EA200401124A1 - Аминозамещённые (e)-2,6-диалкоксистирил-4-замещённые-бензилсульфоны для лечения пролиферативных расстройств - Google Patents
Аминозамещённые (e)-2,6-диалкоксистирил-4-замещённые-бензилсульфоны для лечения пролиферативных расстройствInfo
- Publication number
- EA200401124A1 EA200401124A1 EA200401124A EA200401124A EA200401124A1 EA 200401124 A1 EA200401124 A1 EA 200401124A1 EA 200401124 A EA200401124 A EA 200401124A EA 200401124 A EA200401124 A EA 200401124A EA 200401124 A1 EA200401124 A1 EA 200401124A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- substituted
- dialoxystyl
- benzilsulphones
- amino
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Abstract
Предлагаются соединения формулы (I), полезные в качестве антипролиферативных средств, включая, например, противораковые средства, где X, X, X, R, R, R, R, R, R, R, R, g, M, y, a, b, d, e, V, W, Z и Q являются такими, как определено в настоящем описании.Отчет о международном поиске был опубликован 2003.12.04.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36069702P | 2002-02-28 | 2002-02-28 | |
PCT/US2003/006357 WO2003072062A2 (en) | 2002-02-28 | 2003-02-28 | Amino-substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200401124A1 true EA200401124A1 (ru) | 2005-02-24 |
EA008736B1 EA008736B1 (ru) | 2007-08-31 |
Family
ID=27766240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200401124A EA008736B1 (ru) | 2002-02-28 | 2003-02-28 | Аминозамещенные (e)-2,6-диалкоксистирил-4-замещенные-бензилсульфоны для лечения пролиферативных расстройств |
Country Status (13)
Country | Link |
---|---|
US (2) | US7598232B2 (ru) |
EP (1) | EP1487428B1 (ru) |
JP (1) | JP4588323B2 (ru) |
KR (1) | KR100972131B1 (ru) |
AT (1) | ATE525067T1 (ru) |
AU (1) | AU2003213660C1 (ru) |
CA (1) | CA2477232C (ru) |
EA (1) | EA008736B1 (ru) |
ES (1) | ES2373945T3 (ru) |
IL (2) | IL163607A0 (ru) |
MX (1) | MXPA04008356A (ru) |
NZ (1) | NZ535232A (ru) |
WO (1) | WO2003072062A2 (ru) |
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IL163608A0 (en) * | 2002-02-28 | 2005-12-18 | Univ Temple | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
IL163607A0 (en) * | 2002-02-28 | 2005-12-18 | Univ Temple | Amino-substituted 2,6-dialkoxystyryl 4-substitutedbenzylsulfones for treating proliferative disorders |
WO2005046599A2 (en) * | 2003-11-14 | 2005-05-26 | Temple University - Of The Commonwealth System Of Higher Education | Alpha, beta-unsaturated sulfoxides for treating proliferative disorders |
MXPA06007017A (es) | 2003-12-18 | 2006-08-31 | Janssen Pharmaceutica Nv | Derivados de pirido y pirimidopirimidina como agentes antiproliferativos. |
EA200901236A1 (ru) * | 2004-03-16 | 2009-12-30 | Темпл Юниверсити - Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | Замещённые фенокси- и фенилтиопроизводные для лечения пролиферативных нарушений |
WO2005118543A1 (ja) * | 2004-06-03 | 2005-12-15 | Ono Pharmaceutical Co., Ltd. | キナーゼ阻害薬およびその用途 |
ATE529106T1 (de) | 2004-06-24 | 2011-11-15 | Univ Temple | Alpha-, beta-ungesättigte sulfone, sulfonoxide, sulfonimide, sulfinimide, acylsulfonamide und acylsulfinamide und therapeutische verwendungen damit |
DE602005026293D1 (de) * | 2004-07-19 | 2011-03-24 | Onconova Therapeutics Inc | Formulierungen für die parenterale verabreichung von (e)-2,6-dialkoxystryryl 4-substituierten benzylsulfonen |
NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
KR101427105B1 (ko) * | 2005-01-05 | 2014-08-07 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 약-내성 증식성 질병의 치료 |
US8106033B2 (en) * | 2005-03-11 | 2012-01-31 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of proliferative diseases |
WO2007002441A1 (en) * | 2005-06-24 | 2007-01-04 | Emory University | Methods of use for non-atp competitive tyrosine kinase inhibitors to treat pathogenic infection |
US7504513B2 (en) | 2006-02-27 | 2009-03-17 | Hoffman-La Roche Inc. | Thiazolyl-benzimidazoles |
WO2008006884A2 (en) | 2006-07-13 | 2008-01-17 | Janssen Pharmaceutica N.V. | Mtki quinazoline derivatives |
US8664272B2 (en) | 2006-08-30 | 2014-03-04 | Temple University—Of the Commonwealth System of Higher Education | Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
WO2008033475A2 (en) * | 2006-09-15 | 2008-03-20 | Onconova Therapeutics, Inc. | Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions |
EP2124569A4 (en) * | 2007-01-16 | 2013-02-27 | Onconova Therapeutics Inc | FORMULATIONS FOR THE PARENTERAL ADMINISTRATION OF (E) -2,6-DIALKOXY STYRYL-4-SUBSTITUTED BENZYL SULPHONES |
