IL163607A0 - Amino-substituted 2,6-dialkoxystyryl 4-substitutedbenzylsulfones for treating proliferative disorders - Google Patents
Amino-substituted 2,6-dialkoxystyryl 4-substitutedbenzylsulfones for treating proliferative disordersInfo
- Publication number
- IL163607A0 IL163607A0 IL16360703A IL16360703A IL163607A0 IL 163607 A0 IL163607 A0 IL 163607A0 IL 16360703 A IL16360703 A IL 16360703A IL 16360703 A IL16360703 A IL 16360703A IL 163607 A0 IL163607 A0 IL 163607A0
- Authority
- IL
- Israel
- Prior art keywords
- substitutedbenzylsulfones
- dialkoxystyryl
- amino
- substituted
- proliferative disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyridine Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36069702P | 2002-02-28 | 2002-02-28 | |
PCT/US2003/006357 WO2003072062A2 (en) | 2002-02-28 | 2003-02-28 | Amino-substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
IL163607A0 true IL163607A0 (en) | 2005-12-18 |
Family
ID=27766240
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16360703A IL163607A0 (en) | 2002-02-28 | 2003-02-28 | Amino-substituted 2,6-dialkoxystyryl 4-substitutedbenzylsulfones for treating proliferative disorders |
IL163607A IL163607A (en) | 2002-02-28 | 2004-08-18 | Amino-substituted (e) - 2,6-dialkoxystyryl 4 -substituted benzylsulfones , process for their preparation , antibody conjugates and pharmaceutical compositions comprising them and their use in the preparation of medicaments for treating proliferative disorders |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL163607A IL163607A (en) | 2002-02-28 | 2004-08-18 | Amino-substituted (e) - 2,6-dialkoxystyryl 4 -substituted benzylsulfones , process for their preparation , antibody conjugates and pharmaceutical compositions comprising them and their use in the preparation of medicaments for treating proliferative disorders |
Country Status (13)
Country | Link |
---|---|
US (2) | US7598232B2 (ru) |
EP (1) | EP1487428B1 (ru) |
JP (1) | JP4588323B2 (ru) |
KR (1) | KR100972131B1 (ru) |
AT (1) | ATE525067T1 (ru) |
AU (1) | AU2003213660C1 (ru) |
CA (1) | CA2477232C (ru) |
EA (1) | EA008736B1 (ru) |
ES (1) | ES2373945T3 (ru) |
IL (2) | IL163607A0 (ru) |
MX (1) | MXPA04008356A (ru) |
NZ (1) | NZ535232A (ru) |
WO (1) | WO2003072062A2 (ru) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003213661A1 (en) * | 2002-02-28 | 2003-09-09 | Onconova Therapeutics, Inc. | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
AU2003213660C1 (en) * | 2002-02-28 | 2010-10-28 | Onconova Therapeutics, Inc. | Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders |
CA2546495C (en) * | 2003-11-14 | 2012-10-09 | Temple University - Of The Commonwealth System Of Higher Education | Alpha, beta-unsaturated sulfoxides for treating proliferative disorders |
EP1697384B1 (en) | 2003-12-18 | 2008-04-02 | Janssen Pharmaceutica N.V. | Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents |
AU2005222947B2 (en) | 2004-03-16 | 2010-12-23 | Onconova Therapeutics Inc. | Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders |
WO2005118543A1 (ja) * | 2004-06-03 | 2005-12-15 | Ono Pharmaceutical Co., Ltd. | キナーゼ阻害薬およびその用途 |
EP1773310B9 (en) | 2004-06-24 | 2012-04-25 | Temple University - Of The Commonwealth System of Higher Education | Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof |
AU2005265412B2 (en) * | 2004-07-19 | 2010-09-02 | Onconova Therapeutics, Inc. | Formulations for parenteral administration of (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones |
NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
KR101427105B1 (ko) * | 2005-01-05 | 2014-08-07 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 약-내성 증식성 질병의 치료 |
US8106033B2 (en) * | 2005-03-11 | 2012-01-31 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of proliferative diseases |
