DE60314639D1 - Fusionierte heteroaryl-derivative zur verwendung als p38 kinase inhibitoren zur behandlung von u.a rheumatischer arthritis - Google Patents

Fusionierte heteroaryl-derivative zur verwendung als p38 kinase inhibitoren zur behandlung von u.a rheumatischer arthritis

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Publication number
DE60314639D1
DE60314639D1 DE60314639T DE60314639T DE60314639D1 DE 60314639 D1 DE60314639 D1 DE 60314639D1 DE 60314639 T DE60314639 T DE 60314639T DE 60314639 T DE60314639 T DE 60314639T DE 60314639 D1 DE60314639 D1 DE 60314639D1
Authority
DE
Germany
Prior art keywords
treatment
kinase inhibitors
rheumatic arthritis
fused heteroaryl
heteroaryl derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60314639T
Other languages
English (en)
Other versions
DE60314639T2 (de
Inventor
Richard Martyn Angell
Ian Robert Baldwin
Paul Bamborough
Nigel Marc Deboeck
Timothy Longstaff
Stephen Swanson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of DE60314639D1 publication Critical patent/DE60314639D1/de
Application granted granted Critical
Publication of DE60314639T2 publication Critical patent/DE60314639T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Biomedical Technology (AREA)
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  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Obesity (AREA)
  • Immunology (AREA)
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  • Urology & Nephrology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60314639T 2002-07-31 2003-07-30 Fusionierte heteroaryl-derivate zur verwendung als p38 kinase inhibitoren zur behandlung von u.a rheumatischer arthritis Expired - Lifetime DE60314639T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0217757.4A GB0217757D0 (en) 2002-07-31 2002-07-31 Novel compounds
GB0217757 2002-07-31
PCT/GB2003/003316 WO2004010995A1 (en) 2002-07-31 2003-07-30 Fused heteroaryl derivatives for use as p38 kinase inhibitors in the treatment of i.a. rheumatoid arthristis

Publications (2)

Publication Number Publication Date
DE60314639D1 true DE60314639D1 (de) 2007-08-09
DE60314639T2 DE60314639T2 (de) 2008-03-13

Family

ID=9941464

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Application Number Title Priority Date Filing Date
DE60314639T Expired - Lifetime DE60314639T2 (de) 2002-07-31 2003-07-30 Fusionierte heteroaryl-derivate zur verwendung als p38 kinase inhibitoren zur behandlung von u.a rheumatischer arthritis

Country Status (9)

Country Link
US (1) US7642276B2 (de)
EP (1) EP1531812B1 (de)
JP (1) JP4630662B2 (de)
AT (1) ATE365551T1 (de)
AU (1) AU2003248978A1 (de)
DE (1) DE60314639T2 (de)
ES (1) ES2289336T3 (de)
GB (1) GB0217757D0 (de)
WO (1) WO2004010995A1 (de)

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