DK2185562T3 (en) | 2007-07-27 | 2016-02-22 | Janssen Pharmaceutica Nv | PYRROLOPYRIMIDINES SUITABLE FOR TREATING PROLIFERATIVE DISEASES |
JP2012512223A (ja) | 2008-12-18 | 2012-05-31 | エフ.ホフマン−ラ ロシュ アーゲー | チアゾリル−ベンズイミダゾール類 |
GB201010359D0 (en) * | 2010-06-21 | 2010-08-04 | Univ Nottingham | Compounds for treating proliferative disorders |
EP2838879A1 (en) | 2012-04-20 | 2015-02-25 | Concert Pharmaceuticals Inc. | Deuterated rigosertib |
CN110776447A (zh) | 2012-09-20 | 2020-02-11 | 坦普尔大学 | 取代的烷基二芳基衍生物、制备方法和用途 |
ES2864681T3 (es) | 2012-12-07 | 2021-10-14 | Onconova Therapeutics Inc | Tratamiento del cáncer hematológico refractario a un agente contra el cáncer |
WO2017023912A1 (en) | 2015-08-03 | 2017-02-09 | Temple University - Of The Commonwealth System Of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
WO2018169283A1 (ko) | 2017-03-14 | 2018-09-20 | 국립암센터 | C형 간염 바이러스 질환 치료를 위한 리고세르팁의 신규 용도 |
WO2018190897A1 (en) | 2017-04-13 | 2018-10-18 | Onconova Therapeutics, Inc. | Formulation of (e)-2,4,6-trimethoxystyryl-3-[(carboxymethyl)amino]-4- methoxybenzylsulphone with enhanced stability and bioavailability |
CN109232403A (zh) * | 2017-07-10 | 2019-01-18 | 亚宝药业集团股份有限公司 | 作为蛋白激酶抑制剂的酰胺类前药衍生物 |
WO2020086789A1 (en) | 2018-10-26 | 2020-04-30 | Teva Pharmaceuticals International Gmbh | New crystalline polymorphs of rigosertib sodium |
CA3132656A1 (en) | 2019-04-30 | 2020-11-05 | Instituto De Medicina Molecular Joao Lobo Antunes | Rank pathway inhibitors in combination with cdk inhibitors |
CN110981770A (zh) * | 2019-12-30 | 2020-04-10 | 武汉九州钰民医药科技有限公司 | 制备抗肿瘤新药Rigosertib的方法 |
CN114539110B (zh) * | 2020-11-26 | 2023-02-14 | 东南大学 | 含有ras/raf蛋白干扰基团的hdac抑制剂及其制备方法 |
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JP4302986B2 (ja) * | 2001-02-28 | 2009-07-29 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 細胞及び組織をα,β不飽和アリールスルホンにより電離放射線から防護する方法 |
KR100850330B1 (ko) * | 2001-02-28 | 2008-08-04 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | N-(아릴)-2-아릴에텐술폰아미드 및 이를 이용한 약학적 조성물 |
IL163607A0 (en) * | 2002-02-28 | 2005-12-18 | Univ Temple | Amino-substituted 2,6-dialkoxystyryl 4-substitutedbenzylsulfones for treating proliferative disorders |
IL163608A0 (en) * | 2002-02-28 | 2005-12-18 | Univ Temple | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
-
2003
- 2003-02-28 IL IL16360703A patent/IL163607A0/xx unknown
- 2003-02-28 NZ NZ535232A patent/NZ535232A/en not_active IP Right Cessation
- 2003-02-28 JP JP2003570809A patent/JP4588323B2/ja not_active Expired - Lifetime
- 2003-02-28 EA EA200401124A patent/EA008736B1/ru unknown
- 2003-02-28 CA CA2477232A patent/CA2477232C/en not_active Expired - Lifetime
- 2003-02-28 WO PCT/US2003/006357 patent/WO2003072062A2/en active Application Filing
- 2003-02-28 EP EP03711347A patent/EP1487428B1/en not_active Expired - Lifetime
- 2003-02-28 KR KR1020047013487A patent/KR100972131B1/ko active IP Right Grant
- 2003-02-28 AU AU2003213660A patent/AU2003213660C1/en not_active Expired
- 2003-02-28 MX MXPA04008356A patent/MXPA04008356A/es active IP Right Grant
- 2003-02-28 ES ES03711347T patent/ES2373945T3/es not_active Expired - Lifetime
- 2003-02-28 US US10/506,005 patent/US7598232B2/en active Active
- 2003-02-28 AT AT03711347T patent/ATE525067T1/de not_active IP Right Cessation
-
2004
- 2004-08-18 IL IL163607A patent/IL163607A/en active IP Right Grant
-
2009
- 2009-07-14 US US12/460,182 patent/US8324190B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP1487428A2 (en) | 2004-12-22 |
KR20040091676A (ko) | 2004-10-28 |
US8324190B2 (en) | 2012-12-04 |
CA2477232A1 (en) | 2003-09-04 |
AU2003213660A1 (en) | 2003-09-09 |
EP1487428B1 (en) | 2011-09-21 |
AU2003213660C1 (en) | 2010-10-28 |
EA008736B1 (ru) | 2007-08-31 |
ES2373945T3 (es) | 2012-02-10 |
US20050130942A1 (en) | 2005-06-16 |
AU2003213660B2 (en) | 2010-04-22 |
IL163607A (en) | 2012-07-31 |
IL163607A0 (en) | 2005-12-18 |
US20090281066A1 (en) | 2009-11-12 |
MXPA04008356A (es) | 2005-09-12 |
US7598232B2 (en) | 2009-10-06 |
JP4588323B2 (ja) | 2010-12-01 |
WO2003072062A3 (en) | 2003-12-04 |
NZ535232A (en) | 2007-05-31 |
WO2003072062A2 (en) | 2003-09-04 |
EP1487428A4 (en) | 2006-04-19 |
JP2005531503A (ja) | 2005-10-20 |
CA2477232C (en) | 2011-07-19 |
KR100972131B1 (ko) | 2010-07-26 |
ATE525067T1 (de) | 2011-10-15 |
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