WO2007002441A1 (en) * | 2005-06-24 | 2007-01-04 | Emory University | Methods of use for non-atp competitive tyrosine kinase inhibitors to treat pathogenic infection |
US7504513B2 (en) | 2006-02-27 | 2009-03-17 | Hoffman-La Roche Inc. | Thiazolyl-benzimidazoles |
WO2008006884A2 (en) | 2006-07-13 | 2008-01-17 | Janssen Pharmaceutica N.V. | Mtki quinazoline derivatives |
WO2008027049A1 (en) | 2006-08-30 | 2008-03-06 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
WO2008033475A2 (en) * | 2006-09-15 | 2008-03-20 | Onconova Therapeutics, Inc. | Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions |
US8476320B2 (en) * | 2007-01-16 | 2013-07-02 | Onconova Therapeutics, Inc | Formulations for parenteral administration of amino-substituted (E)-2, 6-dialkoxystyryl 4-substituted benzylsulfones |
EP2185562B1 (en) | 2007-07-27 | 2015-12-02 | Janssen Pharmaceutica, N.V. | Pyrrolopyrimidines useful for the treatment of proliferative diseases |
CA2745596A1 (en) | 2008-12-18 | 2010-10-28 | F. Hoffmann-La Roche Ag | Thiazolyl-benzimidazoles |
GB201010359D0 (en) | 2010-06-21 | 2010-08-04 | Univ Nottingham | Compounds for treating proliferative disorders |
US9249093B2 (en) | 2012-04-20 | 2016-02-02 | Concert Pharmaceuticals, Inc. | Deuterated rigosertib |
ES2863538T3 (es) | 2012-09-20 | 2021-10-11 | Univ Temple | Derivados de alquil diarilo sustituidos, métodos de preparación y usos |
JP6462582B2 (ja) | 2012-12-07 | 2019-01-30 | オンコノバ・セラピューティックス・インコーポレーテッド | がんの治療のための方法および組成物 |
WO2017023912A1 (en) | 2015-08-03 | 2017-02-09 | Temple University - Of The Commonwealth System Of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
WO2018169283A1 (ko) | 2017-03-14 | 2018-09-20 | 국립암센터 | C형 간염 바이러스 질환 치료를 위한 리고세르팁의 신규 용도 |
AR109503A1 (es) | 2017-04-13 | 2018-12-19 | Onconova Therapeutics Inc | Composición farmacéutica que comprende (e)-2,4,6-trimetoxiestiril-3-[(carboximetil)amino]-4-metoxibencilsulfona, forma de dosificación oral y método de tratamiento |
CN109232403A (zh) * | 2017-07-10 | 2019-01-18 | 亚宝药业集团股份有限公司 | 作为蛋白激酶抑制剂的酰胺类前药衍生物 |
EP3870298A1 (en) | 2018-10-26 | 2021-09-01 | Teva Pharmaceuticals International GmbH | New crystalline polymorphs of rigosertib sodium |
US20220195059A1 (en) | 2019-04-30 | 2022-06-23 | Instituto de Medicina Molecular João Lobo Antunes | Rank Pathway Inhibitors in Combination with CDK Inhibitors |
CN110981770A (zh) * | 2019-12-30 | 2020-04-10 | 武汉九州钰民医药科技有限公司 | 制备抗肿瘤新药Rigosertib的方法 |
CN114539110B (zh) * | 2020-11-26 | 2023-02-14 | 东南大学 | 含有ras/raf蛋白干扰基团的hdac抑制剂及其制备方法 |
WO2023196943A1 (en) | 2022-04-08 | 2023-10-12 | Inhibrx, Inc. | Dr5 agonist and plk1 inhibitor or cdk inhibitor combination therapy |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2532612A (en) | 1945-08-29 | 1950-12-05 | Union Oil Co | Preparation of unsaturated thio-ethers |
US2531367A (en) | 1947-07-15 | 1950-11-21 | Sharp & Dohme Inc | N-(substituted sulfonyl)-aminobenzoic acids |
US3185743A (en) | 1960-08-24 | 1965-05-25 | Union Carbide Corp | Production of olefinic compounds from allyl sulfones |
US3463774A (en) | 1963-03-18 | 1969-08-26 | Hoffmann La Roche | Novel 4,1-benzothiazepin-2-(1h)-ones and 4,1-benzothiazepines |
US3418101A (en) | 1965-12-15 | 1968-12-24 | Pennsalt Chemicals Corp | Process for plant desiccation |
US3514386A (en) | 1967-12-11 | 1970-05-26 | Exxon Research Engineering Co | Stereoselective addition of thiols to acetylenic compounds |
US3917714A (en) | 1972-09-06 | 1975-11-04 | American Cyanamid Co | Bis(alkylsulfonyl)vinylbenzenes |
US4161407A (en) | 1977-10-06 | 1979-07-17 | Eastman Kodak Company | Crosslinkable polymers having vinylsulfonyl groups or styrylsulfonyl groups and their use as hardeners for gelatin |
