NO2005007I1 - Pemetrexed og farmasoytisk akseptable salter derav - Google Patents

Pemetrexed og farmasoytisk akseptable salter derav

Info

Publication number
NO2005007I1
NO2005007I1 NO2005007C NO2005007C NO2005007I1 NO 2005007 I1 NO2005007 I1 NO 2005007I1 NO 2005007 C NO2005007 C NO 2005007C NO 2005007 C NO2005007 C NO 2005007C NO 2005007 I1 NO2005007 I1 NO 2005007I1
Authority
NO
Norway
Prior art keywords
pemetrexed
pharmaceutically acceptable
acceptable salts
salts
pharmaceutically
Prior art date
Application number
NO2005007C
Other languages
English (en)
Other versions
NO2005007I2 (no
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26786718&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2005007(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO2005007I1 publication Critical patent/NO2005007I1/no
Publication of NO2005007I2 publication Critical patent/NO2005007I2/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Cephalosporin Compounds (AREA)
NO2005007C 1997-09-26 2005-03-17 Pemetrexed og farmasoytisk akseptable salter derav NO2005007I2 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93838597A 1997-09-26 1997-09-26
US9303997P 1997-09-26 1997-09-26
PCT/US1998/019560 WO1999016742A1 (en) 1997-09-26 1998-09-18 Processes and intermediates useful to make antifolates

Publications (2)

Publication Number Publication Date
NO2005007I1 true NO2005007I1 (no) 2005-04-04
NO2005007I2 NO2005007I2 (no) 2008-02-11

Family

ID=26786718

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20001554A NO314456B1 (no) 1997-09-26 2000-03-24 Fremgangsmåter og mellomprodukter nyttige for å fremstille antifolater
NO2005007C NO2005007I2 (no) 1997-09-26 2005-03-17 Pemetrexed og farmasoytisk akseptable salter derav

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20001554A NO314456B1 (no) 1997-09-26 2000-03-24 Fremgangsmåter og mellomprodukter nyttige for å fremstille antifolater

Country Status (18)

