AR054394A1 - Derivados de 2- (1h-indolilsulfanil)-aril amina - Google Patents

Derivados de 2- (1h-indolilsulfanil)-aril amina

Info

Publication number
AR054394A1
AR054394A1 ARP060102491A ARP060102491A AR054394A1 AR 054394 A1 AR054394 A1 AR 054394A1 AR P060102491 A ARP060102491 A AR P060102491A AR P060102491 A ARP060102491 A AR P060102491A AR 054394 A1 AR054394 A1 AR 054394A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
group
amino
independently
Prior art date
Application number
ARP060102491A
Other languages
English (en)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR054394A1 publication Critical patent/AR054394A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Reivindicacion 1: La presente se refiere a un compuesto representado por la formula general (1) en la cual R1-R2 son seleccionados independientemente de H, alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8, y cicloalqu(en)il C3-8-alqu(en/in)ilo C1-6, o R1 y R2 forman conjuntamente con el N un anillo de 4-7 miembros que no contiene ninguno o contiene un doble enlace, comprendiendo opcionalmente dicho anillo además de dicho N otro heteroátomo seleccionado de O y S; R3-R6 y R8-R12 se seleccionan independientemente de H, halogeno, ciano, nitro, alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8, cicloalqu(en)il C3-8-alqu(en/in)ilo C1-6, amino, alqu(en/in)il C1-6-amino, di-(alqu(en/in)il C1-6)-amino, alqu(en/in)ilC1-6-carbonilo, aminocarbonilo, alqu(en/in)ilo C1-6-amino-carbonilo, di-alqu(en/in)il C1-6)-amino-carbonilo, hiroxilo, alqu(en/in)iloxilo C1-6, alqu(en/in)il C1-6-sulfanilo, haloalqu(en/in)ilo 1-6, haloalqu(en/in)il C1-6-sulfonilo, haloalqu(en/in)ilC1-6-sulfanilo y alqu(en/in)il C1-6-sulfonilo; R7 se selecciona de H, alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8 y cicloalqu(en)il C3-8-alqu(en/in)ilo C1-6; X se selecciona del grupo que consiste en CH2, CHR13 y CR14R15; Y se selecciona del grupo que consiste en CH2, CHR16 y CR17R18; Z se selecciona del grupo que consiste en CH2, CHR19 y CR20R21; y Q se selecciona del grupo que consiste en CH2, CHR22 y CR23R24; y m, n, o y p son independientemente 0 o 1 con la condicion de que cuando m + n + o + p sea igual a 1 entonces ninguna de X, Y, Z y Q son CH2; en donde R13-R24 se seleccionan independientemente del grupo que consiste en alqu(en/in)ilo C1-6, cicloalqu(en)ilo C3-8 y cicloalqu(en)il C3-8-alqu(en/in)ilo C1-6; como la base libre o una sal del mismo.
ARP060102491A 2005-06-17 2006-06-13 Derivados de 2- (1h-indolilsulfanil)-aril amina AR054394A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69200905P 2005-06-17 2005-06-17

Publications (1)

Publication Number Publication Date
AR054394A1 true AR054394A1 (es) 2007-06-20

Family

ID=37532681

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102491A AR054394A1 (es) 2005-06-17 2006-06-13 Derivados de 2- (1h-indolilsulfanil)-aril amina

Country Status (15)

