PL1701940T3 - Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI - Google Patents

Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI

Info

Publication number
PL1701940T3
PL1701940T3 PL04803045T PL04803045T PL1701940T3 PL 1701940 T3 PL1701940 T3 PL 1701940T3 PL 04803045 T PL04803045 T PL 04803045T PL 04803045 T PL04803045 T PL 04803045T PL 1701940 T3 PL1701940 T3 PL 1701940T3
Authority
PL
Poland
Prior art keywords
indolylsulfanyl
ssri
amine derivatives
benzyl amine
benzyl
Prior art date
Application number
PL04803045T
Other languages
English (en)
Inventor
Jan Kehler
Karsten Juhl
Jimmy Sejberg
Morten Bang Norgaard
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of PL1701940T3 publication Critical patent/PL1701940T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL04803045T 2003-12-23 2004-12-21 Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI PL1701940T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53259303P 2003-12-23 2003-12-23
DKPA200301923 2003-12-23
EP04803045A EP1701940B1 (en) 2003-12-23 2004-12-21 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri
PCT/DK2004/000894 WO2005061455A1 (en) 2003-12-23 2004-12-21 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri

Publications (1)

Publication Number Publication Date
PL1701940T3 true PL1701940T3 (pl) 2008-11-28

Family

ID=34712442

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04803045T PL1701940T3 (pl) 2003-12-23 2004-12-21 Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI

Country Status (18)

Country Link
US (4) US7563908B2 (pl)
EP (1) EP1701940B1 (pl)
JP (3) JP4090491B2 (pl)
AT (1) ATE396970T1 (pl)
AU (1) AU2004303461B2 (pl)
BR (1) BRPI0417858B1 (pl)
CY (2) CY1108230T1 (pl)
DE (1) DE602004014190D1 (pl)
DK (1) DK1701940T3 (pl)
ES (1) ES2303960T3 (pl)
HR (2) HRP20080274T3 (pl)
IL (1) IL176111A (pl)
MX (1) MXPA06007172A (pl)
PL (1) PL1701940T3 (pl)
PT (1) PT1701940E (pl)
RS (1) RS50589B (pl)
SI (1) SI1701940T1 (pl)
WO (1) WO2005061455A1 (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06007172A (es) * 2003-12-23 2006-08-23 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-bencilamina como ssri.
AR052308A1 (es) * 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
AR054394A1 (es) * 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de 2- (1h-indolilsulfanil)-aril amina
EP1996948A1 (en) * 2006-03-22 2008-12-03 H.Lundbeck A/S Method for identifying compounds for the treatment of depression
TW200819426A (en) * 2006-08-31 2008-05-01 Lundbeck & Co As H Novel indane compounds
ZA200901739B (en) * 2006-09-28 2010-06-30 Lundbeck & Co As H [2-(6-flouro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders
US8138220B2 (en) 2006-09-28 2012-03-20 H. Lundbeck A/S [2-(6-fluoro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders
CN101868233A (zh) * 2007-09-24 2010-10-20 H.隆德贝克有限公司 与血清素双重作用化合物有关的组合疗法
TW200938189A (en) * 2008-03-13 2009-09-16 Lundbeck & Co As H [2-(6-flouro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders
WO2010006945A1 (en) 2008-07-15 2010-01-21 F. Hoffmann-La Roche Ag Substituted indolyl and indazolyl derivatives and uses thereof
WO2012024620A2 (en) * 2010-08-20 2012-02-23 Amira Pharmaceuticals, Inc. Autotaxin inhibitors and uses thereof
WO2012166415A1 (en) 2011-05-27 2012-12-06 Amira Pharmaceuticals, Inc. Heterocyclic autotaxin inhibitors and uses thereof
US9714240B2 (en) 2013-09-17 2017-07-25 Pharmakea, Inc. Vinyl autotaxin inhibitor compounds
JP2016530210A (ja) 2013-09-17 2016-09-29 ファーマケア，インク． ヘテロ環式ビニルオートタキシン阻害剤化合物
EP3049405A4 (en) 2013-09-26 2017-03-08 Pharmakea Inc. Autotaxin inhibitor compounds
HUE055213T2 (hu) 2013-11-22 2021-11-29 Sabre Therapeutics Llc Autotaxin inhibitor vegyületek
JP6873919B2 (ja) 2015-05-27 2021-05-19 セイバー セラピューティクス エルエルシー オートタキシン阻害剤とその使用
WO2018191146A1 (en) 2017-04-10 2018-10-18 Navitor Pharmaceuticals, Inc. Heteroaryl rheb inhibitors and uses thereof

