 1986-05-09 1992-08-25 Alza Corporation Delayed drug delivery device
CS264222B1 (en) 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
NZ222553A (en) 1986-11-18 1991-07-26 Bristol Myers Co Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions
CA2001715C (en) 1988-11-14 1999-12-28 Muzammil M. Mansuri Carbocyclic nucleosides and nucleotides
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
CA2297294C (en) 1989-05-15 2005-11-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Phosphonomethoxymethylpurine/pyrimidine derivatives
MY104575A (en) 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5302585A (en) 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CZ285420B6 (cs) 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
CA2087446A1 (en) 1990-07-19 1992-01-20 Michael R. Harnden Antiviral phosphono-alken derivatives of purines
EP0468119A1 (de) 1990-07-24 1992-01-29 Merrell Dow Pharmaceuticals Inc. Neue Carbocyclische Analoge einiger Nukleoside
DE69129650T2 (de) 1990-09-14 1999-03-25 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic, Prag/Praha Wirkstoffvorläufer von Phosphonaten
US5208221A (en) 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
CZ284678B6 (cs) 1991-05-20 1999-01-13 Ústav Organické Chemie A Biochemie Avčr Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
JP3497505B2 (ja) 1991-10-11 2004-02-16 インスティテュート オブ オルガニック ケミストリー アンド バイオケミストリー オブ ザ アカデミー オブ サイエンシズ オブ ザ チェコ パブリック 抗ウイルス性非環式ホスホノメトキシアルキル置換アルケニル及びアルキニルプリン及びピリミジン誘導体
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
EP0618214A1 (de) 1993-04-01 1994-10-05 Merrell Dow Pharmaceuticals Inc. Ungesättigte Phosphonatderivate Purinen und Pyrimidinen
WO1995007920A1 (en) 1993-09-17 1995-03-23 Gilead Sciences, Inc. Nucleotide analogs
CN100409844C (zh) 1995-02-27 2008-08-13 吉里德科学公司 神经氨酸苷酶抑制剂
US5977061A (en) 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
WO1998004569A1 (en) 1996-07-26 1998-02-05 Gilead Sciences, Inc. Nucleotide analogs
CZ297267B6 (cs) * 2001-06-29 2006-10-11 Ústav organické chemie a biochemie AV CR Deriváty pyrimidinu nesoucí fosfonátovou skupinu,zpusob jejich prípravy, jejich pouzití pro lécbu a farmaceutické prípravky tyto látky obsahující

Also Published As

Publication number Publication date
WO2004111064A1 (en) 2004-12-23
JP2006527702A (ja) 2006-12-07
IL172015A (en) 2016-07-31
SI1644389T1 (sl) 2011-06-30
JP2012153731A (ja) 2012-08-16
IL172015A0 (en) 2009-02-11
EA011948B1 (ru) 2009-06-30
DK1644389T3 (da) 2011-05-09
KR101102815B1 (ko) 2012-01-05
CA2527805A1 (en) 2004-12-23
EA200600046A1 (ru) 2006-06-30
EP1644389B1 (de) 2011-01-19
AU2004247305A1 (en) 2004-12-23
US20050075318A1 (en) 2005-04-07
EP1644389A1 (de) 2006-04-12
HK1088013A1 (en) 2006-10-27
NZ543864A (en) 2009-10-30
AU2004247305B2 (en) 2010-02-18
CN1805966A (zh) 2006-07-19
DE602004031115D1 (de) 2011-03-03
CA2527805C (en) 2012-08-21
US20060241081A1 (en) 2006-10-26
KR20060041182A (ko) 2006-05-11
CN1805966B (zh) 2013-03-13
US7115592B2 (en) 2006-10-03
JP5280631B2 (ja) 2013-09-04

Similar Documents

Publication Publication Date Title
ATE496056T1 (de) Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
DK1501507T3 (da) Tetrahydropyranyl-cyclopentyl-tertrahydropyridopyrindin-modulatorer af kemokin-receptor-aktivitet
EA200501333A1 (ru) 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
GT200200043A (es) Nuevos compuestos antiinflamatorios de bencimidazol
EA200600677A1 (ru) 5,7-диаминопиразоло[4,3-d]пиримидины c ингибирующей pde-5 активностью
BR0307432A (pt) Difluormetiltiazolilcarboxanilidas
NO20071642L (no) N-Benzensulfonylsubstituerte anilino-pyrimidinanaloger
NO20041493L (no) Kjemiske forbindelser.
BR9915938A (pt) Derivados de pirimidina substituìdos por arila e heterociclila como anticoagulantes
CY1106247T1 (el) Θειοφαινο- και θειαζολοσουλφοναμιδες ως αντινεοπλαστικοι παραγοντες
GB0127903D0 (en) Improvements relating to organic compounds
PE20010751A1 (es) Quinolin-2-ona como inhibidores de las proteinas resistentes a multiples farmacos
DE50209545D1 (de) Flüssigkristallines medium
SE0103710D0 (sv) Compounds
DE60336735D1 (de) Neue biologischaktive molekü le
DK1706414T3 (da) Fremgangsmåde til fluorcytidinderivater
ATE516291T1 (de) Thenopyrimidin-verbindungen mit fungizider aktivität
NO20040388L (no) Fremgangsmåte for fremstilling av beraprost og salter derav, samt forbindelser som er mellomprodukter i fremgangsmåten
CR8350A (es) 4-anilino-3-quinolincarbonitrilos para el tratamiento de leucemia mielogenica cronica
CY1107101T1 (el) Μεθοδος συνθεσης παραγωγων της 1,3-διϋδρο-2h-3-βενζαζεπιν-2-ονης και εφαρμογη στη συνθεση της ιβαβραδινης και των αλατων προσθηκης με φαρμακευτικως αποδεκτο οξυ
BRPI0416678A (pt) pirazolpirimidinas
CO5680420A2 (es) Compuestos de 6-amino-1h-indazol y 4-aminobenzenofurano como inhibidores de la fosfodiesterasa 4
DK1742950T3 (da) Pyrazolo-[4,3-D]-pyrimidiner
ITMI20020933A1 (it) Procedimento per la sintesi di clopidogrel
EA200600092A1 (ru) Новые цитотоксические депсипептиды

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties