ES2147841T3 - Derivados de piridazinona. - Google Patents

Derivados de piridazinona.

Info

Publication number
ES2147841T3
ES2147841T3 ES95906505T ES95906505T ES2147841T3 ES 2147841 T3 ES2147841 T3 ES 2147841T3 ES 95906505 T ES95906505 T ES 95906505T ES 95906505 T ES95906505 T ES 95906505T ES 2147841 T3 ES2147841 T3 ES 2147841T3
Authority
ES
Spain
Prior art keywords
hydrogen atom
atom
alkyl group
group
äwherein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95906505T
Other languages
English (en)
Inventor
Keizo Tanikawa
Takashi Matsumoto
Hiroo Matsumoto
Nobutomo Tsuruzoe
Hitoshi Nakabeppu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Original Assignee
Nissan Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp filed Critical Nissan Chemical Corp
Application granted granted Critical
Publication of ES2147841T3 publication Critical patent/ES2147841T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LOS DERIVADOS DE PIRIDAZINONA REPRESENTADOS POR LA FORMULA (I) Y AGENTES ANTIPLAQUETAS QUE LOS CONTIENEN: [EN DONDE R ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C{SUB,1}C{SUB,4}, X ES UN ATOMO DE HIDROGENO, UN ATOMO DE CLORO O UN ATOMO DE BROMO, AR ES UN GRUPO PIRIDILO O UN GRUPO FENILO SUBSTITUIDO CON OR{SUP,1} (EN DONDE R{SUP,1} ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C{SUB,1}-C{SUB,4}) Y A {EN DONDE A ES UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO ALQUILO C{SUB,1}-C{SUB,4} U OR{SUP,2}(EN DONDE R{SUP,2} ES UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO C{SUB,1}-C{SUB,4})}, Y ES ALQUILENO C{SUB,1}-C{SUB,8} EN DONDE UN ATOMO DE CARBONO EN LA CADENA RECTA ES SUBSTITUIDO CON UN GRUPO OR{SUP,1} (EN DONDE R{SUP,1} ES EL MISMO DEFINIDO ANTERIORMENTE), Y Z{SUP,1} Y Z{SUP,2} SON INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO ALQUILO C{SUB,1}-C{SUB,4} O UN GRUPO OR{SUP,1} (EN DONDE R{SUP,1} ES EL MISMO DEFINIDO ANTERIORMENTE)]. ESTOS COMPUESTOS TIENEN FUERTES EFECTOS ANTIPLAQUETA, SON EXCELENTEMENTE SEGUROS, Y PUEDEN SER USADOS COMO INGREDIENTES ACTIVOS DE PROFILACTICOS Y FARMACOS TERAPEUTICOS PARA VARIAS ENFERMEDADES TROMBOTICAS.
ES95906505T 1994-01-25 1995-01-24 Derivados de piridazinona. Expired - Lifetime ES2147841T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP654194 1994-01-25

Publications (1)

Publication Number Publication Date
ES2147841T3 true ES2147841T3 (es) 2000-10-01

Family

ID=11641211

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95906505T Expired - Lifetime ES2147841T3 (es) 1994-01-25 1995-01-24 Derivados de piridazinona.

Country Status (16)

Country Link
US (2) US5750523A (es)
EP (1) EP0742211B1 (es)
KR (1) KR100318653B1 (es)
CN (1) CN1049892C (es)
AT (1) ATE192741T1 (es)
AU (1) AU1466395A (es)
CA (1) CA2181901C (es)
DE (1) DE69516849T2 (es)
DK (1) DK0742211T3 (es)
ES (1) ES2147841T3 (es)
FI (1) FI112214B (es)
HU (1) HU223963B1 (es)
NO (1) NO307965B1 (es)
PT (1) PT742211E (es)
TW (1) TW420665B (es)
WO (1) WO1995019969A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110040A (en) * 1993-06-29 2000-07-16 Nissan Chemical Ind Ltd Pyridazinone derivatives their preparation and pharmaceutical compositions comprising them
TW482675B (en) * 1997-01-31 2002-04-11 Green Cross Corp Compositions for oral administration containing pyridazinone compounds technical field of the invention
DK1123704T3 (da) 1998-09-01 2004-11-01 Nissan Chemical Ind Ltd Midler til spinalstenose
IL143530A0 (en) * 1998-12-07 2002-04-21 Nissan Chemical Ind Ltd Pyridazinone derivatives
ES2195785B1 (es) * 2002-05-16 2005-03-16 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
RU2339381C2 (ru) * 2004-02-09 2008-11-27 Ниссан Кемикал Индастриз, Лтд. Ингибитор гиперплазии интимы сосудов
KR100854584B1 (ko) 2006-03-20 2008-08-27 주식회사 엘지생명과학 피리다지논, 피리미돈 또는 피리돈 구조를 포함하는선택적인 트롬빈 억제제

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186817B1 (en) * 1984-12-10 1989-08-02 Nissan Chemical Industries Ltd. 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it
JPH0641454B2 (ja) * 1985-02-27 1994-06-01 日産化学工業株式会社 ピリダジノン誘導体
US4892947A (en) * 1985-04-27 1990-01-09 Nissan Chemical Industries Ltd. 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it
US4978665A (en) * 1987-01-20 1990-12-18 Nissan Chemical Industries Ltd. 3(2H)pyridazinone, and antagonistic agent against SRS-A containing it
JPH02256668A (ja) * 1988-12-20 1990-10-17 Nissan Chem Ind Ltd ピリダジノン誘導体
UA27031A1 (uk) * 1990-04-25 2000-02-28 Ніссан Кемікал Індастріз Лтд Похідhі 3(2h)піридазиhоhу або їх фармацевтичhо прийhятhі солі, що мають протитромботичhу, позитивhу іhотропhу, судиhорозширювальhу дію й аhтиалергічhу активhість та фармацевтичhа композиція hа їх осhові
JPH0517357A (ja) * 1991-07-05 1993-01-26 Nissan Chem Ind Ltd 血小板減少療法剤
IL110040A (en) * 1993-06-29 2000-07-16 Nissan Chemical Ind Ltd Pyridazinone derivatives their preparation and pharmaceutical compositions comprising them
CN1056369C (zh) * 1993-09-06 2000-09-13 石原产业株式会社 哒嗪酮衍生物或其盐和制备方法

Also Published As

Publication number Publication date
CA2181901C (en) 2005-09-13
FI112214B (fi) 2003-11-14
NO963095L (no) 1996-09-24
US5750523A (en) 1998-05-12
DE69516849D1 (de) 2000-06-15
WO1995019969A1 (fr) 1995-07-27
CA2181901A1 (en) 1995-07-27
CN1138852A (zh) 1996-12-25
HU223963B1 (hu) 2005-03-29
KR100318653B1 (ko) 2002-04-22
NO307965B1 (no) 2000-06-26
EP0742211B1 (en) 2000-05-10
NO963095D0 (no) 1996-07-24
HUT74742A (en) 1997-02-28
TW420665B (en) 2001-02-01
ATE192741T1 (de) 2000-05-15
FI962957A0 (fi) 1996-07-24
US5856327A (en) 1999-01-05
EP0742211A4 (en) 1997-03-26
DK0742211T3 (da) 2000-08-14
DE69516849T2 (de) 2000-10-12
PT742211E (pt) 2000-10-31
AU1466395A (en) 1995-08-08
FI962957A (fi) 1996-07-24
HU9602021D0 (en) 1996-09-30
EP0742211A1 (en) 1996-11-13
CN1049892C (zh) 2000-03-01

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