BR112012024403A2 - processo de preparo de derivados de amino-benzofurano - Google Patents

processo de preparo de derivados de amino-benzofurano

Info

Publication number
BR112012024403A2
BR112012024403A2 BR112012024403A BR112012024403A BR112012024403A2 BR 112012024403 A2 BR112012024403 A2 BR 112012024403A2 BR 112012024403 A BR112012024403 A BR 112012024403A BR 112012024403 A BR112012024403 A BR 112012024403A BR 112012024403 A2 BR112012024403 A2 BR 112012024403A2
Authority
BR
Brazil
Prior art keywords
formula
alkyl
amino
preparing
benzofuran derivatives
Prior art date
Application number
BR112012024403A
Other languages
English (en)
Inventor
Corinne Leroy
Xavier Bon
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112012024403A2 publication Critical patent/BR112012024403A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

processo de preparo de derivados de amino-benzorurano. a invenção refere-se a um processo de preparo de derivados d 5-amino-benzofurano de fórmula geral: fórmula (i), na qual r~ 1~ representa o hidrogênio ou um grupo alquila e r~ 2~, representa um grupo alquila ou dialquil amino alquila. de acordo com a invenção, os compostos de fórmula (i) são preparados, tratando-se com um ácido forte um derivado de 5-n-alquil amido-benzo-furano de fórmula geral: fórmual (ii), na qua r~ 1~ e r~ 2~ têm a mesma significação que anteriormente e r~ 3~ representa um grupo alquila, para formar um sal de adição de ácido do composto de fórmula (i), sal que é ele próprio tratado, se necessário, com um agente básico para formar esse composto de fórmula (i) sob a forma de base livre.
BR112012024403A 2010-04-01 2011-03-31 processo de preparo de derivados de amino-benzofurano BR112012024403A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1052481A FR2958291B1 (fr) 2010-04-01 2010-04-01 Procede de preparation de derives d'amino-benzofurane
PCT/FR2011/050726 WO2011121245A1 (fr) 2010-04-01 2011-03-31 Procédé de préparation de dérivés d'amino-benzofurane

Publications (1)

Publication Number Publication Date
BR112012024403A2 true BR112012024403A2 (pt) 2015-09-15

Family

ID=42941896

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012024403A BR112012024403A2 (pt) 2010-04-01 2011-03-31 processo de preparo de derivados de amino-benzofurano

Country Status (14)

Country Link
US (1) US8686180B2 (pt)
EP (1) EP2552900A1 (pt)
JP (1) JP2013523700A (pt)
KR (1) KR20130021359A (pt)
CN (1) CN102906081A (pt)
AU (1) AU2011234294A1 (pt)
BR (1) BR112012024403A2 (pt)
CA (1) CA2794648A1 (pt)
FR (1) FR2958291B1 (pt)
IL (1) IL222290A0 (pt)
MX (1) MX2012011413A (pt)
RU (1) RU2012146522A (pt)
SG (1) SG184370A1 (pt)
WO (1) WO2011121245A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2957079B1 (fr) 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction
CN109438403A (zh) * 2018-12-28 2019-03-08 凯瑞斯德生化(苏州)有限公司 一种5-氨基苯并呋喃-2-甲酸乙酯的制备方法
CN114539193A (zh) * 2022-01-20 2022-05-27 海南普利制药股份有限公司 一种盐酸胺碘酮中间体的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666931A (en) * 1984-12-29 1987-05-19 Kaken Pharmaceutical Co., Ltd. Benzofuran derivatives useful in treating diabetic complications
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
FR2817864B1 (fr) 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
FR2817865B1 (fr) 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
IL146389A0 (en) * 2001-11-08 2002-07-25 Isp Finetech Ltd Process for the preparation of dronedarone
UY32657A (es) 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para la fabricación de productos intermedios de dronedarona
TW201107303A (en) 2009-05-27 2011-03-01 Sanofi Aventis Process for the production of benzofurans
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2957079B1 (fr) 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
FR2973027A1 (fr) 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100166A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound
WO2013014479A1 (en) 2011-07-26 2013-01-31 Sanofi Reductive animation process for preparation of dronedarone using aldehyde intermediary compound
WO2013014478A1 (en) 2011-07-26 2013-01-31 Sanofi Reductive amination process for preparation of dronedarone using carboxyl intermediary compound
WO2013014480A1 (en) 2011-07-26 2013-01-31 Sanofi Process for preparation of dronedarone using amide intermediary compound

