ATE490253T1 - Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen - Google Patents

Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen

Info

Publication number
ATE490253T1
ATE490253T1 AT04717703T AT04717703T ATE490253T1 AT E490253 T1 ATE490253 T1 AT E490253T1 AT 04717703 T AT04717703 T AT 04717703T AT 04717703 T AT04717703 T AT 04717703T AT E490253 T1 ATE490253 T1 AT E490253T1
Authority
AT
Austria
Prior art keywords
azaindolines
substituted
synthesis
azaindoline
novel
Prior art date
Application number
AT04717703T
Other languages
English (en)
Inventor
P Graczyk
A Khan
G Bhatia
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Application granted granted Critical
Publication of ATE490253T1 publication Critical patent/ATE490253T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
AT04717703T 2003-03-06 2004-03-05 Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen ATE490253T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0305142.2A GB0305142D0 (en) 2003-03-06 2003-03-06 Synthesis
PCT/GB2004/000946 WO2004078757A2 (en) 2003-03-06 2004-03-05 Synthesis of 5-substituted 7-azaindoles and 7-azaidonines

Publications (1)

Publication Number Publication Date
ATE490253T1 true ATE490253T1 (de) 2010-12-15

Family

ID=9954241

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04717703T ATE490253T1 (de) 2003-03-06 2004-03-05 Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen

Country Status (8)