Country Link
EP (1) EP1893575B1 (es)
JP (1) JP5144507B2 (es)
KR (1) KR20080027462A (es)
CN (1) CN101238101A (es)
AR (1) AR054394A1 (es)
AU (1) AU2006257288A1 (es)
BR (1) BRPI0611748A2 (es)
CA (1) CA2611566C (es)
EA (1) EA200800070A1 (es)
ES (1) ES2616095T3 (es)
IL (1) IL188064A0 (es)
MX (1) MX2007014954A (es)
NO (1) NO20080265L (es)
WO (1) WO2006134499A2 (es)
ZA (1) ZA200710885B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101868233A (zh) * 2007-09-24 2010-10-20 H.隆德贝克有限公司 与血清素双重作用化合物有关的组合疗法
TW200938189A (en) * 2008-03-13 2009-09-16 Lundbeck & Co As H [2-(6-flouro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders
CN103201262B (zh) * 2010-08-20 2016-06-01 艾米拉医药股份有限公司 自分泌运动因子抑制剂及其用途
US9260416B2 (en) 2011-05-27 2016-02-16 Amira Pharmaceuticals, Inc. Heterocyclic autotaxin inhibitors and uses thereof
WO2014151472A1 (en) * 2013-03-15 2014-09-25 Chromocell Corporation Sodium channel modulators for the treatment of pain
EP3046909A4 (en) 2013-09-17 2017-03-29 Pharmakea, Inc. Heterocyclic vinyl autotaxin inhibitor compounds
JP2016530209A (ja) 2013-09-17 2016-09-29 ファーマケア，インク． ビニルオートタキシン阻害剤化合物
JP2016531874A (ja) 2013-09-26 2016-10-13 ファーマケア，インク． オートタキシン阻害剤化合物
PT3071561T (pt) 2013-11-22 2021-06-25 Sabre Therapeutics Llc Compostos inibidores de autotaxina
EP4026549A1 (en) 2015-05-27 2022-07-13 Sabre Therapeutics LLC Autotaxin inhibitors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117129A (en) * 1976-10-22 1978-09-26 Warner-Lambert Company Indolobenzoxazepines as cns depressants
EP0907654B1 (en) * 1995-11-06 2000-08-02 Dsm N.V. De-esterification process
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
TW200400177A (en) * 2002-06-04 2004-01-01 Wyeth Corp 1-(Aminoalkyl)-3-sulfonylindole and-indazole derivatives as 5-hydroxytryptamine-6 ligands
PL1701940T3 (pl) * 2003-12-23 2008-11-28 H Lundbeck As Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI
AR052308A1 (es) * 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto

Also Published As

Publication number Publication date
ES2616095T3 (es) 2017-06-09
CA2611566A1 (en) 2006-12-21
CN101238101A (zh) 2008-08-06
KR20080027462A (ko) 2008-03-27
WO2006134499A3 (en) 2007-04-12
WO2006134499A2 (en) 2006-12-21
AU2006257288A1 (en) 2006-12-21
MX2007014954A (es) 2008-02-15
CA2611566C (en) 2011-08-16
JP2008546679A (ja) 2008-12-25
EP1893575B1 (en) 2017-01-11
EA200800070A1 (ru) 2008-04-28
ZA200710885B (en) 2009-03-25
NO20080265L (no) 2008-01-15
EP1893575A2 (en) 2008-03-05
IL188064A0 (en) 2008-03-20
BRPI0611748A2 (pt) 2016-11-22
JP5144507B2 (ja) 2013-02-13

Similar Documents

Publication Publication Date Title
AR054394A1 (es) Derivados de 2- (1h-indolilsulfanil)-aril amina
CR20160127A (es) Pesticidas de azoles bicíclicos sustituidos con heterociclos
ES2656793T3 (es) Salicilatos acetilados de ácidos grasos y sus usos
NI201900029A (es) COMPUESTOS DE BENZO[b]TIOFENO COMO AGONISTAS DE STING
CU20200080A7 (es) Kit que comprende un inhibidor de lats para el suministro ocular
PE20211333A1 (es) Compuestos de sulfonamidaurea novedosos
AR049443A1 (es) Derivados de pirrolpiridinas
UY38525A (es) 1,3,4-oxadiazoles y derivados de éstos como nuevos agentes fungicidas
PE20210549A1 (es) Derivado de amino-metil piperidina como inhibidor de quinasa
CO6450621A2 (es) Sulfonamidas nematocidas
ES2571779T3 (es) Inhibidores de cinasa a base de nicotinamida
DOP2006000234A (es) Inhibidores de cinasa
AR110768A1 (es) Formas cristalinas de tenofovir alafenamida
CL2022001529A1 (es) Nuevos derivados de metilquinazolinona
DOP2006000233A (es) Inhibidores de cinasa
CL2020000376A1 (es) Compuesto pentacíclico.
AR055420A1 (es) Derivados de pirimidina sustituidos
CL2018001067A1 (es) Compuesto piranodipiridínico.
GT200900282A (es) [4(6-fluoro-7-metilamina-2,4-dioxo-1,4-dihidro-2h-quinazolina-3-ilo)-fenilo]-5-cloro-tiofeno-2-ilo sales de sulfonilurea, y las formas y métodos relacionados con el mismo.
UY38941A (es) Nuevas sulfiliminas o sulfoximinas que contienen compuestos heterocíclicos fungicidas
CL2021000421A1 (es) Nuevo derivado de amina heterocíclico y composición farmacéutica que lo comprende.
CL2023002429A1 (es) Derivados novedosos de pirimidin-2-il sulfonamida
PE20210672A1 (es) Pirazoles fungicidas sustituidos con nitroanilino
UY38053A (es) Mejoras en compuestos orgánicos o relacionadas con estos
UY38397A (es) Nuevos oxadiazoles

Legal Events

Date Code Title Description
FA Abandonment or withdrawal