Country Link
US (1) US6013828A (no)
JP (1) JP2001518459A (no)
KR (1) KR20010030712A (no)
CN (2) CN1246295C (no)
AU (1) AU740087B2 (no)
BR (1) BR9812524A (no)
CA (1) CA2304656A1 (no)
CZ (1) CZ301563B6 (no)
EA (1) EA002452B3 (no)
HU (1) HUP0003954A3 (no)
ID (1) ID24165A (no)
IL (1) IL135190A (no)
NO (2) NO314456B1 (no)
NZ (1) NZ503600A (no)
PL (1) PL196216B1 (no)
TR (1) TR200001220T2 (no)
UA (1) UA53742C2 (no)
WO (1) WO1999016742A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001014379A2 (en) * 1999-08-23 2001-03-01 Eli Lilly And Company A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor
JP4846158B2 (ja) * 2000-02-25 2011-12-28 イーライ リリー アンド カンパニー Ｎ−［４−［２−（２−アミノ−４，７−ジヒドロ−４−オキソ−３Ｈ−ピロロ［２，３−ｄ］ピリミジン−５−イル）エチル］ベンゾイル］−Ｌ−グルタミン酸の新規結晶形およびその製造方法
CN100379729C (zh) * 2006-04-06 2008-04-09 海南天源康泽医药科技有限公司 硝基化合物及其在培美曲塞制备中的应用
WO2008021405A1 (en) * 2006-08-14 2008-02-21 Sicor Inc. Crystalline forms of pemetrexed diacid and processes for the preparation thereof
WO2008021410A2 (en) * 2006-08-14 2008-02-21 Sicor Inc. Highly pure pemetrexed diacid and processes for the preparation thereof
EP2129674A2 (en) * 2007-04-03 2009-12-09 Dr. Reddy's Laboratories Ltd. Solid forms of pemetrexed
CN101417998B (zh) 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
CN101591247B (zh) * 2008-05-30 2012-09-05 上海希迪制药有限公司 合成4-(4-甲酯基苯基)丁醛的方法
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
WO2011064256A1 (en) 2009-11-24 2011-06-03 Azad Pharmaceutical Ingredients Ag A new crystalline form of pemetrexed disodium
IT1401677B1 (it) * 2010-07-22 2013-08-02 Chemi Spa Nuovo processo per la sintesi di pemetrexed sale disodico
WO2012017443A1 (en) 2010-08-02 2012-02-09 Neon Laboratories Ltd. Process for preparation of highly pure dialkyl pemetrexed
WO2012111027A2 (en) * 2011-02-15 2012-08-23 Hetero Research Foundation Process for pemetrexed disodium
US9051322B2 (en) 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
ES2639639T3 (es) 2011-03-25 2017-10-27 Scinopharm Taiwan, Ltd. Proceso para la producción de pemetrexed disódico
TW201307276A (zh) 2011-05-05 2013-02-16 Lonza Ag 製備４，４－二烷氧基－１－丁烯－１－基芳烴
CN102911176B (zh) * 2012-10-10 2015-07-22 德州德药制药有限公司 一种培美曲塞二钠的制备方法
CN102887902B (zh) * 2012-10-10 2015-05-20 北京莱瑞森医药科技有限公司 一种合成高纯度培美酸的制备工艺
KR101578093B1 (ko) * 2013-09-05 2015-12-16 주식회사 삼양바이오팜 고순도 페메트렉세드 제조를 위한 향상된 중간체 제조 방법 및 이를 사용하여 고순도 페메트렉세드를 제조하는 방법
NZ630292A (en) 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
CN104817563B (zh) * 2015-05-11 2017-10-27 宁波美诺华药业股份有限公司 培美曲塞‑n,n‑二苄基乙二胺盐的制备方法
CN109836425B (zh) * 2017-11-24 2023-01-24 江苏创诺制药有限公司 一种合成培美酸的制备工艺
CN109721604B (zh) * 2019-01-25 2021-03-23 南京亚东启天药业有限公司 培美曲塞酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
IL107041A (en) * 1992-09-25 2000-02-17 Lilly Co Eli Process for preparing omega(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo-6-¬2,3-d¾pyrimidin-5-YL)alkarylcarboxylic acids and N-(omega-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo¬2,3-d¾pyrimidin-5-YL)alk-aroyl-4-glutamic acids
CZ283345B6 (cs) * 1993-05-24 1998-03-18 Eli Lilly And Company Způsob přípravy v poloze 5 substituovaného derivátu pyrrolo [2,3-d]pyrimidinu

Also Published As

Publication number Publication date
AU9493798A (en) 1999-04-23
US6013828A (en) 2000-01-11
EA002452B1 (ru) 2002-04-25
CN1271338A (zh) 2000-10-25
AU740087B2 (en) 2001-11-01
CN1475477A (zh) 2004-02-18
BR9812524A (pt) 2000-07-25
IL135190A0 (en) 2001-05-20
CA2304656A1 (en) 1999-04-08
ID24165A (id) 2000-07-13
KR20010030712A (ko) 2001-04-16
WO1999016742A1 (en) 1999-04-08
PL339452A1 (en) 2000-12-18
CN1213998C (zh) 2005-08-10
EA002452B3 (ru) 2018-02-28
HUP0003954A3 (en) 2002-12-28
NZ503600A (en) 2001-08-31
NO314456B1 (no) 2003-03-24
NO2005007I2 (no) 2008-02-11
TR200001220T2 (tr) 2001-05-21
IL135190A (en) 2005-03-20
CZ301563B6 (cs) 2010-04-14
JP2001518459A (ja) 2001-10-16
HUP0003954A2 (hu) 2001-09-28
NO20001554L (no) 2000-05-24
NO20001554D0 (no) 2000-03-24
UA53742C2 (uk) 2003-02-17
EA200000359A1 (ru) 2000-10-30
PL196216B1 (pl) 2007-12-31
CN1246295C (zh) 2006-03-22

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