Country Link
US (1) US7652137B2 (de)
EP (1) EP1633750B1 (de)
JP (1) JP4711950B2 (de)
AT (1) ATE490253T1 (de)
DE (1) DE602004030334D1 (de)
ES (1) ES2355726T3 (de)
GB (1) GB0305142D0 (de)
WO (1) WO2004078757A2 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2365588C2 (ru) * 2002-02-01 2009-08-27 Астразенека Аб Хиназолиновые соединения
WO2003082868A1 (en) * 2002-03-28 2003-10-09 Eisai Co., Ltd. 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
EP1628975A2 (de) * 2003-05-16 2006-03-01 Eisai Co., Ltd. Jnk inhibitoren
GB0405055D0 (en) * 2004-03-05 2004-04-07 Eisai London Res Lab Ltd JNK inhibitors
AU2005269386A1 (en) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7452993B2 (en) 2004-07-27 2008-11-18 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7626021B2 (en) 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
GB0516156D0 (en) * 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
WO2007135398A1 (en) * 2006-05-22 2007-11-29 Astrazeneca Ab Indole derivatives
US8765747B2 (en) 2009-06-12 2014-07-01 Dana-Farber Cancer Institute, Inc. Fused 2-aminothiazole compounds
WO2011060216A1 (en) 2009-11-12 2011-05-19 Concert Pharmaceuticals Inc. Substituted azaindoles
EP2519517B1 (de) 2009-12-29 2015-03-25 Dana-Farber Cancer Institute, Inc. Typ-ii-raf-kinase-hemmer
WO2011109932A1 (en) * 2010-03-09 2011-09-15 F.Hoffmann-La Roche Ag Novel process for the manufacture of 5-halogenated-7-azaindoles
WO2011149822A1 (en) * 2010-05-26 2011-12-01 Boehringer Ingelheim International Gmbh 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
US9382239B2 (en) 2011-11-17 2016-07-05 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-terminal kinase (JNK)
WO2014063068A1 (en) 2012-10-18 2014-04-24 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
EA034922B1 (ru) 2013-03-15 2020-04-07 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
CN105849099B (zh) 2013-10-18 2020-01-17 达纳-法伯癌症研究所股份有限公司 周期蛋白依赖性激酶7(cdk7)的多环抑制剂
CA2927917C (en) 2013-10-18 2022-08-09 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of proliferative diseases
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
US10246455B2 (en) 2014-04-11 2019-04-02 Taipei Medical University Histone deacetylase inhibitors
US10017477B2 (en) 2014-04-23 2018-07-10 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
WO2015164604A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
CN104478909B (zh) * 2014-11-19 2017-01-04 上海泰坦科技股份有限公司 杂环硼酸类化合物的合成工艺
AU2015371251B2 (en) 2014-12-23 2020-06-11 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
EP3273966B1 (de) 2015-03-27 2023-05-03 Dana-Farber Cancer Institute, Inc. Hemmer von cyclinabhängigen kinasen
US10702527B2 (en) 2015-06-12 2020-07-07 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
EP3347018B1 (de) 2015-09-09 2021-09-01 Dana-Farber Cancer Institute, Inc. Hemmer von cyclinabhängigen kinasen
KR20180052635A (ko) 2015-09-18 2018-05-18 가켄 세이야쿠 가부시키가이샤 바이아릴 유도체 및 이를 포함하는 약제
CN105622605B (zh) * 2016-03-01 2017-10-13 苏州艾缇克药物化学有限公司 一种5‑溴‑7‑氮杂吲哚的合成方法
CN106188050A (zh) * 2016-07-20 2016-12-07 南通雅本化学有限公司 一种5‑溴‑7‑氮杂吲哚的生产工艺
CN107033142A (zh) * 2017-05-15 2017-08-11 杭州科耀医药科技有限公司 一种Venetoclax关键中间体的合成方法
WO2020005807A1 (en) 2018-06-25 2020-01-02 Dana-Farber Cancer Institute, Inc. Taire family kinase inhibitors and uses thereof
JP7660063B2 (ja) 2018-12-28 2025-04-10 ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼ７のインヒビターおよびそれらの使用
CN110078726B (zh) * 2019-06-19 2022-05-17 陕西师范大学 一种全取代2,3-二氢-1H-吡咯并[2,3-b]吡啶衍生物的合成方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719218A (en) 1985-12-12 1988-01-12 Smithkline Beckman Corporation Pyrrolo[1,2-a]imidazole and pyrrolo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitor
JPH0830013B2 (ja) * 1989-07-28 1996-03-27 財団法人相模中央化学研究所 ビアリール化合物の製造方法
GB9026926D0 (en) 1990-12-12 1991-01-30 Smith Kline French Lab Novel process
AU9169991A (en) 1990-12-13 1992-07-08 Smithkline Beecham Corporation Novel csaids
SE9100920D0 (sv) 1991-03-27 1991-03-27 Astra Ab New active compounds
JP3119758B2 (ja) 1993-02-24 2000-12-25 日清製粉株式会社 ７−アザインドール誘導体及びこれを有効成分とする抗潰瘍薬
US5705515A (en) * 1994-04-26 1998-01-06 Merck & Co., Inc. Substituted sulfonamides as selective β-3 agonists for the treatment of diabetes and obesity
FR2732969B1 (fr) 1995-04-14 1997-05-16 Adir Nouveaux composes pyridiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO1998047899A1 (en) 1997-04-24 1998-10-29 Ortho-Mcneil Corporation, Inc. Substituted pyrrolopyridines useful in the treatment of inflammatory diseases
GB9721437D0 (en) 1997-10-10 1997-12-10 Glaxo Group Ltd Heteroaromatic compounds and their use in medicine
AU745579B2 (en) 1997-10-20 2002-03-21 F. Hoffmann-La Roche Ag Bicyclic kinase inhibitors
CA2326185A1 (en) 1998-04-02 1999-10-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
CA2348734A1 (en) 1998-10-30 2000-05-11 Merck & Co., Inc. Thrombin inhibitors
CA2348530A1 (en) 1998-10-30 2000-05-11 Merck & Co., Inc. Thrombin inhibitors
CN1158283C (zh) 1998-12-17 2004-07-21 霍夫曼-拉罗奇有限公司 作为蛋白激酶抑制剂的4-和5-吡嗪基羟吲哚
CA2354591A1 (en) 1998-12-17 2000-06-22 F. Hoffmann-La Roche Ag 4-aryloxindoles as inhibitors of jnk protein kinases
US6265403B1 (en) 1999-01-20 2001-07-24 Merck & Co., Inc. Angiogenesis inhibitors
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
ATE425142T1 (de) 1999-04-23 2009-03-15 Vertex Pharma Inhibitoren von c-jun n-terminal kinasen (jnk)
NZ517578A (en) 1999-08-19 2004-02-27 Signal Pharm Inc Pyrazoloanthrone and derivatives thereof as JNK inhibitors and their compositions
DE60006634T2 (de) 1999-12-07 2004-04-15 Fuji Photo Film Co., Ltd., Minami-Ashigara Fluoreszente materialen
PL209572B1 (pl) 1999-12-24 2011-09-30 Aventis Pharma Ltd Kompozycja farmaceutyczna zawierająca podstawione azaindole, podstawione azaindole i ich farmaceutyczne zastosowania
AU779855B2 (en) 2000-01-06 2005-02-17 Axys Pharmaceuticals, Inc. Novel compounds and compositions as protease inhibitors
US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
PE20020506A1 (es) 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
WO2002024648A2 (en) * 2000-09-20 2002-03-28 Abbott Laboratories Process for the preparation of cell proliferation inhibitors
GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
WO2003028724A1 (en) 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
WO2003082868A1 (en) 2002-03-28 2003-10-09 Eisai Co., Ltd. 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders
AU2003214414B2 (en) 2002-03-28 2008-10-09 Eisai R & D Management Co., Ltd. Azaindoles as inhibitors of c-Jun N-terminal kinases
SE0202463D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
EP2295433A3 (de) 2003-03-06 2011-07-06 Eisai R&D Management Co., Ltd. JNK Inhibitoren
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors

