BR9812524A - Processos e intermediários utilizáveis para produzir antifolatos - Google Patents

Processos e intermediários utilizáveis para produzir antifolatos

Info

Publication number
BR9812524A
BR9812524A BR9812524-9A BR9812524A BR9812524A BR 9812524 A BR9812524 A BR 9812524A BR 9812524 A BR9812524 A BR 9812524A BR 9812524 A BR9812524 A BR 9812524A
Authority
BR
Brazil
Prior art keywords
antifolates
processes
produce
usable
sulfonic acid
Prior art date
Application number
BR9812524-9A
Other languages
English (en)
Inventor
Douglas Patton Kjell
Brian James Slattery
Charlie Jackson Barnett
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26786718&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9812524(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9812524A publication Critical patent/BR9812524A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Patente de Invenção: <B>"PROCESSOS E INTERMEDIáRIOS UTILIZáVEIS PARA PRODUZIR ANTIFOLATOS"<D>. A presente invenção refere-se a uma série de novos sais de cátion de metal de ácido sulfónico de fórmula (I), que são intermediários utilizáveis para preparar antifolato pirrolo[2,3-d] pirimidinas 5-substituídas. A presente invenção também se refere a um novo processo para preparar os sais de cátion de metal de ácido sulfónico e a um novo processo para preparar aldeídos de fórmula (II) dos sais de cátion de metal de ácido sulfónico correspondentes.
BR9812524-9A 1997-09-26 1998-09-18 Processos e intermediários utilizáveis para produzir antifolatos BR9812524A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9303997P 1997-09-26 1997-09-26
US93838597A 1997-09-26 1997-09-26
PCT/US1998/019560 WO1999016742A1 (en) 1997-09-26 1998-09-18 Processes and intermediates useful to make antifolates

Publications (1)

Publication Number Publication Date
BR9812524A true BR9812524A (pt) 2000-07-25

Family

ID=26786718

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812524-9A BR9812524A (pt) 1997-09-26 1998-09-18 Processos e intermediários utilizáveis para produzir antifolatos

Country Status (18)

