WO1999011621A3 - Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents - Google Patents
Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents Download PDFInfo
- Publication number
- WO1999011621A3 WO1999011621A3 PCT/US1998/017955 US9817955W WO9911621A3 WO 1999011621 A3 WO1999011621 A3 WO 1999011621A3 US 9817955 W US9817955 W US 9817955W WO 9911621 A3 WO9911621 A3 WO 9911621A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- thiourea
- useful
- cholesterol levels
- increasing hdl
- atherosclerotic agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU92110/98A AU9211098A (en) | 1997-09-03 | 1998-08-31 | Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92264897A | 1997-09-03 | 1997-09-03 | |
US08/922,648 | 1997-09-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999011621A2 WO1999011621A2 (en) | 1999-03-11 |
WO1999011621A3 true WO1999011621A3 (en) | 1999-07-01 |
Family
ID=25447377
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/017955 WO1999011621A2 (en) | 1997-09-03 | 1998-08-31 | Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents |
Country Status (4)
Country | Link |
---|---|
AR (1) | AR017047A1 (en) |
AU (1) | AU9211098A (en) |
WO (1) | WO1999011621A2 (en) |
ZA (1) | ZA987970B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA76977C2 (en) * | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2557438A1 (en) * | 1974-12-20 | 1976-06-24 | Leo Pharm Prod Ltd | N-SUBSTITUTED N "CYANO-N'PYRIDYLGUANIDINE COMPOUNDS |
EP0001979A1 (en) * | 1977-10-08 | 1979-05-30 | Shudo, Koichi, Prof. Dr. | N-(2-chloro-4-pyridyl)-N'-phenylureas, methods for their preparation and plant growth regulators containing them |
US4387106A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas |
DD223445A1 (en) * | 1984-03-18 | 1985-06-12 | Neubauer T Paedagog Hochschule | PROCESS FOR THE PREPARATION OF THIROUS FUEL DERIVATIVES |
CA2072704A1 (en) * | 1991-07-01 | 1993-01-02 | Gary Mark Coppola | N-phenylthiourea derivatives and pharmaceutical use thereof |
JPH0612447A (en) * | 1992-03-31 | 1994-01-21 | Toshiba Corp | Summary sentence preparing device |
WO1996018617A1 (en) * | 1994-12-12 | 1996-06-20 | Merck & Co., Inc. | Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase |
WO1996040673A1 (en) * | 1995-06-07 | 1996-12-19 | Sugen, Inc. | Novel urea- and thiourea-type compounds |
-
1998
- 1998-08-31 AU AU92110/98A patent/AU9211098A/en not_active Abandoned
- 1998-08-31 WO PCT/US1998/017955 patent/WO1999011621A2/en active Application Filing
- 1998-09-01 ZA ZA9807970A patent/ZA987970B/en unknown
- 1998-09-02 AR ARP980104387A patent/AR017047A1/en unknown
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2557438A1 (en) * | 1974-12-20 | 1976-06-24 | Leo Pharm Prod Ltd | N-SUBSTITUTED N "CYANO-N'PYRIDYLGUANIDINE COMPOUNDS |
EP0001979A1 (en) * | 1977-10-08 | 1979-05-30 | Shudo, Koichi, Prof. Dr. | N-(2-chloro-4-pyridyl)-N'-phenylureas, methods for their preparation and plant growth regulators containing them |
US4387106A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas |
DD223445A1 (en) * | 1984-03-18 | 1985-06-12 | Neubauer T Paedagog Hochschule | PROCESS FOR THE PREPARATION OF THIROUS FUEL DERIVATIVES |
CA2072704A1 (en) * | 1991-07-01 | 1993-01-02 | Gary Mark Coppola | N-phenylthiourea derivatives and pharmaceutical use thereof |
EP0528146A1 (en) * | 1991-07-01 | 1993-02-24 | Sandoz Ltd. | N-phenylthiourea derivatives and pharmaceutical use thereof |
JPH0612447A (en) * | 1992-03-31 | 1994-01-21 | Toshiba Corp | Summary sentence preparing device |
WO1996018617A1 (en) * | 1994-12-12 | 1996-06-20 | Merck & Co., Inc. | Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase |
WO1996040673A1 (en) * | 1995-06-07 | 1996-12-19 | Sugen, Inc. | Novel urea- and thiourea-type compounds |
Non-Patent Citations (28)
Title |
---|
ACTA POL. PHARM. (1978), 35(5), 615-18 ;ISSN: 0001-6837 * |
ACTA POL. PHARM. (1989), 46(2), 101-13;, 1989 * |
CHEMICAL ABSTRACTS, vol. 112, no. 23, 4 June 1990, Columbus, Ohio, US; abstract no. 216860, WISTEROWICZ, KRYSTYNA ET AL: "Pyrazine derivatives. XXVI. Synthesis and tuberculostatic activity of N-pyrazinylthioureas" XP002087696 * |
CHEMICAL ABSTRACTS, vol. 120, no. 7, 14 February 1994, Columbus, Ohio, US; abstract no. 71433, YONOVA, P. A. ET AL: "Physiological effects of ureas and thioureas. Synthesis and cytokinin activity of 1-(4-fluorophenyl)-3-pyridyl-2-ureas and thioureas" XP002100743 * |
CHEMICAL ABSTRACTS, vol. 127, no. 20, 17 November 1997, Columbus, Ohio, US; abstract no. 277898, HEINISCH, G. ET AL: "Complete assignment of the 13C NMR spectra of diazinyl-substituted ureas and thioureas" XP002100742 * |
CHEMICAL ABSTRACTS, vol. 70, no. 5, 3 February 1969, Columbus, Ohio, US; abstract no. 19884, NOVIKOV, E. G. ET AL: "The reaction of 3- and 4-aminopyridines with isocyanates and isothiocyanates" XP002100748 * |
CHEMICAL ABSTRACTS, vol. 74, no. 25, 21 June 1971, Columbus, Ohio, US; abstract no. 141216, FUJIKAWA, FUKUJIRO ET AL: "Chemotherapeutic agents against Mycobacterium tuberculosis. XXVI. Synthesis and antituberculous activity of phenylthiourea, p-ethoxyphenylthiourea, and 3-bromo-4-ethoxyphenylthiourea derivatives" XP002087697 * |
CHEMICAL ABSTRACTS, vol. 75, no. 3, 19 July 1971, Columbus, Ohio, US; abstract no. 20217, MINAMI, SHINSAKU ET AL: "Thiourea derivatives" XP002100747 * |
CHEMICAL ABSTRACTS, vol. 81, no. 15, 14 October 1974, Columbus, Ohio, US; abstract no. 91314, LESIAK, TADEUSZ ET AL: "New derivatives of thiourea" XP002100746 * |
CHEMICAL ABSTRACTS, vol. 85, no. 25, 20 December 1976, Columbus, Ohio, US; abstract no. 192015, KASHYAP, B. C. ET AL: "Ionization constants of some N-aryl-N'-(5-halo-2-pyridyl)thioureas" XP002087698 * |
CHEMICAL ABSTRACTS, vol. 90, no. 13, 26 March 1979, Columbus, Ohio, US; abstract no. 97342, GUPTA, R. C. ET AL: "Biologically active thiazolidinone" XP002100745 * |
CHEMICAL ABSTRACTS, vol. 91, no. 15, 8 October 1979, Columbus, Ohio, US; abstract no. 117865, FOKS, HENRYK ET AL: "Pyrazine derivatives. XI. Synthesis and antitubercular activity of pyrazineurea and pyrazinethiourea derivatives" XP002100744 * |
DATABASE CHEMABS Chemical Abstacts Service; XP002100754 * |
DATABASE CHEMABS Chemical Abstracts Service; XP002100752 * |
DATABASE CHEMABS Chemical Abstracts Service; XP002100753 * |
DATABASE CHEMABS Chemical Abstracts Service; XP002100755 * |
DATABASE CHEMABS Chemical Abstracts Service; XP002100756 * |
DATABASE CHEMABS Chemical Abstracts Service; XP002100757 * |
DATABASE CHEMICAL ABSTRACTS Chemical Abstracts Service, Columbus; XP002087699 * |
DATABASE CHEMICAL ABSTRACTS Chemical Abstracts Service, Columbus; XP002087700 * |
HEINISCH, GOTTFRIED ET AL: "Synthesis of N-aryl-N'-heteroaryl-substituted urea and thiourea derivatives and evaluation of their anticonvulsant activity", ARCH. PHARM. (WEINHEIM, GER.) (1997), 330(7), 207-210, 1997, XP002087695 * |
J. INDIAN CHEM. SOC. (1978), 55(8), 832-4 CODEN: JICSAH;ISSN: 0019-4522 * |
KHIM. GETEROTSIKL. SOEDIN. (1968), (2), 281-3 * |
MAGN. RESON. CHEM. (1997), 35(9), 653-655 ;ISSN: 0749-1581 * |
PHYSIOL. BIOCHEM. CYTOKININS PLANTS, SYMP. (1992), MEETING DATE 1990, 219-21. EDITOR(S): KAMINEK, MIROSLAV;MOK, DAVID W. S.; ZAZIMALOVA, EVA. PUBLISHER: SPB ACAD. PUBL., THE HAGUE, NETH. * |
REV. ROUM. CHIM. (1976), 21(6), 903-10, 1976 * |
ROCZ. CHEM. (1974), 48(2), 317-20 CODEN: ROCHAC * |
YAKUGAKU ZASSHI (1971), 91(2), 159-65, 1971 * |
Also Published As
Publication number | Publication date |
---|---|
AR017047A1 (en) | 2001-08-22 |
ZA987970B (en) | 2000-05-31 |
WO1999011621A2 (en) | 1999-03-11 |
AU9211098A (en) | 1999-03-22 |
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