Also Published As

Publication number Publication date
EP1633750B1 (de) 2010-12-01
US20060235042A1 (en) 2006-10-19
GB0305142D0 (en) 2003-04-09
WO2004078757A3 (en) 2005-09-01
EP1633750A2 (de) 2006-03-15
DE602004030334D1 (de) 2011-01-13
WO2004078757A2 (en) 2004-09-16
JP4711950B2 (ja) 2011-06-29
ES2355726T3 (es) 2011-03-30
US7652137B2 (en) 2010-01-26
JP2006520771A (ja) 2006-09-14

Similar Documents

Publication Publication Date Title
ATE490253T1 (de) Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen
ATE360627T1 (de) Pyrrolidindion-substituierte piperidin- phthalazone als pde4-inhibitoren
ATE357434T1 (de) Disubstituierte thiazolylcarboxanilide und ihre verwendung als mikrobizide
EA200500203A1 (ru) Новый способ синтеза и новая кристаллическая форма агомелатина и фармацевтические композиции, которые её содержат
UA87153C2 (ru) Энантиомерно чистые аминогетероарильные соединения как ингибиторы протеинкиназы
ATE469892T1 (de) Substituierte 1h-dihydropyrazole, ihre herstellung und verwendung
NO20073678L (no) Nye fremgangsmater for fremstilling av benzofuran
SE0403171D0 (sv) New compounds
IL178156A0 (en) Intermediates for the preparation of pramipexole
MXPA05011962A (es) Oxiarenos substituidos.
DE50202504D1 (de) Neue 4-aminofuropyrimidine und ihre verwendung
NO20043016L (no) 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav
SE0303541D0 (sv) New compounds
SE0103710D0 (sv) Compounds
DE60316984D1 (de) Benzoylsulfonamide als antitumor-mittel
HRP20080057T3 (en) 9,10-alpha,alpha-oh-taxane analogs and methods for production thereof
ATE399168T1 (de) Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren
DK1377574T3 (da) 6-phenylbenzonaphtyridiner
MXPA06003345A (es) Derivados de aminopiridina como inhibidores de la no-sintasa inducible.
EA200301101A1 (ru) Производные пиперазина и их применение в качестве ингибиторов pde4
DK1644385T3 (da) Siliciumforbindelser og deres anvendelse
EA200600608A1 (ru) Производные имидазопиридина как ингибиторы индуцируемой no-синтазы
ATE390427T1 (de) Diazabicylononan - und decanderivate und ihre verwendung als opioid-rezeptorligande
DE50303586D1 (de) Methylthiophencarboxanilide
ATE437846T1 (de) Cyclooct-(en-)yl-derivate zur verwendung als duftstoffe

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties