HUP0104878A2 - 5-HT újbóli felvétel inhibitorként és 5HT1B/D-ligandumként ható amid- és karbamidszármazékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
5-HT újbóli felvétel inhibitorként és 5HT1B/D-ligandumként ható amid- és karbamidszármazékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0104878A2 HUP0104878A2 HU0104878A HUP0104878A HUP0104878A2 HU P0104878 A2 HUP0104878 A2 HU P0104878A2 HU 0104878 A HU0104878 A HU 0104878A HU P0104878 A HUP0104878 A HU P0104878A HU P0104878 A2 HUP0104878 A2 HU P0104878A2
- Authority
- HU
- Hungary
- Prior art keywords
- ring
- group
- value
- formula
- atom
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
- -1 CH2OA Chemical compound 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004955 1,4-cyclohexylene group Chemical group [H]C1([H])C([H])([H])C([H])([*:1])C([H])([H])C([H])([H])C1([H])[*:2] 0.000 abstract 1
- XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Secondary Cells (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Electric Double-Layer Capacitors Or The Like (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Catalysts (AREA)
Abstract
A tal lm ny szerinti vegyületek (I) ltal nos képletében R1 jelentéseszubsztitu latlan vagy egy vagy kettő A, AO, OH, Hal, CN, NO2, NH2,NHA, NA2, COA, CONH2, CONHA, CONA2, CH2OH, CH2OA, CH2NH2, CH2NHA,CH2NA2, COOH és/vagy COOA csoporttal szubsztitu lt 3-indolilcsoport,R2 jelentése (Ia), Ib), (Ic) vagy (Id) ltal nos képletű csoport, mértéke 1 vagy 2, n értéke 0, 1, 2, 3 vagy 4, Y jelentése 1,4-ciklohexiléngyűrű, 1,3-pirrolidiniléngyűrű, 1,4-piperaziniléngyűrűvagy 1,4-piperidiniléngyűrű, amelyek adott esetben részbendehidrogénezett form ban lehetnek, Z jelentése -(CH2)n- vagy -(CH2)nNH- képletű csoport, q értéke 0 vagy 1, r értéke 0 vagy 1, R3jelentése A, R4 jelentése AO, Hal jelentése fluoratom, klóratom,brómatom vagy jódatom, A jelentése 1-6 szénatomos egyenes vagy el gazószénl ncú alkilcsoport, azzal a megszorít ssal, hogy q és r k"züllegal bb az egyik értéke 0-tól eltérő. A tal lm ny kiterjed a fentivegyületek elő llít s ra és ezeket tartalmazó gyógyszerkészítményekre. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19756036A DE19756036A1 (de) | 1997-12-17 | 1997-12-17 | Amid- und Harnstoffderivate |
PCT/EP1998/008457 WO2000037456A1 (de) | 1997-12-17 | 1998-12-22 | Amid- und harnstoffderivate als 5-ht-reuptake-inhibitoren und als 5-ht1b/1d-liganden |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0104878A2 true HUP0104878A2 (hu) | 2002-04-29 |
HUP0104878A3 HUP0104878A3 (en) | 2003-01-28 |
Family
ID=26042517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0104878A HUP0104878A3 (en) | 1997-12-17 | 1998-12-22 | Amide and urea derivatives as 5-ht reuptake inhibitors and as 5-ht1b/d ligands, process for their preparation and medicaments containing them |
Country Status (19)
Country | Link |
---|---|
US (1) | US6509340B1 (hu) |
EP (1) | EP1140898B1 (hu) |
JP (1) | JP2002533333A (hu) |
CN (1) | CN1336924A (hu) |
AT (1) | ATE222903T1 (hu) |
AU (1) | AU753335B2 (hu) |
BR (1) | BR9816121A (hu) |
CA (1) | CA2355861A1 (hu) |
CZ (1) | CZ20012270A3 (hu) |
DE (2) | DE19756036A1 (hu) |
DK (1) | DK1140898T3 (hu) |
ES (1) | ES2182401T3 (hu) |
HU (1) | HUP0104878A3 (hu) |
NO (1) | NO20013086L (hu) |
PT (1) | PT1140898E (hu) |
SI (1) | SI1140898T1 (hu) |
SK (1) | SK9232001A3 (hu) |
WO (1) | WO2000037456A1 (hu) |
ZA (1) | ZA9811467B (hu) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10252650A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
DE10337184A1 (de) | 2003-08-13 | 2005-03-10 | Gruenenthal Gmbh | Substituierte 3-Pyrrolidin-Indol-Derivate |
PL1701940T3 (pl) * | 2003-12-23 | 2008-11-28 | H Lundbeck As | Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI |
GB0400895D0 (en) * | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
PE20060373A1 (es) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
