TW369536B - Phosphonate nucleotide compounds - Google Patents
Phosphonate nucleotide compoundsInfo
- Publication number
- TW369536B TW369536B TW086100424A TW86100424A TW369536B TW 369536 B TW369536 B TW 369536B TW 086100424 A TW086100424 A TW 086100424A TW 86100424 A TW86100424 A TW 86100424A TW 369536 B TW369536 B TW 369536B
- Authority
- TW
- Taiwan
- Prior art keywords
- halogen
- alkyl
- substituted
- phosphonate nucleotide
- alkoxy
- Prior art date
Links
- -1 Phosphonate nucleotide compounds Chemical class 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical class 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000005042 acyloxymethyl group Chemical group 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000001495 ethyl group Chemical class [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP648096 | 1996-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW369536B true TW369536B (en) | 1999-09-11 |
Family
ID=11639647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW086100424A TW369536B (en) | 1996-01-18 | 1997-01-16 | Phosphonate nucleotide compounds |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5840716A (zh) |
| EP (1) | EP0785208B1 (zh) |
| KR (1) | KR100366727B1 (zh) |
| CN (2) | CN1088712C (zh) |
| AT (1) | ATE199907T1 (zh) |
| CA (1) | CA2195262C (zh) |
| DE (1) | DE69704286T2 (zh) |
| DK (1) | DK0785208T3 (zh) |
| ES (1) | ES2155219T3 (zh) |
| GR (1) | GR3035776T3 (zh) |
| PT (1) | PT785208E (zh) |
| TW (1) | TW369536B (zh) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0632048B1 (en) * | 1993-06-29 | 2001-03-21 | Mitsubishi Chemical Corporation | Phosphonate-nucleotide ester derivatives |
| KR20000029952A (ko) * | 1996-08-13 | 2000-05-25 | 미우라 아끼라 | 포스포네이트뉴클레오티드화합물 |
| US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
| US6767900B2 (en) | 2000-02-29 | 2004-07-27 | Mitsubishi Pharma Corporation | Phosphonate nucleotide compound |
| WO2003028737A1 (en) * | 2001-08-30 | 2003-04-10 | Mitsubishi Pharma Corporation | Anti-viral agents and in-vitro method for the identification of candidates able to inhibit binding of polymerase to epsilon |
| US20040023928A1 (en) * | 2001-10-31 | 2004-02-05 | Colacino Joseph Matthew | Phosphonate nucleotide and thiadiazole compounds for the treatment of smallpox |
| WO2003050129A1 (en) * | 2001-12-07 | 2003-06-19 | Eli Lilly And Company | Use of phosphonate nucleotide analogue for treating hepatitis b virus infections |
| WO2003051881A1 (en) * | 2001-12-17 | 2003-06-26 | Ribapharm Inc. | Substituted purine nucleoside libraries and compounds by solid-phase combinatorial strategies |
| TW200410972A (en) * | 2002-09-13 | 2004-07-01 | Mitsubishi Pharma Corp | Crystal of 2-amino-6-(4-methoxyphenylthio)-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl)ester |
| TW200416034A (en) * | 2002-11-15 | 2004-09-01 | Mitsubishi Pharma Corp | Medicinal composition |
| WO2004046157A1 (ja) * | 2002-11-15 | 2004-06-03 | Mitsubishi Pharma Corporation | ２−[ビス（2,2,2-トリフルオロエチル）ホスホニルメトキシ]エチルハライドの製造方法 |
| WO2005090370A1 (en) * | 2004-02-05 | 2005-09-29 | The Regents Of The University Of California | Pharmacologically active agents containing esterified phosphonates and methods for use thereof |
| CN100475825C (zh) * | 2004-03-19 | 2009-04-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 无环核苷膦酸酯衍生物 |
| ES2401285T3 (es) | 2004-12-16 | 2013-04-18 | The Regents Of The University Of California | Fármacos con el pulmón como diana |
| CN1827627B (zh) * | 2005-03-04 | 2011-05-11 | 北京美倍他药物研究有限公司 | 新的无环核苷膦酸及其酯衍生物及其医药用途 |
| WO2006110655A2 (en) | 2005-04-08 | 2006-10-19 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of poxvirus infections |
| EP2842559A3 (en) | 2005-04-08 | 2015-03-18 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
| WO2009023299A2 (en) | 2007-04-13 | 2009-02-19 | Southern Research Institute | Anti-angiogenic agents and methods of use |
