CL2023002429A1 - Derivados novedosos de pirimidin-2-il sulfonamida - Google Patents

Derivados novedosos de pirimidin-2-il sulfonamida

Info

Publication number
CL2023002429A1
CL2023002429A1 CL2023002429A CL2023002429A CL2023002429A1 CL 2023002429 A1 CL2023002429 A1 CL 2023002429A1 CL 2023002429 A CL2023002429 A CL 2023002429A CL 2023002429 A CL2023002429 A CL 2023002429A CL 2023002429 A1 CL2023002429 A1 CL 2023002429A1
Authority
CL
Chile
Prior art keywords
sulfonamide derivatives
pyrimidin
novel
novel pyrimidin
compounds
Prior art date
Application number
CL2023002429A
Other languages
English (en)
Inventor
Galley Guido
Gobbi Luca
Guba Wolfgang
Mazunin Dmitry
Pinard Emmanuel
Ricci Antonio
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2023002429A1 publication Critical patent/CL2023002429A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a compuestos que tienen la fórmula general I; en los que R1, R2, R3, R4, X1 y X2 son como se describe en el presente documento, la composición que incluye los compuestos y procedimientos de uso de los compuestos.
CL2023002429A 2021-02-26 2023-08-16 Derivados novedosos de pirimidin-2-il sulfonamida CL2023002429A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP21159452 2021-02-26

Publications (1)

Publication Number Publication Date
CL2023002429A1 true CL2023002429A1 (es) 2024-01-12

Family

ID=74797733

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023002429A CL2023002429A1 (es) 2021-02-26 2023-08-16 Derivados novedosos de pirimidin-2-il sulfonamida

Country Status (17)

Country Link
US (1) US20240025883A1 (es)
EP (1) EP4298092A1 (es)
JP (1) JP2024507176A (es)
KR (1) KR20230152006A (es)
CN (1) CN116829550A (es)
AR (1) AR124973A1 (es)
AU (1) AU2022227183A1 (es)
CA (1) CA3203282A1 (es)
CL (1) CL2023002429A1 (es)
CO (1) CO2023010212A2 (es)
CR (1) CR20230410A (es)
IL (1) IL304450A (es)
MX (1) MX2023009045A (es)
PE (1) PE20240125A1 (es)
TW (1) TW202245749A (es)
WO (1) WO2022180136A1 (es)
ZA (1) ZA202305344B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024023129A1 (en) * 2022-07-28 2024-02-01 F. Hoffmann-La Roche Ag Novel 7-substituted indole sulfonamide derivatives
WO2024023128A1 (en) * 2022-07-28 2024-02-01 F. Hoffmann-La Roche Ag Novel 7-substituted indole sulfonamide derivatives
WO2024104462A1 (en) * 2022-11-20 2024-05-23 Myrobalan Therapeutics Nanjing Co. Ltd Gpr17 modulators and uses thereof
WO2024153724A1 (en) 2023-01-20 2024-07-25 F. Hoffmann-La Roche Ag Novel pyrimidinyl sulfonamide derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI754702B (zh) 2016-12-28 2022-02-11 德商Ｕｃｂ製藥有限公司 （氮雜）吲哚－和苯並呋喃－３－磺醯胺類
EP3584244A1 (en) * 2018-06-20 2019-12-25 UCB Pharma GmbH Substituted alkoxypyridinyl indolsulfonamides

Also Published As

Publication number Publication date
TW202245749A (zh) 2022-12-01
US20240025883A1 (en) 2024-01-25
WO2022180136A1 (en) 2022-09-01
AR124973A1 (es) 2023-05-24
ZA202305344B (en) 2024-01-31
CR20230410A (es) 2023-09-25
CA3203282A1 (en) 2022-09-01
PE20240125A1 (es) 2024-01-22
CN116829550A (zh) 2023-09-29
KR20230152006A (ko) 2023-11-02
IL304450A (en) 2023-09-01
EP4298092A1 (en) 2024-01-03
JP2024507176A (ja) 2024-02-16
MX2023009045A (es) 2023-08-10
AU2022227183A1 (en) 2023-06-22
CO2023010212A2 (es) 2023-09-08

Similar Documents

Publication Publication Date Title
CL2023002429A1 (es) Derivados novedosos de pirimidin-2-il sulfonamida
CL2021001330A1 (es) Nuevos compuestos heterocíclicos
CO2021002382A2 (es) Nuevos compuestos heterocíclicos como inhibidores de la monoacilglicerol lipasa
CL2020003007A1 (es) Lactamas biciclicas y metodos de uso de las mismas (divisional solicitud no. 3486-2017)
CO2019009373A2 (es) Compuestos heterocíclicos útiles como inhibidores duales de atx/ca.
AR072016A1 (es) Derivados de isoxazol que funcionan como potenciadores de los receptores de glutamato
CO2018012171A2 (es) Piridinas sustituidas con heteroarilo y métodos de uso
CL2020002423A1 (es) Nuevos compuestos heterocíclicos
CO2022002000A2 (es) Nuevos inhibidores heterocíclicos de monoacilglicerol lipasa (magl)
PE20151781A1 (es) Piridonamidas como moduladores de canales de sodio
CL2023003154A1 (es) Compuestos heterocíclicos
CL2023000594A1 (es) Compuestos heterocíclicos
CO2019002692A2 (es) Nuevos derivados de isoxazolil éter como pam de gaba a alfa5.
CL2022000556A1 (es) Compuestos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inhibidores de magl
CR11220A (es) Derivados de pirimidina 934
CO2022002336A2 (es) Compuestos heterocíclicos
UY32077A (es) Inhibidores de quinasa tipo polo
CR20110381A (es) Antagonistas de 4-azetidinil-1-heteroaril-ciclohexanol de ccr2
CL2022000019A1 (es) Nuevos compuestos heterocíclicos
CO2021013166A2 (es) Compuestos de hexahidro-1h-pirazino[1,2-a]pirazina para el tratamiento de una enfermedad autoinmunitaria
CO2023016204A2 (es) Inhibidores de nlrp3
CL2020002217A1 (es) Uso de alcoxipirazoles como inhibidores de la nitrificación
CL2022002661A1 (es) Derivados de benzodiazepinas como pam de gaba a gamma1
CO2024004552A2 (es) Compuestos heteroarilo bicíclicos fusionados útiles como inhibidores de nlrp3
ECSP20080995A (es) Derivados de tetrahidrotienopiridina n–sustituidos y sus usos