DE69725440D1 - 2-substituierte nukleosid- und oligonukleotid- derivate - Google Patents

2-substituierte nukleosid- und oligonukleotid- derivate

Info

Publication number
DE69725440D1
DE69725440D1 DE69725440T DE69725440T DE69725440D1 DE 69725440 D1 DE69725440 D1 DE 69725440D1 DE 69725440 T DE69725440 T DE 69725440T DE 69725440 T DE69725440 T DE 69725440T DE 69725440 D1 DE69725440 D1 DE 69725440D1
Authority
DE
Germany
Prior art keywords
oligonucleotide derivatives
substituted nucleoside
nucleoside building
building blocks
oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69725440T
Other languages
English (en)
Other versions
DE69725440T2 (de
Inventor
Bernard Cuenoud
Karl-Heinz Altmann
Pierre Martin
Heinz Ernst Moser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE69725440D1 publication Critical patent/DE69725440D1/de
Application granted granted Critical
Publication of DE69725440T2 publication Critical patent/DE69725440T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69725440T 1996-06-06 1997-05-27 2-substituierte nukleosid- und oligonukleotid- derivate Expired - Lifetime DE69725440T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH143296 1996-06-06
CH143296 1996-06-06
PCT/EP1997/002738 WO1997046569A2 (en) 1996-06-06 1997-05-27 2'-substituted nucleosides and oligonucleotide derivatives

Publications (2)

Publication Number Publication Date
DE69725440D1 true DE69725440D1 (de) 2003-11-13
DE69725440T2 DE69725440T2 (de) 2004-07-22

Family

ID=4210329

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69725440T Expired - Lifetime DE69725440T2 (de) 1996-06-06 1997-05-27 2-substituierte nukleosid- und oligonukleotid- derivate

Country Status (11)

Country Link
US (2) US6670468B1 (de)
EP (1) EP0906329B1 (de)
JP (1) JP2000512630A (de)
AT (1) ATE251638T1 (de)
AU (1) AU3029797A (de)
CA (1) CA2256765A1 (de)
CY (1) CY2522B1 (de)
DE (1) DE69725440T2 (de)
DK (1) DK0906329T3 (de)
WO (1) WO1997046569A2 (de)
ZA (1) ZA974952B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0906329B1 (de) * 1996-06-06 2003-10-08 Novartis AG 2-substituierte nukleosid- und oligonukleotid- derivate
US6277967B1 (en) * 1998-07-14 2001-08-21 Isis Pharmaceuticals, Inc. Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages
US6673912B1 (en) 1998-08-07 2004-01-06 Isis Pharmaceuticals, Inc. 2′-O-aminoethyloxyethyl-modified oligonucleotides
US6043352A (en) 1998-08-07 2000-03-28 Isis Pharmaceuticals, Inc. 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
US20060258691A1 (en) * 2005-05-13 2006-11-16 Joseph Barbosa Methods and compositions for improving cognition
EP2217602B1 (de) 2007-11-30 2018-08-29 Boehringer Ingelheim International GmbH 1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-on- derivative und ihre verwendung als pde9a modulatoren zur behandlung von erkrankungen des zns
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
EA201100446A1 (ru) 2008-09-08 2011-10-31 Бёрингер Ингельхайм Интернациональ Гмбх Пиразолопиримидины и их применение для лечения нарушений цнс
AU2010221419B2 (en) * 2009-03-02 2015-10-01 Alnylam Pharmaceuticals, Inc. Nucleic acid chemical modifications
GEP20146098B (en) 2009-03-31 2014-05-27 Boehringer Ingelheim Int 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their usage as pde9a modulators
CN103052639B (zh) 2010-08-12 2016-02-17 贝林格尔.英格海姆国际有限公司 6-环烷基-1,5-二氢-吡唑并[3,4-d]嘧啶-4-酮衍生物及其作为PDE9A抑制剂的用途
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
CN108026136A (zh) 2015-08-06 2018-05-11 奇默里克斯公司 作为有用的抗病毒剂的吡咯并嘧啶核苷及其类似物
US11111264B2 (en) 2017-09-21 2021-09-07 Chimerix, Inc. Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE190981T1 (de) * 1989-10-24 2000-04-15 Isis Pharmaceuticals Inc 2'-modifizierte nukleotide
WO1995006659A1 (en) 1992-07-01 1995-03-09 Isis Pharmaceuticals, Inc. Amine-derivatized nucleosides and oligonucleosides
US5514786A (en) * 1990-01-11 1996-05-07 Isis Pharmaceuticals, Inc. Compositions for inhibiting RNA activity
DE4037363A1 (de) 1990-04-09 1991-10-10 Europ Lab Molekularbiolog 2-0-alkylnukleotide sowie polymere, die solche nukleotide enthalten
JPH0813274B2 (ja) 1990-08-13 1996-02-14 アイシス・ファーマシューティカルス・インコーポレーテッド 遺伝子発現を検出及び変調する糖修飾されたオリゴヌクレオチド
DE4110085A1 (de) 1991-03-27 1992-10-01 Boehringer Ingelheim Int 2'-o-alkyl-oligoribonukleotide, verfahren zu deren herstellung und deren verwendung als antisense-oligonukleotide
EP1331011A3 (de) * 1991-10-24 2003-12-17 Isis Pharmaceuticals, Inc. Derivatisierte Oligonukleotide mit verbessertem Aufnahmevermögen.
DE69233599T2 (de) 1991-12-24 2006-12-14 Isis Pharmaceuticals, Inc., Carlsbad Unterbrochene 2'-modifizierte Oligonukleotide
US5485592A (en) 1992-04-07 1996-01-16 Video Technology Computers, Ltd. Write back cache controller method and apparatus for use in a system having a CPU with internal cache memory
DE69333842T2 (de) * 1992-07-23 2006-04-27 Isis Pharmaceuticals, Inc., Carlsbad Neue 2'-O-Alkyl-Nukleoside und -Phosphoramidite, Verfahren zu ihrer Herstellung und ihre Verwendungen
DE59407895D1 (de) 1993-05-12 1999-04-15 Novartis Ag Nukleoside und Oligonukleotide mit 2'-Ethergruppen
US5571902A (en) * 1993-07-29 1996-11-05 Isis Pharmaceuticals, Inc. Synthesis of oligonucleotides
ES2203635T3 (es) 1994-04-27 2004-04-16 Novartis Ag Nucleosidos y oligonucleotidos con grupos 2'-eter.
US5744362A (en) * 1994-05-31 1998-04-28 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
EP0906329B1 (de) * 1996-06-06 2003-10-08 Novartis AG 2-substituierte nukleosid- und oligonukleotid- derivate

Also Published As

Publication number Publication date
DK0906329T3 (da) 2004-02-09
CA2256765A1 (en) 1997-12-11
US20050159374A1 (en) 2005-07-21
CY2522B1 (en) 2006-02-08
WO1997046569A2 (en) 1997-12-11
EP0906329B1 (de) 2003-10-08
JP2000512630A (ja) 2000-09-26
WO1997046569A3 (en) 1998-02-19
AU3029797A (en) 1998-01-05
ATE251638T1 (de) 2003-10-15
US6670468B1 (en) 2003-12-30
ZA974952B (en) 1997-12-08
EP0906329A2 (de) 1999-04-07
DE69725440T2 (de) 2004-07-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN