ATE251638T1 - 2-substituierte nukleosid- und oligonukleotid- derivate - Google Patents

2-substituierte nukleosid- und oligonukleotid- derivate

Info

Publication number
ATE251638T1
ATE251638T1 AT97924997T AT97924997T ATE251638T1 AT E251638 T1 ATE251638 T1 AT E251638T1 AT 97924997 T AT97924997 T AT 97924997T AT 97924997 T AT97924997 T AT 97924997T AT E251638 T1 ATE251638 T1 AT E251638T1
Authority
AT
Austria
Prior art keywords
oligonucleotide derivatives
substituted nucleoside
nucleoside building
building blocks
oligonucleotide
Prior art date
Application number
AT97924997T
Other languages
English (en)
Inventor
Bernard Cuenoud
Karl-Heinz Altmann
Pierre Martin
Heinz Ernst Moser
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE251638T1 publication Critical patent/ATE251638T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT97924997T 1996-06-06 1997-05-27 2-substituierte nukleosid- und oligonukleotid- derivate ATE251638T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH143296 1996-06-06
PCT/EP1997/002738 WO1997046569A2 (en) 1996-06-06 1997-05-27 2'-substituted nucleosides and oligonucleotide derivatives

Publications (1)

Publication Number Publication Date
ATE251638T1 true ATE251638T1 (de) 2003-10-15

Family

ID=4210329

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97924997T ATE251638T1 (de) 1996-06-06 1997-05-27 2-substituierte nukleosid- und oligonukleotid- derivate

Country Status (11)

Country Link
US (2) US6670468B1 (de)
EP (1) EP0906329B1 (de)
JP (1) JP2000512630A (de)
AT (1) ATE251638T1 (de)
AU (1) AU3029797A (de)
CA (1) CA2256765A1 (de)
CY (1) CY2522B1 (de)
DE (1) DE69725440T2 (de)
DK (1) DK0906329T3 (de)
WO (1) WO1997046569A2 (de)
ZA (1) ZA974952B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0906329T3 (da) * 1996-06-06 2004-02-09 Novartis Ag 2'-Substituerede nukleosider og oligonukleotidderivater
US6277967B1 (en) * 1998-07-14 2001-08-21 Isis Pharmaceuticals, Inc. Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages
US6673912B1 (en) 1998-08-07 2004-01-06 Isis Pharmaceuticals, Inc. 2′-O-aminoethyloxyethyl-modified oligonucleotides
US6043352A (en) 1998-08-07 2000-03-28 Isis Pharmaceuticals, Inc. 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
US20060258691A1 (en) * 2005-05-13 2006-11-16 Joseph Barbosa Methods and compositions for improving cognition
US8648085B2 (en) 2007-11-30 2014-02-11 Boehringer Ingelheim International Gmbh 1, 5-dihydro-pyrazolo (3, 4-D) pyrimidin-4-one derivatives and their use as PDE9A mudulators for the treatment of CNS disorders
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
AP2011005672A0 (en) 2008-09-08 2011-04-30 Boehringer Ingelheim Int Pyrazolopyrimidines and their use for the treatment of CNS disorders.
US8975389B2 (en) * 2009-03-02 2015-03-10 Alnylam Pharmaceuticals, Inc. Nucleic acid chemical modifications
NZ594567A (en) 2009-03-31 2013-12-20 Boehringer Ingelheim Int 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
WO2012020022A1 (en) 2010-08-12 2012-02-16 Boehringer Ingelheim International Gmbh 6-cycloalkyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a inhibitors
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
BR112018002399A2 (pt) 2015-08-06 2018-09-25 Chimerix, Inc. nucleosídeos de pirrolopirimidina e análogos dos mesmos, úteis como agentes antivirais
US11111264B2 (en) 2017-09-21 2021-09-07 Chimerix, Inc. Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006556A1 (en) * 1989-10-24 1991-05-16 Gilead Sciences, Inc. 2' modified oligonucleotides
WO1994002501A1 (en) * 1992-07-23 1994-02-03 Isis Pharmaceuticals, Inc. Novel 2'-o-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof
US5514786A (en) * 1990-01-11 1996-05-07 Isis Pharmaceuticals, Inc. Compositions for inhibiting RNA activity
WO1995006659A1 (en) 1992-07-01 1995-03-09 Isis Pharmaceuticals, Inc. Amine-derivatized nucleosides and oligonucleosides
DE4037363A1 (de) 1990-04-09 1991-10-10 Europ Lab Molekularbiolog 2-0-alkylnukleotide sowie polymere, die solche nukleotide enthalten
CA2089376C (en) 1990-08-13 2010-05-04 Phillip Dan Cook Sugar modified oligonucleotides that detect and modulate gene expression
DE4110085A1 (de) 1991-03-27 1992-10-01 Boehringer Ingelheim Int 2'-o-alkyl-oligoribonukleotide, verfahren zu deren herstellung und deren verwendung als antisense-oligonukleotide
JP2823959B2 (ja) * 1991-10-24 1998-11-11 アイシス・ファーマシューティカルス・インコーポレーテッド 改良された取り込みおよびその他の性質を持つ誘導化オリゴヌクレオチド
EP0618925B2 (de) 1991-12-24 2012-04-18 Isis Pharmaceuticals, Inc. Antisense oligonukleotide
US5485592A (en) 1992-04-07 1996-01-16 Video Technology Computers, Ltd. Write back cache controller method and apparatus for use in a system having a CPU with internal cache memory
ES2128535T3 (es) * 1993-05-12 1999-05-16 Novartis Ag Nucleosidos y oligonucleotidos con grupos 2'-eter.
US5571902A (en) * 1993-07-29 1996-11-05 Isis Pharmaceuticals, Inc. Synthesis of oligonucleotides
ES2203635T3 (es) * 1994-04-27 2004-04-16 Novartis Ag Nucleosidos y oligonucleotidos con grupos 2'-eter.
US5744362A (en) * 1994-05-31 1998-04-28 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
DK0906329T3 (da) * 1996-06-06 2004-02-09 Novartis Ag 2'-Substituerede nukleosider og oligonukleotidderivater

Also Published As

Publication number Publication date
DE69725440D1 (de) 2003-11-13
DK0906329T3 (da) 2004-02-09
EP0906329B1 (de) 2003-10-08
US20050159374A1 (en) 2005-07-21
WO1997046569A2 (en) 1997-12-11
DE69725440T2 (de) 2004-07-22
US6670468B1 (en) 2003-12-30
EP0906329A2 (de) 1999-04-07
JP2000512630A (ja) 2000-09-26
CA2256765A1 (en) 1997-12-11
AU3029797A (en) 1998-01-05
WO1997046569A3 (en) 1998-02-19
ZA974952B (en) 1997-12-08
CY2522B1 (en) 2006-02-08

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