NO20004026L - FremgangsmÕter og mellomprodukter som er nyttige for Õ danne antifolater - Google Patents
FremgangsmÕter og mellomprodukter som er nyttige for Õ danne antifolaterInfo
- Publication number
- NO20004026L NO20004026L NO20004026A NO20004026A NO20004026L NO 20004026 L NO20004026 L NO 20004026L NO 20004026 A NO20004026 A NO 20004026A NO 20004026 A NO20004026 A NO 20004026A NO 20004026 L NO20004026 L NO 20004026L
- Authority
- NO
- Norway
- Prior art keywords
- methods
- antifolates
- forming
- intermediates useful
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Foreliggende oppfinnelse vedrører mellomprodukter, og fremgangsmåter rettet på og fra disse mellomproduktene, på en serie av pyrimidin derivater med formel (V), som er mellomprodukter for nyttige antifolat forbindelser eller som selv er nyttige antifolat forbindelser.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7432798P | 1998-02-11 | 1998-02-11 | |
PCT/US1999/001689 WO1999041230A1 (en) | 1998-02-11 | 1999-01-27 | Processes and intermediates useful to make antifolates |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20004026D0 NO20004026D0 (no) | 2000-08-10 |
NO20004026L true NO20004026L (no) | 2000-10-04 |
Family
ID=22118973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20004026A NO20004026L (no) | 1998-02-11 | 2000-08-10 | FremgangsmÕter og mellomprodukter som er nyttige for Õ danne antifolater |
Country Status (18)
Country | Link |
---|---|
US (1) | US6426417B1 (no) |
EP (1) | EP1054859A4 (no) |
JP (1) | JP2002503648A (no) |
KR (1) | KR20010040836A (no) |
CN (1) | CN1290247A (no) |
AR (1) | AR018538A1 (no) |
AU (1) | AU739292B2 (no) |
BR (1) | BR9907876A (no) |
CA (1) | CA2319424A1 (no) |
EA (1) | EA002723B1 (no) |
HR (1) | HRP20000537A2 (no) |
HU (1) | HUP0100869A3 (no) |
IL (1) | IL137685A0 (no) |
NO (1) | NO20004026L (no) |
NZ (1) | NZ505406A (no) |
PL (1) | PL342161A1 (no) |
TR (1) | TR200002352T2 (no) |
WO (1) | WO1999041230A1 (no) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2391153T3 (es) | 2000-02-28 | 2012-11-22 | Novartis Vaccines And Diagnostics S.R.L. | Expresión heteróloga de proteínas de Neisseria |
KR101686179B1 (ko) | 2015-02-05 | 2016-12-28 | 이삼구 | 산화질소를 생성하는 아르기닌 함유가 증진된 귀뚜라미 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS51113874A (en) | 1975-04-01 | 1976-10-07 | Yamanouchi Pharmaceut Co Ltd | Method for synthesizing 4-hydroxynicotinic acid or its lower alkyl est ers |
JPS55730A (en) | 1978-06-20 | 1980-01-07 | Toyo Soda Mfg Co Ltd | 5-h-pyrido 1',2':1,2-pyrimido 4, 5-b acridine 7, 15-dione and its preparation |
US4927828A (en) * | 1985-03-08 | 1990-05-22 | The Trustees Of Princeton University | Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives |
NZ219971A (en) * | 1986-06-06 | 1989-08-29 | Univ Princeton | Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions |
US4895946A (en) * | 1987-10-26 | 1990-01-23 | The Trustees Of Princeton University | Process for the preparation of fused pyridine compounds |
DK172753B1 (da) * | 1988-05-25 | 1999-06-28 | Lilly Co Eli | N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat |
US5248775A (en) | 1989-12-11 | 1993-09-28 | The Trustees Of Princeton University | Pyrrolo(2,3-d)pyrimidines |
KR0162654B1 (ko) | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
US5028608A (en) | 1989-12-11 | 1991-07-02 | The Trustees Of Princeton University | N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives |
US5536724A (en) * | 1992-03-03 | 1996-07-16 | Sri International | Antiinflammatory and antineoplastic 5-deazaaminopterins and 5,10-dideazaaminopterins |
-
1999
- 1999-01-27 HU HU0100869A patent/HUP0100869A3/hu unknown
- 1999-01-27 CA CA002319424A patent/CA2319424A1/en not_active Abandoned
- 1999-01-27 TR TR2000/02352T patent/TR200002352T2/xx unknown
- 1999-01-27 KR KR1020007008731A patent/KR20010040836A/ko not_active Application Discontinuation
- 1999-01-27 EP EP99903432A patent/EP1054859A4/en not_active Withdrawn
