ATE496056T1 - Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga - Google Patents

Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga

Info

Publication number
ATE496056T1
ATE496056T1 AT04738454T AT04738454T ATE496056T1 AT E496056 T1 ATE496056 T1 AT E496056T1 AT 04738454 T AT04738454 T AT 04738454T AT 04738454 T AT04738454 T AT 04738454T AT E496056 T1 ATE496056 T1 AT E496056T1
Authority
AT
Austria
Prior art keywords
nucleotide analogs
pyrimidine compounds
phosphonate groups
sub
antiviral nucleotide
Prior art date
Application number
AT04738454T
Other languages
English (en)
Inventor
Jan Balzarini
Clercq Erik De
Dana Hockova
Antonin Holy
Original Assignee
Acad Of Science Czech Republic
Leuven K U Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acad Of Science Czech Republic, Leuven K U Res & Dev filed Critical Acad Of Science Czech Republic
Application granted granted Critical
Publication of ATE496056T1 publication Critical patent/ATE496056T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
AT04738454T 2003-06-16 2004-06-16 Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga ATE496056T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47889303P 2003-06-16 2003-06-16
PCT/CZ2004/000034 WO2004111064A1 (en) 2003-06-16 2004-06-16 Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs

Publications (1)

Publication Number Publication Date
ATE496056T1 true ATE496056T1 (de) 2011-02-15

Family

ID=33551859

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04738454T ATE496056T1 (de) 2003-06-16 2004-06-16 Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga

Country Status (16)

Country Link
US (2) US7115592B2 (de)
EP (1) EP1644389B1 (de)
JP (2) JP5280631B2 (de)
KR (1) KR101102815B1 (de)
CN (1) CN1805966B (de)
AT (1) ATE496056T1 (de)
AU (1) AU2004247305B2 (de)
CA (1) CA2527805C (de)
DE (1) DE602004031115D1 (de)
DK (1) DK1644389T3 (de)
EA (1) EA011948B1 (de)
HK (1) HK1088013A1 (de)
IL (1) IL172015A (de)
NZ (1) NZ543864A (de)
SI (1) SI1644389T1 (de)
WO (1) WO2004111064A1 (de)

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EP1906971A2 (de) * 2005-07-27 2008-04-09 Gilead Sciences, Inc. Antivirale verbindungen
FR2908133B1 (fr) 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
MX2012002723A (es) 2009-09-02 2012-04-11 Novartis Ag Composiciones inmunogenicas que incluyen moduladores de la actividad de receptores tipo toll.
CN102939291B (zh) * 2010-04-14 2016-09-07 加利福尼亚大学董事会 用于病毒感染治疗的具有降低的毒性的膦酸酯
ES2700117T3 (es) * 2010-08-31 2019-02-14 Chimerix Inc Derivados de éster de fosfonato y métodos de síntesis de los mismos
ES2458355T3 (es) 2010-09-01 2014-05-05 Novartis Ag Adsorción de inmunopotenciadores sobre sales metálicas insolubles
RU2606845C2 (ru) 2010-12-10 2017-01-10 СИГМАФАРМ ЛЭБОРЭТОРИЗ, ЭлЭлСи Высокостабильные композиции перорально активных аналогов нуклеотидов или перорально активных пролекарств аналогов нуклеотидов
RU2013144207A (ru) 2011-03-02 2015-04-10 Новартис Аг Комбинированные вакцины с пониженными дозами антигена и/или адъюванта
EP2794624B1 (de) 2011-12-22 2019-05-15 Geron Corporation Guanin-analoga als telomerasesubstrate und telomerlängenaffektoren
RU2014140521A (ru) 2012-03-08 2016-04-27 Новартис Аг Адъювантные составы бустерных вакцин
CN103665043B (zh) * 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
CN102796138B (zh) * 2012-09-07 2014-10-22 山东大学 (2-(3-甲硫基-1,2,4-噻二嗪)乙氧基)甲基膦酸酯类衍生物及其制备与应用
WO2014143643A1 (en) 2013-03-15 2014-09-18 The Regents Of The University Of California, A California Corporation Acyclic nucleoside phosphonate diesters
KR102589658B1 (ko) 2014-09-15 2023-10-13 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 뉴클레오타이드 유사체
US10377782B2 (en) 2015-09-15 2019-08-13 The Regents Of The University Of California Nucleotide analogs

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CS233665B1 (en) 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
EP0159604B1 (de) 1984-04-09 1990-11-07 Toyo Boseki Kabushiki Kaisha Präparat mit verzögerter Freigabe zum Aufbringen auf die Schleimhäute der Mundhöhle
WO1987002573A1 (en) * 1985-10-30 1987-05-07 Jens Planert Device for removing crowns, bridges and similar from tooth roots
CS263952B1 (en) 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
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US5141752A (en) 1986-05-09 1992-08-25 Alza Corporation Delayed drug delivery device
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US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
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EP0481214B1 (de) 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Wirkstoffvorläufer von Phosphonaten
US5208221A (en) 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
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CZ284678B6 (cs) 1991-05-20 1999-01-13 Ústav Organické Chemie A Biochemie Avčr Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
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EP0618214A1 (de) 1993-04-01 1994-10-05 Merrell Dow Pharmaceuticals Inc. Ungesättigte Phosphonatderivate Purinen und Pyrimidinen
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DE10299052I1 (de) 1995-02-27 2003-05-22 Gilead Sciences Inc Neue selektive Inhibitoren viraler oder bakterieller Neuraminidasen
US5977061A (en) 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
JP4033494B2 (ja) 1996-07-26 2008-01-16 ギリヤド サイエンシーズ， インコーポレイテッド ヌクレオチドアナログ
BRPI0210746B8 (pt) * 2001-06-29 2021-05-25 Inst Of Organic Chemistry And Biochemistry Ascr derivados de 6-'2-(fosfonometóxi)alcóxi-pirimidina e seu método de preparação

Also Published As

Publication number Publication date
WO2004111064A1 (en) 2004-12-23
KR20060041182A (ko) 2006-05-11
IL172015A (en) 2016-07-31
JP5280631B2 (ja) 2013-09-04
JP2006527702A (ja) 2006-12-07
EP1644389B1 (de) 2011-01-19
CN1805966B (zh) 2013-03-13
JP2012153731A (ja) 2012-08-16
EA011948B1 (ru) 2009-06-30
CA2527805A1 (en) 2004-12-23
DK1644389T3 (da) 2011-05-09
IL172015A0 (en) 2009-02-11
NZ543864A (en) 2009-10-30
US20060241081A1 (en) 2006-10-26
EA200600046A1 (ru) 2006-06-30
CA2527805C (en) 2012-08-21
CN1805966A (zh) 2006-07-19
EP1644389A1 (de) 2006-04-12
SI1644389T1 (sl) 2011-06-30
AU2004247305B2 (en) 2010-02-18
DE602004031115D1 (de) 2011-03-03
US20050075318A1 (en) 2005-04-07
HK1088013A1 (en) 2006-10-27
KR101102815B1 (ko) 2012-01-05
AU2004247305A1 (en) 2004-12-23
US7115592B2 (en) 2006-10-03

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