HUP0003954A2 - Eljárás és közbenső termékek pirrolo [2,3-d] pirimidin-származékok előállítására - Google Patents

Eljárás és közbenső termékek pirrolo [2,3-d] pirimidin-származékok előállítására

Info

Publication number
HUP0003954A2
HUP0003954A2 HU0003954A HUP0003954A HUP0003954A2 HU P0003954 A2 HUP0003954 A2 HU P0003954A2 HU 0003954 A HU0003954 A HU 0003954A HU P0003954 A HUP0003954 A HU P0003954A HU P0003954 A2 HUP0003954 A2 HU P0003954A2
Authority
HU
Hungary
Prior art keywords
general formula
metal cation
processes
acid metal
pyrimidine derivatives
Prior art date
Application number
HU0003954A
Other languages
English (en)
Inventor
Charles Jackson Barnett
Douglas Patton Kjell
Brian James Slattery
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26786718&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0003954(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP0003954A2 publication Critical patent/HUP0003954A2/hu
Publication of HUP0003954A3 publication Critical patent/HUP0003954A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

A jelen szabadalmi bejelentés tárgya (IV) általános képletű újszulfonsav fémkation sók, melyek folsav-gátló, 5-helyzetbenhelyettesített pirrolo[2,3-d]pirimidinek előállítása hasznos közbensőtermékkel. (IV) általános képletben: M jelentése fém kation; n értéke1, vagy 2; R2 jelentése NHCH(CO2R3)CH2CH2CO2R3, vagy OR3 képletűcsoport; R3 jelentése minden egyes előfordulásnál egymástólfüggetlenül karboxil védőcsoport; és X jelentése kötés; vagy 1-4szénatomos alkiléncsoport. A jelen találmány tárgya továbbá új eljárása szulfonsav fémkation sók előállítására, és új eljárás (III)általános képletű aldehidek előállítására a megfelelő szulfonsavfémkation sókból. A (III) általános képletben X és R2 jelentése afenti. Ó
HU0003954A 1997-09-26 1998-09-18 Processes and intermediates useful to prepare pyrrolo [2,3-d] pyrimidine derivatives HUP0003954A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93838597A 1997-09-26 1997-09-26
US9303997P 1997-09-26 1997-09-26
PCT/US1998/019560 WO1999016742A1 (en) 1997-09-26 1998-09-18 Processes and intermediates useful to make antifolates

Publications (2)

Publication Number Publication Date
HUP0003954A2 true HUP0003954A2 (hu) 2001-09-28
HUP0003954A3 HUP0003954A3 (en) 2002-12-28

Family

ID=26786718

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003954A HUP0003954A3 (en) 1997-09-26 1998-09-18 Processes and intermediates useful to prepare pyrrolo [2,3-d] pyrimidine derivatives

Country Status (18)