Country Link
US (1) US6013828A (pt)
JP (1) JP2001518459A (pt)
KR (1) KR20010030712A (pt)
CN (2) CN1246295C (pt)
AU (1) AU740087B2 (pt)
BR (1) BR9812524A (pt)
CA (1) CA2304656A1 (pt)
CZ (1) CZ301563B6 (pt)
EA (1) EA002452B3 (pt)
HU (1) HUP0003954A3 (pt)
ID (1) ID24165A (pt)
IL (1) IL135190A (pt)
NO (2) NO314456B1 (pt)
NZ (1) NZ503600A (pt)
PL (1) PL196216B1 (pt)
TR (1) TR200001220T2 (pt)
UA (1) UA53742C2 (pt)
WO (1) WO1999016742A1 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6890800A (en) * 1999-08-23 2001-03-19 Eli Lilly And Company A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-D]- pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor
JP4846158B2 (ja) * 2000-02-25 2011-12-28 イーライ リリー アンド カンパニー Ｎ−［４−［２−（２−アミノ−４，７−ジヒドロ−４−オキソ−３Ｈ−ピロロ［２，３−ｄ］ピリミジン−５−イル）エチル］ベンゾイル］−Ｌ−グルタミン酸の新規結晶形およびその製造方法
CN100379729C (zh) * 2006-04-06 2008-04-09 海南天源康泽医药科技有限公司 硝基化合物及其在培美曲塞制备中的应用
WO2008021410A2 (en) * 2006-08-14 2008-02-21 Sicor Inc. Highly pure pemetrexed diacid and processes for the preparation thereof
EP2311838A1 (en) * 2006-08-14 2011-04-20 Sicor, Inc. Crystalline form of pemetrexed diacid and process for the preparation thereof
EP2129674A2 (en) * 2007-04-03 2009-12-09 Dr. Reddy's Laboratories Ltd. Solid forms of pemetrexed
CN101417998B (zh) 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
CN101591247B (zh) * 2008-05-30 2012-09-05 上海希迪制药有限公司 合成4-(4-甲酯基苯基)丁醛的方法
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
EP2504341A1 (en) 2009-11-24 2012-10-03 Azad Pharmaceutical Ingredients AG A new crystalline form of pemetrexed disodium
IT1401677B1 (it) * 2010-07-22 2013-08-02 Chemi Spa Nuovo processo per la sintesi di pemetrexed sale disodico
RU2552519C2 (ru) * 2010-08-02 2015-06-10 Неон Лэборэторис Лтд. Способ получения высокочистого диалкилпеметрекседа
WO2012111027A2 (en) * 2011-02-15 2012-08-23 Hetero Research Foundation Process for pemetrexed disodium
US9051322B2 (en) 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
KR101767713B1 (ko) 2011-03-25 2017-08-11 시노팜 타이완 리미티드 페메트렉세드 염의 제조 방법
WO2012150280A2 (en) 2011-05-05 2012-11-08 Lonza Ltd Preparation of 4,4-dialkoxy-1-buten-1-ylarenes
CN102887902B (zh) * 2012-10-10 2015-05-20 北京莱瑞森医药科技有限公司 一种合成高纯度培美酸的制备工艺
CN102911176B (zh) * 2012-10-10 2015-07-22 德州德药制药有限公司 一种培美曲塞二钠的制备方法
KR101578093B1 (ko) * 2013-09-05 2015-12-16 주식회사 삼양바이오팜 고순도 페메트렉세드 제조를 위한 향상된 중간체 제조 방법 및 이를 사용하여 고순도 페메트렉세드를 제조하는 방법
NZ630292A (en) 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
CN104817563B (zh) * 2015-05-11 2017-10-27 宁波美诺华药业股份有限公司 培美曲塞‑n,n‑二苄基乙二胺盐的制备方法
CN109836425B (zh) * 2017-11-24 2023-01-24 江苏创诺制药有限公司 一种合成培美酸的制备工艺
CN109721604B (zh) * 2019-01-25 2021-03-23 南京亚东启天药业有限公司 培美曲塞酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
CZ283281B6 (cs) * 1992-09-25 1998-02-18 Eli Lilly And Company Způsob přípravy v poloze 5 substituovaných pyrrolo(2,3-d)pyrimidinů
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
CZ283345B6 (cs) * 1993-05-24 1998-03-18 Eli Lilly And Company Způsob přípravy v poloze 5 substituovaného derivátu pyrrolo [2,3-d]pyrimidinu

Also Published As

Publication number Publication date
CN1246295C (zh) 2006-03-22
EA002452B3 (ru) 2018-02-28
CN1271338A (zh) 2000-10-25
EA200000359A1 (ru) 2000-10-30
AU740087B2 (en) 2001-11-01
CZ301563B6 (cs) 2010-04-14
NZ503600A (en) 2001-08-31
IL135190A (en) 2005-03-20
PL339452A1 (en) 2000-12-18
CN1475477A (zh) 2004-02-18
NO2005007I2 (no) 2008-02-11
ID24165A (id) 2000-07-13
EA002452B1 (ru) 2002-04-25
NO20001554L (no) 2000-05-24
WO1999016742A1 (en) 1999-04-08
KR20010030712A (ko) 2001-04-16
CA2304656A1 (en) 1999-04-08
HUP0003954A3 (en) 2002-12-28
NO2005007I1 (no) 2005-04-04
AU9493798A (en) 1999-04-23
PL196216B1 (pl) 2007-12-31
US6013828A (en) 2000-01-11
IL135190A0 (en) 2001-05-20
UA53742C2 (uk) 2003-02-17
TR200001220T2 (tr) 2001-05-21
NO20001554D0 (no) 2000-03-24
CN1213998C (zh) 2005-08-10
HUP0003954A2 (hu) 2001-09-28
NO314456B1 (no) 2003-03-24
JP2001518459A (ja) 2001-10-16

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI.