ATE490253T1 - Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen - Google Patents

Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen

Info

Publication number
ATE490253T1
ATE490253T1 AT04717703T AT04717703T ATE490253T1 AT E490253 T1 ATE490253 T1 AT E490253T1 AT 04717703 T AT04717703 T AT 04717703T AT 04717703 T AT04717703 T AT 04717703T AT E490253 T1 ATE490253 T1 AT E490253T1
Authority
AT
Austria
Prior art keywords
azaindolines
substituted
synthesis
azaindoline
novel
Prior art date
Application number
AT04717703T
Other languages
English (en)
Inventor
P Graczyk
A Khan
G Bhatia
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Application granted granted Critical
Publication of ATE490253T1 publication Critical patent/ATE490253T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04717703T 2003-03-06 2004-03-05 Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen ATE490253T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0305142.2A GB0305142D0 (en) 2003-03-06 2003-03-06 Synthesis
PCT/GB2004/000946 WO2004078757A2 (en) 2003-03-06 2004-03-05 Synthesis of 5-substituted 7-azaindoles and 7-azaidonines

Publications (1)

Publication Number Publication Date
ATE490253T1 true ATE490253T1 (de) 2010-12-15

Family

ID=9954241

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04717703T ATE490253T1 (de) 2003-03-06 2004-03-05 Synthese von 5-substituierten 7-azaindolen und 7- azaindolinen

Country Status (8)

