CY2522B1 - 2-Substituted nucleosides and oligonucleotide derivatives - Google Patents

2-Substituted nucleosides and oligonucleotide derivatives

Info

Publication number
CY2522B1
CY2522B1 CY0500020A CY0500020A CY2522B1 CY 2522 B1 CY2522 B1 CY 2522B1 CY 0500020 A CY0500020 A CY 0500020A CY 0500020 A CY0500020 A CY 0500020A CY 2522 B1 CY2522 B1 CY 2522B1
Authority
CY
Cyprus
Prior art keywords
oligonucleotide derivatives
substituted nucleosides
nucleoside building
building blocks
oligonucleotide
Prior art date
Application number
CY0500020A
Other languages
English (en)
Inventor
Bernard Cuenoud
Karl-Heinz Altmann
Pierre Martin
Heinz Ernst Moser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY2522B1 publication Critical patent/CY2522B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CY0500020A 1996-06-06 2005-04-04 2-Substituted nucleosides and oligonucleotide derivatives CY2522B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH143296 1996-06-06

Publications (1)

Publication Number Publication Date
CY2522B1 true CY2522B1 (en) 2006-02-08

Family

ID=4210329

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0500020A CY2522B1 (en) 1996-06-06 2005-04-04 2-Substituted nucleosides and oligonucleotide derivatives

Country Status (11)

Country Link
US (2) US6670468B1 (xx)
EP (1) EP0906329B1 (xx)
JP (1) JP2000512630A (xx)
AT (1) ATE251638T1 (xx)
AU (1) AU3029797A (xx)
CA (1) CA2256765A1 (xx)
CY (1) CY2522B1 (xx)
DE (1) DE69725440T2 (xx)
DK (1) DK0906329T3 (xx)
WO (1) WO1997046569A2 (xx)
ZA (1) ZA974952B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0906329B1 (en) * 1996-06-06 2003-10-08 Novartis AG 2'-substituted nucleosides and oligonucleotide derivatives
US6277967B1 (en) * 1998-07-14 2001-08-21 Isis Pharmaceuticals, Inc. Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages
US6673912B1 (en) 1998-08-07 2004-01-06 Isis Pharmaceuticals, Inc. 2′-O-aminoethyloxyethyl-modified oligonucleotides
US6043352A (en) 1998-08-07 2000-03-28 Isis Pharmaceuticals, Inc. 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
US20060258691A1 (en) * 2005-05-13 2006-11-16 Joseph Barbosa Methods and compositions for improving cognition
EP2217602B1 (en) 2007-11-30 2018-08-29 Boehringer Ingelheim International GmbH 1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one derivatives and their use as pde9a modulators for the treatment of cns disorders
UA105362C2 (xx) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх Похідні 1-гетероцикліл-1,5-дигідропіразоло$3,4-d]піримідин-4-ону та їх застосування як модулятори pde9a$производные 1-гетероциклил-1,5-дигидропиразоло$3,4-d] пиримидин-4-она и их применение в качестве модуляторов pde9a
EA201100446A1 (ru) 2008-09-08 2011-10-31 Бёрингер Ингельхайм Интернациональ Гмбх Пиразолопиримидины и их применение для лечения нарушений цнс
AU2010221419B2 (en) * 2009-03-02 2015-10-01 Alnylam Pharmaceuticals, Inc. Nucleic acid chemical modifications
GEP20146098B (en) 2009-03-31 2014-05-27 Boehringer Ingelheim Int 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their usage as pde9a modulators
CN103052639B (zh) 2010-08-12 2016-02-17 贝林格尔.英格海姆国际有限公司 6-环烷基-1,5-二氢-吡唑并[3,4-d]嘧啶-4-酮衍生物及其作为PDE9A抑制剂的用途
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
CN108026136A (zh) 2015-08-06 2018-05-11 奇默里克斯公司 作为有用的抗病毒剂的吡咯并嘧啶核苷及其类似物
US11111264B2 (en) 2017-09-21 2021-09-07 Chimerix, Inc. Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE190981T1 (de) * 1989-10-24 2000-04-15 Isis Pharmaceuticals Inc 2'-modifizierte nukleotide
WO1995006659A1 (en) 1992-07-01 1995-03-09 Isis Pharmaceuticals, Inc. Amine-derivatized nucleosides and oligonucleosides
US5514786A (en) * 1990-01-11 1996-05-07 Isis Pharmaceuticals, Inc. Compositions for inhibiting RNA activity
DE4037363A1 (de) 1990-04-09 1991-10-10 Europ Lab Molekularbiolog 2-0-alkylnukleotide sowie polymere, die solche nukleotide enthalten
JPH0813274B2 (ja) 1990-08-13 1996-02-14 アイシス・ファーマシューティカルス・インコーポレーテッド 遺伝子発現を検出及び変調する糖修飾されたオリゴヌクレオチド
DE4110085A1 (de) 1991-03-27 1992-10-01 Boehringer Ingelheim Int 2'-o-alkyl-oligoribonukleotide, verfahren zu deren herstellung und deren verwendung als antisense-oligonukleotide
EP1331011A3 (en) * 1991-10-24 2003-12-17 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
DE69233599T2 (de) 1991-12-24 2006-12-14 Isis Pharmaceuticals, Inc., Carlsbad Unterbrochene 2'-modifizierte Oligonukleotide
US5485592A (en) 1992-04-07 1996-01-16 Video Technology Computers, Ltd. Write back cache controller method and apparatus for use in a system having a CPU with internal cache memory
DE69333842T2 (de) * 1992-07-23 2006-04-27 Isis Pharmaceuticals, Inc., Carlsbad Neue 2'-O-Alkyl-Nukleoside und -Phosphoramidite, Verfahren zu ihrer Herstellung und ihre Verwendungen
DE59407895D1 (de) 1993-05-12 1999-04-15 Novartis Ag Nukleoside und Oligonukleotide mit 2'-Ethergruppen
US5571902A (en) * 1993-07-29 1996-11-05 Isis Pharmaceuticals, Inc. Synthesis of oligonucleotides
ES2203635T3 (es) 1994-04-27 2004-04-16 Novartis Ag Nucleosidos y oligonucleotidos con grupos 2'-eter.
US5744362A (en) * 1994-05-31 1998-04-28 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
EP0906329B1 (en) * 1996-06-06 2003-10-08 Novartis AG 2'-substituted nucleosides and oligonucleotide derivatives

Also Published As

Publication number Publication date
DK0906329T3 (da) 2004-02-09
CA2256765A1 (en) 1997-12-11
US20050159374A1 (en) 2005-07-21
WO1997046569A2 (en) 1997-12-11
DE69725440D1 (de) 2003-11-13
EP0906329B1 (en) 2003-10-08
JP2000512630A (ja) 2000-09-26
WO1997046569A3 (en) 1998-02-19
AU3029797A (en) 1998-01-05
ATE251638T1 (de) 2003-10-15
US6670468B1 (en) 2003-12-30
ZA974952B (en) 1997-12-08
EP0906329A2 (en) 1999-04-07
DE69725440T2 (de) 2004-07-22

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