DE2809377A1 (de) | 1978-03-04 | 1979-09-13 | Boehringer Mannheim Gmbh | Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
US4386221A (en) | 1981-10-28 | 1983-05-31 | Eastman Kodak Company | Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones |
US4937388A (en) | 1985-08-09 | 1990-06-26 | Imperial Chemical Industries Plc | Insecticidal ethers |
JPH04202173A (ja) | 1990-11-30 | 1992-07-22 | Zeria Pharmaceut Co Ltd | スルホンアミド誘導体及びそれを含有する5―リポキシゲナーゼ阻害剤 |
AU2096895A (en) | 1994-03-07 | 1995-09-25 | Sugen, Incorporated | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
US5780483A (en) | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
US5659087A (en) | 1995-06-07 | 1997-08-19 | Eli Lilly And Company | Diarylvinyl sulfoxides |
AU6112896A (en) | 1995-06-07 | 1996-12-30 | Sugen, Inc. | Tyrphostin-like compounds for the treatment of cell prolifer ative disorders or cell differentiation disorders |
US5733909A (en) | 1996-02-01 | 1998-03-31 | Merck Frosst Canada, Inc. | Diphenyl stilbenes as prodrugs to COX-2 inhibitors |
US6548553B2 (en) | 1997-10-03 | 2003-04-15 | Temple University-Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
DE69828079T2 (de) * | 1997-10-03 | 2005-12-22 | Temple University Of The Commonwealth System Of Higher Education | Styrolsulfone als antikrebsmittel |
US6191170B1 (en) | 1998-01-13 | 2001-02-20 | Tularik Inc. | Benzenesulfonamides and benzamides as therapeutic agents |
WO2000059495A1 (en) * | 1999-04-02 | 2000-10-12 | Temple University - Of The Commonwealth System Of Higher Education | (e)-styryl sulfone anticancer agents |
WO2000059494A1 (en) * | 1999-04-02 | 2000-10-12 | Temple University- Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
US6762207B1 (en) | 1999-04-02 | 2004-07-13 | Temple University - Of The Commonwealth System Of Higher Education | (E)-styryl sulfone anticancer agents |
US6586617B1 (en) | 1999-04-28 | 2003-07-01 | Sumitomo Chemical Takeda Agro Company, Limited | Sulfonamide derivatives |
US6767926B1 (en) | 1999-10-12 | 2004-07-27 | Temple University - Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
WO2001026645A1 (en) * | 1999-10-12 | 2001-04-19 | Temple University-Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
US6462207B1 (en) * | 1999-10-13 | 2002-10-08 | Southwest Missouri State University | Polyethylene glycol diene derivatives |
US6541475B2 (en) | 2000-04-14 | 2003-04-01 | Temple University - Of The Commonwealth System Of Higher Education | α, β-unsaturated sulfones for treating proliferative disorders |
US6486210B2 (en) * | 2000-04-14 | 2002-11-26 | Temple University—Of the Commonwealth System of Higher Education | Substituted styryl benzylsulfones for treating proliferative disorders |
CA2424884C (en) | 2000-10-05 | 2009-12-15 | E. Premkumar Reddy | Substituted (e)-styryl benzylsulfones for treating proliferative disorders |
US6833480B2 (en) * | 2001-02-27 | 2004-12-21 | Temple University - Of The Commonwealth System Of Higher Education | (Z)-styrylbenzylsulfones and pharmaceutical uses thereof |
WO2002069892A2 (en) | 2001-02-28 | 2002-09-12 | Temple University Of The Commonwealth System Of Higher Education | METHOD FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY WITH α, β UNSATURATED ARYL SULFONES |
DE60237512D1 (de) | 2001-02-28 | 2010-10-14 | Univ Temple | N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungen |
AU2003213660C1 (en) * | 2002-02-28 | 2010-10-28 | Onconova Therapeutics, Inc. | Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders |
AU2003213661A1 (en) | 2002-02-28 | 2003-09-09 | Onconova Therapeutics, Inc. | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
-
2003
- 2003-02-28 AU AU2003213660A patent/AU2003213660C1/en not_active Expired