Country Link
US (1) US7652137B2 (de)
EP (1) EP1633750B1 (de)
JP (1) JP4711950B2 (de)
AT (1) ATE490253T1 (de)
DE (1) DE602004030334D1 (de)
ES (1) ES2355726T3 (de)
GB (1) GB0305142D0 (de)
WO (1) WO2004078757A2 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2292615A1 (de) * 2002-02-01 2011-03-09 AstraZeneca AB Chinazoline Verbindungen
KR20040111445A (ko) * 2002-03-28 2004-12-31 에자이 가부시키가이샤 신경퇴행성 질환 치료용 ｃ─Ｊｕｎ Ｎ─말단 키나아제억제제로서의 ７─아자인돌
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
US7612086B2 (en) * 2003-05-16 2009-11-03 Eisai R & D Management Co. Ltd. JNK inhibitors
GB0405055D0 (en) * 2004-03-05 2004-04-07 Eisai London Res Lab Ltd JNK inhibitors
NZ553267A (en) 2004-07-27 2010-09-30 Sgx Pharmaceuticals Inc Pyrrolo-pyridine kinase modulators
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7452993B2 (en) 2004-07-27 2008-11-18 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7626021B2 (en) 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
GB0516156D0 (en) * 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
WO2007135398A1 (en) * 2006-05-22 2007-11-29 Astrazeneca Ab Indole derivatives
US8765747B2 (en) 2009-06-12 2014-07-01 Dana-Farber Cancer Institute, Inc. Fused 2-aminothiazole compounds
WO2011060216A1 (en) 2009-11-12 2011-05-19 Concert Pharmaceuticals Inc. Substituted azaindoles
EP2937345B1 (de) 2009-12-29 2018-03-21 Dana-Farber Cancer Institute, Inc. Typ-ii-raf-kinase-hemmer
WO2011109932A1 (en) * 2010-03-09 2011-09-15 F.Hoffmann-La Roche Ag Novel process for the manufacture of 5-halogenated-7-azaindoles
EP2576570A1 (de) * 2010-05-26 2013-04-10 Boehringer Ingelheim International GmbH 2-oxo-1,2-dihydropyridin-4-ylborsäure-derivate
JP6106685B2 (ja) 2011-11-17 2017-04-05 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド Ｃ−ｊｕｎ−ｎ−末端キナーゼ（ｊｎｋ）の阻害剤
EP2909194A1 (de) 2012-10-18 2015-08-26 Dana-Farber Cancer Institute, Inc. Hemmer der cyclinabhängigen kinase 7 (cdk7)
US10000483B2 (en) 2012-10-19 2018-06-19 Dana-Farber Cancer Institute, Inc. Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
JP6426694B2 (ja) 2013-03-15 2018-11-21 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
AU2014337044A1 (en) 2013-10-18 2016-05-05 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2015058126A1 (en) 2013-10-18 2015-04-23 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of prolferative diseases
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
WO2015157504A1 (en) * 2014-04-11 2015-10-15 Taipei Medical University Histone deacetylase inhibitors
WO2015164614A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
CN104478909B (zh) * 2014-11-19 2017-01-04 上海泰坦科技股份有限公司 杂环硼酸类化合物的合成工艺
US10870651B2 (en) 2014-12-23 2020-12-22 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
CN107427521B (zh) 2015-03-27 2021-08-03 达纳-法伯癌症研究所股份有限公司 细胞周期蛋白依赖性激酶的抑制剂
CA2986441A1 (en) 2015-06-12 2016-12-15 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
WO2017044858A2 (en) 2015-09-09 2017-03-16 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
WO2017047602A1 (ja) 2015-09-18 2017-03-23 科研製薬株式会社 ビアリール誘導体及びそれを含有する医薬
CN105622605B (zh) * 2016-03-01 2017-10-13 苏州艾缇克药物化学有限公司 一种5‑溴‑7‑氮杂吲哚的合成方法
CN106188050A (zh) * 2016-07-20 2016-12-07 南通雅本化学有限公司 一种5‑溴‑7‑氮杂吲哚的生产工艺
CN107033142A (zh) * 2017-05-15 2017-08-11 杭州科耀医药科技有限公司 一种Venetoclax关键中间体的合成方法
EP3810132A4 (de) 2018-06-25 2022-06-22 Dana-Farber Cancer Institute, Inc. Kinaseinhibitoren der taire und ihre verwendungen
CN113164477A (zh) 2018-12-14 2021-07-23 达纳-法伯癌症研究所股份有限公司 C-jun-n-末端激酶的吡唑并吡啶抑制剂及其用途
EP3902542A4 (de) 2018-12-28 2022-09-07 Dana-Farber Cancer Institute, Inc. Hemmer der cyclinabhängigen kinase 7 und verwendungen davon
CN110078726B (zh) * 2019-06-19 2022-05-17 陕西师范大学 一种全取代2,3-二氢-1H-吡咯并[2,3-b]吡啶衍生物的合成方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719218A (en) 1985-12-12 1988-01-12 Smithkline Beckman Corporation Pyrrolo[1,2-a]imidazole and pyrrolo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitor
JPH0830013B2 (ja) * 1989-07-28 1996-03-27 財団法人相模中央化学研究所 ビアリール化合物の製造方法
GB9026926D0 (en) 1990-12-12 1991-01-30 Smith Kline French Lab Novel process
EP0563286A4 (en) 1990-12-13 1995-01-11 Smithkline Beecham Corp Novel csaids
SE9100920D0 (sv) 1991-03-27 1991-03-27 Astra Ab New active compounds
JP3119758B2 (ja) 1993-02-24 2000-12-25 日清製粉株式会社 ７−アザインドール誘導体及びこれを有効成分とする抗潰瘍薬
US5705515A (en) * 1994-04-26 1998-01-06 Merck & Co., Inc. Substituted sulfonamides as selective β-3 agonists for the treatment of diabetes and obesity
FR2732969B1 (fr) 1995-04-14 1997-05-16 Adir Nouveaux composes pyridiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO1998047899A1 (en) 1997-04-24 1998-10-29 Ortho-Mcneil Corporation, Inc. Substituted pyrrolopyridines useful in the treatment of inflammatory diseases
GB9721437D0 (en) 1997-10-10 1997-12-10 Glaxo Group Ltd Heteroaromatic compounds and their use in medicine
HRP20000209A2 (en) 1997-10-20 2001-04-30 Hoffmann La Roche Bicyclic kinase inhibitors
AU3210799A (en) 1998-04-02 1999-10-25 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO2000026210A1 (en) 1998-10-30 2000-05-11 Merck & Co., Inc. Thrombin inhibitors
AU747776B2 (en) 1998-10-30 2002-05-23 Merck & Co., Inc. Thrombin inhibitors
ES2301255T3 (es) 1998-12-17 2008-06-16 F. Hoffmann-La Roche Ag 4,5-pirazinaxindoles como inhibidores de proteinoquinasas.
KR20010101266A (ko) 1998-12-17 2001-11-14 프리돌린 클라우스너, 롤란드 비. 보레르 Ｊｎｋ 단백질 키나제의 억제제로서의 4-아릴옥신돌
US6265403B1 (en) 1999-01-20 2001-07-24 Merck & Co., Inc. Angiogenesis inhibitors
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6239132B1 (en) 1999-04-23 2001-05-29 Merck & Co., Inc. Thrombin inhibitors
DE60041763D1 (de) 1999-04-23 2009-04-23 Vertex Pharma Inhibitoren von c-jun n-terminal kinasen (jnk)
KR20080028516A (ko) 1999-08-19 2008-03-31 시그널 파머슈티컬스 인크 Ｊｎｋ억제제로서의 피라졸로안트론과 그 유도체 및 이를함유하는 조성물
DE60006634T2 (de) 1999-12-07 2004-04-15 Fuji Photo Film Co., Ltd., Minami-Ashigara Fluoreszente materialen
HUP0203895A3 (en) 1999-12-24 2004-09-28 Aventis Pharma Ltd West Mallin Substituted azaindoles and pharmaceutical compositions containing them and their use
DE60132975T2 (de) 2000-01-06 2009-02-26 Merck Frosst Canada Inc., Kirkland Neue substanzen und verbindungen als protease-inhibitoren
US6897231B2 (en) 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
PE20020506A1 (es) 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
WO2002024648A2 (en) * 2000-09-20 2002-03-28 Abbott Laboratories Process for the preparation of cell proliferation inhibitors
GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
WO2003028724A1 (en) 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors
EP1490365B1 (de) 2002-03-28 2010-02-10 Eisai R&D Management Co., Ltd. Azaindole als hemmstoffe von c-jun n-terminalen kinasen
KR20040111445A (ko) 2002-03-28 2004-12-31 에자이 가부시키가이샤 신경퇴행성 질환 치료용 ｃ─Ｊｕｎ Ｎ─말단 키나아제억제제로서의 ７─아자인돌
SE0202463D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
US7432375B2 (en) 2003-03-06 2008-10-07 Eisai R & D Management Co., Ltd. JNK inhibitors
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors

Also Published As

Publication number Publication date
US20060235042A1 (en) 2006-10-19
GB0305142D0 (en) 2003-04-09
US7652137B2 (en) 2010-01-26
EP1633750B1 (de) 2010-12-01
JP2006520771A (ja) 2006-09-14
JP4711950B2 (ja) 2011-06-29
DE602004030334D1 (de) 2011-01-13
WO2004078757A3 (en) 2005-09-01
WO2004078757A2 (en) 2004-09-16
ES2355726T3 (es) 2011-03-30
EP1633750A2 (de) 2006-03-15

Similar Documents

Publication Publication Date Title
DE602004030334D1 (de) Synthese von 5-substituierten 7-azaindolen und 7-azaindolinen
ATE360627T1 (de) Pyrrolidindion-substituierte piperidin- phthalazone als pde4-inhibitoren
ATE357434T1 (de) Disubstituierte thiazolylcarboxanilide und ihre verwendung als mikrobizide
EA200500203A1 (ru) Новый способ синтеза и новая кристаллическая форма агомелатина и фармацевтические композиции, которые её содержат
UA87153C2 (ru) Энантиомерно чистые аминогетероарильные соединения как ингибиторы протеинкиназы
SE0302811D0 (sv) Novel compounds
SE0202133D0 (sv) Novel compounds
DE60236600D1 (de) Substituierte 1h-dihydropyrazole, ihre herstellung und verwendung
NO20073678L (no) Nye fremgangsmater for fremstilling av benzofuran
SE0403171D0 (sv) New compounds
IL178156A0 (en) Intermediates for the preparation of pramipexole
MXPA05011962A (es) Oxiarenos substituidos.
DE50202504D1 (de) Neue 4-aminofuropyrimidine und ihre verwendung
NO20043016L (no) 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav
SE0303541D0 (sv) New compounds
SE0103710D0 (sv) Compounds
DE60316984D1 (de) Benzoylsulfonamide als antitumor-mittel
ATE399168T1 (de) Imidazopyridin-derivate und ihre verwendung als induzierbare no-synthase inhibitoren
CY1107101T1 (el) Μεθοδος συνθεσης παραγωγων της 1,3-διϋδρο-2h-3-βενζαζεπιν-2-ονης και εφαρμογη στη συνθεση της ιβαβραδινης και των αλατων προσθηκης με φαρμακευτικως αποδεκτο οξυ
DK1377574T3 (da) 6-phenylbenzonaphtyridiner
MXPA06003345A (es) Derivados de aminopiridina como inhibidores de la no-sintasa inducible.
DK1644385T3 (da) Siliciumforbindelser og deres anvendelse
EA200600608A1 (ru) Производные имидазопиридина как ингибиторы индуцируемой no-синтазы
ATE390427T1 (de) Diazabicylononan - und decanderivate und ihre verwendung als opioid-rezeptorligande
DE50303586D1 (de) Methylthiophencarboxanilide

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties