ES2656793T3 - Salicilatos acetilados de ácidos grasos y sus usos - Google Patents

Salicilatos acetilados de ácidos grasos y sus usos Download PDF

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ES2656793T3
ES2656793T3 ES09790168.0T ES09790168T ES2656793T3 ES 2656793 T3 ES2656793 T3 ES 2656793T3 ES 09790168 T ES09790168 T ES 09790168T ES 2656793 T3 ES2656793 T3 ES 2656793T3
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alkyl
independently
formula
fatty acid
null
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Jill C. Milne
Michael R. Jirousek
Jean E. Bemis
Jesse J. Smith
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Astria Therapeutics Inc
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Catabasis Pharmaceuticals Inc
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un compuesto de Fórmula I,**Fórmula** 5 o una sal, un hidrato, un solvato, un enantiómero o un estereoisómero farmacéuticamente aceptables del mismo, en la que: R1, R2, R3 y R4 se seleccionan cada uno independientemente del grupo que consiste en H, Cl, F, CN, -NH(alquilo C1-C3), -N(alquilo C1-C3)2, -NH(C(O)alquilo C1-C3), -N(C(O)alquilo C1-C3)2, -C(O)H, -C(O)alquilo C1-C3, -C(O)Oalquilo C1-C3, -C(O)NH2, -C(O)NH(alquilo C1-C3), -C(O)N(alquilo C1-C3)2, -O-alquilo C1-C3, -S(O)alquilo C1-C3 y -S(O)2-alquilo C1-C3; W1 y W2 son cada uno independientemente nulos, O o NH, o cuando W1 y W2 son ambos NH, entonces tanto W1 como W2 se pueden tomar conjuntamente para formar una fracción de piperazina; - - - - - representa un enlace opcional que cuando está presente, es necesario que Q sea nulo; a y c son cada uno independientemente H, CH3, -OCH3, -OCH2CH3 o C(O)OH; b es H, CH3, C(O)OH u O-Z; d es H o C(O)OH; cada n, o, p y q es independientemente 0 o 1; cada Z es H o**Fórmula** con la condición de que al menos haya un**Fórmula** en el compuesto; cada r es independientemente 2 o 3, y cada s es independientemente 5 o 6; o cada r es independientemente 7 y cada s es independientemente 3; cada t es independientemente 0 o 1; Q es nulo, C(O)CH3, Z,

Description

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y
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En algunas realizaciones, Z es
y s es 5. En algunas realizaciones, Z es
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10 yses6. En algunas realizaciones, t es 1.
15 En otras realizaciones ilustrativas, los compuestos de Fórmula Ie son como se exponen a continuación:
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20 En otro aspecto, se describen compuestos de Fórmula If:
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Claims (1)

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