- 2003-02-28 MX MXPA04008356A patent/MXPA04008356A/es active IP Right Grant
- 2003-02-28 NZ NZ535232A patent/NZ535232A/en not_active IP Right Cessation
- 2003-02-28 WO PCT/US2003/006357 patent/WO2003072062A2/en active Application Filing
- 2003-02-28 ES ES03711347T patent/ES2373945T3/es not_active Expired - Lifetime
- 2003-02-28 CA CA2477232A patent/CA2477232C/en not_active Expired - Lifetime
- 2003-02-28 KR KR1020047013487A patent/KR100972131B1/ko active IP Right Grant
- 2003-02-28 US US10/506,005 patent/US7598232B2/en active Active
- 2003-02-28 JP JP2003570809A patent/JP4588323B2/ja not_active Expired - Lifetime
- 2003-02-28 EA EA200401124A patent/EA008736B1/ru unknown
- 2003-02-28 AT AT03711347T patent/ATE525067T1/de not_active IP Right Cessation
- 2003-02-28 IL IL16360703A patent/IL163607A0/xx unknown
- 2003-02-28 EP EP03711347A patent/EP1487428B1/en not_active Expired - Lifetime
-
2004
- 2004-08-18 IL IL163607A patent/IL163607A/en active IP Right Grant
-
2009
- 2009-07-14 US US12/460,182 patent/US8324190B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2003213660A1 (en) | 2003-09-09 |
JP4588323B2 (ja) | 2010-12-01 |
ES2373945T3 (es) | 2012-02-10 |
AU2003213660B2 (en) | 2010-04-22 |
US20050130942A1 (en) | 2005-06-16 |
MXPA04008356A (es) | 2005-09-12 |
IL163607A (en) | 2012-07-31 |
WO2003072062A2 (en) | 2003-09-04 |
JP2005531503A (ja) | 2005-10-20 |
EP1487428B1 (en) | 2011-09-21 |
EA008736B1 (ru) | 2007-08-31 |
CA2477232A1 (en) | 2003-09-04 |
CA2477232C (en) | 2011-07-19 |
EP1487428A2 (en) | 2004-12-22 |
US8324190B2 (en) | 2012-12-04 |
KR100972131B1 (ko) | 2010-07-26 |
KR20040091676A (ko) | 2004-10-28 |
WO2003072062A3 (en) | 2003-12-04 |
ATE525067T1 (de) | 2011-10-15 |
US20090281066A1 (en) | 2009-11-12 |
EA200401124A1 (ru) | 2005-02-24 |
AU2003213660C1 (en) | 2010-10-28 |
NZ535232A (en) | 2007-05-31 |
EP1487428A4 (en) | 2006-04-19 |
US7598232B2 (en) | 2009-10-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL163607A0 (en) | Amino-substituted 2,6-dialkoxystyryl 4-substitutedbenzylsulfones for treating proliferative disorders | |
MY135841A (en) | Novel benzodioxoles | |
IL183514A (en) | Pyrrolidine as iap inhibitors | |
AP2001002319A0 (en) | Pyrimidine-2,4,6-trione metalloproteinase inhibitors. | |
RS20050116A (en) | Novel phenanthridines | |
RS92004A (en) | Pyrrolo-triazine aniline compounds useful as kinase inhibitors | |
GEP20053660B (en) | Novel Tyrosine Kinase Inhibitors | |
YU29503A (sh) | Novi antiholinergici koji se mogu primeniti kao lekovi, kao i postupak za njihovo dobijanje | |
BG108181A (en) | Novel spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors | |
DE60214591D1 (en) | Pyrazolpyrimidinfungizide | |
GEP20063937B (en) | Substituted pyridinones as modulators of p38 map kinase | |
IL177962A0 (en) | Compounds and methods for treating dyslipidemia | |
MY135477A (en) | 2-(2,6-dichlorophenyl)-diarylimidazoles | |
YU27304A (sh) | Novi dihidropteridinoni, postupak za njihovo dobijanje i njihova primena kao lekova | |
UA84712C2 (en) | N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors | |
MY141011A (en) | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones | |
GB2378948B (en) | Novel compounds for modulating cell proliferation | |
MY138466A (en) | Aminoalkoxyndoles as 5-ht6-receptor ligands for the treatment of cns-disorders | |
AP2002002466A0 (en) | 3-heterocycliylpropanohydroxamic acid PCP INHIBITORS. | |
WO2004033423A3 (en) | Anticancer compounds | |
IL163608A0 (en) | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders | |
SI1377574T1 (ru) | ||
MXPA04005151A (es) | Compuestos terapeuticos. | |
YU22802A (sh) | Izonipekotamidi za lečenje poremećaja nastalih posredstvom integrina | |
MXPA03001272A (es) | Procedimiento para la preparacion de dinapsolina. |