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2003023A (en) * 1930-10-16 1935-05-28 Westinghouse Electric & Mfg Co Mercury vapor or noble gas rectifier with arc control
US3803143A (en) 1969-09-08 1974-04-09 Eisai Co Ltd 6-amino alkylene 6,7-dihydro-5h-dibenzo (b,g),(1,5)thiazocines
US4018830A (en) 1969-09-22 1977-04-19 Merck & Co., Inc. Phenylthioaralkylamines
US4055665A (en) 1974-11-25 1977-10-25 Merck & Co., Inc. Treating arrythmia with phenylthioaralkylamines
US4056632A (en) 1975-07-21 1977-11-01 Burroughs Wellcome Co. 2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use
US4241071A (en) 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
US4198417A (en) 1979-01-10 1980-04-15 American Hoechst Corporation Phenoxyphenylpiperidines
DE3640475A1 (de) 1986-11-27 1988-06-09 Hoechst Sa Lab Arzneimittel auf basis von derivaten des 3,4-diphenylpiperidins, die verwendung der derivate als arzneimittel sowie neue 3,4-diphenylpiperidinderivate und verfahren zu ihrer herstellung
EP0396827A1 (en) 1989-05-09 1990-11-14 SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu 2-Phenylthiobenzylamine dervivatives and acid addition salts thereof
GB8912971D0 (en) 1989-06-06 1989-07-26 Wellcome Found Halogen substituted diphenylsulfides
US6645969B1 (en) 1991-05-10 2003-11-11 Aventis Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
KR0184911B1 (ko) 1991-11-25 1999-05-01 알렌 제이. 스피겔 인돌유도체
GB9126311D0 (en) 1991-12-11 1992-02-12 Wellcome Found Substituted diphenylsulfides
GB9226532D0 (en) 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
AU2395095A (en) 1994-04-29 1995-11-29 G.D. Searle & Co. Method of using (h+/k+) atpase inhibitors as antiviral agents
DE69634678T2 (de) 1995-01-23 2006-01-19 Daiichi Suntory Pharma Co., Ltd. Verbesserung oder heilung von durch ischämischen krankheiten hervorgerufenen symtomen und dafür verwendbare phenylpiperidinverbingungen
DE907654T1 (de) 1995-11-06 1999-09-16 Gist-Brocades B.V. Verfahren zur de-esterifikation
CZ293595A3 (cs) 1995-11-09 1999-12-15 Farmak A. S. Deriváty N,N-dimethyl-2-(arylthio)benzylaminu, jejich soli, způsoby jejich přípravy a jejich použití v léčivých přípravcích
US5912256A (en) 1996-06-20 1999-06-15 Eli Lilly And Company Compounds having effects on serotonin-related systems
ATE234281T1 (de) * 1996-08-27 2003-03-15 Wyeth Corp 4-aminoethoxy-indolderivate als dopamin d2 agonisten und als 5ht1a liganden
US5906078A (en) * 1996-10-09 1999-05-25 Gallagher-Kaiser Corporation Retaining strip for sheet covered enclosures
GB9725953D0 (en) 1997-12-08 1998-02-04 Pfizer Ltd Compounds useful in therapy
DE19756036A1 (de) * 1997-12-17 1999-06-24 Merck Patent Gmbh Amid- und Harnstoffderivate
US6333146B1 (en) 1999-03-10 2001-12-25 Fuji Photo Film Co., Ltd. Methine compound and silver halide photographic material containing the same
EE200100514A (et) 1999-04-02 2002-12-16 Icos Corporation LFA-1 ICAM-idega seondumise inhibiitorid ja nendekasutamine
JP2002543173A (ja) * 1999-04-30 2002-12-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルベニア セロトニン輸送体のためのｓｐｅｃｔ画像化剤