Country Link
US (1) US6013828A (hu)
JP (1) JP2001518459A (hu)
KR (1) KR20010030712A (hu)
CN (2) CN1213998C (hu)
AU (1) AU740087B2 (hu)
BR (1) BR9812524A (hu)
CA (1) CA2304656A1 (hu)
CZ (1) CZ301563B6 (hu)
EA (1) EA002452B3 (hu)
HU (1) HUP0003954A3 (hu)
ID (1) ID24165A (hu)
IL (1) IL135190A (hu)
NO (2) NO314456B1 (hu)
NZ (1) NZ503600A (hu)
PL (1) PL196216B1 (hu)
TR (1) TR200001220T2 (hu)
UA (1) UA53742C2 (hu)
WO (1) WO1999016742A1 (hu)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1212325A2 (en) * 1999-08-23 2002-06-12 Eli Lilly And Company A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor
PT1259513E (pt) * 2000-02-25 2004-02-27 Lilly Co Eli Nova forma cristalina de acido n-¬4- ¬2-amino-4,7-dihidro -4-oxo-3h-pirrolo¬2,3-d|pirimidin-5-il)etil| - benzoil|-l-glutamico e processo para a sua obtencao
CN100379729C (zh) * 2006-04-06 2008-04-09 海南天源康泽医药科技有限公司 硝基化合物及其在培美曲塞制备中的应用
ES2354843T3 (es) * 2006-08-14 2011-03-18 Sicor, Inc. Formas cristalinas de diácido de pemetrexed y procedimientos para la preparación de las mismas.
KR20090052355A (ko) * 2006-08-14 2009-05-25 시코르, 인크. 순도가 높은 페메트렉세드 이산 및 이의 제조 방법
JP2010523589A (ja) * 2007-04-03 2010-07-15 ドクター レディズ ラボラトリーズ リミテッド ペメトレキセドの固体形
CN101417998B (zh) 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
CN101591247B (zh) * 2008-05-30 2012-09-05 上海希迪制药有限公司 合成4-(4-甲酯基苯基)丁醛的方法
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
US9174991B2 (en) 2009-11-24 2015-11-03 Azad Pharmaceutical Ingredients Ag Crystalline form of pemetrexed disodium
IT1401677B1 (it) * 2010-07-22 2013-08-02 Chemi Spa Nuovo processo per la sintesi di pemetrexed sale disodico
RU2552519C2 (ru) * 2010-08-02 2015-06-10 Неон Лэборэторис Лтд. Способ получения высокочистого диалкилпеметрекседа
WO2012111027A2 (en) * 2011-02-15 2012-08-23 Hetero Research Foundation Process for pemetrexed disodium
US9051322B2 (en) 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
AU2011363636B2 (en) * 2011-03-25 2016-03-17 Scinopharm Taiwan Ltd Process for the production of a pemetrexed salt
WO2012150280A2 (en) 2011-05-05 2012-11-08 Lonza Ltd Preparation of 4,4-dialkoxy-1-buten-1-ylarenes
CN102911176B (zh) * 2012-10-10 2015-07-22 德州德药制药有限公司 一种培美曲塞二钠的制备方法
CN102887902B (zh) * 2012-10-10 2015-05-20 北京莱瑞森医药科技有限公司 一种合成高纯度培美酸的制备工艺
KR101578093B1 (ko) * 2013-09-05 2015-12-16 주식회사 삼양바이오팜 고순도 페메트렉세드 제조를 위한 향상된 중간체 제조 방법 및 이를 사용하여 고순도 페메트렉세드를 제조하는 방법
NZ630292A (en) 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
CN104817563B (zh) * 2015-05-11 2017-10-27 宁波美诺华药业股份有限公司 培美曲塞‑n,n‑二苄基乙二胺盐的制备方法
CN109836425B (zh) * 2017-11-24 2023-01-24 江苏创诺制药有限公司 一种合成培美酸的制备工艺
CN109721604B (zh) * 2019-01-25 2021-03-23 南京亚东启天药业有限公司 培美曲塞酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
RU2127274C1 (ru) * 1992-09-25 1999-03-10 Эли Лилли Энд Компани СПОСОБ ПОЛУЧЕНИЯ 5-ЗАМЕЩЕННЫХ ПИРРОЛО (2,3-α)ПИРИМИДИНОВ
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
CZ283345B6 (cs) * 1993-05-24 1998-03-18 Eli Lilly And Company Způsob přípravy v poloze 5 substituovaného derivátu pyrrolo [2,3-d]pyrimidinu

Also Published As

Publication number Publication date
TR200001220T2 (tr) 2001-05-21
JP2001518459A (ja) 2001-10-16
IL135190A0 (en) 2001-05-20
EA002452B3 (ru) 2018-02-28
AU740087B2 (en) 2001-11-01
US6013828A (en) 2000-01-11
NZ503600A (en) 2001-08-31
UA53742C2 (uk) 2003-02-17
EA002452B1 (ru) 2002-04-25
NO2005007I2 (no) 2008-02-11
NO314456B1 (no) 2003-03-24
HUP0003954A3 (en) 2002-12-28
CZ301563B6 (cs) 2010-04-14
NO2005007I1 (no) 2005-04-04
CN1475477A (zh) 2004-02-18
KR20010030712A (ko) 2001-04-16
CA2304656A1 (en) 1999-04-08
CN1213998C (zh) 2005-08-10
AU9493798A (en) 1999-04-23
IL135190A (en) 2005-03-20
WO1999016742A1 (en) 1999-04-08
ID24165A (id) 2000-07-13
BR9812524A (pt) 2000-07-25
NO20001554D0 (no) 2000-03-24
CN1271338A (zh) 2000-10-25
NO20001554L (no) 2000-05-24
PL196216B1 (pl) 2007-12-31
PL339452A1 (en) 2000-12-18
CN1246295C (zh) 2006-03-22
EA200000359A1 (ru) 2000-10-30

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