- 1999-01-27 NZ NZ505406A patent/NZ505406A/xx unknown
- 1999-01-27 BR BR9907876-7A patent/BR9907876A/pt not_active IP Right Cessation
- 1999-01-27 PL PL99342161A patent/PL342161A1/xx unknown
- 1999-01-27 IL IL13768599A patent/IL137685A0/xx unknown
- 1999-01-27 EA EA200000829A patent/EA002723B1/ru not_active IP Right Cessation
- 1999-01-27 JP JP2000531425A patent/JP2002503648A/ja not_active Withdrawn
- 1999-01-27 WO PCT/US1999/001689 patent/WO1999041230A1/en not_active Application Discontinuation
- 1999-01-27 AU AU23452/99A patent/AU739292B2/en not_active Ceased
- 1999-01-27 CN CN99802883A patent/CN1290247A/zh active Pending
- 1999-01-27 US US09/601,707 patent/US6426417B1/en not_active Expired - Fee Related
- 1999-01-29 AR ARP990100384A patent/AR018538A1/es unknown
-
2000
- 2000-08-10 NO NO20004026A patent/NO20004026L/no not_active Application Discontinuation
- 2000-08-11 HR HR20000537A patent/HRP20000537A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HRP20000537A2 (en) | 2000-10-31 |
TR200002352T2 (tr) | 2000-12-21 |
EA200000829A1 (ru) | 2001-02-26 |
EA002723B1 (ru) | 2002-08-29 |
AU739292B2 (en) | 2001-10-11 |
WO1999041230A1 (en) | 1999-08-19 |
NZ505406A (en) | 2003-01-31 |
NO20004026D0 (no) | 2000-08-10 |
EP1054859A4 (en) | 2003-03-05 |
CN1290247A (zh) | 2001-04-04 |
HUP0100869A2 (hu) | 2001-08-28 |
AU2345299A (en) | 1999-08-30 |
EP1054859A1 (en) | 2000-11-29 |
IL137685A0 (en) | 2001-10-31 |
PL342161A1 (en) | 2001-05-21 |
HUP0100869A3 (en) | 2002-12-28 |
KR20010040836A (ko) | 2001-05-15 |
AR018538A1 (es) | 2001-11-28 |
JP2002503648A (ja) | 2002-02-05 |
BR9907876A (pt) | 2000-10-31 |
US6426417B1 (en) | 2002-07-30 |
CA2319424A1 (en) | 1999-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1483265T3 (da) | Purinderivater som kinaseinhibitorer | |
EA200500721A1 (ru) | Пиримидины, ингибирующие chk, pdk и акт, их получение и применение в качестве лекарственных средств | |
NO20032831L (no) | Pyrimidinaminer som angiogenese-modulatorer | |
BR9915938A (pt) | Derivados de pirimidina substituìdos por arila e heterociclila como anticoagulantes | |
CY1105553T1 (el) | Υποκαταστατα 2-πυριμιδινυλιο-6,7,8,9-τετραϋδροπυριμιδο[1,2-α]πυριμιδιν-4-ονιο και 7-πυριμιδινυλιο-2,3-διυδροιμιδαζο[1,2-α]πυριμιδιν-5(1η)ονιο για νευροεκφυλιστικες διαταραχες | |
DK0539086T3 (da) | Kondenserede pyrimidinderivater og deres anvendelse som angiotensin II-antagonister | |
DK1686119T3 (da) | Pyrimidin-5-on-derivater som LDL-PLA2 inhibitorer | |
MXPA05011643A (es) | 5,7-diaminopirazolo[4,3-d]pirimidinas en el tratamiento de hipertension. | |
IL160915A0 (en) | Indolizines inhibiting kinase proteins | |
DK0922045T3 (da) | Bicykliske pyrimidinderivater og deres anvendelse som antikoagulanter | |
ATE347555T1 (de) | 6-aminomorphinanderivate, herstellungsverfahren dafür und deren verwendung | |
DE60336735D1 (de) | Neue biologischaktive molekü le | |
DK0971922T3 (da) | Tetrahydropyrido-forbindelser | |
DE69725440D1 (de) | 2-substituierte nukleosid- und oligonukleotid- derivate | |
WO2003002580A8 (en) | 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity | |
NO20004026L (no) | FremgangsmÕter og mellomprodukter som er nyttige for Õ danne antifolater | |
BR0207102A (pt) | Forma cristalina, composição farmacêutica, uso de uma forma cristalina, e, método para a prevenção ou o tratamento de doença | |
SE9604582D0 (sv) | Novel compounds | |
EP1613606A4 (en) | PROCESS FOR PREPARING 2,3,5,6-SUBSTITUTED 3H-PYRIMIDIN-4-ONES | |
DE50001717D1 (en) | Herbizide substituierte thienocycloalk(en)ylamino-1,3,5-triazine | |
BR0313302A (pt) | Processos para a preparação de nucleosìdeos de 1,3-dioxolano | |
ID27656A (id) | Turunan azabisikloheptana n-tersubstitusi, pembuatan dan penggunaannya | |
UA80871C2 (en) | 5,7-diaminopyrazolo[4,3-d]pyrimidines useful in the treatment of hypertension | |
SE9603726D0 (sv) | Novel compounds | |
ES2182541T3 (es) | Pyrazolo(3,4-d)pirimidinas con actividad anticonvulsiva y antialergica /aniasmatica. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |