PL335424A1 - Heterocyclic compounds and their application in inhibiting beta-amyloid peptide secretion - Google Patents
Heterocyclic compounds and their application in inhibiting beta-amyloid peptide secretionInfo
- Publication number
- PL335424A1 PL335424A1 PL98335424A PL33542498A PL335424A1 PL 335424 A1 PL335424 A1 PL 335424A1 PL 98335424 A PL98335424 A PL 98335424A PL 33542498 A PL33542498 A PL 33542498A PL 335424 A1 PL335424 A1 PL 335424A1
- Authority
- PL
- Poland
- Prior art keywords
- application
- heterocyclic compounds
- amyloid peptide
- peptide secretion
- inhibiting beta
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80826397A | 1997-02-28 | 1997-02-28 | |
| PCT/US1998/003373 WO1998038177A1 (en) | 1997-02-28 | 1998-02-27 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR INHIBITING β-AMYLOID PEPTIDE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL335424A1 true PL335424A1 (en) | 2000-04-25 |
Family
ID=25198310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL98335424A PL335424A1 (en) | 1997-02-28 | 1998-02-27 | Heterocyclic compounds and their application in inhibiting beta-amyloid peptide secretion |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0968198A1 (en) |
| JP (1) | JP2001513107A (en) |
| KR (1) | KR20000075767A (en) |
| CN (1) | CN1253554A (en) |
| AR (1) | AR011164A1 (en) |
| AU (1) | AU6662298A (en) |
| BR (1) | BR9807876A (en) |
| CA (1) | CA2278674A1 (en) |
| CO (1) | CO4920244A1 (en) |
| EA (1) | EA199900778A1 (en) |
| HR (1) | HRP980093A2 (en) |
| HU (1) | HUP0001293A3 (en) |
| ID (1) | ID22873A (en) |
| IL (1) | IL130851A0 (en) |
| NO (1) | NO994016L (en) |
| NZ (1) | NZ336613A (en) |
| PE (1) | PE59399A1 (en) |
| PL (1) | PL335424A1 (en) |
| TR (1) | TR199902071T2 (en) |
| WO (1) | WO1998038177A1 (en) |
| YU (1) | YU7998A (en) |
| ZA (1) | ZA981627B (en) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| BR9812773A (en) * | 1997-12-22 | 2000-10-10 | Elan Pharm Inc | "polycyclic alpha-amino-epsilon-caprolactams and related compounds" |
| US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6774125B2 (en) | 1998-06-22 | 2004-08-10 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| AU4707999A (en) * | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6528505B1 (en) | 1998-06-22 | 2003-03-04 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6569851B1 (en) | 1998-06-22 | 2003-05-27 | Elan Pharmaceutials, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
| JP2002538151A (en) | 1999-03-02 | 2002-11-12 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | Compounds useful as reversible inhibitors of cathepsin |
| US7160880B1 (en) | 1999-05-14 | 2007-01-09 | Cenes Limited | Short-acting benzodiazepines |
| GB9911803D0 (en) * | 1999-05-20 | 1999-07-21 | Merck Sharp & Dohme | Therapeutic combination |
| EP1210338A2 (en) * | 1999-08-05 | 2002-06-05 | IGT Pharma Inc. | 1,4-diazepine derivatives for the treatment of diseases related to the central nervous system |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| US6878363B2 (en) | 2000-05-17 | 2005-04-12 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
| MXPA02000862A (en) | 2000-06-01 | 2003-07-14 | Bristol Myers Squibb Pharma Co | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abgr; PROTEIN PRODUCTION. |
| DE10029077A1 (en) * | 2000-06-13 | 2001-12-20 | Bayer Ag | New heterocyclic-substituted thiazole derivatives, useful as total or selective herbicides, insecticides, acaricides, nematocides, ectoparasiticides or antifouling agents |
| US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
| FR2840899B1 (en) * | 2002-06-12 | 2005-02-25 | Sanofi Synthelabo | ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS |
| AR039059A1 (en) * | 2001-08-06 | 2005-02-09 | Sanofi Aventis | COMPOUND DERIVED FROM ACILAMINOTIAZOL, ITS USE, PROCEDURES TO PREPARE IT, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, AND INTERMEDIARY COMPOUNDS |
| EP1550725A4 (en) | 2002-06-05 | 2010-08-25 | Kaneka Corp | PROCESS FOR PRODUCING OPTICALLY ACTIVE alpha-METHYLCYSTEINE DERIVATIVE |
| EP2433634A3 (en) | 2004-09-17 | 2012-07-18 | The Whitehead Institute for Biomedical Research | Compounds, compositions and methods of inhibiting a-synuclein toxicity |
| US7449486B2 (en) | 2004-10-19 | 2008-11-11 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| UA95907C2 (en) | 2005-05-02 | 2011-09-26 | Эррей Биофарма Инк. | Mitotic kinesin inhibitors and methods of use thereof |
| EP1757290A1 (en) | 2005-08-16 | 2007-02-28 | Zentaris GmbH | Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors |
| US8324257B2 (en) | 2006-10-03 | 2012-12-04 | Array Biopharma Inc. | Mitotic kinesin inhibitors and methods of use thereof |
| US8598346B2 (en) * | 2008-07-16 | 2013-12-03 | Bitop Ag | Synthesis of cyclic amidines |
| EP2560488B1 (en) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| AR081626A1 (en) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS |
| AR081331A1 (en) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME |
| EP2431035A1 (en) | 2010-09-16 | 2012-03-21 | Æterna Zentaris GmbH | Novel Triazole Derivatives with Improved Receptor Activity and Bioavailability Properties as Ghrelin Antagonists of Growth Hormone Secretagogue Receptors |
| US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
| US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
| CN103435549A (en) * | 2013-08-14 | 2013-12-11 | 无锡惠飞生物医药技术有限公司 | 5-methyl-7-amino-5H,7H-dibenzo[b,d]azepin-6-ketone preparation method |
| CN105646208B (en) * | 2016-02-24 | 2018-10-16 | 潍坊晶润化工股份有限公司 | The preparation method of methyl pyruvate |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0831920A4 (en) * | 1995-06-06 | 2003-03-19 | Athena Neurosciences Inc | Novel cathepsin and methods and compositions for inhibition thereof |
-
1998
- 1998-02-24 AR ARP980100812A patent/AR011164A1/en unknown
- 1998-02-24 HR HR08/808,236A patent/HRP980093A2/en not_active Application Discontinuation
- 1998-02-26 ZA ZA9801627A patent/ZA981627B/en unknown
- 1998-02-27 IL IL13085198A patent/IL130851A0/en unknown
- 1998-02-27 PL PL98335424A patent/PL335424A1/en unknown
- 1998-02-27 WO PCT/US1998/003373 patent/WO1998038177A1/en not_active Application Discontinuation
- 1998-02-27 BR BR9807876-3A patent/BR9807876A/en not_active IP Right Cessation
- 1998-02-27 CN CN98802875A patent/CN1253554A/en active Pending
- 1998-02-27 EA EA199900778A patent/EA199900778A1/en unknown
- 1998-02-27 CO CO98010854A patent/CO4920244A1/en unknown
- 1998-02-27 ID IDW990811A patent/ID22873A/en unknown
- 1998-02-27 JP JP53773298A patent/JP2001513107A/en active Pending
- 1998-02-27 YU YU7998A patent/YU7998A/en unknown
- 1998-02-27 NZ NZ336613A patent/NZ336613A/en unknown
- 1998-02-27 PE PE1998000144A patent/PE59399A1/en not_active Application Discontinuation
- 1998-02-27 AU AU66622/98A patent/AU6662298A/en not_active Abandoned
- 1998-02-27 HU HU0001293A patent/HUP0001293A3/en unknown
- 1998-02-27 KR KR1019997007839A patent/KR20000075767A/en not_active Application Discontinuation
- 1998-02-27 EP EP98908637A patent/EP0968198A1/en not_active Withdrawn
- 1998-02-27 TR TR1999/02071T patent/TR199902071T2/en unknown
- 1998-02-27 CA CA002278674A patent/CA2278674A1/en not_active Abandoned
-
1999
- 1999-08-19 NO NO994016A patent/NO994016L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2278674A1 (en) | 1998-09-03 |
| JP2001513107A (en) | 2001-08-28 |
| CN1253554A (en) | 2000-05-17 |
| YU7998A (en) | 2002-06-19 |
| PE59399A1 (en) | 1999-06-21 |
| CO4920244A1 (en) | 2000-05-29 |
| HUP0001293A3 (en) | 2000-09-28 |
| NZ336613A (en) | 2001-10-26 |
| EP0968198A1 (en) | 2000-01-05 |
| NO994016D0 (en) | 1999-08-19 |
| HUP0001293A1 (en) | 2000-08-28 |
| ZA981627B (en) | 1999-10-05 |
| NO994016L (en) | 1999-10-18 |
| KR20000075767A (en) | 2000-12-26 |
| WO1998038177A1 (en) | 1998-09-03 |
| EA199900778A1 (en) | 2000-04-24 |
| ID22873A (en) | 1999-12-16 |
| AU6662298A (en) | 1998-09-18 |
| TR199902071T2 (en) | 2000-01-21 |
| BR9807876A (en) | 2000-02-29 |
| AR011164A1 (en) | 2000-08-02 |
| HRP980093A2 (en) | 1998-12-31 |
| IL130851A0 (en) | 2001-01-28 |
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