ES2155219T3 - Compuestos nucleotidos de fosfonato. - Google Patents

Compuestos nucleotidos de fosfonato.

Info

Publication number
ES2155219T3
ES2155219T3 ES97100652T ES97100652T ES2155219T3 ES 2155219 T3 ES2155219 T3 ES 2155219T3 ES 97100652 T ES97100652 T ES 97100652T ES 97100652 T ES97100652 T ES 97100652T ES 2155219 T3 ES2155219 T3 ES 2155219T3
Authority
ES
Spain
Prior art keywords
halogen
alkyl
substituted
phosphonate
nucleotid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97100652T
Other languages
English (en)
Inventor
Masaru Ubasawa
Kouichi Sekiya
Hideaki Takashima
Naoko Ueda
Satoshi Yuasa
Naohiro Kamiya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chemical Corp filed Critical Mitsubishi Chemical Corp
Application granted granted Critical
Publication of ES2155219T3 publication Critical patent/ES2155219T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

UN COMPUESTO DE NUCLEOTIDO DE FOSFONATO QUE TIENE ACTIVIDAD ANTIVIRAL ES UTIL PARA UNA DISPONIBILIDAD ORAL Y AGENTE ANTIVIRAL ALTAMENTE SEGURO, EL CUAL ESTA REPRESENTADO POR LA SIGUIENTE FORMULA (I): EN DONDE R{SUP,1} REPRESENTA HIDROGENO, ALCOXI C{SUB,1}-C{SUB,6}, UN ALCOXI C{SUB,1}-C{SUB,4} SUSTITUIDO POR HALOGENO, HALOGENO, AMINO, O NITRO; R{SUP,2} Y R{SUP,3} REPRESENTAN INDEPENDIENTEMENTE HIDROGENO, UN ALQUILO C{SUB,1}-C{SUB,22}, UN ACILOXIMETILO, UN ACILTIOETILO, O UN ETILO SUSTITUIDO POR HALOGENO; R{SUP,4} REPRESENTA HIDROGENO, UN ALQUILO C{SUB,1}C{SUB,4}, UN HIDROXIALQUILO C{SUB,1}-C{SUB,4}, O UN ALQUILO C{SUB,1}-C{SUB,4} SUSTITUIDO POR HALOGENO; Y X REPRESENTA.
ES97100652T 1996-01-18 1997-01-17 Compuestos nucleotidos de fosfonato. Expired - Lifetime ES2155219T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP648096 1996-01-18

Publications (1)

Publication Number Publication Date
ES2155219T3 true ES2155219T3 (es) 2001-05-01

Family

ID=11639647

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97100652T Expired - Lifetime ES2155219T3 (es) 1996-01-18 1997-01-17 Compuestos nucleotidos de fosfonato.

Country Status (12)

Country Link
US (1) US5840716A (es)
EP (1) EP0785208B1 (es)
KR (1) KR100366727B1 (es)
CN (2) CN1088712C (es)
AT (1) ATE199907T1 (es)
CA (1) CA2195262C (es)
DE (1) DE69704286T2 (es)
DK (1) DK0785208T3 (es)
ES (1) ES2155219T3 (es)
GR (1) GR3035776T3 (es)
PT (1) PT785208E (es)
TW (1) TW369536B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0632048B1 (en) * 1993-06-29 2001-03-21 Mitsubishi Chemical Corporation Phosphonate-nucleotide ester derivatives
CN1085673C (zh) 1996-08-13 2002-05-29 三菱化学株式会社 膦酸酯－核苷酸化合物
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
US6767900B2 (en) 2000-02-29 2004-07-27 Mitsubishi Pharma Corporation Phosphonate nucleotide compound
JP2005508924A (ja) * 2001-08-30 2005-04-07 三菱ウェルファーマ株式会社 抗ウイルス剤
US20040023928A1 (en) * 2001-10-31 2004-02-05 Colacino Joseph Matthew Phosphonate nucleotide and thiadiazole compounds for the treatment of smallpox
CN1617877A (zh) * 2001-12-07 2005-05-18 三菱制药株式会社 膦酸酯核苷酸类似物在治疗乙肝病毒感染方面的用途
AU2002359732A1 (en) * 2001-12-17 2003-06-30 Ribapharm Inc. Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies
WO2004024743A1 (ja) * 2002-09-13 2004-03-25 Mitsubishi Pharma Corporation ２−アミノ−６−（４−メトキシフェニルチオ）−９−[２−（ホスホノメトキシ）エチル]プリン ビス（２，２，２−トリフルオロエチル）エステルの結晶
TW200416034A (en) * 2002-11-15 2004-09-01 Mitsubishi Pharma Corp Medicinal composition
TW200413399A (en) * 2002-11-15 2004-08-01 Mitsubishi Pharma Corp Process for producing 2-[bis(2,2,2-trifluoroethyl)phosphonylmethoxy]ethyl halide
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
CN100475825C (zh) * 2004-03-19 2009-04-08 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物
WO2006066074A2 (en) * 2004-12-16 2006-06-22 The Regents Of The University Of California Lung-targeted drugs
CN1827627B (zh) * 2005-03-04 2011-05-11 北京美倍他药物研究有限公司 新的无环核苷膦酸及其酯衍生物及其医药用途
US20070003608A1 (en) * 2005-04-08 2007-01-04 Almond Merrick R Compounds, compositions and methods for the treatment of viral infections and other medical disorders
US8642577B2 (en) 2005-04-08 2014-02-04 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
CA2681267C (en) 2007-04-13 2013-11-19 Southern Research Institute Anti-angiogenic agents and methods of use
CN101293899B (zh) * 2007-04-28 2011-12-07 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
US8993542B2 (en) * 2008-01-25 2015-03-31 Chimerix Inc. Methods of treating viral infections
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
US20120164104A1 (en) 2009-08-03 2012-06-28 Chimerix, Inc. Composition and Methods of Treating Viral Infections and Viral Induced Tumors
CN102093422B (zh) 2009-12-10 2015-02-25 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
AU2011248620B2 (en) 2010-04-26 2015-11-26 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
CN102286026B (zh) * 2010-06-18 2014-07-02 中国人民解放军军事医学科学院毒物药物研究所 无环核苷酸类似物的盐及其晶型和药物组合物
DK2794624T3 (da) 2011-12-22 2019-07-22 Geron Corp Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde
JP2015520144A (ja) 2012-05-11 2015-07-16 アクロン・モレキュールズ・アクチェンゲゼルシャフトＡｋｒｏｎ Ｍｏｌｅｃｕｌｅｓ Ａｇ 疼痛の治療のための化合物の使用
SI2970346T1 (sl) 2013-03-15 2018-12-31 The Regents Of The University Of California Aciklični diestri nukleozid fosfonata
EP3623364A1 (en) 2014-02-13 2020-03-18 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
EP3194411B1 (en) 2014-09-15 2022-05-04 The Regents of the University of California Nucleotide analogs
US10377782B2 (en) 2015-09-15 2019-08-13 The Regents Of The University Of California Nucleotide analogs
JP2021509907A (ja) 2018-01-09 2021-04-08 リガンド・ファーマシューティカルズ・インコーポレイテッド アセタール化合物およびその治療的使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9020932D0 (en) * 1990-09-26 1990-11-07 Wellcome Found Heterocyclic compounds
US5532225A (en) * 1992-07-31 1996-07-02 Sri International Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods
EP0618214A1 (en) * 1993-04-01 1994-10-05 Merrell Dow Pharmaceuticals Inc. Unsaturated phosphonate derivatives of purines and pyrimidines
EP0632048B1 (en) * 1993-06-29 2001-03-21 Mitsubishi Chemical Corporation Phosphonate-nucleotide ester derivatives

Also Published As

Publication number Publication date
KR970059181A (ko) 1997-08-12
DK0785208T3 (da) 2001-04-23
CN1088712C (zh) 2002-08-07
CN1164534A (zh) 1997-11-12
PT785208E (pt) 2001-06-29
TW369536B (en) 1999-09-11
CA2195262C (en) 2005-08-09
CN1398864A (zh) 2003-02-26
CA2195262A1 (en) 1997-07-19
DE69704286D1 (de) 2001-04-26
CN1216060C (zh) 2005-08-24
EP0785208B1 (en) 2001-03-21
EP0785208A1 (en) 1997-07-23
ATE199907T1 (de) 2001-04-15
US5840716A (en) 1998-11-24
KR100366727B1 (ko) 2003-03-15
DE69704286T2 (de) 2001-10-25
GR3035776T3 (en) 2001-07-31

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