| CN101293899B (zh) * | 2007-04-28 | 2011-12-07 | 中国人民解放军军事医学科学院毒物药物研究所 | 无环核苷膦酸酯衍生物及其医药用途 |
| CN102670628B (zh) * | 2008-01-25 | 2015-11-25 | 奇默里克斯公司 | 治疗病毒感染的方法 |
| US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| BR112012002551A2 (pt) | 2009-08-03 | 2017-06-13 | Chimerix Inc | composição e métodos de tratamento de infecções virais e tumores induzidos por vírus |
| CN102093422B (zh) | 2009-12-10 | 2015-02-25 | 中国人民解放军军事医学科学院毒物药物研究所 | 无环核苷膦酸酯衍生物及其医药用途 |
| EP2534150B1 (en) | 2010-02-12 | 2017-04-05 | Chimerix, Inc. | Methods of treating viral infection |
| EP2563367A4 (en) | 2010-04-26 | 2013-12-04 | Chimerix Inc | METHODS OF TREATING RETROVIRAL INFECTIONS AND ASSOCIATED DOSAGE REGIMES |
| CN102286026B (zh) * | 2010-06-18 | 2014-07-02 | 中国人民解放军军事医学科学院毒物药物研究所 | 无环核苷酸类似物的盐及其晶型和药物组合物 |
| DK3578563T3 (da) | 2011-12-22 | 2021-05-31 | Geron Corp | Guanin-analoger som telomerase-substrater og påvirkere af telomerlængde |
| JP2015520144A (ja) | 2012-05-11 | 2015-07-16 | アクロン・モレキュールズ・アクチェンゲゼルシャフトＡｋｒｏｎ Ｍｏｌｅｃｕｌｅｓ Ａｇ | 疼痛の治療のための化合物の使用 |
| PT2970346T (pt) | 2013-03-15 | 2018-11-09 | Univ California | Diésteres de fosfonato nucleosídico acíclico |
| CN114404427A (zh) | 2014-02-13 | 2022-04-29 | 配体药物公司 | 前药化合物及其用途 |
| CN106687118A (zh) | 2014-07-02 | 2017-05-17 | 配体药物公司 | 前药化合物及其用途 |
| HUE059067T2 (hu) | 2014-09-15 | 2022-10-28 | Univ California | Nukleotid analógok |
| US10377782B2 (en) | 2015-09-15 | 2019-08-13 | The Regents Of The University Of California | Nucleotide analogs |
| EP3737676B1 (en) | 2018-01-09 | 2024-03-06 | Ligand Pharmaceuticals, Inc. | Acetal compounds and therapeutic uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9020932D0 (en) * | 1990-09-26 | 1990-11-07 | Wellcome Found | Heterocyclic compounds |
| US5532225A (en) * | 1992-07-31 | 1996-07-02 | Sri International | Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods |
| EP0618214A1 (en) * | 1993-04-01 | 1994-10-05 | Merrell Dow Pharmaceuticals Inc. | Unsaturated phosphonate derivatives of purines and pyrimidines |
| EP0632048B1 (en) * | 1993-06-29 | 2001-03-21 | Mitsubishi Chemical Corporation | Phosphonate-nucleotide ester derivatives |
-
1997
- 1997-01-16 TW TW086100424A patent/TW369536B/zh active
- 1997-01-16 CA CA002195262A patent/CA2195262C/en not_active Expired - Fee Related
- 1997-01-17 AT AT97100652T patent/ATE199907T1/de not_active IP Right Cessation
- 1997-01-17 PT PT97100652T patent/PT785208E/pt unknown
- 1997-01-17 US US08/785,606 patent/US5840716A/en not_active Expired - Fee Related
- 1997-01-17 DK DK97100652T patent/DK0785208T3/da active
- 1997-01-17 DE DE69704286T patent/DE69704286T2/de not_active Expired - Fee Related
- 1997-01-17 ES ES97100652T patent/ES2155219T3/es not_active Expired - Lifetime
- 1997-01-17 EP EP97100652A patent/EP0785208B1/en not_active Expired - Lifetime
- 1997-01-18 CN CN97103169A patent/CN1088712C/zh not_active Expired - Fee Related
- 1997-01-18 KR KR1019970001362A patent/KR100366727B1/ko not_active IP Right Cessation
-
2001
- 2001-04-23 GR GR20010400489T patent/GR3035776T3/el not_active IP Right Cessation
-
2002
- 2002-03-28 CN CN021085013A patent/CN1216060C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5840716A (en) | 1998-11-24 |
| DE69704286D1 (de) | 2001-04-26 |
| KR970059181A (ko) | 1997-08-12 |
| EP0785208A1 (en) | 1997-07-23 |
| DK0785208T3 (da) | 2001-04-23 |
| CN1088712C (zh) | 2002-08-07 |
| CA2195262C (en) | 2005-08-09 |
| GR3035776T3 (en) | 2001-07-31 |
| CN1398864A (zh) | 2003-02-26 |
| KR100366727B1 (ko) | 2003-03-15 |
| EP0785208B1 (en) | 2001-03-21 |
| ES2155219T3 (es) | 2001-05-01 |
| PT785208E (pt) | 2001-06-29 |
| ATE199907T1 (de) | 2001-04-15 |
| CA2195262A1 (en) | 1997-07-19 |
| DE69704286T2 (de) | 2001-10-25 |
| CN1164534A (zh) | 1997-11-12 |
| CN1216060C (zh) | 2005-08-24 |
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