ID24165A - Proses-proses dan zat antara untuk membuat antifolat - Google Patents
Proses-proses dan zat antara untuk membuat antifolatInfo
- Publication number
- ID24165A ID24165A IDW20000531A ID20000531A ID24165A ID 24165 A ID24165 A ID 24165A ID W20000531 A IDW20000531 A ID W20000531A ID 20000531 A ID20000531 A ID 20000531A ID 24165 A ID24165 A ID 24165A
- Authority
- ID
- Indonesia
- Prior art keywords
- substance
- processes
- antifolates
- make
- make antifolates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9303997P | 1997-09-26 | 1997-09-26 | |
US93838597A | 1997-09-26 | 1997-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ID24165A true ID24165A (id) | 2000-07-13 |
Family
ID=26786718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW20000531A ID24165A (id) | 1997-09-26 | 1998-09-18 | Proses-proses dan zat antara untuk membuat antifolat |
Country Status (18)
Country | Link |
---|---|
US (1) | US6013828A (id) |
JP (1) | JP2001518459A (id) |
KR (1) | KR20010030712A (id) |
CN (2) | CN1246295C (id) |
AU (1) | AU740087B2 (id) |
BR (1) | BR9812524A (id) |
CA (1) | CA2304656A1 (id) |
CZ (1) | CZ301563B6 (id) |
EA (1) | EA002452B3 (id) |
HU (1) | HUP0003954A3 (id) |
ID (1) | ID24165A (id) |
IL (1) | IL135190A (id) |
NO (2) | NO314456B1 (id) |
NZ (1) | NZ503600A (id) |
PL (1) | PL196216B1 (id) |
TR (1) | TR200001220T2 (id) |
UA (1) | UA53742C2 (id) |
WO (1) | WO1999016742A1 (id) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6890800A (en) * | 1999-08-23 | 2001-03-19 | Eli Lilly And Company | A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-D]- pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor |
CZ303772B6 (cs) * | 2000-02-25 | 2013-05-02 | Eli Lilly And Company | Heptahydrátová krystalická forma disodné soli N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-benzoyl]L-glutamové kyseliny a zpusob její prípravy |
CN100379729C (zh) * | 2006-04-06 | 2008-04-09 | 海南天源康泽医药科技有限公司 | 硝基化合物及其在培美曲塞制备中的应用 |
EP1934226A2 (en) * | 2006-08-14 | 2008-06-25 | Sicor, Inc. | Highly pure pemetrexed diacid and processes for the preparation thereof |
EP2322526A1 (en) * | 2006-08-14 | 2011-05-18 | Sicor, Inc. | Crystalline form of pemetrexed diacid and process for the preparation thereof |
JP2010523589A (ja) * | 2007-04-03 | 2010-07-15 | ドクター レディズ ラボラトリーズ リミテッド | ペメトレキセドの固体形 |
CN101417998B (zh) | 2007-10-24 | 2012-10-24 | 重庆医药工业研究院有限责任公司 | 一种培美曲塞盐的纯化方法 |
CN101591247B (zh) * | 2008-05-30 | 2012-09-05 | 上海希迪制药有限公司 | 合成4-(4-甲酯基苯基)丁醛的方法 |
CN101684121B (zh) * | 2008-09-22 | 2013-04-03 | 重庆医药工业研究院有限责任公司 | 培美曲塞二酸的新晶型及其制备方法 |
US9174991B2 (en) | 2009-11-24 | 2015-11-03 | Azad Pharmaceutical Ingredients Ag | Crystalline form of pemetrexed disodium |
IT1401677B1 (it) * | 2010-07-22 | 2013-08-02 | Chemi Spa | Nuovo processo per la sintesi di pemetrexed sale disodico |
UA105580C2 (uk) * | 2010-08-02 | 2014-05-26 | Неон Лабораторіс Лтд. | Спосіб одержання діалкілпеметрекседу високої чистоти |
EP2675808A4 (en) * | 2011-02-15 | 2014-07-09 | Hetero Research Foundation | PROCESS FOR OBTAINING DISODIUM PEMETREXED |
US9051322B2 (en) | 2011-03-23 | 2015-06-09 | Scinopharm Taiwan, Ltd. | Process for the production of a pemetrexed salt |
AU2011363636B2 (en) * | 2011-03-25 | 2016-03-17 | Scinopharm Taiwan Ltd | Process for the production of a pemetrexed salt |
TW201307276A (zh) | 2011-05-05 | 2013-02-16 | Lonza Ag | 製備4,4-二烷氧基-1-丁烯-1-基芳烴 |
CN102887902B (zh) * | 2012-10-10 | 2015-05-20 | 北京莱瑞森医药科技有限公司 | 一种合成高纯度培美酸的制备工艺 |
CN102911176B (zh) * | 2012-10-10 | 2015-07-22 | 德州德药制药有限公司 | 一种培美曲塞二钠的制备方法 |
KR101578093B1 (ko) * | 2013-09-05 | 2015-12-16 | 주식회사 삼양바이오팜 | 고순도 페메트렉세드 제조를 위한 향상된 중간체 제조 방법 및 이를 사용하여 고순도 페메트렉세드를 제조하는 방법 |
NZ630292A (en) | 2013-11-25 | 2015-02-27 | Shilpa Medicare Ltd | Process for crystalline pemetrexed dipotassium salt |
CN104817563B (zh) * | 2015-05-11 | 2017-10-27 | 宁波美诺华药业股份有限公司 | 培美曲塞‑n,n‑二苄基乙二胺盐的制备方法 |
CN109836425B (zh) * | 2017-11-24 | 2023-01-24 | 江苏创诺制药有限公司 | 一种合成培美酸的制备工艺 |
CN109721604B (zh) * | 2019-01-25 | 2021-03-23 | 南京亚东启天药业有限公司 | 培美曲塞酸的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4895946A (en) * | 1987-10-26 | 1990-01-23 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
NO169490C (no) * | 1988-03-24 | 1992-07-01 | Takeda Chemical Industries Ltd | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater |
JP2983254B2 (ja) * | 1989-06-14 | 1999-11-29 | 武田薬品工業株式会社 | ピロロ〔2,3―d〕ピリミジン誘導体の製造法およびその中間体 |
EP0438261A3 (en) * | 1990-01-16 | 1992-02-26 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic glutamic acid derivatives, their production and use |
IL107041A (en) * | 1992-09-25 | 2000-02-17 | Lilly Co Eli | Process for preparing omega(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo-6-¬2,3-d¾pyrimidin-5-YL)alkarylcarboxylic acids and N-(omega-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo¬2,3-d¾pyrimidin-5-YL)alk-aroyl-4-glutamic acids |
US5416211A (en) * | 1992-09-25 | 1995-05-16 | Eli Lilly And Company | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines |
CZ283345B6 (cs) * | 1993-05-24 | 1998-03-18 | Eli Lilly And Company | Způsob přípravy v poloze 5 substituovaného derivátu pyrrolo [2,3-d]pyrimidinu |
-
1998
- 1998-09-18 CA CA002304656A patent/CA2304656A1/en not_active Abandoned
- 1998-09-18 CZ CZ20050764A patent/CZ301563B6/cs not_active IP Right Cessation
- 1998-09-18 AU AU94937/98A patent/AU740087B2/en not_active Ceased
- 1998-09-18 BR BR9812524-9A patent/BR9812524A/pt not_active Application Discontinuation
- 1998-09-18 PL PL339452A patent/PL196216B1/pl unknown
- 1998-09-18 NZ NZ503600A patent/NZ503600A/en unknown
- 1998-09-18 ID IDW20000531A patent/ID24165A/id unknown
- 1998-09-18 JP JP2000513828A patent/JP2001518459A/ja active Pending
- 1998-09-18 TR TR2000/01220T patent/TR200001220T2/xx unknown
- 1998-09-18 WO PCT/US1998/019560 patent/WO1999016742A1/en not_active Application Discontinuation
- 1998-09-18 KR KR1020007003219A patent/KR20010030712A/ko not_active Application Discontinuation
- 1998-09-18 UA UA2000031700A patent/UA53742C2/uk unknown
- 1998-09-18 IL IL13519098A patent/IL135190A/xx active IP Right Grant
- 1998-09-18 CN CNB031490409A patent/CN1246295C/zh not_active Expired - Fee Related
- 1998-09-18 EA EA200000359A patent/EA002452B3/ru not_active IP Right Cessation
- 1998-09-18 CN CNB98809553XA patent/CN1213998C/zh not_active Expired - Fee Related
- 1998-09-18 HU HU0003954A patent/HUP0003954A3/hu unknown
- 1998-09-24 US US09/160,129 patent/US6013828A/en not_active Expired - Fee Related
-
2000
- 2000-03-24 NO NO20001554A patent/NO314456B1/no not_active Application Discontinuation
-
2005
- 2005-03-17 NO NO2005007C patent/NO2005007I2/no unknown
Also Published As
Publication number | Publication date |
---|---|
EA200000359A1 (ru) | 2000-10-30 |
EA002452B1 (ru) | 2002-04-25 |
CZ301563B6 (cs) | 2010-04-14 |
PL196216B1 (pl) | 2007-12-31 |
UA53742C2 (uk) | 2003-02-17 |
NO20001554D0 (no) | 2000-03-24 |
NO20001554L (no) | 2000-05-24 |
US6013828A (en) | 2000-01-11 |
JP2001518459A (ja) | 2001-10-16 |
NO314456B1 (no) | 2003-03-24 |
WO1999016742A1 (en) | 1999-04-08 |
CN1246295C (zh) | 2006-03-22 |
KR20010030712A (ko) | 2001-04-16 |
NZ503600A (en) | 2001-08-31 |
CN1271338A (zh) | 2000-10-25 |
IL135190A0 (en) | 2001-05-20 |
EA002452B3 (ru) | 2018-02-28 |
TR200001220T2 (tr) | 2001-05-21 |
PL339452A1 (en) | 2000-12-18 |
CN1213998C (zh) | 2005-08-10 |
AU9493798A (en) | 1999-04-23 |
NO2005007I2 (no) | 2008-02-11 |
BR9812524A (pt) | 2000-07-25 |
HUP0003954A3 (en) | 2002-12-28 |
NO2005007I1 (no) | 2005-04-04 |
CA2304656A1 (en) | 1999-04-08 |
AU740087B2 (en) | 2001-11-01 |
HUP0003954A2 (hu) | 2001-09-28 |
CN1475477A (zh) | 2004-02-18 |
IL135190A (en) | 2005-03-20 |
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