CA2381008A1 (en) 1999-08-04 2001-02-15 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
EA005671B1 (ru) * 1999-10-13 2005-04-28 Пфайзер Продактс Инк. Производные биариловых эфиров, полезные в качестве ингибиторов обратного захвата моноамина
US6410736B1 (en) 1999-11-29 2002-06-25 Pfizer Inc. Biaryl ether derivatives useful as monoamine reuptake inhibitors
AU2152001A (en) * 1999-12-30 2001-07-16 H. Lundbeck A/S Phenylpiperazinyl derivatives
KR100790916B1 (ko) 1999-12-30 2008-01-03 하. 룬트벡 아크티에 셀스카브 치환 페닐-피페라진 유도체, 그들의 제조 및 사용
DE60038911D1 (de) * 1999-12-30 2008-06-26 Lundbeck & Co As H 4-Phenylpiperazinyl, -piperidinyl und -tetrahydropyridyl-Derivate als Dopamin D4-Antagonisten
EP1857109B1 (en) 2000-02-29 2010-09-22 MediQuest Therapeutics, Inc. Inhibitors of melanocyte tyrosinase as topical skin lighteners
CN1251671C (zh) 2000-05-19 2006-04-19 武田药品工业株式会社 β分泌酶抑制剂
US6455738B1 (en) 2000-07-13 2002-09-24 Rhodia Chimie Process for the sulfonation of an aromatic compound
CA2416384A1 (en) 2000-07-17 2003-01-16 Takeda Chemical Industries, Ltd. Sulfone derivatives, their production and use
AU2001279955A1 (en) 2000-08-18 2002-03-04 Sterix Limited 2-substituted estradiol derivative for inhibiting superoxid dismutase
HUP0500470A3 (en) 2000-09-01 2005-11-28 Fmc Corp 1,4-disubstituted benzenes as insecticides and use thereof
US6777446B2 (en) 2000-09-05 2004-08-17 Tularik, Inc. FXR modulators
EP1193268A1 (en) 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases
DE60129148T2 (de) 2000-10-06 2008-02-28 Biocompatibles Uk Ltd., Farnham Zwitterionische polymere
EP1578341A4 (en) 2000-10-11 2005-09-28 Tularik Inc MODULATION OF THE CCR4 FUNCTION
DE60131675T2 (de) 2000-11-14 2008-11-20 Merck Patent Gmbh Neue verwendung von substanzen mit kombinierten 5-ht1a agonistischen und serotonin reuptake inhibitor-aktivitäten
US6436938B1 (en) 2001-01-22 2002-08-20 Pfizer Inc. Combination treatment for depression
WO2002062766A2 (en) 2001-02-07 2002-08-15 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
SK16052003A3 (en) 2001-06-07 2004-10-05 Hoffmann La Roche New indole derivatives with 5-HT6 receptor affinity
JPWO2002100833A1 (ja) 2001-06-12 2004-09-24 住友製薬株式会社 Ｒｈｏキナーゼ阻害剤
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
US7064139B2 (en) 2001-10-29 2006-06-20 Uniroyal Chemical Company, Inc. Method for treating retroviral infections
MXPA04004674A (es) 2001-11-14 2004-08-12 Schering Corp Ligados de los receptors de los canabinodies.
CN1606552A (zh) 2001-12-21 2005-04-13 H.隆德贝克有限公司 氨基茚满衍生物作为5－羟色胺和去甲肾上腺素摄取抑制剂
EP1465933B1 (en) 2002-01-16 2007-08-29 Biocompatibles UK Limited Polymer conjugates
US20050261298A1 (en) 2002-01-18 2005-11-24 David Solow-Cordero Methods of treating conditions associated with an Edg-7 receptor
US20040058284A1 (en) 2002-03-01 2004-03-25 Fuji Photo Film Co., Ltd. Silver halide color photographic light-sensitive material
JP4151842B2 (ja) 2002-03-04 2008-09-17 独立行政法人科学技術振興機構 新規なホスホン酸アミド化合物、その製造方法及び用途
CA2934970C (en) 2002-03-29 2019-04-30 Massachusetts Institute Of Technology Light emitting device including semiconductor nanocrystals
DE10217006A1 (de) 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
AU2003243637A1 (en) 2002-06-19 2004-01-06 Schering Corporation Cannabinoid receptor agonists
TW200401641A (en) 2002-07-18 2004-02-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands
JP4267573B2 (ja) 2002-09-17 2009-05-27 エフ．ホフマン−ラ ロシュ アーゲー ２，４−置換インドールおよびそれらの５−ｈｔ６モジュレーターとしての使用
KR100686758B1 (ko) 2002-09-17 2007-02-26 에프. 호프만-라 로슈 아게 2,7-치환된 인돌 및 5-ｈｔ6 조절 인자로서의 그 용도
EP1402888A1 (en) 2002-09-18 2004-03-31 Jerini AG The use of substituted carbocyclic compounds as rotamases inhibitors
US20040266732A1 (en) 2002-09-20 2004-12-30 Jorge Galvez Therapeutic agents, methods, and treatments
US20060189519A1 (en) * 2002-09-26 2006-08-24 Karl Volz Anti-angiogenic fragments fo pigment epithelium-derived factor (pedf)
US20040137389A1 (en) 2002-12-19 2004-07-15 Kouta Fukui Heat-developable light-sensitive material
JP4457017B2 (ja) 2002-12-20 2010-04-28 アムジエン・インコーポレーテツド 喘息及びアレルギー性炎症モジュレーター
CN1512264B (zh) 2002-12-27 2010-05-26 富士胶片株式会社 卤化银彩色照相感光材料
DE10300098A1 (de) 2003-01-07 2004-07-15 Bayer Ag Kupfer-Carben-Komplexe und ihre Verwendung
EP1590388A2 (en) 2003-02-05 2005-11-02 Biocompatibles UK Limited Block copolymers
TW200505902A (en) 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
ES2423800T3 (es) 2003-03-28 2013-09-24 Novartis Vaccines And Diagnostics, Inc. Uso de compuestos orgánicos para la inmunopotenciación
US7244763B2 (en) 2003-04-17 2007-07-17 Warner Lambert Company Llc Compounds that modulate PPAR activity and methods of preparation
US20070060595A1 (en) 2003-10-10 2007-03-15 Toshio Yoshizawa Novel fused heterocyclic compound and use thereof
US7229751B2 (en) 2003-11-20 2007-06-12 Konica Minolta Medical & Graphic, Inc. Silver salt photothermographic dry imaging material and image forming method using the same
US20050250794A1 (en) 2003-12-19 2005-11-10 Andrew Napper Methods of treating a disorder
MXPA06007172A (es) * 2003-12-23 2006-08-23 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-bencilamina como ssri.
SE528250C2 (sv) 2004-02-27 2006-10-03 Calignum Technologies Ab Komposition innefattande en initiator och ett förfarande för att behandla trä med kompositionen
JP4569142B2 (ja) 2004-03-22 2010-10-27 コニカミノルタホールディングス株式会社 表示素子
JP4448730B2 (ja) 2004-04-20 2010-04-14 富士フイルム株式会社 感光性組成物、該感光性組成物に用いられる化合物及び該感光性組成物を用いたパターン形成方法
WO2006006172A2 (en) 2004-07-15 2006-01-19 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
EP1793816B1 (en) 2004-08-19 2012-01-04 Tel Aviv University Future Technology Development L.P. Compositions for treating amyloid associated diseases
US7687229B2 (en) 2004-08-24 2010-03-30 Fujifilm Corporation Silver halide color photographic light-sensitive material and image forming method
CN101068777A (zh) 2004-10-08 2007-11-07 万有制药株式会社 硫醚化合物的制备方法
EP1833894A1 (en) 2004-12-16 2007-09-19 Pirelli & C. S.p.A. Process for manufacturing a thermoplastic elastomeric material

