ID22873A - Senyawa-senyawa heterosiklik dan pemakaiannya untuk menginhibisi b-amyloid peptida - Google Patents
Senyawa-senyawa heterosiklik dan pemakaiannya untuk menginhibisi b-amyloid peptidaInfo
- Publication number
- ID22873A ID22873A IDW990811A ID990811A ID22873A ID 22873 A ID22873 A ID 22873A ID W990811 A IDW990811 A ID W990811A ID 990811 A ID990811 A ID 990811A ID 22873 A ID22873 A ID 22873A
- Authority
- ID
- Indonesia
- Prior art keywords
- heterosiclic
- initiate
- compounds
- amyloid peptides
- amyloid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80826397A | 1997-02-28 | 1997-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID22873A true ID22873A (id) | 1999-12-16 |
Family
ID=25198310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDW990811A ID22873A (id) | 1997-02-28 | 1998-02-27 | Senyawa-senyawa heterosiklik dan pemakaiannya untuk menginhibisi b-amyloid peptida |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0968198A1 (id) |
| JP (1) | JP2001513107A (id) |
| KR (1) | KR20000075767A (id) |
| CN (1) | CN1253554A (id) |
| AR (1) | AR011164A1 (id) |
| AU (1) | AU6662298A (id) |
| BR (1) | BR9807876A (id) |
| CA (1) | CA2278674A1 (id) |
| CO (1) | CO4920244A1 (id) |
| EA (1) | EA199900778A1 (id) |
| HR (1) | HRP980093A2 (id) |
| HU (1) | HUP0001293A3 (id) |
| ID (1) | ID22873A (id) |
| IL (1) | IL130851A0 (id) |
| NO (1) | NO994016L (id) |
| NZ (1) | NZ336613A (id) |
| PE (1) | PE59399A1 (id) |
| PL (1) | PL335424A1 (id) |
| TR (1) | TR199902071T2 (id) |
| WO (1) | WO1998038177A1 (id) |
| YU (1) | YU7998A (id) |
| ZA (1) | ZA981627B (id) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| BR9812773A (pt) * | 1997-12-22 | 2000-10-10 | Elan Pharm Inc | "alfa-amino-epsilon-caprolactamas policìclicas e compostos relacionados" |
| JP2002518481A (ja) * | 1998-06-22 | 2002-06-25 | エラン ファーマシューティカルズ，インコーポレイテッド | β−アミロイドペプチドの放出および／またはその合成を阻害するための化合物 |
| US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6528505B1 (en) | 1998-06-22 | 2003-03-04 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6569851B1 (en) | 1998-06-22 | 2003-05-27 | Elan Pharmaceutials, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6774125B2 (en) | 1998-06-22 | 2004-08-10 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
| EP1159273A1 (en) | 1999-03-02 | 2001-12-05 | Boehringer Ingelheim Pharmaceuticals Inc. | Compounds useful as reversible inhibitors of cathepsin s |
| US7160880B1 (en) | 1999-05-14 | 2007-01-09 | Cenes Limited | Short-acting benzodiazepines |
| GB9911803D0 (en) * | 1999-05-20 | 1999-07-21 | Merck Sharp & Dohme | Therapeutic combination |
| JP2003506440A (ja) * | 1999-08-05 | 2003-02-18 | プレサイエント ニューロファーマ インコーポレイテッド | 中枢神経系に関連する疾患の処置のための１，４−ジアゼピン誘導体 |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| US6878363B2 (en) | 2000-05-17 | 2005-04-12 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
| WO2001092235A1 (en) | 2000-06-01 | 2001-12-06 | Bristol-Myers Squibb Pharma Company | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
| DE10029077A1 (de) * | 2000-06-13 | 2001-12-20 | Bayer Ag | Thiazolylsubstituierte Heterocyclen |
| US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
| AR039059A1 (es) * | 2001-08-06 | 2005-02-09 | Sanofi Aventis | Compuesto derivado de acilaminotiazol, su utilizacion, procedimientos para prepararlo, composicion farmaceutica que lo comprende, y compuestos intermediarios |
| FR2840899B1 (fr) * | 2002-06-12 | 2005-02-25 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique |
| EP1550725A4 (en) | 2002-06-05 | 2010-08-25 | Kaneka Corp | PROCESS FOR PRODUCING OPTICALLY ACTIVE alpha-METHYLCYSTEINE DERIVATIVE |
| ES2376108T3 (es) | 2004-09-17 | 2012-03-09 | Whitehead Institute For Biomedical Research | Compuestos, composiciones y método para inhibir la toxicidad de la a-sinucleina. |