US8063071B2 (en) * | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
CN100448849C (zh) * | 2006-02-02 | 2009-01-07 | 深圳市天和医药科技开发有限公司 | 一种4位-酰基取代-2-甲基哌嗪化合物的制备方法 |
AR065804A1 (es) | 2007-03-23 | 2009-07-01 | Smithkline Beecham Corp | Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento |
WO2009049030A1 (en) * | 2007-10-09 | 2009-04-16 | Triton Biopharma, Llc | Method to use compositions having antidepressant anxiolytic and other neurological activity and compositions of matter |
JP2012520257A (ja) | 2009-03-10 | 2012-09-06 | グラクソ グループ リミテッド | Ikk2阻害剤としてのインドール誘導体 |
JPWO2011078369A1 (ja) * | 2009-12-25 | 2013-05-09 | 持田製薬株式会社 | 新規アリールウレア誘導体 |
WO2013085954A1 (en) * | 2011-12-06 | 2013-06-13 | Janssen Pharmaceutica Nv | Substituted piperidinyl-carboxamide derivatives useful as scd 1 inhibitors |
WO2013085957A1 (en) | 2011-12-06 | 2013-06-13 | Janssen Pharmaceutica Nv | Substituted piperidinyl-pyridazinyl derivatives useful as scd 1 inhibitors |
UY36390A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
CA2964276A1 (en) | 2014-11-05 | 2016-05-12 | Flexus Biosciences, Inc. | Immunoregulatory agents |
CN112334192A (zh) * | 2018-07-12 | 2021-02-05 | Ucb生物制药有限责任公司 | 作为il-17调节剂的螺环茚满类似物 |
WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2084531A1 (en) | 1991-12-19 | 1993-06-20 | David W. Smith | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines |
FR2740134B1 (fr) | 1995-10-18 | 1998-01-09 | Pf Medicament | Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant |
DE19615232A1 (de) * | 1996-04-18 | 1997-10-23 | Merck Patent Gmbh | Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten |
-
1997
- 1997-12-17 DE DE19756036A patent/DE19756036A1/de not_active Withdrawn
-
1998
- 1998-12-14 ZA ZA9811467A patent/ZA9811467B/xx unknown
- 1998-12-22 PT PT98966851T patent/PT1140898E/pt unknown
- 1998-12-22 CZ CZ20012270A patent/CZ20012270A3/cs unknown
- 1998-12-22 DK DK98966851T patent/DK1140898T3/da active
- 1998-12-22 EP EP98966851A patent/EP1140898B1/de not_active Expired - Lifetime
- 1998-12-22 AT AT98966851T patent/ATE222903T1/de not_active IP Right Cessation
- 1998-12-22 CN CN98814399A patent/CN1336924A/zh active Pending
- 1998-12-22 US US09/868,840 patent/US6509340B1/en not_active Expired - Fee Related
- 1998-12-22 SK SK923-2001A patent/SK9232001A3/sk unknown
- 1998-12-22 ES ES98966851T patent/ES2182401T3/es not_active Expired - Lifetime
- 1998-12-22 WO PCT/EP1998/008457 patent/WO2000037456A1/de not_active Application Discontinuation
- 1998-12-22 DE DE59805363T patent/DE59805363D1/de not_active Expired - Fee Related
- 1998-12-22 BR BR9816121-0A patent/BR9816121A/pt not_active IP Right Cessation
- 1998-12-22 AU AU25140/99A patent/AU753335B2/en not_active Ceased
- 1998-12-22 HU HU0104878A patent/HUP0104878A3/hu unknown
- 1998-12-22 CA CA002355861A patent/CA2355861A1/en not_active Abandoned
- 1998-12-22 SI SI9830281T patent/SI1140898T1/xx unknown
- 1998-12-22 JP JP2000589528A patent/JP2002533333A/ja active Pending
-
2001
- 2001-06-21 NO NO20013086A patent/NO20013086L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0104878A3 (en) | 2003-01-28 |
DE59805363D1 (de) | 2002-10-02 |
AU2514099A (en) | 2000-07-12 |
CN1336924A (zh) | 2002-02-20 |
DK1140898T3 (da) | 2002-11-25 |
US6509340B1 (en) | 2003-01-21 |
NO20013086D0 (no) | 2001-06-21 |
EP1140898A1 (de) | 2001-10-10 |
SI1140898T1 (en) | 2003-02-28 |
BR9816121A (pt) | 2001-11-13 |
DE19756036A1 (de) | 1999-06-24 |
EP1140898B1 (de) | 2002-08-28 |
AU753335B2 (en) | 2002-10-17 |
ZA9811467B (en) | 1999-06-14 |
JP2002533333A (ja) | 2002-10-08 |
ATE222903T1 (de) | 2002-09-15 |
PT1140898E (pt) | 2003-01-31 |
WO2000037456A1 (de) | 2000-06-29 |
CA2355861A1 (en) | 2000-06-29 |
NO20013086L (no) | 2001-08-21 |
SK9232001A3 (en) | 2001-12-03 |
CZ20012270A3 (cs) | 2001-12-12 |
ES2182401T3 (es) | 2003-03-01 |
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