BR9907876A - Processos e intermediários úteis para produção de antifolatos - Google Patents

Processos e intermediários úteis para produção de antifolatos

Info

Publication number
BR9907876A
BR9907876A BR9907876-7A BR9907876A BR9907876A BR 9907876 A BR9907876 A BR 9907876A BR 9907876 A BR9907876 A BR 9907876A BR 9907876 A BR9907876 A BR 9907876A
Authority
BR
Brazil
Prior art keywords
processes
antifolates
production
intermediates
intermediates useful
Prior art date
Application number
BR9907876-7A
Other languages
English (en)
Inventor
Charles Jackson Barnett
Steven Eugene Dunlap
Michael Edward Kobierski
John Arnold Werner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9907876A publication Critical patent/BR9907876A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Steroid Compounds (AREA)

Abstract

Patente de Invenção: <B>''PROCESSOS E INTERMEDIáRIOS úTEIS PARA PRODUçãO DE ANTIFOLATOS"<D>. A presente invenção refere-se a intermediários e a processos direcionados a esses intermediários e a partir deles, a uma série de derivados pirimidina de fórmula (V) que são intermediários para compostos antifolato úteis ou são, eles próprios, compostos antifolatos úteis.
BR9907876-7A 1998-02-11 1999-01-27 Processos e intermediários úteis para produção de antifolatos BR9907876A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7432798P 1998-02-11 1998-02-11
PCT/US1999/001689 WO1999041230A1 (en) 1998-02-11 1999-01-27 Processes and intermediates useful to make antifolates

Publications (1)

Publication Number Publication Date
BR9907876A true BR9907876A (pt) 2000-10-31

Family

ID=22118973

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9907876-7A BR9907876A (pt) 1998-02-11 1999-01-27 Processos e intermediários úteis para produção de antifolatos

Country Status (18)

Country Link
US (1) US6426417B1 (pt)
EP (1) EP1054859A4 (pt)
JP (1) JP2002503648A (pt)
KR (1) KR20010040836A (pt)
CN (1) CN1290247A (pt)
AR (1) AR018538A1 (pt)
AU (1) AU739292B2 (pt)
BR (1) BR9907876A (pt)
CA (1) CA2319424A1 (pt)
EA (1) EA002723B1 (pt)
HR (1) HRP20000537A2 (pt)
HU (1) HUP0100869A3 (pt)
IL (1) IL137685A0 (pt)
NO (1) NO20004026L (pt)
NZ (1) NZ505406A (pt)
PL (1) PL342161A1 (pt)
TR (1) TR200002352T2 (pt)
WO (1) WO1999041230A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02008314A (es) * 2000-02-28 2002-12-09 Chiron Spa Expresion heterologa de proteinas de neisseria.
KR101686179B1 (ko) 2015-02-05 2016-12-28 이삼구 산화질소를 생성하는 아르기닌 함유가 증진된 귀뚜라미

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51113874A (en) 1975-04-01 1976-10-07 Yamanouchi Pharmaceut Co Ltd Method for synthesizing 4-hydroxynicotinic acid or its lower alkyl est ers
JPS55730A (en) 1978-06-20 1980-01-07 Toyo Soda Mfg Co Ltd 5-h-pyrido 1',2':1,2-pyrimido 4, 5-b acridine 7, 15-dione and its preparation
US4927828A (en) * 1985-03-08 1990-05-22 The Trustees Of Princeton University Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
DK172753B1 (da) 1988-05-25 1999-06-28 Lilly Co Eli N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
US5248775A (en) 1989-12-11 1993-09-28 The Trustees Of Princeton University Pyrrolo(2,3-d)pyrimidines
KR0162654B1 (ko) 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
US5028608A (en) 1989-12-11 1991-07-02 The Trustees Of Princeton University N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
US5536724A (en) * 1992-03-03 1996-07-16 Sri International Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins

Also Published As

Publication number Publication date
HUP0100869A2 (hu) 2001-08-28
PL342161A1 (en) 2001-05-21
EA200000829A1 (ru) 2001-02-26
JP2002503648A (ja) 2002-02-05
HUP0100869A3 (en) 2002-12-28
EP1054859A1 (en) 2000-11-29
EA002723B1 (ru) 2002-08-29
IL137685A0 (en) 2001-10-31
CA2319424A1 (en) 1999-08-19
NO20004026L (no) 2000-10-04
NO20004026D0 (no) 2000-08-10
AU739292B2 (en) 2001-10-11
US6426417B1 (en) 2002-07-30
AR018538A1 (es) 2001-11-28
HRP20000537A2 (en) 2000-10-31
TR200002352T2 (tr) 2000-12-21
AU2345299A (en) 1999-08-30
EP1054859A4 (en) 2003-03-05
WO1999041230A1 (en) 1999-08-19
CN1290247A (zh) 2001-04-04
NZ505406A (en) 2003-01-31
KR20010040836A (ko) 2001-05-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007.