| US7449486B2 (en) | 2004-10-19 | 2008-11-11 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| UA95907C2 (en) | 2005-05-02 | 2011-09-26 | Эррей Биофарма Инк. | Mitotic kinesin inhibitors and methods of use thereof |
| EP1757290A1 (en) | 2005-08-16 | 2007-02-28 | Zentaris GmbH | Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors |
| JP2010505870A (ja) | 2006-10-03 | 2010-02-25 | アレイ バイオファーマ、インコーポレイテッド | 有糸分裂キネシン阻害剤としてのオキサジアゾール誘導体およびチアジアゾール誘導体、ならびにそれらの使用方法 |
| WO2010006792A1 (de) * | 2008-07-16 | 2010-01-21 | Bitop Ag | Synthese von zyklischen amidinen |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| EP2560488B1 (en) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| EP2431035A1 (en) | 2010-09-16 | 2012-03-21 | Æterna Zentaris GmbH | Novel Triazole Derivatives with Improved Receptor Activity and Bioavailability Properties as Ghrelin Antagonists of Growth Hormone Secretagogue Receptors |
| US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
| US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
| CN103435549A (zh) * | 2013-08-14 | 2013-12-11 | 无锡惠飞生物医药技术有限公司 | 5-甲基-7-氨基-5H,7H-二苯并[b,d]氮杂环庚-6-酮的制备方法 |
| CN105646208B (zh) * | 2016-02-24 | 2018-10-16 | 潍坊晶润化工股份有限公司 | 丙酮酸甲酯的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2221684A1 (en) * | 1995-06-06 | 1996-12-12 | Athena Neurosciences, Inc. | Novel cathepsin and methods and compositions for inhibition thereof |
-
1998
- 1998-02-24 HR HR08/808,236A patent/HRP980093A2/hr not_active Application Discontinuation
- 1998-02-24 AR ARP980100812A patent/AR011164A1/es unknown
- 1998-02-26 ZA ZA9801627A patent/ZA981627B/xx unknown
- 1998-02-27 WO PCT/US1998/003373 patent/WO1998038177A1/en not_active Application Discontinuation
- 1998-02-27 YU YU7998A patent/YU7998A/sh unknown
- 1998-02-27 CA CA002278674A patent/CA2278674A1/en not_active Abandoned
- 1998-02-27 PE PE1998000144A patent/PE59399A1/es not_active Application Discontinuation
- 1998-02-27 BR BR9807876-3A patent/BR9807876A/pt not_active IP Right Cessation
- 1998-02-27 HU HU0001293A patent/HUP0001293A3/hu unknown
- 1998-02-27 EP EP98908637A patent/EP0968198A1/en not_active Withdrawn
- 1998-02-27 ID IDW990811A patent/ID22873A/id unknown
- 1998-02-27 AU AU66622/98A patent/AU6662298A/en not_active Abandoned
- 1998-02-27 KR KR1019997007839A patent/KR20000075767A/ko not_active Application Discontinuation
- 1998-02-27 EA EA199900778A patent/EA199900778A1/ru unknown
- 1998-02-27 CN CN98802875A patent/CN1253554A/zh active Pending
- 1998-02-27 JP JP53773298A patent/JP2001513107A/ja active Pending
- 1998-02-27 CO CO98010854A patent/CO4920244A1/es unknown
- 1998-02-27 NZ NZ336613A patent/NZ336613A/en unknown
- 1998-02-27 PL PL98335424A patent/PL335424A1/xx unknown
- 1998-02-27 TR TR1999/02071T patent/TR199902071T2/xx unknown
- 1998-02-27 IL IL13085198A patent/IL130851A0/xx unknown
-
1999
- 1999-08-19 NO NO994016A patent/NO994016L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TR199902071T2 (xx) | 2000-01-21 |
| PE59399A1 (es) | 1999-06-21 |
| AU6662298A (en) | 1998-09-18 |
| NO994016L (no) | 1999-10-18 |
| WO1998038177A1 (en) | 1998-09-03 |
| NO994016D0 (no) | 1999-08-19 |
| CO4920244A1 (es) | 2000-05-29 |
| EA199900778A1 (ru) | 2000-04-24 |
| AR011164A1 (es) | 2000-08-02 |
| IL130851A0 (en) | 2001-01-28 |
| JP2001513107A (ja) | 2001-08-28 |
| HUP0001293A1 (hu) | 2000-08-28 |
| PL335424A1 (en) | 2000-04-25 |
| BR9807876A (pt) | 2000-02-29 |
| ZA981627B (en) | 1999-10-05 |
| CN1253554A (zh) | 2000-05-17 |
| HRP980093A2 (en) | 1998-12-31 |
| YU7998A (sh) | 2002-06-19 |
| KR20000075767A (ko) | 2000-12-26 |
| EP0968198A1 (en) | 2000-01-05 |
| HUP0001293A3 (en) | 2000-09-28 |
| CA2278674A1 (en) | 1998-09-03 |
| NZ336613A (en) | 2001-10-26 |
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