Also Published As

Publication number Publication date
IL222290A0 (en) 2012-12-31
MX2012011413A (es) 2012-11-23
AU2011234294A1 (en) 2012-11-08
US20130023677A1 (en) 2013-01-24
RU2012146522A (ru) 2014-05-10
US8686180B2 (en) 2014-04-01
FR2958291B1 (fr) 2013-07-05
SG184370A1 (en) 2012-11-29
FR2958291A1 (fr) 2011-10-07
JP2013523700A (ja) 2013-06-17
KR20130021359A (ko) 2013-03-05
EP2552900A1 (fr) 2013-02-06
CA2794648A1 (fr) 2011-10-06
WO2011121245A1 (fr) 2011-10-06
CN102906081A (zh) 2013-01-30

Similar Documents

Publication Publication Date Title
BR112012024403A2 (pt) processo de preparo de derivados de amino-benzofurano
BR112012019762A2 (pt) composto, composição, e, método para tratar uma doença.
BR112018076600A2 (pt) processo para a preparação de derivado de piridona policíclica substituída e cristal do mesmo
BR112013001335A2 (pt) processo de preparo de derivados de amino-benzoil-benzofurano
BRPI0516911A (pt) método para a preparação de um composto e composto de anilina
BR112015008037A2 (pt) compostos, processo para a preparação de um composto, composição farmacêutica, utilização do composto, método para o tratamento do câncer e invenção
BR112012028637A2 (pt) composição de gasolina, pacote de aditivo, uso de aditivo e método
BRPI0708685B8 (pt) composto de 4-oxoquinolina, seu uso e método para produção dos mesmos
BRPI1009333B8 (pt) compostos inibidores de beta-secretase, seus usos, bem como composição farmacêutica
CO6382110A2 (es) Compuestos para el tratamiento de la hepatitis c.
AR079205A1 (es) Morfolinotiazoles como moduladores alostericos positivos alfa 7
BRPI0813284A8 (pt) Processo para a preparação de um composto da fórmula (i) e composto
EA201690879A1 (ru) Новое триазолопиридиновое соединение
BRPI0911404A2 (pt) Derivados de pirano, sua preparação e uso dos mesmos em perfumaria
BR112012032251A2 (pt) processo para a preparação de derivados da 2, 2-difluoroetilamina pela alquilação com 2,2 difluoroetil-1-haloetanos
NZ605010A (en) Novel calcium salts of compound as anti-inflammatory, immunomodulatory and anti-proliferatory agents
BR112014018636A8 (pt) Derivados de benzil sulfonamida úteis como inibidores de mogat-2
CO6230986A2 (es) Compuesto de 4-piridinona y su uso para cancer
DE602006008962D1 (de) Verfahren zur herstellung von valsartan
MA32721B1 (fr) Composition pharmaceutique solide
BR112012031314A2 (pt) "processo de preparo de compostos esteramidas"
BR112018069712A2 (pt) composto ou um sal farmacologicamente aceitável do mesmo, composição farmacêutica, método para administração de uma quantidade eficaz de uma composição farmacêutica, e, inibidor de tnf-a.
BRPI1014802B8 (pt) profármacos de triptolida.
BR112013028598A2 (pt) método para promover o crescimento de plantas
EA201290872A1 (ru) Способ получения бензоксаборолов

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.