Also Published As

Publication number Publication date
EP1701940B1 (en) 2008-05-28
BRPI0417858B1 (pt) 2017-10-10
ATE396970T1 (de) 2008-06-15
RS50589B (sr) 2010-05-07
HRP20110400T1 (hr) 2011-06-30
US20080176922A1 (en) 2008-07-24
IL176111A (en) 2011-10-31
BRPI0417858A (pt) 2007-04-27
SI1701940T1 (sl) 2008-10-31
DK1701940T3 (da) 2008-09-08
JP4090491B2 (ja) 2008-05-28
IL176111A0 (en) 2006-10-05
WO2005061455A1 (en) 2005-07-07
CY1108230T1 (el) 2014-02-12
DE602004014190D1 (de) 2008-07-10
US7737170B2 (en) 2010-06-15
US20060160880A1 (en) 2006-07-20
US7652150B2 (en) 2010-01-26
CY1111733T1 (el) 2015-10-07
US20080214645A1 (en) 2008-09-04
JP2007515436A (ja) 2007-06-14
US20080214644A1 (en) 2008-09-04
JP4091648B2 (ja) 2008-05-28
US7737171B2 (en) 2010-06-15
EP1701940A1 (en) 2006-09-20
ES2303960T3 (es) 2008-09-01
JP2008110984A (ja) 2008-05-15
AU2004303461A1 (en) 2005-07-07
AU2004303461B2 (en) 2011-04-28
US7563908B2 (en) 2009-07-21
HRP20080274T3 (en) 2008-12-31
JP2007277254A (ja) 2007-10-25
MXPA06007172A (es) 2006-08-23
PT1701940E (pt) 2008-07-30

Similar Documents

Publication Publication Date Title
IL176111A0 (en) 2-(1h-indolylsulfanyl)-benzyl amine derivatives as ssri
UA83875C2 (ru) Производные хинолина для применения в качестве микобактериальных ингибиторов
GEP20084551B (en) 4-phenylamino-quinazolin-6-yl-amides
UA102251C2 (ru) Производные аминодигидротиазина как ингибиторы васе для лечения болезни альцгеймера
SE0303180D0 (sv) Novel compounds
TW200726753A (en) 2,4-diamino-pyrimidines as aurora inhibitors
SE0302232D0 (sv) Novel Compounds
TW200531689A (en) Therapeutic agents
MY142988A (en) Novel aminobenzophenone compounds
MX2007011023A (es) 2-(4-oxo-4h-quinazolin-3-il) acetamidas y su uso como antagonistas de vasopresin v3.
IS2517B (is) Notkun á setnum 2-amínótetralínum í fyrirbyggjandi meðferð á Parkinsons-veiki
TW200800976A (en) New compounds for the treatment of neurological, psychiatric or pain disorders
TW200510325A (en) 2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof
TW200630374A (en) Thiazolyldihydroindazoles
NO20082096L (no) Azaindol-2-karboksamidderivativer
DE602006010738D1 (de) Pyrroloä2,3-cüpyridinderivate
MX2010002938A (es) Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer.
MXPA05010000A (es) Derivados de p-diaminobenceno substituidos.
SE0401465D0 (sv) New substituted piperdines as modulators of dopamine neurotransmission
TW200734324A (en) Therapeutic agents
GB0514811D0 (en) Compounds
TW200745133A (en) New compounds II
UA86873C2 (en) SUBSTITUTED ARYL 1,4-PYRAZlNE DERIVATIVES
MXPA05009282A (es) Derivados de anilina sustituidos.
UA94054C2 (en) Nitrocatechol derivatives as comt inhibitors